Article
Multidisciplinary Sciences
Dao X. Nguyen, Helen M. Baldwin, Amara N. Ezeonyeji, Mohammed Rohan Butt, Michael R. Ehrenstein
Summary: The study revealed that patients with PsA have an increased Th17:Treg ratio, which can be reversed by anti-TNF therapy. Treg from patients treated with different therapies showed contrasting effects on regulating effector T-cell migration, with TNF blockade boosting Treg suppression of migration.
Article
Rheumatology
Maria Prendecki, Candice Clarke, Helena Edwards, Stacey McIntyre, Paige Mortimer, Sarah Gleeson, Paul Martin, Tina Thomson, Paul Randell, Anand Shah, Aran Singanayagam, Liz Lightstone, Alison Cox, Peter Kelleher, Michelle Willicombe, Stephen P. McAdoo
Summary: SARS-CoV-2 vaccines are immunogenic in patients receiving immunosuppression, though the response is impaired compared to healthy individuals. B-cell depletion following rituximab impairs serological responses, but T-cell responses are preserved in this group. Repeat vaccine doses for serological non-responders could be considered to induce more robust immunological response.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Chemistry, Multidisciplinary
David A. A. McBride, Matthew D. D. Kerr, Wade T. T. Johnson, Anders Nguyen, Martina Zoccheddu, Mina Yao, Edward B. B. Prideaux, Nicholas C. C. Dorn, Wei Wang, Mattias N. D. Svensson, Nunzio Bottini, Nisarg J. J. Shah
Summary: An immunoregulatory approach based on sustained release of all-trans retinoic acid (ATRA) has been developed to modulate local immune activation and enhance disease-protective T cells for the treatment of autoimmune inflammatory arthritides. The ATRA is encapsulated in biodegradable microparticles and injected into the arthritic mouse joints, leading to the migration of T cells and reduction of inflammation. This approach shows potential as a disease modifying agent for autoimmune arthritis.
Review
Pharmacology & Pharmacy
Xiaoya Li, Huihui Xu, Jing Huang, Dan Luo, Shuang Lv, Xiangchen Lu, Cheng Xiao
Summary: Regulatory T cells (Tregs) play a crucial role in promoting immune tolerance and maintaining immune system homeostasis. Dysfunction of Tregs is closely linked to rheumatoid arthritis (RA), and research on Tregs in RA has made significant progress in both basic and clinical aspects.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Immunology
Konstantin Kotschenreuther, Shuaifeng Yan, David M. Kofler
Summary: Regulatory T (T-reg) cells are crucial in the pathogenesis of rheumatoid arthritis (RA), contributing to immune homeostasis and tissue migration.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jian Lu, Jing Wu, Xueli Xia, Huiyong Peng, Shengjun Wang
Summary: RA is a chronic autoimmune disease characterized by joint and systemic inflammation, with Tfh cells playing a crucial role in the pathogenesis of the disease and affecting disease activity.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Rheumatology
Mitsuhiro Akiyama, Waleed Alshehri, Keiko Yoshimoto, Yuko Kaneko
Summary: Recent technological progress has advanced our understanding of human immunology through the discovery of T follicular helper (Tfh) and T peripheral helper (Tph) cells. These cells play critical roles in B cell differentiation and maturation, with differences in their functional properties. In various rheumatic and musculoskeletal diseases, the contribution of Tfh and Tph cells varies, with Tph cells predominating in peripheral inflammatory lesions and Tfh cells predominating in affected lesions of IgG4-related disease. This review provides an overview of these novel T cell subsets and their involvement in these diseases.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Immunology
Qi Jiang, Guocan Yang, Qi Liu, Shengjun Wang, Dawei Cui
Summary: Rheumatoid arthritis is a systemic and heterogeneous autoimmune disease characterized by symmetrical polyarthritis, with dysfunction of regulatory T (Treg) cells potentially contributing to the breakdown of self-tolerance. The ideal treatment strategy for RA should focus on re-inducing self-tolerance to prevent obvious tissue injury.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
William Murray-Brown, Yanxia Guo, Annabelle Small, Katie Lowe, Helen Weedon, Malcolm D. Smith, Susan E. Lester, Susanna M. Proudman, Navin L. Rao, Ling-Yang Hao, Sunil Nagpal, Mihir D. Wechalekar
Summary: This study aimed to characterize PD-1-expressing Tph cells in early rheumatoid arthritis and found that these cells accumulate prior to fully established disease.
