Article
Oncology
Andrew E. E. Sloan, Charles J. J. Nock, Xiaobu Ye, Robert Buerki, Susan Chang, Glenn Lesser, Andrew Norden, Timothy Cloughesy, Jeffrey Olson, Amber Kerstetter-Fogle, Jeremy Rich, Joy Fisher, Serena Desideri, Naoko Takebe, William Timmer, Stuart Grossman, Michael Prados
Summary: SHH signaling promotes the proliferation and self-renewal of glioma stem cells (GSC). A study on patients with recurrent glioblastoma (GBM) treated with GDC-0449 found that the drug can inhibit the formation and proliferation of GSC, but its clinical efficacy is limited as a single agent. This suggests that the growth and maintenance of GBM may not solely depend on the SHH pathway, and targeting SMO may require combined approaches.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Richard Huang, Jalna Meens, Scott Yuzwa, Laurie Ailles, Michael Ohh, Claire M. Robinson
Summary: Cancer stem cells play an important role in tumor biology. This study aimed to identify the existence of clear cell renal cell carcinoma (ccRCC) stem cells using the side population approach, but the results did not support the presence of cancer stem cells in ccRCC.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Liu-Ya Tang, Marie Spezia, Ting Chen, Jee-Hye Shin, Feng Wang, Frank Stappenbeck, Andres M. Lebensohn, Farhad Parhami, Ying E. Zhang
Summary: The study revealed that oxysterols Oxy186 and Oxy210 can inhibit proliferation of NSCLC cells, with Oxy186 exhibiting potent inhibition of tumor growth. The mechanism of action involves inhibiting the WNT/beta-catenin signaling pathway.
CELL AND BIOSCIENCE
(2022)
Article
Multidisciplinary Sciences
Keila Alvarado-Estrada, Lina Marenco-Hillembrand, Sushila Maharjan, Valerio Luca Mainardi, Yu Shrike Zhang, Natanael Zarco, Paula Schiapparelli, Hugo Guerrero-Cazares, Rachel Sarabia-Estrada, Alfredo Quinones-Hinojosa, Kaisorn L. Chaichana
Summary: Cancer cells circulating in the blood vessels can survive and lead to increased metastatic disease under the pressure of circulation. Specific transition phenotypes of cancer cells play a critical role in their survival and metastatic potential in the circulatory system.
SCIENTIFIC REPORTS
(2021)
Editorial Material
Oncology
Jihan K. Osborne, John D. Minna
Summary: In this study, Yin and colleagues utilized Gprc5a knockout genetically engineered mouse models to investigate the cell(s) of origin for lung adenocarcinoma, and suggested that the bronchioalveolar stem cell is the cancer-initiating cell in this model.
Article
Cell Biology
Fangfang Wang, Zhang Dan, Hongmei Luo, Jingcao Huang, Yushan Cui, Hong Ding, Juan Xu, Zhimei Lin, Yuhan Gao, Xinyu Zhai, Yan Yang, Ying Qu, Li Zhang, Fengjiao Chen, Qiang Wang, Xin Wang, Yu Feng, Ting Liu, Qing Yi, Ting Niu, Yuhuan Zheng
Summary: Drug-resistance is a major problem in multiple myeloma (MM) patients. This study reveals that activated-leukocyte-cell-adhesion-molecule (ALCAM) regulates MM side population (SP)-mediated drug-resistance through the ALCAM-EGF/EGFR axis. EGFR activation promotes the SP ratio, while ALCAM inhibits EGFR downstream signaling in MM cells. SP MM cells have a higher number of mitochondria and interference of mitochondrial function inhibits SP-genesis. Combination therapy with an anti-MM agent and EGFR inhibitor gefitinib improves MM therapeutic efficacy and prolongs survival in MM-bearing mice.
