Article
Medicine, General & Internal
Hoa Le Mai, Nicolas Degauque, Sabine Le Bot, Marie Rimbert, Karine Renaudin, Richard Danger, Florent Le Borgne, Clarisse Kerleau, Gaelle Tilly, Anais Vivet, Florent Delbos, Alexandre Walencik, Magali Giral, Sophie Brouard
Summary: The study found that the percentage and absolute number of CD28-CD8+ T cells were significantly increased in kidney transplant patients with antibody-mediated rejection (ABMR). Moreover, CD28-CD8+ T cells from patients with ABMR showed a more rigorous response to stimulation compared to their CD28+ counterparts. These findings suggest that differentiated CD28-CD8+ T cells, with increased frequency, number, and function, may play a role in the pathobiology of ABMR.
Article
Immunology
Rosa Sottile, M. Kazim Panjwani, Colleen M. Lau, Anthony F. Daniyan, Kento Tanaka, Juliet N. Barker, Renier J. Brentjens, Joseph C. Sun, Jean-Benoit Le Luduec, Katharine C. Hsu
Summary: CD8(+) T cells expressing NKG2C exhibit properties of both innate and adaptive immunity, with a strong effector function against leukemia cells and HCMV-infected fibroblasts. These cells do not up-regulate PD-1 even with persistent activation, suggesting a potential for cellular therapy including CAR T cell-based therapies.
SCIENCE IMMUNOLOGY
(2021)
Article
Hematology
Yu Akahoshi, Shun-Ichi Kimura, Yuma Tada, Toshihiro Matsukawa, Masaharu Tamaki, Noriko Doki, Naoyuki Uchida, Masatsugu Tanaka, Hirohisa Nakamae, Takuro Kuriyama, Ken-Ichi Matsuoka, Takashi Ikeda, Takafumi Kimura, Takahiro Fukuda, Yoshinobu Kanda, Yoshiko Atsuta, Makoto Murata, Seitaro Terakura, Hideki Nakasone
Summary: CMV gastroenteritis is a life-threatening complication after allogeneic hematopoietic cell transplantation. The incidence of CMV gastroenteritis is influenced by factors such as advanced age, GVHD prophylaxis, lower-gut aGVHD, and the use of systemic steroids. Development of CMV gastroenteritis is associated with an increased risk of nonrelapse mortality. Letermovir prophylaxis can significantly reduce the incidence of CMV gastroenteritis and the risk of nonrelapse mortality.
Article
Multidisciplinary Sciences
Yujie Ren, An Wang, Bowen Zhang, Wenting Ji, Xiao-Xu Zhu, Jing Lou, Muhan Huang, Yang Qiu, Xi Zhou
Summary: UL36 encoded by human cytomegalovirus not only inhibits apoptosis but also suppresses immune signaling by targeting IRF3 directly. Although UL36-mediated inhibition of apoptosis enhances immune signaling, its immunosuppressive activity counterbalances this effect.
Article
Immunology
Mostafa G. G. Aly, Eman H. H. Ibrahim, Hristos Karakizlis, Rolf Weimer, Gerhard Opelz, Christian Morath, Martin Zeier, Naruemol Ekpoom, Volker Daniel
Summary: In this study, the relationship between regulatory cells and immunosuppressive drugs in transplant recipients was investigated. The results showed a negative correlation between CD4+CD25+CD127-Foxp3+ Tregs and CD19+IL-10+ Bregs in early transplant recipients, with Tregs being affected by steroid dose and tacrolimus levels, while Bregs seemed less affected by potent immunosuppression. It was also found that CD4+CD25+CD127-Foxp3+ Tregs were lower in patients treated with certain antibodies compared to end-stage kidney disease patients. Early transplant recipients exhibited different patterns of Tregs and Bregs within the first 3 months post-transplant, indicating a complex relationship between these regulatory cells and immunosuppression.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Virology
K. Yeon Choi, Nadia El-Hamdi, Julia Hornig, Alistair McGregor
Summary: Research shows that GP83 plays an important role in guinea pig cytomegalovirus, particularly in infecting nonfibroblast cells, and is crucial in innate immune evasion. Although GP83 can induce a cellular-mediated response, its efficacy in providing cross-strain protection is limited.
