Review
Immunology
Jesus Hernandez, Yanli Li, Enric Mateu
Summary: Dendritic cells in pigs consist of three types, with different pathogens having the ability to infect these cells, especially Porcine Reproductive and Respiratory Syndrome Virus (PRRSV). Research has shown that some dendritic cells are refractory to PRRSV infection, while others may have different responses depending on the type of PRRSV involved.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Xingyu Gong, Tianyi Ma, Jingjing Wang, Xinran Cao, Qiaoya Zhang, Yanhong Wang, Chengchuang Song, Min Lai, Chunlei Zhang, Xingtang Fang, Xi Chen
Summary: This study reveals the role of the PRRSV nucleocapsid protein in modulating IL-8 production and provides insight into an additional mechanism by which PRRSV regulates immune responses and inflammation.
MICROBIAL PATHOGENESIS
(2023)
Article
Immunology
Tiphany Chrun, Emmanuel A. Maze, Eleni Vatzia, Veronica Martini, Basudev Paudyal, Matthew D. Edmans, Adam McNee, Tanuja Manjegowda, Francisco J. Salguero, Nanchaya Wanasen, Surapong Koonpaew, Simon P. Graham, Elma Tchilian
Summary: The study indicated that co-infection of PRRSV-2 and swine influenza H3N2 virus weakened the protective effect of PRRS modified live virus vaccine while enhancing antibody responses. In contrast, co-infection in non-immunized animals helped reduce viral load and potentiate T cell responses. The upregulation of inhibitory cytokines gene expression in vaccinated pigs' lungs may have influenced responses to H3N2 and PRRSV-2.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Mariana Kikuti, Catalina Picasso-Risso, Claudio Marcello Melini, Cesar A. A. Corzo
Summary: Porcine Reproductive and Respiratory Syndrome (PRRS) is a major infectious disease in U.S. swine herds, and eliminating the virus poses challenges. Only about 1/6 of breeding herds successfully eliminated PRRS and remained virus-free for an average of two years. After elimination, the average annual outbreak rate was 23%, similar to the national average of 20-25%. Further studies are needed to understand the factors influencing the decision to pursue elimination.
Review
Microbiology
Xin-xin Chen, Songlin Qiao, Rui Li, Jing Wang, Xuewu Li, Gaiping Zhang
Summary: By studying how PRRSV evades host immune responses, we can understand that the virus establishes long-term infection through various complex mechanisms, which is a major obstacle in controlling PRRS disease. Understanding the exact mechanisms of PRRSV immune evasion will contribute to the development of novel antiviral strategies.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Cell Biology
Ruifang Liu, Zidong Liu, Ming Guo, Wenxian Zeng, Yi Zheng
Summary: This study examined the expression of SETDB1 in porcine testes and found that SETDB1 is expressed in undifferentiated spermatogonia and gradually disappears as the cells differentiate. Deficiency of SETDB1 alters the cell-adhesion ability, proliferative activity, and H3K9me3 level in porcine SSCs. Additionally, MMP3/10 expression is upregulated.
Article
Immunology
Yanli Li, Enric Mateu
Summary: The study demonstrates that exposure to PRRSV1.1 isolate 3267 did not induce maturation of cDC1, cDC2, or CD14(+) DCs, but altered TLR3 and TLR7-associated responses. Infected cells led to increased expression of maturation molecules and release of cytokines by cDC2 and CD14(+) DCs.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Agriculture, Dairy & Animal Science
Qin Luo, Yajie Zheng, Hang Zhang, Zhiyu Yang, Huiyang Sha, Weili Kong, Mengmeng Zhao, Nina Wang
Summary: Research on the GP5 protein is crucial for the diagnosis, prevention, and control of porcine reproductive and respiratory syndrome virus (PRRSV). We provide a summary of its genetic variation, immunity, replication, apoptosis, virulence, and interaction with viral and host proteins, which lays a foundation for understanding PRRSV replication mechanisms and vaccine development.
