Article
Multidisciplinary Sciences
Eyerus Gesesse, Sofonias Addis Fekadu, Gizachew Tilahun Belete
Summary: The study found that 43.9% of adult patients attending the University of Gondar Comprehensive and Specialized Hospital were willing to donate their corneas. Factors positively associated with willingness to donate included Christian religious beliefs and good knowledge about corneal donation, while being above the age of 43 was negatively associated with willingness to donate.
Article
Engineering, Biomedical
Shibu Chameettachal, Animith Venuganti, Yash Parekh, Deeksha Prasad, Vineet P. Joshi, Anviti Vashishtha, Sayan Basu, Vivek Singh, Kiran Kumar Bokara, Falguni Pati
Summary: Corneal scarring and opacification are a major cause of blindness worldwide. This study demonstrates the potential clinical application of a human corneal extracellular matrix hydrogel in preventing scar formation and opacification after corneal injury.
ACTA BIOMATERIALIA
(2023)
Article
Chemistry, Multidisciplinary
M. Y. Thanuja, Suraksha S. Tellakula, Samarth V. Suryavanshi, G. S. Keerthana, S. Chandan Vasudev, Sudhir H. Ranganath
Summary: The use of fusogenic liposome-coated nanoparticles allows for efficient and rapid internalization into donor corneal endothelial cells and tissue, reducing damage caused by hypothermia and cytokine stress. This technology has the potential to facilitate prophylactic drug delivery during storage and transplantation.
NANOSCALE ADVANCES
(2023)
Review
Medicine, General & Internal
Jay Thakkar, Sandhya Jeria, Aditi Thakkar
Summary: The COVID-19 pandemic has had a significant impact on corneal transplantation, leading to a need for reevaluation of storage techniques and consideration of potential vaccine-related graft rejection.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Review
Medicine, General & Internal
Morteza Mousavi, Nicolas Kahuam-Lopez, Alfonso Iovieno, Sonia N. Yeung
Summary: The purpose of this study is to review the available literature on the impact of the COVID-19 pandemic on corneal transplantation and eye banking. The study found that donor tissue volumes decreased globally during lockdown periods and rates of elective surgeries also decreased. The effect on different types of corneal grafts varied depending on region-specific factors.
FRONTIERS IN MEDICINE
(2023)
Review
Infectious Diseases
Yi-Tian Fu, Chaoqun Yao, Yuan-Ping Deng, Hany M. Elsheikha, Renfu Shao, Xing-Quan Zhu, Guo-Hua Liu
Summary: This review summarizes the biology, epidemiology, diagnosis, and control of human lice infestation, as well as the latest advances in molecular taxonomy and genetics of lice. Lice infestation is a global public health issue affecting millions of people. In addition to directly impacting human health, lice can also act as vectors for disease-causing pathogens. The use of insecticides is crucial for treatment and prevention. Genome sequencing has provided insights into the genetic structure and evolution of human lice.
INFECTIOUS DISEASES OF POVERTY
(2022)
Review
Microbiology
Jeremy J. Hoffman, Matthew J. Burton, Astrid Leck
Summary: Mycotic or fungal keratitis is a sight-threatening disease caused by infection of the cornea by filamentous fungi or yeasts. In tropical and some low-income countries, it accounts for the majority of cases of microbial keratitis. Trauma with organic plant-based material is the predominant risk factor for filamentous fungal keratitis.
Article
Biotechnology & Applied Microbiology
Mehrdad Rafat, Mahmoud Jabbarvand, Namrata Sharma, Maria Xeroudaki, Shideh Tabe, Raha Omrani, Muthukumar Thangavelu, Anthony Mukwaya, Per Fagerholm, Anton Lennikov, Farshad Askarizadeh, Neil Lagali
Summary: This study presents a cell-free engineered corneal tissue (BPCDX) and a minimally invasive surgical method for treating patients with corneal stromal disease. The results show that the implantation of BPCDX can improve corneal thickness, corneal curvature, and visual acuity, and restore vision while improving tolerance to contact lens wear.