JOURNAL OF VIROLOGY
(2021)
Article
Clinical Neurology
Melanie Eschborn, Marc Pawlitzki, Timo Wirth, Christopher Nelke, Steffen Pfeuffer, Andreas Schulte-Mecklenbeck, Lisa Lohmann, Leoni Rolfes, Katrin Pape, Maria Eveslage, Stefan Bittner, Catharina C. Gross, Tobias Ruck, Heinz Wiendl, Sven G. Meuth, Luisa Klotz
Summary: This study revealed age-related changes in immune cell composition in patients with multiple sclerosis, especially in the CD8 T-cell compartment. The expression of immunoregulatory molecules decreased with age in healthy donors but not in MS patients, while the increase in CD226 expression on memory CD8 T cells with age was absent in MS patients. This suggests a dysregulation of immune signals in MS and premature immune aging in young MS patients, with potential implications for disease severity.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2021)
Article
Immunology
Hoa Le Mai, Nicolas Degauque, Marine Lorent, Marie Rimbert, Karine Renaudin, Richard Danger, Clarisse Kerleau, Gaelle Tilly, Anais Vivet, Sabine Le Bot, Florent Delbos, Alexandre Walencik, Magali Giral, Sophie Brouard
Summary: This study found that kidney allograft rejection is associated with an imbalance between immune cells with effector/memory functions and those with regulatory properties, manifested as a decrease in the percentage of circulating B cells and an increase in the ratio of CD28-CD8+ T cells to Tregs.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Nan-Ping Weng
Summary: The aging of T cells plays a role in the increased susceptibility to diseases among older adults. To better understand T cell aging, improved measurements of age-related cellular changes in T cells are necessary. The recent development of machine learning-assisted transcriptome-based quantification of individual CD8+ T cell age is a significant step forward in this regard.
TRENDS IN IMMUNOLOGY
(2023)
Review
Immunology
Sara Hamdan, Matthias J. Reddehase, Rafaela Holtappels
Summary: Cytomegalovirus (CMV) infections have conflicting hallmarks. Immune evasion proteins raise the avidity threshold for activation, allowing only high-avidity cells to provide protection.
MEDICAL MICROBIOLOGY AND IMMUNOLOGY
(2023)
Article
Immunology
June-Young Koh, Sang-Bo Lee, Borahm Kim, Younhee Park, Jong Rak Choi, Sohee Son, Yae-Jean Kim, Seung Min Hahn, Jong Gyun Ahn, Ji-Man Kang, Eui-Cheol Shin
Summary: This study describes a patient with SCID carrying a novel IL2RG mutation associated with expanded maternal engrafted CD8(+) T cells, which were able to exert antiviral function against human cytomegalovirus infection. The findings suggest a possible functional role of maternal engraftment in controlling CMV infection in SCID patients.
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2021)
Article
Geriatrics & Gerontology
Olivia B. Parks, Taylor Eddens, Jorna Sojati, Jie Lan, Yu Zhang, Tim D. Oury, Manda Ramsey, John J. Erickson, Craig A. Byersdorfer, John V. Williams
Summary: This study reveals that CD8(+) T cell exhaustion is a mechanism of severe respiratory viral infections in the elderly. The aged mouse model of human metapneumovirus infection showed worsened symptoms, pathology, and delayed viral clearance compared to young mice. Aged CD8(+) T cells exhibited fewer virus-specific cells and functional impairment, suggesting an age-associated defect in the immune response.
Article
Multidisciplinary Sciences
Cecily Choy, Joseph Chen, Jiangyuan Li, D. Travis Gallagher, Jian Lu, Daichao Wu, Ainslee Zou, Humza Hemani, Beverly A. Baptiste, Emily Wichmann, Qian Yang, Jeffrey Ciffelo, Rui Yin, Julia Mckelvy, Denise Melvin, Tonya Wallace, Christopher Dunn, Cuong Nguyen, Chee W. Chia, Jinshui Fan, Jeannie Ruffolo, Linda Zukley, Guixin Shi, Tomokazu Amano, Yang An, Osorio Meirelles, Wells W. Wu, Chao-Kai Chou, Rong-Fong Shen, Richard A. Willis, Minoru S. H. Ko, Yu-Tsueng Liu, Supriyo De, Brian G. Pierce, Luigi Ferrucci, Josephine Egan, Roy Mariuzza, Nan-Ping Weng
Summary: This study analyzed CD8(+) T cells recognizing epitopes from the nucleocapsid protein of SARS-CoV-2 and found that SARS-CoV-2 infection increased the frequencies and proliferation of these specific T cells. The N222-230 peptide was identified as the dominant epitope eliciting the greatest proliferative response. Single-cell sequencing revealed a restricted TCR repertoire for these CD8(+) T cells. Transcriptome analysis showed increased chromatin modification and innate immune functions in non-expanders.
