Article
Cardiac & Cardiovascular Systems
Hertzel C. Gerstein, Chinthanie Ramasundarahettige, Alvero Avezum, Jan Basile, Ignacio Conget, William C. Cushman, Gilles R. Dagenais, Edward Franek, Mark Lakshmanan, Fernando Lanas, Lawrence A. Leiter, Nana Pogosova, Jeffrey Probstfield, Peter J. Raubenheimer, Matthew Riddle, Jonathan Shaw, Wayne H-H Sheu, Theodora Temelkova-Kurktschiev, Ibrahim Turfanda, Denis Xavier
Summary: This study combines baseline eGFR and ACR into a novel composite risk factor, the KDI, which has a simple linear relationship with incident serious outcomes in individuals with diabetes and additional cardiovascular risk factors.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Medicine, General & Internal
Yi-Chia Chan, Cheng-Hsi Yeh, Lung-Chih Li, Chao-Long Chen, Chih-Chi Wang, Chih-Chi Lin, Aldwin D. Ong, Ting-Yu Chiou, Chee-Chien Yong
Summary: Acute kidney injury (AKI) after liver transplantation (LT) is associated with major adverse cardiovascular events (MACE) and major adverse kidney events (MAKE). It is also an independent predictor and risk factor for cardiovascular disease and end-stage renal disease.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Patrick B. Mark, Juan J. Carrero, Kunihiro Matsushita, Yingying Sang, Shoshana H. Ballew, Morgan E. Grams, Josef Coresh, Aditya Surapaneni, Nigel J. Brunskill, John Chalmers, Lili Chan, Alex R. Chang, Rajkumar Chinnadurai, Gabriel Chodick, Massimo Cirillo, Dick de Zeeuw, Marie Evans, Amit X. Garg, Orlando M. Gutierrez, Hiddo J. L. Heerspink, Gunnar H. Heine, William G. Herrington, Junichi Ishigami, Florian Kronenberg, Jun Young Lee, Adeera Levin, Rupert W. Major, Angharad Marks, Girish N. Nadkarni, David M. J. Naimark, Christoph Nowak, Mahboob Rahman, Charumathi Sabanayagam, Mark Sarnak, Simon Sawhney, Markus P. Schneider, Varda Shalev, Jung-Im Shin, Moneeza K. Siddiqui, Nikita Stempniewicz, Keiichi Sumida, Jose M. Valdivielso, Jan van den Brand, Angela Yee-Moon Wang, David C. Wheeler, Lihua Zhang, Frank L. J. Visseren, Benedicte Stengel
Summary: This study investigated the association between cardiovascular disease (CVD) and future risk of kidney failure with replacement therapy (KFRT). It found that both prevalent and incident CVD were strongly associated with KFRT risk, with incident HF showing the strongest association.
EUROPEAN HEART JOURNAL
(2023)
Article
Immunology
Fan Zhang, Saifu Yin, Yu Fan, Turun Song, Zhongli Huang, Jiayu Liang, Jiapei Wu, Youmin Yang, Tao Lin, Xianding Wang
Summary: This study found that the secretor status of both donors and recipients may have an impact on the outcomes of ABO incompatibility kidney transplantation. Recipients with weak secretor status may have better post-transplant renal function, while recipients from secretor donors had a lower incidence of graft rejection in the first year after transplantation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Urology & Nephrology
Carrie Thiessen, Jacqueline Gannon, Sienna Li, Laura Skrip, Danielle Dobosz, Geilang Gan, Yanhong Deng, Kristie Kennedy, Daniel Gray, Adam Mussell, Peter P. Reese, Elisa J. Gordon, Sanjay Kulkarni
Summary: The study found that the closeness of the relationship between donors and recipients was independently associated with donors' willingness to accept postdonation kidney failure risk. This suggests that visual aids can provide transplant teams with personalized donor perspectives on risk thresholds and potentially facilitate greater patient-centered care.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Chunxia Deng, Shuo Wang, Zhili Niu, Yahong Ye, Ling Gao
Summary: The study utilized an LC-MS/MS method to measure plasma BH4 levels in diabetes patients and found a correlation between BH4 levels and ACR and eGFR, suggesting its potential as a biomarker for kidney injury in diabetes.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Nutrition & Dietetics
Kao-Ming Hsu, Pei-Ru Lin, Ping-Fang Chiu, Yao-Peng Hsieh
Summary: This study investigated the subsequent renal function change following incident infectious diseases in living-donor liver transplant recipients. The results showed that hospitalization with major infections or pneumonia increased the risk of eGFR decline and adverse renal outcomes in these patients.
