Article
Multidisciplinary Sciences
Erola Ainsua-Enrich, Nuria Pedreno-Lopez, Carmen Bracke, Carlos Avila-Nieto, Maria Luisa Rodriguez de la Concepcion, Edwards Pradenas, Benjamin Trinite, Silvia Marfil, Cristina Miranda, Sandra Gonzalez, Ruth Toledo, Marta Font, Susana Benet, Tuixent Escriba, Esther Jimenez-Moyano, Ruth Pena, Samandhy Cedeno, Julia G. Prado, Beatriz Mothe, Christian Brander, Nuria Izquierdo-Useros, Julia Vergara-Alert, Joaquim Segales, Marta Massanella, Rosa Maria Benitez, Alba Romero, Daniel Molina-Morant, Julia Blanco, Bonaventur Clotet, Lourdes Mateu, Maria Luisa Pedro-Botet, Jorge Carrillo
Summary: Mass vaccination campaigns have been effective in reducing COVID-19 transmission and severity. However, the immune responses developed in patients with predominantly antibody-deficiencies (PAD) after vaccination vary. Different PAD patients show different levels of response to the vaccine, highlighting the need for immunomonitoring and personalized therapeutic strategies.
Article
Multidisciplinary Sciences
Bukola Adeoye, Lydia Nakiyingi, Yvetane Moreau, Ethel Nankya, Alex J. Olson, Mo Zhang, Karen R. Jacobson, Amita Gupta, Yukari C. Manabe, Mina C. Hosseinipour, Johnstone Kumwenda, Manish Sagar
Summary: HIV infection is commonly seen in individuals infected with Mycobacterium tuberculosis (Mtb). Inflammation caused by Mtb disease could affect immune responses to HIV in these individuals. Our research reveals that HIV antibodies are broader and more potent in individuals with co-existing Mtb disease compared to those without. We speculate that the co-localization of Mtb and HIV in lymphatic tissues leads to the emergence of these potent HIV antibodies.
Article
Microbiology
Wilfried Posch, Marta Bermejo-Jambrina, Marion Steger, Christina Witting, Gabriel Diem, Paul Hoertnagl, Hubert Hackl, Cornelia Lass-Floerl, Lukas A. Huber, Teunis B. H. Geijtenbeek, Doris Wilflingseder
Summary: Complement-opsonized HIV-1 triggers efficient antiviral responses in dendritic cells by activating multiple signaling pathways. Complement plays a crucial role in inducing effective antiviral immune responses by preventing HIV-1 suppressive mechanisms and activating specific cytosolic sensors.
Article
Chemistry, Multidisciplinary
Mohammad Murshid Alam, Cassie M. Jarvis, Robert Hincapie, Craig S. McKay, Jiri Schimer, Carlos A. Sanhueza, Ke Xu, Roger C. Diehl, M. G. Finn, Laura L. Kiessling
Summary: DC surface lectins recognize glycans not typically present on host tissue to facilitate antigen uptake and presentation. Signal transduction through DC-SIGN depends on the ligand displayed on the VLP, promoting DC maturation and induction of a T(H)1-type immune response.
Review
Immunology
Edgar Angelats, Pere Santamaria
Summary: TR1 cells are an immunosuppressive T cell subset that produces high levels of IL-10. Recent studies suggest that TR1 cells have potential therapeutic applications in immune-mediated diseases. However, the developmental biology of TR1 cells remains unclear.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biology
Mie Kobayashi-Ishihara, Katarina Frazao Smutna, Florencia E. Alonso, Jordi Argilaguet, Anna Esteve-Codina, Kerstin Geiger, Meritxell Genesca, Judith Grau-Exposito, Clara Duran-Castells, Selina Rogenmoser, Rene Boettcher, Jennifer Jungfleisch, Baldomero Oliva, Javier P. Martinez, Manqing Li, Michael David, Makoto Yamagishi, Marta Ruiz-Riol, Christian Brander, Yasuko Tsunetsugu-Yokota, Maria J. Buzon, Juana Diez, Andreas Meyerhans
Summary: In cell lines and HIV-1 patient PBMCs, the Schlafen 12 protein (SLFN12) is shown to be an HIV-1 restriction factor that inhibits HIV-1 replication and virus reactivation. SLFN12 establishes a post-transcriptional block in HIV-1-infected cells, dependent on the HIV-1 codon usage and its RNase active sites. SLFN12 expression in PBMCs of HIV-1-infected individuals correlates with viral loads.
