Review
Pharmacology & Pharmacy
Urvi M. Parmar, Manjiri P. Jalgaonkar, Yogesh A. Kulkarni, Manisha J. Oza
Summary: The incidence of diabetes is increasing globally, and it is associated with hyperglycemia and disrupted metabolic pathways. Autophagy plays a crucial role in maintaining cellular homeostasis, but disrupted autophagy contributes to metabolic disorders such as obesity and diabetes. Nutrient-sensing pathways, including SIRT1, mTOR, and AMPK, regulate autophagy and they could be potential therapeutic targets for reducing diabetic complications.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Jeeyoun Jung, Woo Yeong Park, Yun Jin Kim, Mikyung Kim, Misun Choe, Kyubok Jin, Ji Hae Seo, Eunyoung Ha
Summary: This study demonstrates that 3-OHB delays the progression of diabetic nephropathy (DN) by enhancing autophagy and inhibiting oxidative stress, as observed in both in vivo and in vitro models.
Review
Pharmacology & Pharmacy
Qichao Hu, Lan Jiang, Qi Yan, Jinhao Zeng, Xiao Ma, Yanling Zhao
Summary: Diabetic nephropathy is a common complication of diabetes and a leading cause of end-stage renal disease. Despite the complex mechanisms involved, there are currently no effective therapeutic drugs other than ACEIs and ARBs. Recent studies have highlighted the multiple signaling pathways and targets involved in diabetic nephropathy, presenting an opportunity for treatment with natural products. Over the past two decades, numerous natural products have shown potential in preclinical studies and a few compounds are being investigated in clinical trials. This review focuses on the cellular and molecular mechanisms of natural products in alleviating diabetic nephropathy, providing insights for treatment and new drug development.
PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Integrative & Complementary Medicine
Qichao Hu, Caiyan Qu, Xiaolin Xiao, Wenwen Zhang, Yinxiao Jiang, Zhao Wu, Dan Song, Xi Peng, Xiao Ma, YanLing Zhao
Summary: Flavonoids, a class of active natural products with a wide range of pharmacological effects, have been found to alleviate diabetic nephropathy by regulating oxidative stress and inflammation. The review systematically summarizes the use of common flavonoids for the treatment of diabetic nephropathy, showing promising potential as drugs for this condition.
Article
Urology & Nephrology
Delun Li, Siyu Yuan, Yiyao Deng
Summary: Autophagy is activated in late stage diabetic nephropathy and is associated with disturbance in metabolism and inflammation.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
Review
Endocrinology & Metabolism
Yu-Peng Han, Li-Juan Liu, Jia-Lin Yan, Meng-Yuan Chen, Xiang-Fei Meng, Xin-Ru Zhou, Ling-Bo Qian
Summary: Diabetic nephropathy (DN) is a major complication of diabetes with limited treatment options. Autophagy, a process that maintains cellular homeostasis by degrading damaged proteins and organelles, plays a critical role in the development of DN. Autophagy is regulated by nutrient-sensing pathways and cellular stress signaling pathways. Dysregulation of autophagy due to abnormal nutrient status and cellular stresses caused by diabetes-related metabolic disorders leads to cellular dysfunction and the progression of DN.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Theodomir Dusabimana, Eun Jung Park, Jihyun Je, Kyuho Jeong, Seung Pil Yun, Hye Jung Kim, Hwajin Kim, Sang Won Park
Summary: Geniposide has been shown to have protective effects in a mouse model of diabetic nephropathy, improving renal function and reducing pathological changes through modulation of AMPK and AKT pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Jinfei Yang, Li Li, Chenrui Li, Wei Chen, Yan Liu, Shilu Luo, Chanyue Zhao, Yachun Han, Ming Yang, Hao Zhao, Na Jiang, Yiyun Xi, Chengyuan Tang, Juan Cai, Li Xiao, Huafeng Liu, Lin Sun
Summary: In diabetic kidney disease (DKD), impaired ER-phagy of renal tubular cells worsens tubular injury. It has been found that the deficiency of PACS-2 aggravates tubular injury in DKD by inhibiting ER-phagy via the TFEB/FAM134B pathway.
