Article
Cardiac & Cardiovascular Systems
R. M. Bell, M. Basalay, H. E. Botker, S. Beikoghli Kalkhoran, R. D. Carr, J. Cunningham, S. M. Davidson, T. J. England, S. Giesz, A. K. Ghosh, P. Golforoush, A. V. Gourine, D. J. Hausenloy, G. Heusch, B. Ibanez, P. Kleinbongard, S. Lecour, K. Lukhna, M. Ntsekhe, M. Ntsekhe, M. Ovize, A. D. Salama, G. Vilahur, J. M. Walker, D. M. Yellon
Summary: The Hatter Cardiovascular Institute biennial workshop focused on the future of Remote Ischaemic Conditioning (RIC), discussing the mechanisms of conditioning, the disconnect between preclinical and clinical studies, and the potential applications of RIC in other diseases. The workshop proposed specific classifications to identify responders and non-responders.
BASIC RESEARCH IN CARDIOLOGY
(2022)
Review
Respiratory System
Dimitrios Vlastos, Mohamed Zeinah, George Ninkovic-Hall, Stefanos Vlachos, Agni Salem, Athanasios Asonitis, Hemangi Chavan, Lazaros Kalampalikis, Abdullah Al Shammari, Jose Maria Alvarez Gallesio, Aina Pons, Ioanna Andreadou, Ignatios Ikonomidis
Summary: This article provides a narrative review of the existing experimental and clinical evidence regarding the effects of ischemic conditioning on lung ischemia-reperfusion injury (LIRI) and prompts further investigation to refine its clinical application.
RESPIRATORY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Gino A. Kurian, Mahalakshmi Ansari, Priyanka N. Prem
Summary: This study investigates the effectiveness of post-conditioning (POC) in protecting the diabetic heart with myopathy (DCM) against I/R injury. The results indicate that POC failed to recover cardiac dysfunction in DCM, and this failure is related to mitochondrial dysfunction.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Cardiac & Cardiovascular Systems
Hiran A. Prag, Anja Gruszczyk, Margaret M. Huang, Timothy E. Beach, Timothy Young, Laura Tronci, Efterpi Nikitopoulou, John F. Mulvey, Raimondo Ascione, Anna Hadjihambi, Michael J. Shattock, Luc Pellerin, Kourosh Saeb-Parsy, Christian Frezza, Andrew M. James, Thomas Krieg, Michael P. Murphy, Dunja Aksentijevic
Summary: Release of accumulated succinate in the ischaemic heart upon reperfusion is mediated by MCT1 and is facilitated by acidification of the myocardium during ischaemia.
CARDIOVASCULAR RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Petra Kleinbongard, Helmut Lieder, Andreas Skyschally, Gerd Heusch
Summary: This study compared the infarct size in female, castrated male, and male pigs undergoing ischemia/reperfusion (I/R) and ischemic preconditioning (IPC). The results showed no sex- or castration-related differences in infarct size, coronary microvascular injury, and cardioprotection by IPC.
CARDIOVASCULAR RESEARCH
(2023)
Article
Cell Biology
Qingtong Zhang, Jiangwen Yin, Feng Xu, Jingwen Zhai, Jieting Yin, Mingyue Ge, Wenyi Zhou, Nian Li, Xinlei Qin, Yan Li, Sheng Wang
Summary: MEF2D is involved in neuroprotection after cerebral ischaemia/reperfusion injury, and post-conditioning with ISO promotes ERK5 phosphorylation, enhances MEF2D transcriptional activity, inhibits caspase-3 expression, and plays a role in brain protection.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Helmut Raphael Lieder, Felix Braczko, Nilgun Gedik, Merlin Stroetges, Gerd Heusch, Petra Kleinbongard
Summary: The study investigated the impact of T3 on infarct size and its underlying signal transduction, finding that T3 reduces infarct size during reperfusion by activating the RISK pathway.
BASIC RESEARCH IN CARDIOLOGY
(2021)
Article
Cell Biology
Liqun Jia, Ling Yang, Yikui Tian, Lieming Yang, Dawei Wu, Hao Zhang, Mingbiao Li, Naishi Wu
Summary: This research focused on the effect of Nrf2 in the treatment of myocardial ischaemia-reperfusion injury (MIRI) through mitochondrial transplantation. The study found that exogenous mitochondria can be internalized into cardiomyocytes and activate the Nrf2 pathway, leading to improved cardiac function and alleviated mitochondrial dysfunction.