COMMUNICATIONS BIOLOGY
(2023)
Article
Immunology
Long Liu, Cheng-Jie Deng, Ya-Li Duan, Chen-Jun Ye, Dao-Hua Gong, Xiao-Long Guo, Wen-Hui Lee, Jumin Zhou, Sheng-An Li, Yun Zhang
Summary: The study demonstrates that a toxin aerolysin-like protein and trefoil factor complex (βγ-CAT) from the frog Bombina maxima can directly block enveloped virus invasion by interfering with cytoplasmic entry, particularly inhibiting HSV-1 infection. βγ-CAT induces pore formation on the HSV-1 envelope, hindering viral entry into host cells and providing a potential antiviral strategy.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Virology
Jinlin Wang, Tao Shu, Weiqi Deng, Yali Zheng, Min Liao, Xianmiao Ye, Lujie Han, Ping He, Xuehua Zheng, Ting Li, Ying Feng, Fengyu Hu, Pingchao Li, Caijun Sun, Ling Chen, Feng Li, Liqiang Feng
Summary: A replication-competent IAV vector expressing the HIV-1 p24 gene was successfully generated and shown to elicit HIV-specific immune responses. The vector exhibited attenuated pathogenicity in mice and induced robust and long-lasting immune responses systemically and in mucosal sites.
JOURNAL OF VIROLOGY
(2021)
Article
Microbiology
Zheng Qu, Yanping Fu, Yang Lin, Zhenzhen Zhao, Xuekun Zhang, Jiasen Cheng, Jiatao Xie, Tao Chen, Bo Li, Daohong Jiang
Summary: This study revealed that infection by SsHADV-1 caused differential expression of 3110 genes in S. sclerotiorum, with 1741 up-regulated and 1369 down-regulated. Pathways such as DNA replication, DNA damage response, carbohydrate and lipid metabolism, ribosomal assembly, and translation were affected upon infection. Furthermore, SsHADV-1 infection suppressed the expression of antiviral RNA silencing and virulence factor genes.
Article
Microbiology
Balaji Olety, Yoshiko Usami, Yuanfei Wu, Paul Peters, Heinrich Gottlinger, Stephen P. Goff
Summary: The HIV-1 Nef protein downregulates the viral receptor CD4 and the antiviral proteins SERINC3 and SERINC5. In the absence of SERINC3 and SERINC5, Nef is no longer required for viral infectivity and replication in Jurkat Tag T cells, but remains crucial for HIV-1 replication in MOLT-3 cells. The Nef-mediated enhancement of HIV-1 replication in MOLT-3 cells is independent of the Nef-interacting kinases LCK and PAK2.
Article
Immunology
Michael Quinn, Luis Parra-Rodriguez, Wafaa B. Alsoussi, Chapelle Ayres, Michael K. Klebert, Chang Liu, Teresa Suessen, Suzanne M. Scheaffer, William D. Middleton, Sharlene A. Teefey, William G. Powderly, Michael S. Diamond, Rachel M. Presti, Ali H. Ellebedy, Jackson S. Turner, Jane A. O'Halloran, Philip A. Mudd
Summary: COVID-19 has a greater impact on people with HIV in areas with limited access to vaccines. HIV patients show impaired immune responses to some vaccines, possibly due to abnormal lymph node structure.
JOURNAL OF IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Vipin Bhardwaj, Aman Singh, Aditi Choudhary, Rishikesh Dalavi, Lalchhanhima Ralte, Richard L. Chawngthu, Nachimuthu Senthil Kumar, Nagarjun Vijay, Ajit Chande
Summary: HIV-1 infection induces the expression of ciTRAN, which interacts with SRSF1 to promote viral transcription. Additionally, an SRSF1-inspired mimic can inhibit viral transcription.
Article
Cell Biology
Hannah L. Itell, Daryl Humes, Julie Overbaugh
Summary: This study identifies new ISGs that inhibit HIV and confirms the role of certain factors in IFN restriction in T cells. The findings demonstrate the multifaceted nature of IFN restriction against HIV and establish a screening model for identifying HIV-restricting ISGs.