CELL DEATH & DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Qianqian Yang, Shuqing Yang, Yuehong Liang, Qi Sun, Yi Fang, Lei Jiang, Ping Wen, Junwei Yang
Summary: This study aimed to investigate whether UCP2 promotes autophagy in podocytes and explore the regulation mechanism of UCP2. The results showed that UCP2 expression increased in podocytes under diabetic conditions, and it protected against podocyte injury. However, UCP2 deficiency impaired autophagy and exacerbated podocyte injury and proteinuria in diabetic nephropathy.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Food Science & Technology
Yujie Zhong, Ruilin Luo, Qi Liu, Jiachang Zhu, Min Lei, Xiaofei Liang, Xin Wang, Xiaoli Peng
Summary: Jujuboside A shows renoprotective effects on type II diabetic nephropathy by inhibiting oxidative stress and apoptosis, while enhancing autophagy and mitophagy.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Endocrinology & Metabolism
Hanzhou Li, Yuansong Wang, Xiuhai Su, Qinghai Wang, Shufang Zhang, Wenjuan Sun, Tianyu Zhang, Mengxue Dong, Zhaiyi Zhang, Shuquan Lv
Summary: San-Huang-Yi-Shen capsule (SHYS) has therapeutic effects on diabetic kidney disease (DKD) by promoting PINK1/Parkin-mediated mitophagy and inhibiting NLRP3 inflammasome activation to improve mitochondrial injury and inflammatory responses.
JOURNAL OF DIABETES RESEARCH
(2022)
Article
Zoology
Zhe-Lun Peng, Bin-Xu Yin, Rui-Min Ren, Yin-Long Liao, Hao Cai, Heng Wang
Summary: Salamanders are unique among tetrapods for their ability to regenerate limbs throughout life and survive long periods of starvation. Under extreme physiological stress, salamanders can utilize autophagy to promote limb regeneration, demonstrating a special regulation of regenerative capacity.
ZOOLOGICAL RESEARCH
(2021)
Article
Microbiology
Audrey C. Brown, Michelle D. Warthan, Anush Aryal, Shiwei Liu, Jennifer L. Guler
Summary: There is a dire need for effective treatments against microbial pathogens. Yet, the continuing emergence of drug resistance necessitates a deeper knowledge of how pathogens respond to treatments. We assessed the effect of nutrient limitation on the protozoan parasite that causes malaria and demonstrated that short-term growth under physiologically relevant mild nutrient stress triggers increased tolerance of a potent antimalarial drug. This finding highlights the important connections among nutrient levels, protective cellular pathways, and resistance evolution.
Article
Cell Biology
Li Chen, Guibin Mei, Chunjie Jiang, Xueer Cheng, Dan Li, Ying Zhao, Huimin Chen, Cheng Wan, Ping Yao, Chao Gao, Yuhan Tang
Summary: The study revealed senescence occurring in DN mice and the reversal effect of CO, which improved autophagy dysfunction through dissociating Beclin-1-Bcl-2 complex. Further results showed that autophagy inhibitors blocked the improvement of CO on senescence, and autophagy regulated the degradation of senescence-related secretory phenotype.
CELL PROLIFERATION
(2021)
Article
Biotechnology & Applied Microbiology
Jiayong Xie, Ying Yuan, Gang Yao, Zhi Chen, Wenjuan Yu, Qiang Zhu
Summary: This study demonstrates that silencing the NUP160 gene promotes autophagy, inhibits inflammation and fibrosis, thereby alleviating diabetic injury in DN.
Article
Endocrinology & Metabolism
Hideka Inoue, Katsutaro Morino, Satoshi Ugi, Sachiko Tanaka-Mizuno, Keiko Fuse, Itsuko Miyazawa, Keiko Kondo, Daisuke Sato, Natsuko Ohashi, Shogo Ida, Osamu Sekine, Masahiro Yoshimura, Kiyoshi Murata, Katsuyuki Miura, Hisatomi Arima, Hiroshi Maegawa
JOURNAL OF DIABETES INVESTIGATION
(2019)
Article
Endocrinology & Metabolism
Shinji Kume, Shin-ichi Araki, Satoshi Ugi, Katsutaro Morino, Daisuke Koya, Yoshihiko Nishio, Masakazu Haneda, Atsunori Kashiwagi, Hiroshi Maegawa