NATURE COMMUNICATIONS
(2023)
Review
Cardiac & Cardiovascular Systems
Tomonobu Yanase, Masaru Hatano, Chie Bujo, Masaki Tsuji, Junichi Ishida, Eisuke Amiya, Koh Okamoto, Masahiko Ando, Shogo Shimada, Osamu Kinoshita, Shuetsu Fukushi, Souichi Yamada, Minoru Ono, Issei Komuro
Summary: Currently available anti-CMV agents can have significant side effects. Letermovir, a novel drug, is approved for CMV prophylaxis in stem cell transplant recipients and has fewer side effects. We present a case of successful off-label use of letermovir to treat ganciclovir-resistant CMV colitis in a heart transplant recipient. CMV-pp65 antigenemia may be a useful marker of treatment efficacy.
INTERNATIONAL HEART JOURNAL
(2023)
Article
Cell & Tissue Engineering
Jerome Mertens, Joseph R. Herdy, Larissa Traxler, Simon T. Schafer, Johannes C. M. Schlachetzki, Lena Bohnke, Dylan A. Reid, Hyungjun Lee, Dina Zangwill, Diana P. Fernandes, Ravi K. Agarwal, Raffaella Lucciola, Lucia Zhou-Yang, Lukas Karbacher, Frank Edenhofer, Shani Stern, Steve Horvath, Apua C. M. Paquola, Christopher K. Glass, Shauna H. Yuan, Manching Ku, Attila Szucs, Lawrence S. B. Goldstein, Douglas Galasko, Fred H. Gage
Summary: Our study identifies AD-related neuronal changes as age-dependent cellular programs that impair neuronal identity.
Article
Infectious Diseases
Jose A. Perez-Molina, Rosa Polo, Jose Lopez-Aldeguer, Fernando Lozano, Koldo Aguirrebengoa, Jose Ramon Arribas, Vicente Boix, Juan Berenguer, Jose Ramon Blanco, Pere Domingo, Vicente Estrada, Maria Jose Galindo, Federico Garcia, Jose Maria Gatell, Juan Gonzalez-Garcia, Felix Gutierrez, Jose Antonio Iribarren, Hernando Knobel, Josep Maria Llibre, Juan Carlos Lopez-Bernaldo de Quiros, Luis Fernando Lopez-Cortes, Juan Emilio Losa, Ana Marino, Jose M. Miro, Maria L. Montes, Santiago Moreno, Eugenia Negredo, Maria J. Perez-Elias, Daniel Podzamczer, Joaquin Portilla, Eva Poveda, Federico Pulido, Esteban Ribera, Antonio Rivero, Rafael Rubio, Jesus Santos, Jose Sanz-Moreno, Jesus Sanz-Sanz, Sergio Serrano, Javier de la Torre, Montserrat Tuset, Miguel A. von Wichman, Esteban Martinez
ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
(2019)
Article
Infectious Diseases
Antonio Rivero-Juarez, Antonio Aguilera, Ana Avellon, Miguel Garcia-Deltoro, Federico Garcia, Christian Gortazar, Rafael Granados, Juan Macias, Nicolas Merchante, Jose Antonio Oteo, Maria Teresa Perez-Gracia, Juan Antonio Pineda, Antonio Rivero, David Rodriguez-Lazaro, Francisco Tellez, Luis E. Morano-Amado
ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
(2020)
Article
Infectious Diseases
Ignacio Garcia-Bocanegra, Antonio Rivero, Javier Caballero-Gomez, Pedro Lopez-Lopez, David Cano-Terriza, Mario Frias, Saul Jimenez-Ruiz, Maria A. Risalde, Jose C. Gomez-Villamandos, Antonio Rivero-Juarez
TRANSBOUNDARY AND EMERGING DISEASES
(2019)
Article
Gastroenterology & Hepatology
Antonio Rivero-Juarez, Maria Jarilla-Fernandez, Mario Frias, Elena Madrigal-Sanchez, Pedro Lopez-Lopez, Giselle Andujar-Troncoso, Isabel Machuca, Angela Camacho, Pilar Munoz-Valbuena, Antonio Rivero
JOURNAL OF VIRAL HEPATITIS
(2019)
Review
Oncology
Beatriz Sanchez-Correa, Nelson Lopez-Sejas, Esther Duran, Fernando Labella, Corona Alonso, Rafael Solana, Raquel Tarazona
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2019)
Article
Immunology
Ana Navas, Juan Molina, Maria-Luisa Aguera, Ipek Guler, Aurora Jurado, Alberto Rodriguez-Benoto, Corona Alonso, Rafael Solana
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Immunology
Jani-Sofia Almeida, Patricia Couceiro, Nelson Lopez-Sejas, Vera Alves, Lenka Ruzickova, Raquel Tarazona, Rafael Solana, Paulo Freitas-Tavares, Manuel Santos-Rosa, Paulo Rodrigues-Santos
FRONTIERS IN IMMUNOLOGY
(2019)
Review
Oncology
Raquel Tarazona, Nelson Lopez-Sejas, Beatriz Guerrero, Fakhri Hassouneh, Isabel Valhondo, Alejandra Pera, Beatriz Sanchez-Correa, Nieves Pastor, Esther Duran, Corona Alonso, Rafael Solana