CELLULAR SIGNALLING
(2022)
Article
Cardiac & Cardiovascular Systems
Zongyi Xia, Bing Chen, Chi Zhou, Yitian Wang, Jinyang Ren, Xujin Yao, Yifan Yang, Qi Wan, Zhexun Lian
Summary: The combination therapy of I-Post and nicorandil shows a significant reduction in myocardial injury in diabetic heart subjected to I/R, providing important clinical implications considering the high sensitivity of diabetic heart to I/R injury.
BMC CARDIOVASCULAR DISORDERS
(2022)
Article
Urology & Nephrology
Alexis Piedrafita, Stephane Balayssac, Nicolas Mayeur, Stephane Gazut, Julia Grossac, Marie Buleon, Melinda Alves, Julie Klein, Vincent Minville, Bertrand Marcheix, Joost P. Schanstra, Stanislas Faguer
Summary: The study found a significant decrease in tryptophan and kynurenin in AKI patients, but NAM supplementation did not have a significant effect on improving kidney outcomes.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Kishal Lukhna, Derek J. Hausenloy, Abdelbagi Sidahmed Ali, Abdullah Bajaber, Alistair Calver, Arthur Mutyaba, Awad Abdalla Mohamed, Brian Kiggundu, Chishala Chishala, Ebrahim Variava, Ehab Ali Elmakki, Elijah Ogola, Eltayeb Hamid, Emmy Okello, Isam Gaafar, Keiran Mwazo, Makoali Makotoko, Mergan Naidoo, Mohamed Elhadi Abdelhameed, Motasim Badri, Nasief van der Schyff, Omaima Abozaid, Paul Xafis, Sara Giesz, Trevor Gould, Waldo Welgemoed, Malcolm Walker, Mpiko Ntsekhe, Derek M. Yellon
Summary: Despite evidence of myocardial infarct size reduction in animal studies, remote ischaemic conditioning (RIC) failed to improve clinical outcomes in the large CONDI-2/ERIC-PPCI trial. The RIC-AFRICA trial aims to investigate whether RIC can improve clinical outcomes in higher-risk STEMI patients in environments with limited access to early reperfusion or PPCI.
CARDIOVASCULAR DRUGS AND THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Yongliang Hua, Yanan Xu, Xinglong Li, Bing Yin, Shounan Lu, Chaoqun Wang, Shanjia Ke, Baolin Qian, Hongjun Yu, Miaoyu Bai, Yong Ma
Summary: The aim of this study was to investigate the protective mechanisms of ischaemic preconditioning (IPC) against ischaemia-reperfusion (I/R) injury and explore the role of long non-coding RNAs (lncRNAs). The results showed that IPC improved liver damage by reducing liver transaminase levels and pro-inflammatory cytokines. Gene ontology and pathway analyses revealed that the differentially expressed genes (DEGs) were mainly associated with protein folding and metabolism. Additionally, several DEGs were validated using the lncRNA-mRNA weighted coexpression network.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Immunology
Qian Xia, Shuai Gao, Tangrui Han, Meng Mao, Gaofeng Zhan, Yonghong Wang, Xing Li
Summary: This study reveals that SIRT5 expression in microglia is increased in the early phase of ischaemic stroke. SIRT5 interacts with and desuccinylates ANXA1, resulting in the inhibition of its membrane recruitment and extracellular secretion, leading to hyperactivation of microglia and excessive inflammatory response, ultimately causing neuronal cell damage.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Biochemistry & Molecular Biology
Kayleigh Griffiths, Tomoaki Ida, Masanobu Morita, Reece J. Lamb, Jordan J. Lee, Michael P. Frenneaux, Jon M. Fukuto, Takaaki Akaike, Martin Feelisch, Melanie Madhani
Summary: Earlier studies have shown that CysSSH, a sulfur-containing compound, has antioxidant and oxidant properties and can mitigate oxidative stress. However, its role in myocardial IRI was not understood. This study investigated the production and consumption of CysSSH in the heart under normoxic and hypoxic conditions and found that exogenous administration of Cys-SSS-Cys can rescue the heart from injury and improve cardiac function.
Article
Endocrinology & Metabolism
Yi-Na Zhang, Ying-Jie Dai, Yu Cui, Qiong Wu, Nan-Nan Zhang, Hui-Sheng Chen
Summary: This study aimed to investigate whether diabetes and fasting blood glucose (FBG) levels affect the efficacy of remote ischaemic conditioning (RIC) in acute moderate ischaemic stroke. The results showed that diabetes and high FBG levels were associated with functional outcomes, but did not influence the neuroprotective effect of RIC.
DIABETES OBESITY & METABOLISM
(2023)