JOURNAL OF DIABETES INVESTIGATION
(2019)
Article
Medicine, Research & Experimental
Ichiro Nakamura, Hiroshi Maegawa, Kazuyuki Tobe, Satoshi Uno
ADVANCES IN THERAPY
(2019)
Article
Endocrinology & Metabolism
Fang L. Zhou, Hirotaka Watada, Yuki Tajima, Mathilde Berthelot, Dian Kang, Cyril Esnault, Yujin Shuto, Hiroshi Maegawa, Daisuke Koya
DIABETES OBESITY & METABOLISM
(2019)
Article
Urology & Nephrology
Sho Sugahara, Shinji Kume, Masami Chin-Kanasaki, Issei Tomita, Mako Yasuda-Yamahara, Kosuke Yamahara, Naoko Takeda, Norihisa Osawa, Motoko Yanagita, Shin-ichi Araki, Hiroshi Maegawa
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2019)
Article
Endocrinology & Metabolism
Mariko Hatta, Kazuya Fujihara, Sakiko Yoshizawa Morikawa, Yasutake Takeda, Dai Ishii, Chika Horikawa, Mitsutoshi Kato, Hiroki Yokoyama, Yoshio Kurihara, Koichi Iwasaki, Kazuhiro Miyazawa, Katsuya Yamazaki, Shiro Tanaka, Hiroshi Maegawa, Hirohito Sone
Article
Medicine, General & Internal
Hiroshi Maegawa, Kazuyuki Tobe, Ichiro Nakamura, Satoshi Uno
CURRENT MEDICAL RESEARCH AND OPINION
(2019)
Article
Biochemistry & Molecular Biology
Mamoru Yoshibayashi, Shinji Kume, Mako Yasuda-Yamahara, Kosuke Yamahara, Naoko Takeda, Norihisa Osawa, Masami Chin-Kanasaki, Yuki Nakae, Hideki Yokoi, Masashi Mukoyama, Katsuhiko Asanuma, Hiroshi Maegawa, Shin-ichi Araki
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Endocrinology & Metabolism
Keiko Fuse, Aya Kadota, Keiko Kondo, Katsutaro Morino, Akira Fujiyoshi, Takashi Hisamatsu, Sayaka Kadowaki, Itsuko Miyazawa, Satoshi Ugi, Hiroshi Maegawa, Katsuyuki Miura, Hirotsugu Ueshima
DIABETES RESEARCH AND CLINICAL PRACTICE
(2020)
Article
Multidisciplinary Sciences
Tomoyuki Tsukiyama, Kenichi Kobayashi, Masataka Nakaya, Chizuru Iwatani, Yasunari Seita, Hideaki Tsuchiya, Jun Matsushita, Kahoru Kitajima, Ikuo Kawamoto, Takahiro Nakagawa, Koji Fukuda, Teppei Iwakiri, Hiroyuki Izumi, Iori Itagaki, Shinji Kume, Hiroshi Maegawa, Ryuichi Nishinakamura, Saori Nishio, Shinichiro Nakamura, Akihiro Kawauchi, Masatsugu Ema
NATURE COMMUNICATIONS
(2019)
Article
Nutrition & Dietetics
Yasunaga Takeda, Kazuya Fujihara, Rina Nedachi, Izumi Ikeda, Sakiko Yoshizawa Morikawa, Mariko Hatta, Chika Horikawa, Mitsutoshi Kato, Noriko Kato, Hiroki Yokoyama, Yoshio Kurihara, Kazuhiro Miyazawa, Hiroshi Maegawa, Hirohito Sone
Summary: The study found a positive association between dietary energy density (DED) and obesity in individuals with type 2 diabetes mellitus. DED was more strongly associated with obesity and body mass index (BMI) than other nutritional factors, such as energy intake or macronutrients.
Article
Endocrinology & Metabolism
Yuki Nishida, Shigeho Tanaka, Satoshi Nakae, Yosuke Yamada, Katsutaro Morino, Keiko Kondo, Kaori Nishida, Akiko Ohi, Mika Kurihara, Masaya Sasaki, Satoshi Ugi, Hiroshi Maegawa, Naoyuki Ebine, Satoshi Sasaki, Fuminori Katsukawa
ANNALS OF NUTRITION AND METABOLISM
(2020)
Article
Endocrinology & Metabolism
Satoshi Ugi, Katsutaro Morino, Tsuyoshi Yamaguchi, Hiroshi Yamamoto, Sachiko Kaida, Itsuko Miyazawa, Daisuke Sato, Osamu Sekine, Yukihiro Fujita, Atsunori Kashiwagi, Masaji Tani, Hiroshi Maegawa
Article
Endocrinology & Metabolism
Katsutaro Morino, Keiko Kondo, Shigeho Tanaka, Yuki Nishida, Satoshi Nakae, Yosuke Yamada, Satoshi Ugi, Keiko Fuse, Itsuko Miyazawa, Akiko Ohi, Kaori Nishida, Mika Kurihara, Masaya Sasaki, Naoyuki Ebine, Satoshi Sasaki, Fuminori Katsukawa, Hiroshi Maegawa, Kelko Kosaka, Eriko Naiki, Chikako Ikeuchi, Takako Fujii, Noriko Yamamoto, Kaori Nagano, Mayumi Yotsushika, Mai Nakaizumi, Akiko Sakata, Hiroko Kogure
BMJ OPEN DIABETES RESEARCH & CARE
(2019)
Article
Endocrinology & Metabolism
Hiromi Tabuchi, Hiroshi Maegawa, Kazuyuki Tobe, Ichiro Nakamura, Satoshi Uno