Article
Medicine, General & Internal
Ahmed Abdallah Salman, Mohamed Abdalla Salman, Mostafa Said, Hesham Elkassar, Mohammad El Sherbiny, Ahmed Youssef, Mohammed Elbaz, Ahmed M. Elmeligui, Mohamed Badr Hassan, Mahmoud Gouda Omar, Hussien Samir, Mohamed Abdelkader Morad, Hossam El-Din Shaaban, Mohamed Youssef, Ahmed Moustafa, Mohamed Sabry Tourky, Ahmed Elewa, Sadaf Khalid, Khaled Monazea, Mohamed Shawkat
Summary: This study found that preoperative albuminuria is a significant predictor of mortality within 3 years after living donor liver transplantation in diabetic patients. Myocardial infarction is the leading cause of death.
ANNALS OF MEDICINE
(2022)
Editorial Material
Urology & Nephrology
Alberto Ortiz, Christoph Wanner, Ron Gansevoort, Era Council
Summary: The European Society of Cardiology's 2021 guideline on cardiovascular disease prevention has important implications for CV risk screening and kidney health. It emphasizes the need for categorizing individuals based on established conditions such as atherosclerotic CVD, diabetes, hypercholesterolemia, or chronic kidney disease. The inclusion of albuminuria as a step in CVD risk assessment should change clinical practice. Further research is needed to determine the optimal method for assessing CV risk in the general population, including the role of systematic screening for CKD.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Chang-Sheng Sheng, Dan Wang, Jiangzi Yuan, Yi Cheng, Siming Sun, Yulin Yang, Ya Miao, Weiming Wang, Jingyan Tian, Zachary T. Bloomgarden
Summary: Non-albuminuric chronic kidney disease (CKD) is associated with increased risk of all-cause and cardiovascular mortality when eGFR is less than 45 mL/min/1.73 m(2). Increased albuminuria is associated with higher risk of primary outcome and all-cause mortality.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Jun Young Lee, Sung Hwan Cha, Sung Hwa Kim, Kyung Hwan Jeong, Ku Yong Chung, Hong Rae Cho, Juhan Lee, Kyu Ha Huh, Jaeseok Yang, Myoung Soo Kim, Deok Gie Kim
Summary: The combination of ABO incompatibility and donor-recipient weight mismatch is an independent risk factor for graft and patient survival in living donor kidney transplantation, leading to an increased risk of pneumonia.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Megumi Oshima, Tadashi Toyama, Akinori Hara, Miho Shimizu, Shinji Kitajima, Yasunori Iwata, Norihiko Sakai, Kengo Furuichi, Masakazu Haneda, Tetsuya Babazono, Hiroki Yokoyama, Kunitoshi Iseki, Shin-ichi Araki, Toshiharu Ninomiya, Shigeko Hara, Yoshiki Suzuki, Masayuki Iwano, Eiji Kusano, Tatsumi Moriya, Hiroaki Satoh, Hiroyuki Nakamura, Hirofumi Makino, Takashi Wada
Summary: This study found that combined changes in albuminuria and eGFR over 2 years were strongly associated with future risk of end-stage kidney disease in patients with type 2 diabetes. Specifically, a decrease in albuminuria was associated with lower risk while a decline in eGFR was associated with higher risk of developing end-stage kidney disease.
