Article
Endocrinology & Metabolism
Chun Zhou, Panpan He, Ziliang Ye, Yuanyuan Zhang, Yanjun Zhang, Sisi Yang, Qimeng Wu, Mengyi Liu, Jing Nie, Xianhui Qin
Summary: The study found an inverse association between serum vitamin D levels and new-onset chronic kidney disease in participants with diabetes. However, this association was not observed in participants without diabetes.
Article
Pediatrics
Emre Leventoglu, Bahar Bueyuekkaragoez, Furkan cagri Kavas, Mert Can Hologlu, Akif Kavgaci, Kibriya Fidan, Aydin Dalgic, Sevcan A. Bakkaloglu, Fatma Sedef Tunaoglu, Oguz Soeylemezoglu
Summary: Cardiovascular diseases are the main causes of morbidity in children with chronic kidney disease (CKD). This study evaluates the use of electrocardiography (ECG) in detecting dangerous changes in CKD and kidney replacement therapies and compares its value in predicting cardiovascular outcomes with echocardiography. The findings suggest that ECG can be used to detect cardiovascular problems, especially in hemodialysis (HD) patients. ECG abnormalities suggestive of left ventricular hypertrophy (LVH) should prompt referrals for echocardiographic assessment.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Nutrition & Dietetics
Lailiang Wang, Qun Luo, Fangfang Zhou, Beixia Zhu
Summary: This study investigated the correlation between serum 25-hydroxyvitamin D (25(OH)D) and brachial-ankle pulse wave velocity (baPWV) as well as mortality among peritoneal dialysis (PD) patients. Results showed that serum 25(OH)D concentration was negatively associated with baPWV, and lower 25(OH)D levels were significantly related to higher total mortality in PD patients. Additional studies with larger sample sizes are needed to confirm these findings.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2021)
Review
Nutrition & Dietetics
Giuseppe Cianciolo, Maria Cappuccilli, Francesco Tondolo, Lorenzo Gasperoni, Fulvia Zappulo, Simona Barbuto, Francesca Iacovella, Diletta Conte, Irene Capelli, Gaetano La Manna
Summary: The text highlights the common issue of poor vitamin D status in patients with chronic kidney disease, attributing it to various factors such as uremic malnutrition, dietary restrictions, and proteinuria. Furthermore, it points out the lack of large-scale interventional studies on the non-calcemic activities of vitamin D in the literature.
Article
Pediatrics
Dogan Barut, Mete Akisu, Ozge Altun Koroglu, Demet Terek, Firat Ergin, Huseyin Onay, Mehmet Yalaz, Nilgun Kultursay
Summary: This study aimed to reveal that VDR gene polymorphisms may constitute a risk factor for necrotizing enterocolitis (NEC). The study found that the TT genotype of VDR Fok1 C/T increased the risk of NEC, and there was a significant relationship between this genotype and the risk of NEC.
PEDIATRIC RESEARCH
(2023)
Review
Nutrition & Dietetics
Aleksandra Beata Juszczak, Maciej Kupczak, Tomasz Konecki
Summary: This narrative review summarizes 98 studies of chronic kidney disease (CKD) and the effects of vitamin supplementation on patients on dialysis. The findings suggest potential effectiveness of certain vitamins, such as B, D, or C, but recommendations for vitamins A and K are still unclear due to potential toxicity. Further research is needed to evaluate the effectiveness and risks of vitamin supplementation for CKD patients.
Article
Physiology
Xiaoyi Zhang, Li Zhang, Yingzhen Wen, Mengxian Zhang, Shuangxin Liu, Houqin Xiao
Summary: This study investigated the protective effect and potential mechanism of vitamin D on podocyte injury in diabetic kidney disease (DKD). The results showed that treatment with a vitamin D analogue significantly reduced albuminuria and improved renal pathology in diabetic mice. Furthermore, vitamin D enhanced podocyte autophagy activity, restored the expression of slit diaphragm proteins, and inhibited podocyte apoptosis under diabetic conditions.