Article
Multidisciplinary Sciences
Vilma Urbonaviciute, Laura Romero-Castillo, Bingze Xu, Huqiao Luo, Nadine Schneider, Sylvia Weisse, Nhu-Nguyen Do, Ana Oliveira-Coelho, Gonzalo Fernandez Lahore, Taotao Li, Pierre Sabatier, Christian M. Beusch, Johan Viljanen, Roman A. Zubarev, Jan Kihlberg, Johan Baecklund, Harald Burkhardt, Rikard Holmdahl
Summary: The long-term goal is to find a vaccine for autoimmune diseases. It has been challenging to safely regulate the targeting of natural regulatory antigen. This study shows that the administration of exogenous MHC II protein binding a unique galactosylated COL2 peptide leads to the expansion of VISTA-positive regulatory T cells, resulting in potent suppression and protection against arthritis in mice. The tolerogenic approach described here may be a promising therapy for rheumatoid arthritis and autoimmune diseases.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Immunology
Kazuhiko Higashioka, Motoki Yoshimura, Takahide Sakuragi, Masahiro Ayano, Yasutaka Kimoto, Hiroki Mitoma, Nobuyuki Ono, Yojiro Arinobu, Makoto Kikukawa, Hisakata Yamada, Takahiko Horiuchi, Koichi Akashi, Hiroaki Niiro
Summary: The identification of IL-21-producing PD-1(hi)CD8(+) T cells in patients with RA expands understanding of T cell subsets with B helper functions in the disease. Selective targeting of these subsets could lead to the development of novel treatment strategies for RA.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell & Tissue Engineering
P. Luo, P. Wang, J. Xu, W. Hou, P. Xu, K. Xu, L. Liu
Summary: Rheumatoid arthritis is an autoimmune disease involving T and B cells and their interactions with proinflammatory cytokines. T cells, including Th1, Th2, Th17, and Tfh cells, play important roles in RA by secreting different cytokines and promoting joint destruction and disease progression.
BONE & JOINT RESEARCH
(2022)
Article
Immunology
Gaoyang Li, Shrikant Shantilal Kolan, Shuai Guo, Katarzyna Marciniak, Pratibha Kolan, Giulia Malachin, Franco Grimolizzi, Guttorm Haraldsen, Bjorn Steen Skalhegg
Summary: The development of Delayed-type hypersensitivity arthritis (DTHA) in mice involves increased levels of activated, pro-inflammatory Th1, Th17, and memory CD4+ T cells with differential dynamic patterns, while B cells seem to not be involved. Methotrexate (MTX) and dexamethasone (DEX) can suppress DTHA-induced paw swelling and inflammation by regulating levels of Th1, Th17, memory T cells, and B cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell Biology
Maryam Masoumi, Samira Alesaeidi, Hossein Khorramdelazad, Mousa Behzadi, Rasoul Baharlou, Shahin Alizadeh-Fanalou, Jafar Karami
Summary: Evidence has shown that metabolic-associated T cell abnormalities can be detected in the early stages of rheumatoid arthritis (RA) development. Molecular evaluations have revealed changes in metabolic pathways in RA T cells, leading to an aggressive phenotype. Many genes involved in metabolic pathways exhibit abnormal expression in RA T cells. Additionally, metabolic alterations affect DNA repair and fatty acid oxidation pathways, which impact the functionality and invasive phenotype of RA T cells. Understanding the role of metabolic pathways in RA pathogenesis can provide insights into the interactions between the environment, genes, and host/microbiota, and aid in the development of potential therapeutic approaches.
Article
Immunology
Carolin Brueck, Viktoria Golumba-Nagy, Shuaifeng Yan, Ruth L. Esser, Jan Thiele, David Stahl, Carola tho Pesch, Eva Steinbach-Knoedgen, David M. Kofler
Summary: This study confirmed the downregulation of CD6 on certain CD4+ T cell subsets in healthy individuals and patients with rheumatoid arthritis following T cell activation. However, Th1 cells and Th17 cells showed resistance to CD6 downregulation.