Article
Biotechnology & Applied Microbiology
Junxin Gao, Yu Pan, Yunfei Xu, Wenli Zhang, Lin Zhang, Xi Li, Zhijun Tian, Hongyan Chen, Yue Wang
Summary: This study identified a total of 350 annotated lncRNAs and 1792 novel lncRNAs in PAMs through RNA-seq analysis, with 86 differentially expressed lncRNAs and 406 DE protein-coding mRNAs identified upon PRRSV incubation. GO category and KEGG pathway enrichment analyses revealed that these DE lncRNAs and mRNAs were mainly involved in inflammation- and pathogen infection-induced pathways. The co-expression analysis demonstrated that several lncRNAs are positively correlated with their predicted target genes, suggesting that porcine lncRNAs play a role in regulating immune responses against PRRSV infection.
Review
Veterinary Sciences
Dengshuai Zhao, Bo Yang, Xingguo Yuan, Chaochao Shen, Dajun Zhang, Xijuan Shi, Ting Zhang, Huimei Cui, Jinke Yang, Xuehui Chen, Yu Hao, Haixue Zheng, Keshan Zhang, Xiangtao Liu
Summary: PRRSV is a pathogen prevalent in swine-farming countries worldwide, causing a range of consequences such as persistent infection, secondary infection, and co-infection. The occurrence of coinfections with PRRSV and other pathogens in pigs has made it challenging to define and diagnose PRRSV-related diseases, highlighting the need for further research in this area.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Virology
Jia Li, Dang Wang, Puxian Fang, Yu Pang, Yanrong Zhou, Liurong Fang, Shaobo Xiao
Summary: DDX21 plays an important role in regulating PRRSV proliferation through multiple mechanisms, promoting virus replication and stabilizing the expression of interferon antagonists. Additionally, PRRSV infection enhances DDX21 expression and its nucleus-to-cytoplasm translocation.
Article
Immunology
Loic Vivien Bocard, Andrew Robert Kick, Corinne Hug, Heidi Erika Lisa Lischer, Tobias Kaser, Artur Summerfield
Summary: This study aimed to understand the nature of innate and adaptive immune responses to PRRSV, revealing differences in regulation by PRRSV-2 strains and MLV. Different PRRSV strains induced varied immune responses, impacting platelet activation, dendritic cell activity, interferon type I, and plasma cell responses. Correlations of BTMs with T-cell responses showed both positive and negative associations post-infection, indicating complexities in immune regulation.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Agriculture, Dairy & Animal Science
Hang Zhang, Huiyang Sha, Limei Qin, Nina Wang, Weili Kong, Liangzong Huang, Mengmeng Zhao
Summary: Studying the interactions between PRRSV and host proteins is crucial for understanding host defense against viral infections and the pathogenesis of viral infectious diseases.
Article
Veterinary Sciences
Giulia D'Annunzio, Fabio Ostanello, Luisa Vera Muscatello, Massimo Orioles, Niccolo Jacumin, Nicola Tommasini, Giorgio Leotti, Andrea Luppi, Luciana Mandrioli, Giuseppe Sarli
Summary: This study examines the impact of Porcine Circovirus type 2 (PCV2) and Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) on Porcine Respiratory Disease Complex (PRDC). The results show that PCV2 and PRRSV are the primary infections associated with PRDC in Italy, and co-infections can worsen the pathology. Therefore, selecting appropriate preventive measures is crucial.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Genetics & Heredity
Jianyu Fang, Hongkui Wang, Limin Lang, Haili Li, Shaoyu Li, Keling Wang
Summary: PRRSV infection activates AMPK, which can both inhibit and promote virus replication, suggesting that AMPK may be a potential target for antiviral intervention against PRRSV infection.
Article
Nanoscience & Nanotechnology
Noralvis Fleitas-Salazar, Seidy Pedroso-Santana, Erika Silva-Campa, Aracely Angulo-Molina, Jorge R. Toledo, Raul Riera, Martin Pedroza-Montero
Summary: This study addresses the limitations of SERS substrates in membrane molecule studies using Raman spectroscopy, successfully detecting membrane-associated hemoglobin in human erythrocytes. The results show that oxyRBCs incubated with AgNPs exhibit enhanced deoxyHb signals, supporting the detection of Hb(m) through deoxyHb markers.