CELL DEATH & DISEASE
(2022)
Review
Cell Biology
Mia C. Borlongan, Hongbin Wang
Summary: Tumorigenic cancer stem cells (CSCs) are a subset of cells within tumors that have distinct genetic and phenotypic profiles and signaling pathways compared to other tumor cells. Targeting the unique self-renewal and differentiation properties of CSCs could revolutionize cancer therapy. Understanding the signaling mechanisms of CSCs will improve our knowledge of cancer pathology and treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Xiaoli Dong, Yingying Wei, Tao Xu, Xiaoyue Tan, Na Li
Summary: Cancer stem cells (CSCs) play a crucial role in tumor growth, metastasis, and recurrence. Techniques such as staining tumor cells with Hoechst 33342 and analyzing the proportion of side population (SP) cells using flow cytometry provide convenient, fast, and cost-effective methods for the identification and purification of CSCs. Data generated from these assays can contribute to a better understanding of the stemness properties of tumor cells in response to various signals.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Article
Oncology
Li Li, Jing Zhao, Quanbao Zhang, Yifeng Tao, Conghuan Shen, Ruidong Li, Zhengyu Ma, Jianhua Li, Zhengxin Wang
Summary: This study demonstrated that HCC cells secrete Shh via exosomes to promote tumorigenesis through the activated Hedgehog pathway. The expression of Shh via exosomes is associated with later tumor stages and higher recurrence rates in liver cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Hiba Abou Daya, Sana Kouba, Hakim Ouled-Haddou, Nazim Benzerdjeb, Marie-Sophie Telliez, Charles Dayen, Henri Sevestre, Loic Garcon, Frederic Hague, Halima Ouadid-Ahidouch
Summary: Resistance to platinum drugs in the treatment of non-small cell lung cancer is closely related to the enrichment of cancer stem cell populations. The Orai3 channel has been identified as a predictive marker for metastasis and survival, playing a role in inducing CSC populations and affecting the efficacy of chemotherapy.
Article
Pharmacology & Pharmacy
Weiyu Wang, Shengyao Ma, Zhenyu Ding, Yang Yang, Huaijie Wang, Kunning Yang, Xiaoshan Cai, Hanyue Li, Zhiqin Gao, Meihua Qu
Summary: XPC expression levels in lung adenocarcinoma have been found to influence patients' prognosis and inhibit tumor invasion and metastasis by regulating the stemness of lung cancer cells.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Xia Liu, Valery Adorno-Cruz, Ya-Fang Chang, Yuzhi Jia, Madoka Kawaguchi, Nurmaa K. Dashzeveg, Rokana Taftaf, Erika K. Ramos, Emma J. Schuster, Lamiaa El-Shennawy, Dhwani Patel, Youbin Zhang, Massimo Cristofanilli, Huiping Liu
Summary: Research has shown that inhibiting EGFR can block the circulating cancer stem cell (cCSC) clustering and lung metastasis of triple-negative breast cancer (TNBC). In addition to CD44, microRNA-30c also plays a negative regulatory role in cCSC clustering and lung metastasis.
Article
Biochemistry & Molecular Biology
Nazilah Abdul Satar, Mohd Nazri Ismail, Badrul Hisham Yahaya
Summary: This study demonstrates the potential of curcumin as a chemosensitizer for targeting cancer stem cell subpopulations in non-small cell lung cancer. Curcumin reduces cellular proliferation and inhibits self-renewal capability of lung cancer stem cells, while also regulating the stem cell niche to inhibit chemoresistance and cancer-related protein expression.
Article
Medicine, Research & Experimental
Yan-jie Weng, Xiao-xiao Zhang, Xue Wu, Li-li Guo, Chang-yu Wang
Summary: The study found that different subtypes of ovarian cancer SP cells have varying levels of stemness, with the LSP cell subtype exhibiting higher stem cell marker expression, greater in vitro sphere-forming capability, increased cisplatin resistance, and enhanced in vivo tumorigenicity compared to USP cells. NSP cells showed no stemness characteristics.
CURRENT MEDICAL SCIENCE
(2021)
Article
Oncology
Kota Ishioka, Hiroyuki Yasuda, Junko Hamamoto, Hideki Terai, Katsura Emoto, Tae-Jung Kim, Shigemichi Hirose, Takashi Kamatani, Sachiyo Mimaki, Daisuke Arai, Keiko Ohgino, Tetsuo Tani, Keita Masuzawa, Tadashi Manabe, Taro Shinozaki, Akifumi Mitsuishi, Toshiki Ebisudani, Takahiro Fukushima, Mari Ozaki, Shinnosuke Ikemura, Ichiro Kawada, Katsuhiko Naoki, Morio Nakamura, Takashi Ohtsuka, Hisao Asamura, Katsuya Tsuchihara, Yuichiro Hayashi, Ahmed E. Hegab, Susumu S. Kobayashi, Takashi Kohno, Hideo Watanabe, David M. Ornitz, Tomoko Betsuyaku, Kenzo Soejima, Koichi Fukunaga
Summary: In this study, FGF9 was found to play a crucial role in the transdifferentiation of lung adenocarcinoma to small cell lung cancer. The upregulation of FGF9 was confirmed to induce neuroendocrine differentiation in established human lung adenocarcinoma cells, providing direct evidence for FGF9-mediated SCLC transdifferentiation and proposing the FGF9-FGFR axis as a therapeutic target for transdifferentiated SCLC.