CLINICAL IMMUNOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Cinzia Forni, Francesco Facchiano, Manuela Bartoli, Stefano Pieretti, Antonio Facchiano, Daniela D'Arcangelo, Sandro Norelli, Giorgia Valle, Roberto Nisini, Simone Beninati, Claudio Tabolacci, Ravirajsinh N. Jadeja
BIOMED RESEARCH INTERNATIONAL
(2019)
Article
Infectious Diseases
Paola Stefanelli, Giovanni Faggioni, Alessandra Lo Presti, Stefano Fiore, Antonella Marchi, Eleonora Benedetti, Concetta Fabiani, Anna Anselmo, Andrea Ciammaruconi, Antonella Fortunato, Riccardo De Santis, Silvia Fillo, Maria Rosaria Capobianchi, Maria Rita Gismondo, Alessandra Ciervo, Giovanni Rezza, Maria Rita Castrucci, Florigio Lista
Review
Allergy
Paolo Maria Matricardi, Roberto Walter Dal Negro, Roberto Nisini
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2020)
Letter
Microbiology
Sabrina Mariotti, Raffaela Teloni, Valeria de Turris, Manuela Pardini, Daniela Peruzzu, Katia Fecchi, Roberto Nisini, Maria Cristina Gagliardi
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2020)
Article
Immunology
Fabiola Mancini, Fabrizio Barbanti, Maria Scaturro, Stefano Fontana, Angela Di Martino, Giulia Marsili, Simona Puzelli, Laura Calzoletti, Marzia Facchini, Giuseppina Di Mario, Concetta Fabiani, Antonino Bella, Flavia Riccardo, Patrizio Pezzotti, Paola Stefanelli, Giovanni Rezza, Alessandra Ciervo
Summary: The study demonstrates that the multiplex real-time reverse-transcription polymerase chain reaction (PCR) assay is a rapid, valid, and accurate method for detecting SARS-CoV-2 and influenza viruses in clinical samples. This test is able to distinguish different virus targets, detect coinfections, and serve as an important diagnostic and surveillance tool during seasonal influenza activity.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Noemi Poerio, Federica De Santis, Alice Rossi, Serena Ranucci, Ida De Fino, Ana Henriquez, Marco M. D'Andrea, Fabiana Ciciriello, Vincenzina Lucidi, Roberto Nisini, Alessandra Bragonzi, Maurizio Fraziano
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Claudia Ferlito, Roberto Biselli, Vincenzo Visco, Maria Sofia Cattaruzza, Maria Rosaria Capobianchi, Concetta Castilletti, Daniele Lapa, Loredana Nicoletti, Antonella Marchi, Fabio Magurano, Anna Rita Ciccaglione, Paola Chionne, Elisabetta Madonna, Isabella Donatelli, Laura Calzoletti, Concetta Fabiani, Michela Ileen Biondo, Raffaela Teloni, Sabrina Mariotti, Gerardo Salerno, Andrea Picchianti-Diamanti, Simonetta Salemi, Sara Caporuscio, Alberto Autore, Patrizia Lulli, Francesco Borelli, Marco Lastilla, Roberto Nisini, Raffaele D'Amelio
Summary: A study on Italian military personnel analyzed the response to various vaccinations and found excellent vaccine immunogenicity, long antibody persistence, and apparent lack of vaccine interference between different vaccines.
Article
Biochemistry & Molecular Biology
Claudio Tabolacci, Martina Cordella, Sabrina Mariotti, Stefania Rossi, Cinzia Senatore, Carla Lintas, Lauretta Levati, Daniela D'Arcangelo, Antonio Facchiano, Stefania D'Atri, Roberto Nisini, Francesco Facchiano
Summary: The study focused on secretome profiling of melanoma cells sensitive or resistant to the BRAFi vemurafenib, finding that vemurafenib-resistant melanoma cells can influence dendritic cell maturation and produce higher levels of pro-inflammatory cytokines. Proteomic and cytokine/chemokine secretion analyses suggest a possible involvement of the proteasome pathway in BRAFi resistance, with BRAFi-resistant cells displaying a more aggressive phenotype and increased production of specific proteins. Plasma levels of CD147/basigin and MMP-2 were observed to increase in melanoma patients at the time of treatment failure, supporting the hypothesis that CD147/basigin might play a role in BRAFi resistance.
Review
Biochemistry & Molecular Biology
Raffaele D'Amelio, Riccardo Asero, Marco Antonio Cassatella, Bruno Lagana, Claudio Lunardi, Paola Migliorini, Roberto Nisini, Paola Parronchi, Isabella Quinti, Vito Racanelli, Gianenrico Senna, Angelo Vacca, Enrico Maggi
Summary: The COVID-19 pandemic has posed an unprecedented challenge to humanity since February 2020, affecting health, economy, and society globally. Italy was the first Western country deeply impacted, prompting immunological societies to address issues of vaccine safety, immunogenicity, and efficacy for patients with compromised immune systems, such as AIAIDs, PIDs, and SIDs.
