Article
Immunology
Nina Vindegaard, Liselotte Petersen, Bodil Ingrid Lyng-Rasmussen, Soren Dalsgaard, Michael Eriksen Benros
Summary: Infectious mononucleosis is associated with a 40% increased risk of subsequent depression, especially in the periods one to four years and five years after diagnosis, with no differences according to age or sex.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Biochemistry & Molecular Biology
Emilio-Manuel Paez-Guillan, Joaquin Campos-Franco, Rosario Alende, Yago Garitaonaindia, Arturo Gonzalez-Quintela
Summary: This study found that patients with infectious mononucleosis often exhibit mild, transient hypertriglyceridemia during the acute phase, which decreases during convalescence and is lower than the initial measurement in a majority of cases. It was also observed that older patients are more likely to have hypertriglyceridemia than younger patients, and there is a significant correlation between triglyceride levels and white blood cell counts, total cholesterol levels, and liver damage markers. Further research is needed to understand the mechanisms behind these findings.
LIPIDS IN HEALTH AND DISEASE
(2021)
Article
Multidisciplinary Sciences
Sipang Pangprasertkul, Chinnuwat Sanguansermsri, Tavitiya Sudjaritruk
Summary: Epstein-Barr virus (EBV) usually causes mild infections in young children, but it can also lead to neurological problems. We describe a case of a 2-year-old girl with EBV meningoencephalitis who recovered well with proper treatment.
Article
Medicine, General & Internal
Emilio-Manuel Paez-Guillan, Joaquin Campos-Franco, Rosario Alende, Hector Lazare, Carmen Beceiro, Arturo Gonzalez-Quintela
Summary: This study aimed to investigate serum bilirubin concentrations in patients with infectious mononucleosis and immune abnormalities associated with jaundice. The results showed that 15.1% of patients had serum bilirubin concentrations between 1.5 and 3 mg/dL, and 12.0% had serum bilirubin > 3 mg/dL. Patients with increased bilirubin concentrations had a distinct clinical presentation and higher levels of immune activation markers.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2023)
Article
Hematology
Hannes Vietzen, Philippe L. Furlano, Jan J. Cornelissen, Georg A. Boehmig, Peter Jaksch, Elisabeth Puchhammer-Stoeckl
Summary: This study found that nonclassic human leukocyte antigen E (HLA-E)-restricted immune responses have a significant impact on the development of Epstein-Barr virus (EBV) diseases in the individual host. The highly expressed HLA-E*0103/0103 genotype is protective against infectious mononucleosis (IM) by inducing potent EBV BZLF1-specific HLA-E-restricted CD8(+) T-cell responses. Variations in the inhibitory NKG2A/LMP-1/HLA-E axis are associated with the risk of symptomatic EBV reactivations in both immunocompetent individuals and immunocompromised transplant recipients.
Article
Multidisciplinary Sciences
Yangcan Ming, Shengnan Cheng, Zhixin Chen, Wen Su, Shuangyan Lu, Na Wang, Huifu Xu, Lizhe Zhang, Jing Yu, Jianqiao Tang
Summary: This study retrospectively analyzed the pathogens and features of infectious mononucleosis (IM) in children admitted to Wuhan Children's Hospital from 2013 to 2022. The results showed that Epstein-Barr virus (EBV) was the main pathogen, followed by Mycoplasma pneumoniae and cytomegalovirus. Evaluation of blood biomarkers and myocardial damage markers can help physicians take preventive actions to avoid serious complications in children with IM.
Article
Virology
Zhuo Li, Xin Wang, Fahong Jing, Jian Zhou, Yang Han
Summary: This study explored the application value of two laboratory tests in diagnosing EBV-IM in children. The combination of EBV-DNA, EBV-CA IgM, and low-affinity EBV-CA IgG testing showed the highest diagnostic efficacy with a sensitivity of 100% and specificity of 89.8%. The combined immunofluorescence and real-time PCR methods have high sensitivity and specificity in the clinical diagnosis of EBV-IM.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Virology
Ting Shi, Linlin Huang, Ling Luo, Qiuyao Yu, Jianmei Tian
Summary: In this study, it was found that plasma EBV-DNA test has a higher diagnostic value than VCA-IgG avidity test in different age stages and over the course of the disease. Peripheral lymphocyte test and plasma EBV-DNA test are suitable for the early stage of the disease, while the VCA-IgG avidity test is suitable for after 7 days of the disease.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Oncology
Christoph Roderburg, Sarah Krieg, Andreas Krieg, Tom Luedde, Karel Kostev, Sven H. Loosen
Summary: Patients with infectious mononucleosis have a higher incidence of certain types of cancer, especially tumors of the hematopoietic and lymphoid tissues. The study findings support the role of EBV in the development of different malignancies.