BMJ OPEN DIABETES RESEARCH & CARE
(2021)
Article
Environmental Sciences
Ram B. Jain
Summary: The associations between urinary concentrations of oxidant polycyclic aromatic hydrocarbon (PAH) metabolites and serum concentrations of anti-oxidant alpha-klotho were examined in US adults aged 40-79 years. The study found that increased PAH metabolite concentrations were associated with decreased alpha-klotho concentrations in individuals with normal or near normal kidney function. However, the associations were not significant in individuals with albuminuria. These findings suggest that exposure to PAH may lead to reduced alpha-klotho concentrations.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Ram B. Jain
Summary: Exposure to cadmium and lead can cause oxidative stress and result in kidney and cardiovascular diseases. The antiaging protein klotho acts as an antioxidant. This study found that the concentrations of klotho were affected by cadmium and lead exposure, with an observed decrease in klotho concentrations during kidney dysfunction, particularly with blood cadmium concentrations.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Urology & Nephrology
Takahisa Hiramitsu, Toshihide Tomosugi, Kenta Futamura, Manabu Okada, Yutaka Matsuoka, Norihiko Goto, Toshihiro Ichimori, Shunji Narumi, Asami Takeda, Takaaki Kobayashi, Kazuharu Uchida, Yoshihiko Watarai
Summary: This study investigated the impact of age differences between older adult living donors and recipients on kidney transplantation outcomes. The results showed that kidney transplants from older adult donors to older adult recipients had the highest risk of graft loss and mortality, with recipients having lower estimated glomerular filtration rates.
KIDNEY INTERNATIONAL REPORTS
(2021)
Article
Urology & Nephrology
Yukako Ohyama, Masahiko Yazawa, Yoichiro Haji, Akihiro Ryuge, Naoho Takizawa, Atsushi Nomura, Hideaki Shimizu, Yoshiro Fujita
JOURNAL OF NEPHROLOGY
(2022)
Review
Urology & Nephrology
Takamasa Miyauchi, Maho Terashita, Masatomo Ogata, Marie Murata, Kiyomi Osako, Naohiko Imai, Yuko Sakurai, Hideo Sasaki, Yuki Ohashi, Kimiyoshi Ichida, Yugo Shibagaki, Masahiko Yazawa
Summary: This article reports a case of RHUC developed in a kidney transplant recipient from a living donor with hypouricemia. Detailed urinary and genetic tests revealed differences between the recipient and the donor. The study highlights the importance of investigating the pathogenesis of RHUC in both donors and recipients.
Letter
Urology & Nephrology
Keisuke Yoshida, Masahiko Yazawa, Maho Terashita, Yugo Shibagaki, Naoto Tominaga
CLINICAL NEPHROLOGY
(2022)
Article
Medicine, General & Internal
Tomohiko Inoue, Mikako Hisamichi, Daisuke Ichikawa, Yugo Shibagaki, Masahiko Yazawa
Summary: In this report, we present two cases where add-on acetazolamide to furosemide effectively treated diuretic-resistant volume overload and hypercapnia. Symptoms in both cases resolved after the administration of acetazolamide, regardless of the degree of proteinuria and kidney function.
Article
Medicine, General & Internal
Masatomo Ogata, Satoru Morikubo, Naohiko Imai, Yugo Shibagaki, Masahiko Yazawa
Summary: This article reports a case of hyponatremia in a patient with acute alcoholic pancreatitis. The cause of hyponatremia was considered complex, involving pseudo- and translocational hyponatremia secondary to hyperglycemia and hypertriglyceridemia. By monitoring tonicity instead of serum sodium concentration, rapid correction was safely managed to avoid brain damage.