Article
Multidisciplinary Sciences
Nora-Guadalupe P. Ramirez, Jeon Lee, Yue Zheng, Lianbo Li, Bryce Dennis, Didi Chen, Ashwini Challa, Vicente Planelles, Kenneth D. Westover, Neal M. Alto, Ivan D'Orso
Summary: This study revealed an undescribed modulator, ADAP1, that influences the fate of HIV-1 provirus. The experimental results showed that ADAP1 can enhance T cell signaling and facilitate the escape of latent HIV-1 by activating the ERK-AP-1 axis.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Benjamin D. Hobson, Adrien T. Stanley, Mark B. De Los Santos, Bruce Culbertson, Eugene Mosharov, Peter A. Sims, David Sulzer
Summary: Dysregulated inflammation in the CNS contributes to neuropathology, and the expression of MHC proteins in the CNS is normally very low. However, IFN-gamma can induce the expression of MHC-I and related genes in microglia, astrocytes, oligodendrocytes, and various types of neurons in vivo. Neurons respond to IFN-gamma through cell-autonomous IFNGR signaling, although their expression level is lower compared to other CNS cell types.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Oncology
Sami Antoun, Emilie Lanoy, Samy Ammari, Siham Farhane, Lisa Martin, Caroline Robert, David Planchard, Emilie Routier, Anne Laure Voisin, Sabine Messayke, Stephane Champiat, Jean Marie Michot, Salim Laghouati, Olivier Lambotte, Aurelien Marabelle, Vickie Baracos
Summary: The association between high body mass index (BMI) and longer survival in patients on immune checkpoint inhibitors (ICIs) is inconsistent. This study found that the 'obesity paradox' disappeared when accounting for confounders such as cancer type and manifestations of depletion. Weight loss and reduced skeletal muscle mass were observed in patients across all BMI categories, and weight loss was associated with shorter survival in both melanoma and non-small cell lung cancer (NSCLC) patients.
EUROPEAN JOURNAL OF CANCER
(2023)
Editorial Material
Biochemistry & Molecular Biology
Nicholas Dopkins, Douglas F. Nixon
Summary: A new study by Yoh et al. revealed that the host factor PQBP1 enhances immune recognition of retroviral DNA by recruiting the cytosolic DNA scavenger cGAS to the HIV-1 capsid, leading to the production of interferons. These findings highlight the significance of innate immune sensing in HIV-1 infection.
TRENDS IN MICROBIOLOGY
(2023)
Article
Oncology
Luc Ollivier, Charles Orione, Paul Bore, Laurent Misery, Delphine Legoupil, Jean-Christophe Leclere, Anne Coste, Gilles Girault, Iona Sicard-Cras, Clemence Kacperek, Francois Lucia, Dinu Stefan, Francois Thillays, Emmanuel Rio, Paul Lesueur, Christian Berthou, Dominique Heymann, Stephane Champiat, Stephane Supiot, Loig Vaugier
Summary: This retrospective study investigated the incidence of abscopal response (AR) in patients with metastatic melanoma who received palliative radiotherapy. The study found that AR is highly prognostic of overall survival, although it is a rare phenomenon. Multiple concurrent treatments with radiotherapy and immunotherapy, as well as acute inflammatory events such as infection, may promote AR.
Article
Oncology
Maud Velev, Barouyr Baroudjian, Roxane Pruvost, Eleonora De Martin, Ariane Laparra, Samy Babai, Sandra Teysseire, Francois-Xavier Danlos, Laurence Albiges, Charlotte Bernigaud, Marc-Antoine Benderra, Pauline Pradere, Mohamad Zaidan, Chantal Decroisette, Fatma Fallah, Gaelle Matergia, Pernelle Lavaud, Helene Jantzem, Marina Atzenhoffer, Veronique Buyse, Samy Ammari, Caroline Robert, Stephane Champiat, Sabine Messayke, Aurelien Marabelle, Catherine Guettier, Celeste Lebbe, Olivier Lambotte, Jean-Marie Michot
Summary: This study investigated the frequency, clinical and pathological characteristics, and patient outcomes of immune-related generalised oedema (ir-GE) associated with immune checkpoint inhibitors (ICPIs). The results show that ir-GE is a rare but life-threatening adverse event that can be caused by ICPIs. The pathophysiology of ir-GE may be related to endothelial dysfunctions.
