期刊
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
卷 40, 期 4, 页码 282-288出版社
WILEY
DOI: 10.1111/1440-1681.12063
关键词
insulin resistance; non-alcoholic fatty liver disease; osteocalcin
资金
- National Natural Science Foundation of China [81170788]
- 973 Program of China [2012CB524906]
- National Key Technology R&D Program of China [2012BAI02B03]
- Special Scientific Research Fund of Medicine Sanitary [201002002]
The present study was designed to investigate the relationship between serum osteocalcin levels and non-alcoholic fatty liver disease (NAFLD) in Chinese men. In all, 1558 men (2178years old) were recruited to the study. Serum osteocalcin, glucose and lipid profiles were determined. Demographic and clinical characteristics were recorded. All participants underwent hepatic ultrasonographic examination. Serum osteocalcin levels were significantly lower in subjects with NAFLD than those without (P<0.01). All study subjects were divided into four subgroups according to quartiles of serum osteocalcin levels. The frequency of NAFLD increased progressively with declining serum osteocalcin levels (Ptrend<0.01). Serum osteocalcin levels were inversely correlated with NAFLD (P<0.01). However, the significant association between serum osteocalcin levels and NAFLD disappeared in logistic regression analyses. Furthermore, multiple stepwise regression analysis showed that serum osteocalcin levels were independently associated with serum alanine aminotransferase levels in Chinese men (P<0.01). The findings of the present study suggest that serum osteocalcin levels are not directly correlated with NAFLD.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据