NATURE BIOTECHNOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Kieran S. O'Brien, Raghunandan Byanju, Ram P. Kandel, Bimal Poudyal, John A. Gonzales, Travis C. Porco, John P. Whitcher, Muthiah Srinivasan, Madan Upadhyay, Thomas M. Lietman, Jeremy D. Keenan
Summary: This study aimed to evaluate whether a community-based corneal ulcer prevention program would reduce the incidence of corneal ulcers. The study found that the incidence of corneal ulcers did not decrease under the existing community program.
LANCET GLOBAL HEALTH
(2022)
Article
Ophthalmology
Parya Abdolalizadeh, Samira Chaibakhsh, Khalil Ghasemi Falavarjani
Summary: The global prevalence of distance and/or near vision impairment for children aged 1-14 in 2017 was 2.8%. The highest DALYs were observed in teenagers, with a positive correlation between DALY rate of refractive disorders and national socioeconomic development. From 1990 to 2015, DALY numbers remained stable but rates showed a significant trend of reduction in all paediatric age groups.
Review
Ophthalmology
Venugopal Anitha, Radhika Tandon, Sushmita G. Shah, Naveen Radhakrishnan, Sankalp Singh, Vanathi Murugesan, Veena Patwardhan, Meenakshi Ravindran
Summary: This article discusses the importance of eye banking in corneal transplantation and ocular research, particularly in India and global eye banking networks. The article emphasizes the challenges faced by eye banks and explores strategies to improve corneal donation rates, enhance processing techniques, and maintain high-quality standards. It highlights the potential for knowledge sharing and collaborative efforts among different regions to achieve optimal outcomes.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Cell & Tissue Engineering
Zubin Master, Kirstin R. W. Matthews, Mohamed Abou-el-Enein
Summary: The unproven stem cell intervention industry is a global health issue that requires a coordinated global approach through the establishment of a World Health Organization Expert Advisory Committee on Regenerative Medicine to address regulations, regulatory approaches, and education campaigns. Fostering international dialogues and developing recommendations that can be adopted by member states would effectively tackle the global market of unproven SCIs.
Article
Engineering, Environmental
Lisa Melymuk, Jonathan Blumenthal, Ondrej Sanka, Adriana Shu-Yin, Veena Singla, Katerina Sebkova, Kristi Pullen Fedinick, Miriam L. Diamond
Summary: The environmentally sound management (ESM) of polychlorinated biphenyls (PCBs) is a major challenge globally, with only 30% of countries on track to achieve the 2028 goal. While countries like Canada and Czechia are close to reaching the goal, the USA still faces significant inventory and reduction challenges. The failure to manage global PCB stocks after more than 30 years highlights the need to prioritize reducing production and use of other persistent organic pollutants (POPs).
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Mathematics, Applied
Louis Jeanjean, Sheng-Sen Lu
Summary: In this paper, the conditions for the existence of global minimizers of the energy functional under a given mass constraint are investigated. The properties of energy ground states and the least action solutions are derived under certain assumptions, providing a positive answer to a long-standing issue.