KIDNEY & BLOOD PRESSURE RESEARCH
(2023)
Article
Endocrinology & Metabolism
Joao Victor Salgado, Miguel Angelo Goes, Natalino Salgado Filho
Summary: The global nephrology community acknowledges the increasing burden of kidney disease and emphasizes on early diagnosis, understanding of disease progression, and development of new therapeutic interventions. FGF21 is considered a key regulator of lipid, glucose, and energy metabolism, as well as stress responses. While promising results have been shown with FGF21 analogs in metabolic disease, its exact role in kidney function remains poorly understood.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Review
Multidisciplinary Sciences
Miaomiao Zhao, Zhenhua Liu, Hongtai Shi, Jianxiang Song
Summary: The prognostic value of vitamin D receptor (VDR) in various digestive system tumors is still controversial. This meta-analysis found that high VDR expression is generally associated with better overall survival (OS) in digestive system tumors, but the association is not significant in colorectal cancer. VDR expression can serve as a prognostic indicator and a reference for vitamin D supplementation, helping to evaluate prognosis and formulate precise treatment plans for patients with digestive system tumors.
Review
Nutrition & Dietetics
Carlo Garofalo, Chiara Ruotolo, Claudia Annoiato, Maria Elena Liberti, Roberto Minutolo, Luca De Nicola, Giuseppe Conte, Silvio Borrelli
Summary: A systematic review and meta-analysis revealed that approximately 1.5% of patients undergoing maintenance dialysis experience recovery of kidney function unrelated to acute kidney injury. The prevalence of recovery is higher in the United States compared to other countries.
Article
Biochemistry & Molecular Biology
Aleksandra Marchwicka, Kuba Nowak, Anastasiia Satyr, Dariusz Wolowiec, Ewa Marcinkowska
Summary: Hematological malignancies are characterized by uncontrolled proliferation and differentiation block of blood cells, leading to loss of function. 1,25-dihydroxyvitamin D has been proposed as a potential therapy to stimulate the immune system and inhibit proliferation of leukemic cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Tiphaine Raia-Barjat, Camille Sarkis, Florence Rancon, Lise Thibaudin, Jean-Christophe Gris, Nadia Alfaidy, Celine Chauleur
Summary: Maternal vitamin D insufficiency during pregnancy may increase the risk of preeclampsia, and lower vitamin D levels at 32 weeks are associated with a higher risk of placenta-mediated complications. Maintaining adequate levels of vitamin D in pregnant women can help prevent the onset of late PMC.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Simona Fenizia, Melania Gaggini, Cristina Vassalle
Summary: This review discusses the interaction between vitamin D and sphingolipids, with a focus on cardiometabolic diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Sunny Malhotra, Luciana Midaglia, Omar Chuquisana, Nikolaos A. A. Patsopoulos, Roser Ferrer, Marina Giralt, Nicolas Fissolo, Elia Gil-Varea, Juan Carlos Trivino, Jan D. D. Luenemann, Xavier Montalban, Manuel Comabella
Summary: This study found an association between the CYP24A1 rs2762943 polymorphism and increased risk of multiple sclerosis (MS). Carriers of this risk allele had lower levels of active vitamin D and higher levels of inflammatory factors. However, this genetic variant had no significant impact on disease activity and disability outcomes of MS patients, only with a younger age at disease onset.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Review
Medicine, General & Internal
Hanna Cholerzynska, Wiktoria Zasada, Hanna Michalak, Milosz Miedziaszczyk, Andrzej Oko, Ilona Idasiak-Piechocka
Summary: Acute kidney injury (AKI) and sudden exacerbation of chronic kidney disease (CKD) often require urgent kidney replacement therapy (UKRT). Peritoneal dialysis (PD) is seen as a viable option for managing these patients. This review examines recent literature on the clinical outcomes of urgent-start peritoneal dialysis (USPD) in CKD and AKI.
JOURNAL OF CLINICAL MEDICINE
(2023)