期刊
CLINICAL AND VACCINE IMMUNOLOGY
卷 15, 期 8, 页码 1282-1291出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/CVI.00044-08
关键词
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资金
- Bill and Melinda Gates Foundation [IPTi03-0]
- Banco de Bilbao, Vizcaya, Argentaria Foundation [BBVA 02-0]
- WHO/TDR [OD/TS-0700017]
- Spanish Agency for International Cooperation
We evaluated the impact of intermittent preventive treatment in infants (IPTi) with sulfadoxine-pyrimethamine (SP), which was given at ages 3, 4, and 9 months through the Expanded Program on Immunization (EPI), on the development of antibody responses to Plasmodium falciparum in Mozambique. Immunoglobulin M (IgM) and IgG subclass antibodies specific to whole asexual parasites and to recombinant MSP-1(19), AMA-1, and EBA-175 were measured at ages 5, 9, 12, and 24 months for 302 children by immunofluorescence antibody tests and by enzyme-linked immunosorbent assays. Antibody responses did not significantly differ between children receiving IPTi with SP and those receiving a placebo at any time point measured, with the exception of the responses of IgG and IgG1 to AMA-1 and/or MSP-119, which were significantly higher in the SP-treated group than in the placebo group at ages 5, 9, and/or 24 months. IPTi with SP given through the EPI reduces the frequency of malarial illness while allowing the development of naturally acquired antibody responses to P. falciparum antigens.
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