Article
Microbiology
Snjezana Zidovec-Lepej, Margarita Batovic, Marija Rozman, Kristian Bodulic, Laura Prtoric, Ante Sokota, Andrea Nikcevic, Petra Simicic, Goran Tesovic
Summary: Through analysis of 73 patients with infectious mononucleosis (IM), it was found that EBV type 1 was predominant and there was a limited repertoire of LMP1 variants, with some patients having multiple LMP1 variants. Co-infections with different LMP1 variants were associated with increased levels of C-reactive protein and decreased neutrophil and platelet counts.
Article
Pediatrics
Xiaoqing Yang, Baohua Lin, Tong Shen
Summary: The aim of this study was to understand the renal damage and clinical features of pediatric patients with acute Epstein-Barr virus (EBV) infection. A total of 41 out of 548 enrolled patients showed renal damage, mainly manifested as hematuria, proteinuria, edema, and hypertension. Compared to the non-renal damage group, patients in the renal damage group had longer fever durations, higher blood EBV-DNA loads, and lower blood CD4(+)/CD8(+) T lymphocyte ratios.
FRONTIERS IN PEDIATRICS
(2023)
Article
Immunology
Zhicheng Ye, Luxi Chen, Huaqing Zhong, Lingfeng Cao, Pan Fu, Jin Xu
Summary: This study investigated the epidemiology and infectious characteristics of Epstein-Barr virus (EBV) infection among children in Shanghai, China from 2017 to 2022. The results showed that EBV was prevalent among children, and coinfection with bacteria or other viruses increased the viral loads of EBV. The primary EBV-related diseases were systemic lupus erythematosus (SLE), immunodeficiency, and infectious mononucleosis (IM).
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Clinical Neurology
Klaus Rostgaard, Nete Munk Nielsen, Mads Melbye, Morten Frisch, Henrik Hjalgrim
Summary: Epstein-Barr virus infection is a prerequisite for the development of multiple sclerosis, particularly delayed infections. Siblings provide protection against infectious mononucleosis by occasionally preventing delayed primary Epstein-Barr virus infection. The age difference between siblings determines the level of protection, with closer age gaps providing higher protection.
Article
Pediatrics
Yunyun Zhang, Chengrong Huang, Hao Zhang, Zhi Duan, Qian Liu, Jianfei Li, Qiyin Zong, Yu Wei, Futing Liu, Wanlu Duan, Liwen Chen, Qiang Zhou, Qin Wang
Summary: This study assessed the immune events and laboratory indicators of EBV infection, as well as the clinical usefulness of evaluating AIM patients. Children with AIM showed specific changes in the immune environment, including increased CD8(+) T cells and decreased CD4(+) T cells and B cells. CD8(+) T cells exhibited reduced CD62L expression and increased PD-1 and CTLA-4 expression. During the convalescent phase, CD8(+) T cell frequency and CD62L expression on T cells were restored. Additionally, AST level, CD8(+) T cell number, and CD62L expression on T cells may serve as markers for IM severity and antiviral treatment effectiveness.
FRONTIERS IN PEDIATRICS
(2023)
Article
Immunology
Borre Fevang, Vegard Bruun Bratholm Wyller, Tom Eirik Mollnes, Maria Pedersen, Tarjei Torre Asprusten, Annika Michelsen, Thor Ueland, Kari Otterdal
Summary: The CEBA project followed 200 adolescents with infectious mononucleosis, finding that patients developing chronic fatigue syndrome showed signs of T-cell activation and low-grade chronic inflammation at baseline and after 6 months.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Infectious Diseases
Marta Hernandez-Garcia, Maria Garcia-Castillo, Sergio Garcia-Fernandez, Jose Melo-Cristino, Margarida F. Pinto, Elsa Goncalves, Valquiria Alves, Ana Raquel Vieira, Elmano Ramalheira, Luisa Sancho, Jose Diogo, Rui Ferreira, Tania Silva, Catarina Chaves, German Bou, Emilia Cercenado, Mercedes Delgado-Valverde, Antonio Oliver, Cristina Pitart, Jesus Rodriguez-Lozano, Nuria Tormo, Joao Romano, Leonor Passaro, Laura Paixao, Diego Lopez-Mendoza, Jazmin Diaz-Reganon, Rafael Canton
Summary: The study analyzed ceftolozane/tazobactam-susceptible or -resistant Pseudomonas aeruginosa clinical isolates from surveillance studies in Portugal and Spain. The most frequent MDR/XDR P. aeruginosa clones causing infections in Portuguese and Spanish ICU patients were found to be GES-13-CC235 and VIM type-CC175, respectively. Ceftolozane/tazobactam resistance was mainly due to carbapenemase production, although mutations in PBP-encoding genes may additionally be involved.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Infectious Diseases