Article
Oncology
Diego Kauffmann-Guerrero, Amanda Tufman, Kathrin Kahnert, Benjamin Alexander Bollmann, Simone Reu, Zulfiya Syunyaeva, Christian Schneider, Farkhad Manapov, Rudolf M. Huber, Heiko Golpon
ONCOLOGY RESEARCH AND TREATMENT
(2020)
Article
Oncology
Gabriele Multhoff, Sophie Seier, Stefan Stangl, Wolfgang Sievert, Maxim Shevtsov, Caroline Werner, A. Graham Pockley, Christiane Blankenstein, Martin Hildebrandt, Robert Offner, Norbert Ahrens, Konrad Kokowski, Matthias Hautmann, Claus Roedel, Rainer Fietkau, Dorota Lubgan, Rudolf Huber, Hubert Hautmann, Thomas Duell, Michael Molls, Hanno Specht, Bernhard Haller, Michal Devecka, Andreas Sauter, Stephanie E. Combs
CLINICAL CANCER RESEARCH
(2020)
Article
Oncology
Sabine Wessels, Thomas Muley, Petros Christopoulos, Michael Meister, Ingrid Heinzmann-Groth, Arne Warth, Esther Herpel, Simone Hummler, Ursula Klingmuller, Jonas Kuon, Claus-Peter Heussel, Ralf Eberhardt, Felix J. F. Herth, Hauke Winter, Helge Bischoff, Albrecht Stenzinger, Martin Reck, Rudolf Maria Huber, Michael Thomas, Marc A. Schneider
TRANSLATIONAL LUNG CANCER RESEARCH
(2020)
Review
Pharmacology & Pharmacy
Diego Kauffmann-Guerrero, Kathrin Kahnert, Rudolf M. Huber
Summary: Non-small-cell lung cancer (NSCLC) constitutes the majority of lung cancer cases, with emerging targeted therapies providing significant progress in treating a subset of patients. ALK tyrosine kinase inhibitors have greatly improved treatment options and outcomes for ALK-positive NSCLC patients.
Article
Respiratory System
Michaela Schunk, Lien Le, Zulfiya Syunyaeva, Birgit Haberland, Susanne Taenzler, Ulrich Mansmann, Larissa Schwarzkopf, Hildegard Seidl, Sabine Streitwieser, Miriam Hofmann, Thomas Mueller, Tobias Weiss, Philipp Morawietz, Eva Annette Rehfuess, Rudolf Maria Huber, Ursula Berger, Claudia Bausewein
Summary: The Munich Breathlessness Service (MBS) was tested in the BreathEase trial for patients with chronic breathlessness in advanced disease and their carers, showing positive effects in reducing burden caused by chronic breathlessness. Further evaluation in subgroups of patients and with a longitudinal perspective is needed.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Article
Respiratory System
Rudolf M. Huber, Diego Kauffmann-Guerrero, Hans Hoffmann, Michael Flentje
Summary: Recent developments in the treatment of locally advanced nonsmall cell lung cancer have focused on integrating immunotherapy with radiotherapy, chemotherapy, and adjuvant targeted therapy. The importance of consolidation therapy, pathological evaluation, and investigation of immunological features and driver mutations in improving management and prognosis has been emphasized.
