期刊
CLINICAL AND EXPERIMENTAL MEDICINE
卷 8, 期 3, 页码 141-145出版社
SPRINGER-VERLAG ITALIA SRL
DOI: 10.1007/s10238-008-0170-2
关键词
angiogenesis; cytokines; non-Hodgkin; lymphoma; prognosis; radiotherapy
资金
- Associazione Italiana per la Ricerca sul Cancro AIRC
- Ministry of Education, Universities and Research MUR [2005]
- CARSO Project [72/2]
- Ministry for Health - Regione Puglia [BS2]
- Fondazione Italiana per la Ricerca sul Cancro (FIRC), Milan, Italy
Serum levels of angiogenic cytokines decrease after radiotherapy in patients with cancer, and this may be relevant for treatment response and progression-free survival. Herein, we set out to determine whether circulating fibroblast growth factor-2 (FGF-2), vascular endothelial growth factor (VEGF), hepatocyte growth factor (HGF) and platelet-derived growth factor-beta (PDGF-beta) decrease after radiotherapy in patients with non-Hodgkin lymphomas (NHLs) and if so, whether their decrease correlates with age, tumour histotype and stage, and radiation dose. Material and methods The serum levels of FGF-2, VEGF, HGF and PDGF-beta were evaluated before and after radiotherapy by an enzyme-linked immunosorbent assay ( ELISA). These levels were correlated both reciprocally and with age, histotype, stage and radiation dose. Results After radiotherapy, FGF-2, VEGF and PDGF-beta, but not HGF, significantly decreased in relation to the radiation dose and response. No correlation was established between cytokine levels, except for VEGF and PDGF-beta, which decreased in parallel. Haemoglobin levels did not decrease after radiotherapy, while FGF-2, VEGF, HGF and PDGF-beta levels did not correlate with age, NHL stage and histotype. Conclusions Soluble FGF-2, VEGF and PDGF-beta levels decline after radiotherapy in NHLs, and may have predictive significance for response to treatment and recurrence.
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