Article
Ophthalmology
Fatima Sofia Magana-Guerrero, Diana Hinojosa Trujillo, Beatriz Buentello-Volante, Jose Eduardo Aguayo-Flores, Edgar Alonso Melgoza-Gonzalez, Jesus Hernandez, Maria C. Jimenez-Martinez, Sonia Mayra Perez-Tapia, Yonathan Garfias
Summary: During the COVID-19 pandemic, healthcare workers are at a high risk of being infected with SARS-CoV-2, especially those in ophthalmology departments. A study conducted in Mexico City found that 32% of HCWs at an Ophthalmological Reference Centre tested RT-PCR positive, with 20% presenting IgG antibodies against SARS-CoV-2. Despite the high infection rate, most HCWs showed mild symptoms, and a significant portion of RT-PCR positive participants did not show IgG antibodies.
OPHTHALMIC EPIDEMIOLOGY
(2022)
Review
Immunology
Jesus Hernandez, Yanli Li, Enric Mateu
Summary: Dendritic cells in pigs consist of three types, with different pathogens having the ability to infect these cells, especially Porcine Reproductive and Respiratory Syndrome Virus (PRRSV). Research has shown that some dendritic cells are refractory to PRRSV infection, while others may have different responses depending on the type of PRRSV involved.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Marina Arenas-Padilla, Anna Gonzalez-Rascon, Adrian Hernandez-Mendoza, Ana Maria Calderon de la Barca, Jesus Hernandez, Veronica Mata-Haro
Summary: The study analyzed the miRNA expression profile in swine monocytes exposed to Bb12 using an anti-TLR2 blocking strategy and investigated Bb12's involvement in the regulation of the TLR2 pathway. The results showed that 40 miRNAs were influenced by the treatments, with 15 differentially expressed miRNAs identified with validated interactions with proteins related to the TLR2 pathway.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2022)
Editorial Material
Infectious Diseases
Dirk Werling, Jesus Hernandez, Xiangdong Li
TRANSBOUNDARY AND EMERGING DISEASES
(2021)
Article
Infectious Diseases
Edgar A. Melgoza-Gonzalez, Diana Hinojosa-Trujillo, Monica Resendiz-Sandoval, Veronica Mata-Haro, Sofia Hernandez-Valenzuela, Melissa Garcia-Vega, Marlene Bravo-Parra, Aldo A. Arvizu-Flores, Olivia Valenzuela, Edgar Velazquez, Alan Soto-Gaxiola, Martha B. Gomez-Meza, Fernando Perez-Jacobo, Luis Villela, Jesus Hernandez
Summary: The SARS-CoV-2 virus, first detected in Wuhan, China in December 2019, has led to the rapid development of diagnostic tools, therapies, and vaccines to control COVID-19. ELISA antibody detection has been widely used to recognize infection and vaccine response. Research showed that IgG antibodies can be detected up to 42 weeks after natural infection, and that one dose of CanSinoBio vaccine induces a lower IgG antibody response compared to the complete Pfizer-BioNTech vaccine regimen.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Immunology
Edgar Alonso Melgoza-Gonzalez, Monica Resendiz-Sandoval, Diana Hinojosa-Trujillo, Sofia Hernandez-Valenzuela, Melissa Garcia-Vega, Veronica Mata-Haro, Araceli Tepale-Segura, Laura C. Bonifaz, Armando Perez-Torres, Jesus Hernandez
Summary: The research demonstrated the ability of rAb ZH9F7 to target and trigger internalization in dendritic cells, promoting their migration in vivo. The antigenized rAb ZH9F7-Cap induced a higher frequency of IFN-gamma-secreting CD4(+)CD8(+) T lymphocytes and antibodies against the Cap protein.
Article
Veterinary Sciences
Pavel Isa, Luis Felipe Paulin, Jesus Hernandez, Maricela Montalvo-Corral, Susana Lopez, Carlos F. Arias
Summary: Genetic characterization of field samples from Mexican wetlands revealed the genomics and virus circulation of influenza A viruses, highlighting the importance of further studies in this region.