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2020)
Article
Oncology
Isabel Valhondo, Fakhri Hassouneh, Nelson Lopez-Sejas, Alejandra Pera, Beatriz Sanchez-Correa, Beatriz Guerrero, Juan M. Bergua, Maria Jose Arcos, Helena Banas, Ignacio Casas-Aviles, Joaquin Sanchez-Garcia, Josefina Serrano, Carmen Martin, Esther Duran, Corona Alonso, Rafael Solana, Raquel Tarazona
Article
Geriatrics & Gerontology
Martina Formentini, Ana Navas, Fakhri Hassouneh, Nelson Lopez-Sejas, Corona Alonso, Raquel Tarazona, Rafael Solana, Alejandra Pera
Summary: Immunosenescence affects innate and adaptive immunity, with chronic CMV infection contributing to early immunosenescence. The markers CD57, CD300a, and CD161 define distinct T-cell subsets, showing varied functionality and molecular signatures. Different T-cell populations based on these markers have implications for disease risk in older adults.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Review
Immunology
Alexander Batista-Duharte, Alejandra Pera, Salvador F. Alino, Rafael Solana
Summary: Regulatory T cells play a crucial role in maintaining immune tolerance, but their excessive activity may reduce the effectiveness of vaccines. Increased activity of regulatory T cells in older adults may contribute to the observed lower vaccine effectiveness in this age group.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Fakhri Hassouneh, David Goldeck, Alejandra Pera, Diana van Heemst, P. Eline Slagboom, Graham Pawelec, Rafael Solana
Summary: The study revealed that CMV infection and aging impact the function and phenotype of T-cells, with CD57+ T-cells being more polyfunctional than CD57- T-cells. The expansion of cytotoxic T-cells is mainly associated with CMV infection, highlighting the significant role of CMV in driving the expansion of highly polyfunctional CD57+ T-cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Alexander Batista-Duharte, Fakhri Hassouneh, Pablo Alvarez-Heredia, Alejandra Pera, Rafael Solana
Summary: The combination of immune checkpoint inhibitors (ICIs) with vaccines has shown promise in improving vaccine immunogenicity and efficacy. Most studies have focused on anti-tumor vaccines combined with monoclonal antibodies targeting specific checkpoints. However, new strategies using ICIs as molecular adjuvants hold great potential for future advances in vaccine research.
Article
Biochemistry & Molecular Biology
Pablo Alvarez-Heredia, Jose Joaquin Dominguez-del-Castillo, Irene Reina-Alfonso, Carmen Gutierrez-Gonzalez, Fakhri Hassouneh, Alexander Batista-Duharte, Antonio Trujillo-Aguilera, Rosalia Lopez-Romero, Ignacio Munoz, Rafael Solana, Alejandra Pera
Summary: Aortic stenosis is a common cardiac disease characterized by valvular calcification, fibrosis, and inflammation. Recent studies suggest that it is an active inflammatory atherosclerotic-like process involving immune cells and persistent antigens. However, the study of calcified aortic valves has been limited by histological and immunohistochemical methods. This study presents a cytometry-based protocol that allows for the identification and quantification of inflammatory leukocytes in aortic valve explants, providing a more in-depth analysis of cell markers. This protocol can be applied to other cardiac diseases with an inflammatory component.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Sofia Carreira-Santos, Nelson Lopez-Sejas, Marina Gonzalez-Sanchez, Eva Sanchez-Hernandez, Alejandra Pera, Fakhri Hassouneh, Esther Duran, Rafael Solana, Javier G. Casado, Raquel Tarazona
Summary: This study provides a deep phenotypic characterization of in vitro-expanded CIML NK cells. Moreover, the correlations found between NK cell receptors and degranulation capacity of CIML NK cells allowed the identification of several biomarkers that could be useful in clinical settings.
FRONTIERS IN IMMUNOLOGY
(2023)