Article
Immunology
Sabrina Mariotti, Antonio Capocefalo, Maria Vincenza Chiantore, Angelo Iacobino, Raffaela Teloni, Maria Laura De Angelis, Alessandra Gallinaro, Maria Franca Pirillo, Martina Borghi, Andrea Canitano, Zuleika Michelini, Melissa Baggieri, Antonella Marchi, Paola Bucci, Paul F. McKay, Chiara Acchioni, Silvia Sandini, Marco Sgarbanti, Fabio Tosini, Antonio Di Virgilio, Giulietta Venturi, Francesco Marino, Valeria Esposito, Paola Di Bonito, Fabio Magurano, Andrea Cara, Donatella Negri, Roberto Nisini
Summary: This study produced neutralizing antibodies that can bind to the spike protein of SARS-CoV-2, which are important tools for diagnosis and therapy of COVID-19.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Marta De Angelis, David Della-Morte, Gabriele Buttinelli, Angela Di Martino, Francesca Pacifici, Paola Checconi, Luigina Ambrosio, Paola Stefanelli, Anna Teresa Palamara, Enrico Garaci, Camillo Ricordi, Lucia Nencioni
Summary: Studies have shown that the A5+ mixture is more effective in inhibiting influenza virus and SARS-CoV-2 infections, reducing viral protein expression and viral release. Additionally, A5+ treatment significantly decreases IL-6 cytokine production in influenza virus-infected cells.
Article
Biochemistry & Molecular Biology
Claudia Ferlito, Vincenzo Visco, Roberto Biselli, Maria Sofia Cattaruzza, Giulia Carreras, Gerardo Salerno, Florigio Lista, Maria Rosaria Capobianchi, Concetta Castilletti, Daniele Lapa, Guido Antonelli, Massimo Gentile, Maurizio Sorice, Gloria Riitano, Giuseppe Lucania, Valeria Riccieri, Fabrizio Mainiero, Antonio Angeloni, Marco Lucarelli, Giampiero Ferraguti, Alberto Autore, Marco Lastilla, Simonetta Salemi, Michela Ileen Biondo, Andrea Picchianti-Diamanti, Sara Caporuscio, Raffaela Teloni, Sabrina Mariotti, Roberto Nisini, Raffaele D'Amelio
Summary: This study analyzed the possible late appearance of side effects and the half-life of induced antibodies in a military cohort. The results showed no late side effects and confirmed the long duration of certain vaccine-induced antibodies.
Article
Virology
Alessandra Lo Presti, Angela Di Martino, Giovanni Faggioni, Francesco Giordani, Silvia Fillo, Anna Anselmo, Vanessa Vera Fain, Antonella Fortunato, Giancarlo Petralito, Filippo Molinari, Stefano Palomba, Riccardo De Santis, Stefano Fiore, Concetta Fabiani, Giuseppina Di Mario, Marzia Facchini, Laura Calzoletti, Florigio Lista, Giovanni Rezza, Paola Stefanelli
Summary: In this study, we analyzed the SARS-CoV-2 genomes from different regions in Italy. The results showed that the spread primarily occurred from the north to the center and south, consistent with epidemiological data. The estimated evolutionary rate was similar to previous studies, and the phylogenetic analysis suggested that the virus entered Italy in late January or early February 2020. Continuous molecular surveillance is necessary to track virus circulation and evolution.
Article
Infectious Diseases
Daniele Petrone, Alberto Mateo-Urdiales, Chiara Sacco, Flavia Riccardo, Antonino Bella, Luigina Ambrosio, Alessandra Lo Presti, Angela Di Martino, Emiliano Ceccarelli, Martina Del Manso, Massimo Fabiani, Paola Stefanelli, Patrizio Pezzotti, AnnaTeresa Palamara
Summary: This study aimed to assess the impact of the Omicron variant on severe COVID-19 compared to the Delta variant in Italy. The study found that cases with Omicron had a reduced risk of severe COVID-19 compared to Delta. The protective effect was most significant in the 40-59 age group, while no protection was observed in the 12-39 age group. Vaccination was associated with a lower risk of severe COVID-19 in both variants.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Public, Environmental & Occupational Health
Luigi Bertinato, Gianfranco Brambilla, Paola De Castro, Antonella Rosi, Roberto Nisini, Annarita Barbaro, Donatella Gentili, Franco Toni, Antonio Mistretta, Raffaella Bucciardini, Duilio Carusi, Aurora Angelozzi, Luca Busanis, Ernesto Costabile, Patrizia Mochi, Susanna Caminada, Fabio Magurano, Silvio Brusaferroo
Summary: The Istituto Superiore di Sanita (ISS) established a Working Group on Scientific Literature updates (WG SL) during the Sars-CoV-2 pandemic, screening a large number of pre-prints and peer reviewed papers to provide real-time knowledge and evidence for health-workers. They submitted daily summary reports of pre-print selection to the ISS President and published weekly open access papers of interest for health professionals, monitored through satisfaction questionnaires. Promoting health literacy with a cross-cutting approach has been proven to be an effective non-pharmacological intervention.
ANNALI DELL ISTITUTO SUPERIORE DI SANITA
(2021)