期刊
CLINICAL AND VACCINE IMMUNOLOGY
卷 15, 期 9, 页码 1429-1435出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/CVI.00169-08
关键词
-
资金
- National Institute of Allergy and Infectious Diseases [R01 AI055652]
- Fundacion Alfonso Martin Escudero, Spain
- [R44 AI058364]
- [R43 AI074092]
- [R43 AI072810]
Mucosal immunization is advantageous over other routes of antigen delivery because it can induce both mucosal and systemic immune responses. Our goal was to develop a mucosal delivery vehicle based on bacteria generally regarded as safe, such as Lactobacillus spp. In this study, we used the Lyme disease mouse model as a proof of concept. We demonstrate that an oral vaccine based on live recombinant Lactobacillus plantarum protects mice from tick-transmitted Borrelia burgdorferi infection. Our method of expressing vaccine antigens in L. plantarum induces both systemic and mucosal immunity after oral administration. This platform technology can be applied to design oral vaccine delivery vehicles against several microbial pathogens.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据