Felipe Fernandez-Cuenca, Inmaculada Lopez-Hernandez, Emilia Cercenado, Carmen Conejo, Nuria Tormo, Concha Gimeno, Alvaro Pascual
Summary: The study evaluated the proficiency of microbiology laboratories in Spain in antimicrobial susceptibility testing of Staphylococcus spp. It found discrepancies and errors, particularly with gradient diffusion, EUCAST breakpoints, and certain antimicrobials, highlighting the need for improvement.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Letter
Infectious Diseases
Juan Vicente Mulet-Bayona, Carme Salvador-Garcia, Nuria Tormo-Palop, Concepcion Gimeno-Cardona
ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
(2022)
Article
Microbiology
Marta Hernandez-Garcia, Maria Garcia-Castillo, Patricia Ruiz-Garbajosa, German Bou, Maria Siller-Ruiz, Cristina Pitart, Irene Gracia-Ahufinger, Xavier Mulet, Alvaro Pascual, Nuria Tormo, Rafael Canton
Summary: This study evaluated the activity of cefepime-taniborbactam against carbapenemase-producing bacteria and found it to be effective against both Enterobacterales and Pseudomonas species.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Infectious Diseases
Felipe Fernandez-Cuenca, Inmaculada Lopez-Hernandez, Emilia Cercenado, Maria Carmen Conejo, Nuria Tormo, Concepcion Gimeno, Alvaro Pascual
Summary: The ability of Spanish microbiology laboratories to determine antimicrobial susceptibility and correctly detect vancomycin resistance in VRE was evaluated. Most laboratories showed reliable determination of antimicrobial susceptibility, but there were significant issues in interpreting teicoplanin susceptibility in VanB phenotype isolates.
ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
(2023)
Article
Infectious Diseases
Nuria Tormo, Estela Gimenez, Maria Martinez-Navarro, Eliseo Albert, David Navalpotro, Ignacio Torres, Concepcion Gimeno, David Navarro
Summary: This study compared an in-house-developed flow cytometry assay with a commercially-available cytokine release assay for detecting SARS-CoV-2-Spike (S)-reactive-IFN-gamma-producing T cells after COVID-19 vaccination. The results showed significant discordant qualitative results between the two assays, suggesting that the flow cytometry assay is more sensitive than the cytokine release assay.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Jorge Arca-Suarez, Bruno K. Rodino-Janeiro, Astrid Perez, Paula Guijarro-Sanchez, Juan C. Vazquez-Ucha, Fernando Cruz, Jessica Gomez-Garrido, Tyler S. Alioto, Miguel Alvarez-Tejado, Marta Gut, Ivo Gut, Marina Oviano, Alejandro Beceiro, German Bou
Summary: This study investigated the prevalence, resistance mechanisms, molecular epidemiology, and genetic support of 16S rRNA methyltransferases (RMTs) in carbapenemase-producing Enterobacterales (CPE) isolates from Spain. The findings show an emerging trend of RMTs among clinical CPE isolates, posing a threat to the clinical utility of aminoglycosides and plazomicin.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Article
Infectious Diseases
Nuria Tormo, David Navalpotro, Maria Martinez-Serrano, Marta Moreno, Fernando Grosson, Irene Tur, Maria Remedios Guna, Pepa Soriano, Ana Tornero, Concepcion Gimeno
Summary: In this study, we analyzed the immunological response during vaccination and found that individuals previously infected by SARS-CoV-2 showed significant immune response after the first vaccine dose, while those who were not infected showed lower response after each dose. Older individuals who were infected responded better to the vaccine, while younger uninfected individuals had the best response. Therefore, the second vaccine dose may not be necessary for individuals with previous COVID-19 infection, and QuantiFERON (R) can be a useful method for monitoring SARS-CoV-2 cellular immunity.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2022)
Article
Microbiology
Juan Vicente Mulet Bayona, Carme Salvador Garcia, Nuria Tormo Palop, Amparo Valentin Martin, Carmelo Gonzalez Padron, Javier Colomina Rodriguez, Javier Peman, Concepcion Gimeno Cardona
Summary: The CHROMagar(TM) Candida Plus (CC-Plus) medium is able to rapidly identify most clinical Candida species and differentiate C. auris. A multicentric study demonstrated that CC-Plus performed well in detecting C. auris and other clinically relevant Candida species in surveillance and environmental cultures.