EUROPEAN JOURNAL OF CANCER
(2023)
Review
Neurosciences
Teresa H. Evering, Jez L. Marston, Li Gan, Douglas F. Nixon
Summary: Alzheimer's disease (AD) is characterized by the accumulation of amyloid beta (A beta) plaques and hyperphosphorylated tau, which trigger the abnormal transcription of transposable elements (TE) by microglia and astrocytes. This forum presents new data linking dysregulated TE expression to AD pathogenesis.
TRENDS IN NEUROSCIENCES
(2023)
Article
Microbiology
Nicholas Dopkins, Bhavya Singh, Stephanie Michael, Morgan M. O'Mara, Jez L. Marston, Tongyi Fei, Matthew L. Bendall, Douglas F. Nixon
Summary: Transposable elements (TEs) are mobile genomic sequences that constitute a significant portion of the human genome. They can be induced by immunostimulatory cues and play a role in host-microbiota interaction. This study demonstrates that toll-like receptor activation alters the expression of retrotransposons and that reverse transcriptase inhibitor delivery can ameliorate the inflammatory response.
Article
Oncology
Francois-Xavier Danlos, Matthieu Texier, Bastien Job, Severine Mouraud, Lydie Cassard, Capucine Baldini, Andrea Varga, Andrey A. Yurchenko, Audrey Rabeau, Stephane Champiat, Diane Letourneur, Delphine Bredel, Sandrine Susini, Yuna Blum, Aurelien Parpaleix, Cedric Parlavecchio, Lambros Tselikas, Jean-Eudes Fahrner, Anne-Gaelle Goubet, Mathieu Rouanne, Saloomeh Rafie, Alae Abbassi, Ines Kasraoui, Marie Breckler, Siham Farhane, Samy Ammari, Salim Laghouati, Anas Gazzah, Ludovic Lacroix, Benjamin Besse, Nathalie Droin, Marc Deloger, Sophie Cotteret, Julien Adam, Laurence Zitvogel, Sergey I. Nikolaev, Nathalie Chaput, Christophe Massard, Jean-Charles Soria, Carlos Gomez-Roca, Gerard Zalcman, David Planchard, Aurelien Marabelle
Summary: Recent research has shown that cancer immunotherapy combinations can improve the overall survival of advanced mesotheliomas, especially for patients who respond to the treatments. This study aimed to understand the biological factors that contribute to the primary resistance of mesotheliomas to immunotherapy and antiangiogenics. The combination of pembrolizumab and nintedanib was tested in thirty patients with advanced malignant pleural mesothelioma, and it was observed that refractory patients recruited cytotoxic T cells in their tumors but had high levels of somatic copy-number alterations and proinflammatory cytokines.
Article
Oncology
Jarushka Naidoo, Catherine Murphy, Michael B. Atkins, Julie R. Brahmer, Stephane Champiat, David Feltquate, Lee M. Krug, Javid Moslehi, M. Catherine Pietanza, Joanne Riemer, Caroline Robert, Elad Sharon, Maria E. Suarez-Almazor, Karthik Suresh, Michelle Turner, Jeffrey Weber, Laura C. Cappelli
Summary: Immune checkpoint inhibitor (ICI) therapy can lead to immune-related adverse events (irAEs) that vary in their clinical presentation, making it challenging to apply clinical guidelines due to inconsistent terminology. A consensus panel composed of international experts developed clinical definitions for irAE terminology to establish a standardized vocabulary and improve the uniform application of guidelines and future clinical trials.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Sophie Postel-Vinay, Vincent K. Lam, Willeke Ros, Todd M. Bauer, Aaron R. Hansen, Daniel C. Cho, F. Stephen Hodi, Jan H. M. Schellens, Jennifer K. Litton, Sandrine Aspeslagh, Karen A. Autio, Frans L. Opdam, Meredith McKean, Neeta Somaiah, Stephane Champiat, Mehmet Altan, Anna Spreafico, Osama Rahma, Elaine M. Paul, Christoph M. Ahlers, Helen Zhou, Herbert Struemper, Shelby A. Gorman, Maura Watmuff, Kaitlin M. Yablonski, Niranjan Yanamandra, Michael J. Chisamore, Emmett Schmidt, Axel Hoos, Aurelien Marabelle, Jeffrey S. Weber, John Heymach
