Article
Biochemistry & Molecular Biology
Zhangcheng Fei, Renjun Pei, Bo Pan, Shengliang Ye, Rong Zhang, Li Ma, Zongkui Wang, Changqing Li, Xi Du, Haijun Cao
Summary: Alzheimer's disease (AD) is a neurodegenerative disease without a known cure. Intravenous immunoglobulin (IVIG), containing AD-related antibodies and having anti-inflammatory properties, shows potential as a treatment for AD, although clinical trial efficacy has been inconsistent. This study compared three IVIGs with notable differences in therapeutic effects to investigate the relationship between IVIG composition, function, and efficacy in treating AD. The results suggest that the efficacy of IVIG against AD may be correlated with its level of AD-related antibodies and anti-inflammatory ability, emphasizing the importance of antibody analysis and functional evaluation of IVIG before clinical trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Hun-Ju Yu, Meng-Ni Chuang, Chiao-Lun Chu, Pei-Lin Wu, Shu-Chen Ho, Ho-Chang Kuo
Summary: Kawasaki disease (KD) is a systemic vasculitis that primarily affects children under the age of 5, with significant complications such as coronary artery lesions. Recent studies have shown an increasing incidence of myopia among KD patients, indicating that IVIG treatment may decrease the risk of myopia in this population.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Shuran Shao, Kaiyu Zhou, Xiaoliang Liu, Lei Liu, Mei Wu, Yuxin Deng, Hongyu Duan, Yifei Li, Yimin Hua, Chuan Wang
Summary: This study found that lipid profiles were significantly dysregulated in KD patients with IVIG resistance and CALs. Some of them, such as LDL-C and Apo A, could serve as complementary laboratory markers for predicting both IVIG resistance and CALs.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Immunology
Xi Chen, Lu Gao, Zhen Zhen, Ying Wang, Jia Na, Wen Yu, Xinyuan Chu, Yue Yuan, Suyun Qian
Summary: The purpose of this study was to explore the risk factors and develop predictive models for intravenous immunoglobulin (IVIG) resistance in children with recurrent KD. The study found that age and IVIG resistance at the first episode, as well as some laboratory variables, may be risk factors for IVIG resistance. Two predictive models for IVIG resistance with excellent performance were established.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Yimeng Gao, Hongzhong Jin
Summary: Our systematic review suggests that IVIG therapy is a safe and effective treatment alternative for refractory LV patients, showing good clinical response and reducing dependence on other medications.
THERAPEUTIC ADVANCES IN CHRONIC DISEASE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Gemma Cuberas-Borros, Isabel Roca, Joan Castell-Conesa, Laura Nunez, Merce Boada, Oscar L. Lopez, Carlota Grifols, Miquel Barcelo, Deborah Pareto, Antonio Paez
Summary: The study aimed to investigate the effects of therapeutic plasma exchange (PE) with albumin replacement on structural and functional brain changes in Alzheimer's disease patients. The results showed that patients receiving high-dose albumin + IVIG treatment had fewer volume changes in certain brain regions compared to other groups. The analysis of F-18-fluorodeoxyglucose positron emission tomography (18FDG-PET) showed worsening metabolic activity in the specific areas affected in Alzheimer's disease. The group treated with high-dose albumin + IVIG showed the greatest metabolic stability and least progression of defect compared to placebo.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Pediatrics
Yaheng Lu, Tingting Chen, Yizhou Wen, Feifei Si, Xindan Wu, Yanfeng Yang
Summary: This study found that predictors PCT and CRP can be used to predict resistance to repeated IVIG treatment in patients with Kawasaki disease.
Article
Immunology
Xiaoliang Liu, Shuran Shao, Nanjun Zhang, Mei Wu, Lei Liu, Hongyu Duan, Zhongqiang Liu, Kaiyu Zhou, Yimin Hua, Chuan Wang
Summary: This study investigated the role of prognostic nutritional index (PNI) in predicting intravenous immunoglobulin (IVIG) resistance and cardiovascular complications in Kawasaki disease (KD). The results showed that lower levels of PNI were independent risk factors for initial IVIG resistance and cardiovascular complications. The sampling-time specific PNI cut-off values demonstrated good predictive power for both IVIG resistance and cardiovascular complications.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Fengchuan Jing, Haobo Weng, Qiongfei Pei, Jing Zhang, Ruixi Liu, Qijian Yi
Summary: miR-221-3p may be involved in the pathogenesis of KD and IVIG resistance, and miR-221-3p can be used as a new potential biomarker to predict IVIG resistance in children with KD.
CLINICAL AND EXPERIMENTAL MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Caroline von Achenbach, Giselle Hevia Hernandez, Stephan von Gunten
Summary: IVIG and SCIG are used to treat various immunodeficiencies and inflammatory conditions, with treatment decisions influenced by patient conditions, preferences, and economic factors. Understanding and comparing the two treatment modalities are crucial for optimal therapeutic options.
Article
Critical Care Medicine
Tim Rahmel, Felix Kraft, Helge Haberl, Ute Achtzehn, Timo Brandenburger, Holger Neb, Dominik Jarczak, Maximilian Dietrich, Harry Magunia, Frieda Zimmer, Jale Basten, Claudia Landgraf, Thea Koch, Kai Zacharowski, Markus A. Weigand, Peter Rosenberger, Roman Ullrich, Patrick Meybohm, Axel Nierhaus, Detlef Kindgen-Milles, Nina Timmesfeld, Michael Adamzik
Summary: A retrospective multicentric cohort study found that intravenous IgM-enriched immunoglobulins may have clinically relevant effects in certain subgroups of critically ill patients with COVID-19.
Article
Microbiology
Michal Yakubovsky, Yoav Golan, Alex Guri, Itzhak Levy, Daniel Glikman, Moshe Ephros, Michael Giladi
Summary: This study reports the misdiagnosis of neurological patients and Kawasaki disease patients as cat scratch disease (CSD) due to false-positive serology following intravenous immunoglobulin (IVIG) therapy. IVIG treatment can result in false-positive serology for B. henselae, and caution is needed to ensure accurate diagnosis.
Article
Pediatrics
Cassandra Cardenas-Brown, Ryan D. Lucas, Jim Buttery, Philip N. Britton, Nicholas Wood, Davinder Singh-Grewal, David Burgner
Summary: Australian and New Zealand guidelines recommend postponing live vaccines for 11 months after treatment of Kawasaki disease (KD) with intravenous immunoglobulin (IVIG). This study aimed to assess the adherence to guidelines regarding live-vaccine administration after KD treatment and found that the majority of Australian children treated for KD with IVIG may not be optimally protected by MMRV vaccination.
JOURNAL OF PAEDIATRICS AND CHILD HEALTH
(2023)
Article
Clinical Neurology
Xue Gong, Rong Luo, Jie Liu, Kundian Guo, Aiqing Li, Xu Liu, Yue Liu, Dong Zhou, Zhen Hong
Summary: This study compared the effectiveness and safety of different treatment strategies as initial therapy for anti-NMDAR encephalitis. The results showed that combined treatment with IVIg and IVMP had a higher response rate, improved Rankin Scale scores, and lower recurrence rate compared to either IVIg or IVMP monotherapy.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Immunology
Yoshihiko Morikawa, Hiroshi Sakakibara, Takahisa Kimiya, Toshimasa Obonai, Masaru Miura
Summary: The study showed that the effectiveness of live attenuated vaccine (LAV) was low at six months after IVIG therapy for Kawasaki disease, but seroconversion was achievable with a booster vaccination at 12 months.