Article
Infectious Diseases
Marta Hernandez-Garcia, Maria Garcia-Castillo, Jose Melo-Cristino, Margarida F. Pinto, Elsa Goncalves, Valquiria Alves, Ana Raquel Vieira, Elmano Ramalheira, Luisa Sancho, Jose Diogo, Rui Ferreira, Hugo Cruz, Catarina Chaves, German Bou, Emilia Cercenado, Mercedes Delgado-Valverde, Antonio Oliver, Cristina Pitart, Jesus Rodriguez-Lozano, Nuria Tormo, Jazmin Diaz-Reganon, Leonor Passaro, Joana Duarte, Rafael Canton
Summary: This study analyzed the in vitro activity and resistance mechanisms of imipenem/relebactam in Pseudomonas aeruginosa isolates from Portugal and Spain. The results showed that imipenem/relebactam displayed comparable activity to other comparators and had a relatively low resistance rate. Different genetic structures and carbapenemase gene distributions were found in isolates from the two countries.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Infectious Diseases
Andrea Sanchez-Serrano, Neris Garcia-Gonzalez, Daniel Bonillo, Paula Ruiz-Hueso, Rebeca Villanova, Israel Campo-Bes, Nuria Tormo, Carme Salvador, Concepcion Gimeno, Fernando Gonzalez-Candelas
Summary: In this study, 190 MRSA isolates obtained at a hospital in Spain from 2013 to 2018 were analyzed using multiple typing methods, revealing a decrease in the frequency of MRSA isolates but a high level of antimicrobial resistance. The study highlights the importance of epidemiological surveillance for this pathogen.
MICROBIAL DRUG RESISTANCE
(2022)
Article
Microbiology
Marta Hernandez-Garcia, Maria Garcia-Castillo, German Bou, Emilia Cercenado, Mercedes Delgado-Valverde, Antonio Oliver, Cristina Pitart, Jesus Rodriguez-Lozano, Nuria Tormo, Jose Melo-Cristino, Margarida F. Pinto, Elsa Goncalves, Valquiria Alves, Ana Raquel Vieira, Elmano Ramalheira, Luisa Sancho, Jose Diogo, Rui Ferreira, Hugo Cruz, Catarina Chaves, Joana Duarte, Leonor Passaro, Jazmin Diaz-Reganon, Rafael Canton
Summary: This study evaluated the in vitro activity of imipenem-relebactam and comparators against Enterobacterales clinical isolates and found that imipenem-relebactam showed excellent activity against extended-spectrum beta-lactamase and carbapenemase-producing isolates, with low resistance rates in multidrug-resistant strains.
MICROBIOLOGY SPECTRUM
(2022)
Article
Microbiology
Neris Garcia-Gonzalez, Beatriz Beamud, Begona Fuster, Salvador Giner, Maria Victoria Dominguez, Antonia Sanchez, Jordi Sevilla, Teresa M. Coque, Concepcion Gimeno, Fernando Gonzalez-Candelas
Summary: At a time when antimicrobial resistance has become one of the biggest concerns worldwide, the emergence of novel alleles and extremely drug-resistant plasmids is a threat to public health worldwide, especially when they produce carbapenem resistance in one of the most problematic pathogens, such as Klebsiella pneumoniae. We used genomic epidemiology to describe the emergence of a novel NDM-23 allele and identify it in a MDR plasmid that has disseminated through a K. pneumoniae ST437 clone in several hospitals in Spain.
MICROBIOLOGY SPECTRUM
(2023)
Article
Genetics & Heredity
Neris Garcia-Gonzalez, Begona Fuster, Nuria Tormo, Carme Salvador, Concepcion Gimeno, Fernando Gonzalez-Candelas
Summary: This study investigated the emergence and spread of carbapenem-resistant Klebsiella pneumoniae in a Spanish hospital from 2015 to 2019. The results showed a complex situation with six different lineages, various resistance genes, and different plasmids involved.
MICROBIAL GENOMICS
(2023)
Article
Dermatology
Juan Vicente Mulet Bayona, Nuria Tormo Palop, Carme Salvador Garcia, Maria del Remedio Guna Serrano, Concepcion Gimeno Cardona
Summary: This study evaluated an outbreak of Candida auris in a hospital setting over a 4-year period. The study identified risk factors for developing candidemia in previously colonised patients and evaluated the treatment and outcomes of both candidemia and colonisation cases. The study also assessed the susceptibility of C. auris isolates to antifungal drugs.