CALCULUS OF VARIATIONS AND PARTIAL DIFFERENTIAL EQUATIONS
(2022)
Article
Biochemistry & Molecular Biology
Wenben Chen, Ruiyang Li, Qinji Yu, Andi Xu, Yile Feng, Ruixin Wang, Lanqin Zhao, Zhenzhe Lin, Yahan Yang, Duoru Lin, Xiaohang Wu, Jingjing Chen, Zhenzhen Liu, Yuxuan Wu, Kang Dang, Kexin Qiu, Zilong Wang, Ziheng Zhou, Dong Liu, Qianni Wu, Mingyuan Li, Yifan Xiang, Xiaoyan Li, Zhuoling Lin, Danqi Zeng, Yunjian Huang, Silang Mo, Xiucheng Huang, Shulin Sun, Jianmin Hu, Jun Zhao, Meirong Wei, Shoulong Hu, Liang Chen, Bingfa Dai, Huasheng Yang, Danping Huang, Xiaoming Lin, Lingyi Liang, Xiaoyan Ding, Yangfan Yang, Pengsen Wu, Feihui Zheng, Nick Stanojcic, Ji-Peng Olivia Li, Carol Y. Cheung, Erping Long, Chuan Chen, Yi Zhu, Patrick Yu-Wai-Man, Ruixuan Wang, Wei-shi Zheng, Xiaowei Ding, Haotian Lin
Summary: Early detection of visual impairment in young children is challenging due to their limited cooperation with standard vision tests. In this study, a smartphone-based mHealth system called Apollo Infant Sight (AIS) was developed to identify visually impaired children by analyzing their gazing behaviors and facial features. The system achieved high accuracy in detecting visual impairment in both internal and external validation sets.
Article
Ophthalmology
Maria Cabrera-Aguas, Pauline Khoo, Stephanie L. Watson
Summary: This study reviewed cases of presumed microbial keratitis resulting in evisceration/enucleation in Sydney, Australia from 2012 to 2016. The results showed that elderly patients with a history of topical corticosteroid use were at higher risk, and educating them on prompt hospital presentation and treatment could decrease the probability of losing the eye.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Ophthalmology
Blanca Benito-Pascual, Himal Kandel, Marco Abbondanza, Richard Mills, Laurence Sullivan, Stephanie L. Watson
Summary: The study compared the effectiveness and safety of short and standard riboflavin induction times in cross-linking for keratoconus. The results showed that both short and standard induction times achieved similar improvements in K2 and vision after one year. However, the short induction group had greater improvements in Kmax and TCT, but also higher rates of haze.
Article
Ophthalmology
Alex C. Ferdi, Himal Kandel, Vuong Nguyen, Jeremy Tan, Francisco Arnalich-Montiel, Marco Abbondanza, Stephanie L. Watson
Summary: The long-term outcomes of epithelium-off cross-linking (CXL) in keratoconus patients were determined in this study. Most patients showed stable keratoconus up to 5 years after the CXL treatment, but a small proportion experienced reduced vision.
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Himal Kandel, Jern Yee Chen, Srujana Sahebjada, Elaine W. Chong, Steven Wiffen, Stephanie L. Watson
Summary: The purpose of this study was to evaluate the patient-reported quality-of-life outcomes after corneal cross-linking for keratoconus. The results showed that corneal cross-linking was associated with improved activity limitation, symptoms, and emotional status in keratoconus patients.
Letter
Ophthalmology
Jackie Tan, Leslie John Ray Foster, Frank James Lovicu, Stephanie Louise Watson
CURRENT EYE RESEARCH
(2023)
Review
Public, Environmental & Occupational Health
Annette K. Hoskin, Stephanie Watson, Tengku A. Kamalden
Summary: This study reviewed the literature to report the nature of badminton-related eye injuries. The results showed that from 1974 to 2020, 19 studies from 12 countries reported 378 monocular badminton-related eye injuries from 378 patients, with a male-to-female ratio of 2.5:1. A closed globe injury was the most common type of injury, with the shuttlecock being responsible for 85% of the injuries. Doubles play, the shuttlecock, and a lack of eye protection were associated with eye injuries.