Correction
Urology & Nephrology
Shunsuke Goto, Hideyo Oguchi, Ken Sakai, Tetsuo Mikami, Daisuke Ichikawa, Masahiko Yazawa, Junki Koike, Kengo Furuichi, Masahiko Kawabata, Hitoshi Yokoyama, Tadashi Sofue, Emi Ibuki, Shinichi Nishi
JOURNAL OF NEPHROLOGY
(2022)
Article
Urology & Nephrology
Shunsuke Goto, Hideyo Oguchi, Ken Sakai, Tetsuo Mikami, Daisuke Ichikawa, Masahiko Yazawa, Junki Koike, Kengo Furuichi, Masahiko Kawabata, Hitoshi Yokoyama, Tadashi Sofue, Emi Ibuki, Shinichi Nishi
Summary: This study investigated the association between clinical characteristics and kidney biopsy findings in living kidney donors. The results showed that age was positively correlated with global glomerulosclerosis and intimal thickening, while diabetes was possibly correlated with tubular atrophy. These findings suggest that age and diabetes may be more important factors in selecting suitable living kidney donors than other clinical factors.
JOURNAL OF NEPHROLOGY
(2022)
Letter
Urology & Nephrology
Masatomo Ogata, Takamasa Miyauchi, Yuko Sakurai, Marie Murata, Kazunobu Shinoda, Yugo Shibagaki, Masahiko Yazawa
CLINICAL KIDNEY JOURNAL
(2022)
Article
Urology & Nephrology
Yoko Fujita, Keisuke Yoshida, Daisuke Ichikawa, Yugo Shibagaki, Masahiko Yazawa
Summary: A case report describes a patient who developed acute hematuria and nephrotic range proteinuria after receiving the first dose of SARS-CoV-2 vaccine, leading to a diagnosis of IgA nephropathy. This highlights the importance of monitoring kidney diseases after SARS-CoV-2 vaccination.
Editorial Material
Urology & Nephrology
Ryunosuke Noda, Wei Han, Yugo Shibagaki, Masahiko Yazawa
KIDNEY INTERNATIONAL
(2022)
Review
Urology & Nephrology
Tatsuhiko Azegami, Noriyuki Kounoue, Tadashi Sofue, Masahiko Yazawa, Makoto Tsujita, Kosuke Masutani, Yuki Kataoka, Hideyo Oguchi
Summary: This study found that pre-emptive kidney transplantation has potential benefits in terms of lower mortality and graft failure rates, and it is recommended for adults with end-stage kidney disease.
Letter
Urology & Nephrology
Ryunosuke Noda, Masahiko Yazawa
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Urology & Nephrology
Yoko Fujita, Rie Fujishima, Kenji Ueki, Akihiro Tsuchimoto, Takuya Matsuda, Masaki Kato, Kosuke Masutani, Kazunobu Shinoda, Masahiko Yazawa
Summary: Excessive immunosuppression can occur in kidney transplant patients receiving additional treatment with immunosuppressive medications, particularly biologic agents. We present a rare case of adenovirus nephritis causing severe acute allograft injury and hemorrhagic cystitis in a kidney transplant recipient who received infliximab therapy for Crohn's disease. The patient was successfully treated by reducing immunosuppressive medications and administering immunoglobulin, leading to partial recovery of allograft function.
Article
Multidisciplinary Sciences
Tadashi Sofue, Hideyo Oguchi, Masahiko Yazawa, Makoto Tsujita, Kenta Futamura, Morikuni Nishihira, Mariko Toyoda, Toshiki Kano, Hitoshi Suzuki
Summary: This study aimed to establish a classification system for IgA deposition in kidney allografts based on serological and histological evaluation of Gd-IgA1. The population with IgA deposition after kidney transplantation is serologically and pathologically heterogeneous. Serological and histological assessment of Gd-IgA1 is useful for identifying cases that should be carefully observed.
Review
Urology & Nephrology
Takamasa Miyauchi, Hiroki Nishiwaki, Aya Mizukami, Masahiko Yazawa
Summary: This systematic review and meta-analysis examined the association between hyponatremia and worse outcomes in patients undergoing maintenance hemodialysis. The study found that hyponatremia is associated with increased all-cause mortality. Therefore, healthcare providers should be vigilant for any indication of hyponatremia.
SEMINARS IN DIALYSIS
(2023)