Summary: The ENGAGE-1 study evaluated the use of GSK3174998, an OX40 agonistic monoclonal antibody, alone or in combination with pembrolizumab in patients with advanced solid tumors. The combination therapy demonstrated good safety and tolerability, but limited clinical activity, suggesting that further development may not be warranted.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Review
Cell Biology
Nicholas Dopkins, Douglas F. Nixon
Summary: This review discusses the importance of human endogenous retroviruses (HERVs), how they have influenced human evolution and physiology, and how they are regulated. It has been found that these viruses play a crucial role in human health, but their study is still underrepresented.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2023)
Article
Virology
Danielle E. Lyons, Priti Kumar, Nadia R. Roan, Patricia A. Defechereux, Cedric Feschotte, Ulrike C. Lange, Niren Murthy, Pauline Sameshima, Eric Verdin, Julie A. Ake, Matthew S. Parsons, Avindra Nath, Sara Gianella, Davey M. Smith, Esper G. Kallas, Thomas J. Villa, Richard Strange, Betty Mwesigwa, Robert L. Furler O'Brien, Douglas F. Nixon, Lishomwa C. Ndhlovu, Susana T. Valente, Melanie Ott
Summary: This article proposes a novel approach to cure HIV-1 infection by silencing viral expression for long-term control without antiretroviral therapy. The approach is based on research into HIV-1 latency mechanisms, lessons from latency reversing agents, and knowledge of retroviral evolution. Insights from elite controllers and advanced genome engineering technologies offer potential routes to a rapid cure for HIV-1.
Article
Multidisciplinary Sciences
Daniel B. Reeves, Charline Bacchus-Souffan, Mark Fitch, Mohamed Abdel-Mohsen, Rebecca Hoh, Haelee Ahn, Mars Stone, Frederick Hecht, Jeffrey Martin, Steven G. Deeks, Marc K. Hellerstein, Joseph M. McCune, Joshua T. Schiffer, Peter W. Hunt
Summary: The persistence of HIV in people on suppressive antiretroviral therapy is linked to physiological mechanisms of CD4+ T cells. This study investigates the longitudinal kinetics of HIV DNA and cell turnover rates in different CD4 cell subsets. The results indicate that HIV clears faster in more proliferative/differentiated CD4 cell subsets and therapies targeting proliferation and differentiation may reduce HIV DNA levels.
NATURE COMMUNICATIONS
(2023)
Article
Infectious Diseases
Wania Ferraz Pereira-Manfro, Giselle Pereira da Silva, Priscilla Ramos Costa, Dayane Alves Costa, Bianca da Silva Ferreira, Daniela Mena Barreto, Ana Cristina Cisne Frota, Cristina Barroso Hofer, Esper Georges Kallas, Lucimar Goncalves Milagres
Summary: This study investigated immune exhaustion and senescence in pediatric patients with HIV. Flow cytometry was used to examine the activation/exhaustion and senescent phenotype of CD8 T cells in these patients, revealing higher frequencies of TIGIT+, PD-1+, or CD57+ CD8 T cells in untreated patients compared to treated patients or uninfected individuals. CD8 T cells co-expressing CD38/HLA-DR/TIGIT or CD38/HLA-DR/PD-1 were also more prevalent in untreated patients. Additionally, the expression of CD38/DR/TIGIT or CD38/DR/PD-1 on CD8 T cells was inversely associated with the CD4/CD8 ratio and positively correlated with viral load.
REVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO
(2023)
Meeting Abstract
Oncology
Johann De Bono, Stephane Champiat, Francois-Xavier Danlos, Martin Wermke, Volker Kunzmann, Aude de Gassart, Emmanuel Valentin, Marina Iche, Maelle Mairesse, Patrick Brune, Daniel Olive, Paul Frohna
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Meeting Abstract
Oncology
Stephane Champiat, Aurelien Marabelle, Diwakar Davar, Peter Grell, Kaissa Ouali, Anna Patrikidou, Andreu Schoenenberger, Lenka Palova Jelinkova, Irena Adkins, Sascha Tillmanns, Joachim Kiemle-Kallee, Richard Sachse, Elena Garralda
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