EUROPEAN RESPIRATORY REVIEW
(2021)
Correction
Pharmacology & Pharmacy
Diego Kauffmann-Guerrero, Kathrin Kahnert, Rudolf M. Huber
Meeting Abstract
Oncology
Scott N. Gettinger, Rudolf M. Huber, Dong-Wan Kim, Lyudmila Bazhenova, Karin Holmskov Hansen, Marcello Tiseo, Corey J. Langer, Luis G. Paz-Ares, Howard West, Karen L. Reckamp, Glen J. Weiss, Egbert F. Smit, Maximilian Hochmair, Sang-We Kim, Myung-Ju Ahn, Edward S. Kim, Harry J. M. Groen, Joanna Pye, Florin Vranceanu, D. Ross Camidge
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Oncology
Anna Kerpel-Fronius, Martin Tammemagi, Milena Cavic, Claudia Henschke, Long Jiang, Ella Kazerooni, Choon-Taek Lee, Luigi Ventura, Dawei Yang, Stephen Lam, Rudolf M. Huber
Summary: The feasibility and effectiveness of lung cancer screening for individuals who never smoked are uncertain due to current screening guidelines typically excluding this group. Evaluation in each country considering various factors, including risk assessment accuracy and cost-effectiveness, is necessary. Current evidence supporting widespread implementation of screening for never smokers is lacking.
JOURNAL OF THORACIC ONCOLOGY
(2022)
Article
Oncology
Rudolf M. Huber, Milena Cavic, Anna Kerpel-Fronius, Lucia Viola, John Field, Long Jiang, Ella A. Kazerooni, Coenraad F. N. Koegelenberg, Anant Mohan, Ricardo Sales Dos Santos, Luigi Ventura, Murry Wynes, Dawei Yang, Javier Zulueta, Choon-Taek Lee, Martin C. Tammemagi, Claudia Henschke, Stephen Lam
Summary: This report discusses the importance of global implementation of lung cancer screening and the impact of respiratory infections such as COVID-19 on screening. It highlights the risk of false positive results due to respiratory infections and provides guidance and recommendations for these situations, while also calling for further research and discussions.
JOURNAL OF THORACIC ONCOLOGY
(2022)
Letter
Oncology
Anna Kerpel-Fronius, Martin C. Tammemagi, Milena Cavic, Rudolf M. Huber, Dawei Yang, Javier Zulueta, Lucia Viola, Anant Mohan, Choon-Taek Lee, Milena Cavic, Heidi Schmidt, Ella Kazerooni, Ricardo Sales dos Santos, Claudia Henschke, Luigi Ventura, Long Jiang, Gabriella Sozzi, Stephen Lam, Rudolf Huber
JOURNAL OF THORACIC ONCOLOGY
(2022)
Article
Oncology
Amanda Tufman, Jens Neumann, Farkhad Manapov, Laura Sellmer, Andreas Jung, Diego Kauffmann-Guerrero, Kathrin Kahnert, Pontus Mertsch, Astrid Borgmeier, Sabine Semrau, Achim Rittmeyer, Bernhard Ulm, Kurt Ulm, Michael Flentje, Rainer Fietkau, Rudolf Maria Huber
Summary: This study explored the prognostic role of PD-L1 expression and tumor infiltrating lymphocytes in locally advanced non-small cell lung cancer post-radiochemotherapy. While PD-L1 expression did not correlate with progression-free survival, patients with high TiL score showed longer overall survival, particularly in those receiving consolidation chemotherapy after RTCT. Further analysis is needed to assess the prognostic and predictive relevance of TiLs in the context of consolidative checkpoint inhibition with durvalumab.
Article
Respiratory System
Michaela Schunk, Ursula Berger, Lien Le, Eva Rehfuess, Larissa Schwarzkopf, Sabine Streitwieser, Thomas Mueller, Miriam Hofmann, Rolf Holle, Rudolf Maria Huber, Ulrich Mansmann, Claudia Bausewein
Summary: The Munich Breathlessness Service has adapted novel support services to the German context in order to reduce burden in patients and carers from breathlessness in advanced disease. The BreathEase study has a larger and more heterogeneous sample compared to other trials and involves self-referral-based recruitment drawing on media sources. Integrating qualitative and quantitative components will allow a better understanding and interpretation of the results of the main effectiveness study.
Meeting Abstract
Oncology
Gabriele Multhoff, Stephanie E. Combs, Sophie Seier, Stefan Stangl, Wolfgang Sievert, Maxim Shevtsov, Christiane Blankenstein, Martin Hildebrandt, Konrad Kokowski, Matthias Hautmann, Hubert Hautmann, Claus Roedel, Rainer Fietkau, Rudolf M. Huber, Bernhard Haller, Christina Ertl, Michal Devecka, Robert Offner, Norbert Ahrens
Article
Oncology
Xiaoqing Liu, Amanda Tufman, Juergen Behr, Rosemarie Kiefl, Torsten Goldmann, Rudolf M. Huber