VETERINARIA MEXICO
(2022)
Article
Immunology
Noe Juvenal Mendoza-Ramirez, Julio Garcia-Cordero, Sandra Paola Martinez-Frias, Daniela Roa-Velazquez, Rosendo Luria-Perez, Jose Bustos-Arriaga, Jesus Hernandez-Lopez, Carlos Cabello-Gutierrez, Joaquin Alejandro Zuniga-Ramos, Edgar Morales-Rios, Sonia Mayra Perez-Tapia, Martha Espinosa-Cantellano, Leticia Cedillo-Barron
Summary: This study analyzes the combination of two SARS-CoV-2 viral antigens and finds that immunization with a combination of S1 or RBD and the N protein can elicit a stronger immune response. The sera from immunized mice can recognize different variants of SARS-CoV-2. This study identifies potential antigens for the second generation of COVID-19 vaccines.
Article
Microbiology
Freddy Dehesa-Canseco, Roxana Pastrana-Unzueta, Nadia Carrillo-Guzman, Francisco Liljehult-Fuentes, Juan Diego Perez-De la Rosa, Humberto Ramirez-Mendoza, Jose Guillermo Estrada-Franco, Roberto Navarro-Lopez, Jesus Hernandez, Mario Solis-Hernandez
Summary: This study aimed to evaluate the seroprevalence of neutralizing antibodies against the ancestral strain and the Omicron BA.1 subvariant in dogs and cats in Mexico. The results showed that 14.2% of cats and 1.5% of dogs presented nAbs against the ancestral strain of SARS-CoV-2, while a lower proportion had nAbs against Omicron BA.1.
Article
Nursing
Maria Josse Navarro-Ibarra, Maria del Socorro Saucedo-Tamayo, Heliodoro Aleman-Mateo, Hector Parra-Sanchez, Paola Othon-Ontiveros, Jesus Hernandez, Graciela Caire-Juvera
Summary: This study found that body fat percentage and fat mass index were positively associated with C-reactive protein (CRP) levels in female breast cancer survivors, while appendicular skeletal lean mass index (ASMI) decreased as CRP levels increased. Interleukin 6 (IL-6) was positively associated with fat mass index. Interventions to improve body composition in breast cancer survivors should consider the role of inflammatory markers to avoid sarcopenic obesity and the risk of recurrence.
BIOLOGICAL RESEARCH FOR NURSING
(2023)
Article
Multidisciplinary Sciences
Tania Lucia Madrigal-Valencia, Manuel Saavedra-Montanez, Armando Perez-Torres, Jesus Hernandez, Joaquim Segales, Yesmin Dominguez Hernandez, Irma Eugenia Candanosa-Aranda, Alfredo Perez-Guiot, Humberto Ramirez-Mendoza
Summary: This study describes an outbreak of sheep-associated malignant catarrhal fever (SA-MCF) caused by OvHV-2 in Mexico. The virus was identified using various methods and observed in primary rabbit testis cultures. It is also the first report of OvHV-2 presence in horses and Artiodactyla buffy coats in Mexico.
Letter
Biochemistry & Molecular Biology
Jesus Hernandez, Freddy Dehesa-Canseco, Alma B. Vazquez-Lopez, Monica Resendiz-Sandoval, Graciela Caire-Juvera, Mario Solis-Hernandez, Olivia Valenzuela, Bruno Gomez-Gil, Veronica Mata-Haro
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Virology
Monica Resendiz-Sandoval, Veronica A. Vazquez-Garcia, Kenneth Contreras-Vega, Edgar A. Melgoza-Gonzalez, Veronica Mata-Haro, Luis Gimenez-Lirola, Jesus Hernandez
Summary: This study investigated the presence of PCV3 in samples collected in Mexico and found that PCV3 has been circulating in the region since 2008. The virus has a higher prevalence in pigs with clinical manifestations of diseases.
Article
Agriculture, Dairy & Animal Science
Maritza Cordero-Ortiz, Monica Resendiz-Sandoval, Freddy Dehesa-Canseco, Mario Solis-Hernandez, Jahir Perez-Sanchez, Carlos Martinez-Borges, Veronica Mata-Haro, Jesus Hernandez
Summary: Summary: This study aimed to develop a double-antigen sandwich enzyme-linked immunosorbent assay (ELISA) to detect SARS-CoV-2 antibodies in serum samples from various animal species. The results showed that this assay was able to detect antibodies against SARS-CoV-2 in serum samples from cats, dogs, guinea pigs, rats, tigers, and humans.