Review
Biochemistry & Molecular Biology
Clarice H. Y. Yeoh, Jerome J. R. Lee, Blanche X. H. Lim, Gangadhara Sundar, Jodhbir S. Mehta, Anita S. Y. Chan, Dawn K. A. Lim, Stephanie L. Watson, Santosh G. Honavar, Ray Manotosh, Chris H. L. Lim
Summary: The rise of primary topical monotherapy with chemotherapeutic drugs and immunomodulatory agents suggests a potential shift away from surgery as the standard of care in managing ocular surface squamous neoplasia (OSSN). Currently, there is no consensus or guidelines on the best treatment approach for OSSN. This paper evaluates available treatments and proposes an algorithm to guide ophthalmologists in selecting the most appropriate treatment regime.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Ophthalmology
Emily Durakovic, Himal Kandel, Stephanie L. L. Watson
Summary: The aim of this study was to investigate the impact of keratoconus on the mental health and emotional well-being of affected patients. A literature search was conducted, and 31 articles met the inclusion criteria. Most studies reported keratoconus to have a negative effect on mental health or emotional well-being, and worsening mental health scores were correlated with various factors. Over time, mental health outcomes improved, suggesting disease stabilization and patient acceptance. Further research is needed to determine the potential benefits of routine mental health screening for patients with keratoconus.
Article
Ophthalmology
Kuniyoshi Kanai, Meredith Whiteside, Michael Wong, Tammy La, Maryam Nassiri, Sam Lee, Sze Kei Yeung, Adrienne Coulter, Mareena Roufail, Kevin Ruder, Cindi Chen, David Liu, Thomas Abraham, Armin M. Hinterwirth, Thomas Lietman, Thuy D. Doan, Gerami Seitzman
Summary: This study uses unbiased deep sequencing to identify causative pathogens of acute infectious conjunctivitis, potentially allowing for improved approaches to diagnosis and management.
OPTOMETRY AND VISION SCIENCE
(2023)
Editorial Material
Ophthalmology
Annette K. Hoskin, Stephanie L. Watson
JAMA OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Andrew Nguyen, Maria Cabrera-Aguas, Stephanie L. Watson
Summary: The aim of this study was to assess the adherence of clinicians at Sydney Eye Hospital to the evidence-based guidelines for treating herpes simplex keratitis (HSK) in order to evaluate the sustainability of guideline implementation. A retrospective review found that clinicians showed a high level of adherence to the treatment guidelines, but regular educational activities are still needed to maintain knowledge levels.
EXPERT REVIEW OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Himal Kandel, Marco Abbondanza, Aanchal Gupta, Richard Mills, Adam S. Watson, Constantinos Petsoglou, Yves Kerdraon, Stephanie L. Watson
Summary: This study compared the long-term effectiveness of standard and accelerated corneal cross-linking in stabilizing keratoconus. The results showed that standard cross-linking had better effects in improving visual acuity and keratometry.
Article
Ophthalmology
Stephanie L. Watson, Lyndon W. Jones, Fiona Stapleton, Mark Hinds, Alison Ng, Jacqueline Tan, Yair Alster, Charles Bosworth, Omer Rafaeli, CELESTIAL STUDY Grp
Summary: This study investigated the use of AZR-MD-001 0.5% as a potential treatment for Meibomian gland dysfunction (MGD). The treatment resulted in significant improvements in both the number of open glands and patient-reported ocular surface symptoms. The study focused on the changes in these outcomes before and after treatment in MGD patients.
Article
Ophthalmology
Danial Roshandel, Farbod Semnani, Amirmasoud Rayati Damavandi, Ali Masoudi, Alireza Baradaran-Rafii, Stephanie L. Watson, William H. Morgan, Samuel McLenachan
Summary: The ocular surface, consisting of the corneal and conjunctival epithelium, plays a crucial role in maintaining ocular integrity and function. Gene defects can lead to ocular surface disorders, either as congenital conditions or through the interaction of genetic and environmental factors. Advanced gene-based technologies have shown promise in disease modeling and gene therapy for monogenic ocular surface disorders. Understanding the genetic factors involved in both monogenic and multifactorial ocular surface disorders could pave the way for personalized disease models and treatment strategies.
Article
Biochemistry & Molecular Biology
Kenneth G. Ooi, Stephanie L. Watson
Summary: Posterior blepharitis and dry eye are common disorders associated with meibomian gland dysfunction (MGD). Ocular rosacea can manifest as MGD and dyslipidaemia. Treating ocular rosacea-associated dyslipidaemia and systemic inflammation may improve cardiovascular health and reduce tear film instability.
