Article
Dentistry, Oral Surgery & Medicine
Marquise Snipes, Chao Sun, Hong Yu
Summary: In this study, it was found that inhibition of sphingosine-1-phosphate receptor 2 (S1PR2) by its specific antagonist JTE013 could alleviate ligature-induced periodontitis in mice. Treatment with JTE013 reduced alveolar bone loss, inflammatory cytokine levels, leukocyte infiltration, and osteoclast numbers in the periodontal tissues compared to control. Oral topical administration of JTE013 shows promise as a potential therapeutic approach for periodontal inflammatory bone loss.
Article
Biochemistry & Molecular Biology
Rachel S. Knipe, Jillian J. Spinney, Elizabeth A. Abe, Clemens K. Probst, Alicia Franklin, Amanda Logue, Francesca Giacona, Matt Drummond, Jason Griffith, Patricia L. Brazee, Lida P. Hariri, Sydney B. Montesi, Katherine E. Black, Timothy Hla, Andrew Kuo, Andreane Cartier, Eric Engelbrecht, Christina Christoffersen, Barry S. Shea, Andrew M. Tager, Benjamin D. Medoff
Summary: Idiopathic pulmonary fibrosis is a chronic disease that causes respiratory failure. This study reveals the importance of vascular permeability in lung repair and fibrosis following injury, and the potential role of lipid mediator S1P in regulating this process.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rachel S. Resop, Bradley Salvatore, Shawn J. Kim, Brent R. Gordon, Bianca Blom, Dimitrios N. Vatakis, Christel H. Uittenbogaart
Summary: HIV-1 infection leads to upregulation of S1P receptor 1 (S1PR1) in the human thymus, potentially increasing the number and speed of thymocyte egress. This may have implications for immune function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Na Wang, Jing-Yi Li, Bo Zeng, Gui-Lan Chen
Summary: Sphingosine-1-phosphate (S1P) is a crucial sphingolipid molecule that regulates cardiovascular functions through binding and activating multiple G protein-coupled receptors in different cell types. It affects cell proliferation, migration, differentiation, and apoptosis through various downstream signaling pathways. Abnormal S1P levels are associated with cardiovascular disorders, and further research is needed to explore the potential therapeutic use of S1P in these diseases.
Article
Chemistry, Medicinal
Oscar Mammoliti, Adeline Palisse, Caroline Joannesse, Sandy El Bkassiny, Brigitte Allart, Alex Jaunet, Christel Menet, Beatrice Coornaert, Kathleen Sonck, Inge Duys, Philippe Clement-Lacroix, Line Oste, Monica Borgonovi, Emanuelle Wakselman, Thierry Christophe, Nicolas Houvenaghel, Mia Jans, Bertrand Heckmann, Laurent Saniere, Reginald Brys
Summary: Studies suggest that blocking S1P2 receptor signaling could be effective for treating idiopathic pulmonary fibrosis, with only a few antagonists disclosed so far. A chemical enablement strategy led to the discovery of a pyridine series with good antagonist activity, and further optimization identified a compound with potent activity in a phenotypic IL8 release assay and bleomycin-induced model of pulmonary fibrosis.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Cell Biology
Kana Masuda-Kuroki, Shahrzad Alimohammadi, Anna Di Nardo
Summary: Psoriasis is a chronic skin condition that lacks a complete cure. Recent studies have identified sphingolipid metabolites as significant contributors to psoriasis, particularly ceramide and sphingosine-1-phosphate (S1P). The modulation of S1P and its receptor has shown potential in improving psoriasis inflammation.
Article
Microbiology
Jiah Yeom, Dong Joon Yim, Seongho Ma, Young-Hee Lim
Summary: P. freudenreichii MJ2 inhibits osteoclast differentiation and improves rheumatoid arthritis in both in vitro and in vivo studies. Live and dead MJ2 showed similar therapeutic effects in the arthritis model.
Article
Immunology
Anil K. Singh, Mahamudul Haque, Bhanupriya Madarampalli, Yuanyuan Shi, Benjamin J. Wildman, Abdul Basit, Sadik A. Khuder, Bhagwat Prasad, Quamarul Hassan, Salahuddin Ahmed, Madhu M. Ouseph
Summary: IL-6 trans-signaling induces molecular reprogramming of RASFs to osteoclast-like cells through the activation of transcription factor Ets2, leading to increased expression of osteoclast-specific proteins and markers of invasive phenotype.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Silvia Squillace, Michael L. Niehoff, Timothy M. Doyle, Michael Green, Emanuela Esposito, Salvatore Cuzzocrea, Christopher K. Arnatt, Sarah Spiegel, Susan A. Farr, Daniela Salvemini
Summary: This study identifies the molecular mechanisms of the S1P/S1PR1 axis in CRCI and proposes S1PR1 antagonism as a potential therapeutic approach with fast-track clinical application for CRCI.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Immunology
Yingqin Wang, Chen Wang, Qiaolan He, Guannan Chen, Jie Yu, Jing Cang, Ming Zhong
Summary: Inhibition of S1PR3 attenuates NLRP3 inflammasome activation by suppressing the expression of NLRP3 and pro-IL-1 beta during LPS priming and impeding the membrane trafficking of TWIK2 and potassium efflux induced by ATP. However, inhibition of S1PR3 leads to increased bacterial loads and mortality in CLP mice.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Leiye Yu, Licong He, Bing Gan, Rujuan Ti, Qingjie Xiao, Hongli Hu, Lizhe Zhu, Sheng Wang, Ruobing Ren
Summary: This study reveals the activation and regulation mechanism of human S1PR1 receptor through cryo-electron microscopy analysis. The S1PR1 receptor plays an essential role in the immune and vascular systems, and understanding its function in depth contributes to the development of related therapeutic approaches.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Clinical Neurology
Ben Gaastra, John Zhang, Will Tapper, Diederik Bulters, Ian Galea
Summary: Sphingosine-1-phosphate (S1P) plays a role in the pathophysiology of neurological injury after aneurysmal subarachnoid haemorrhage (aSAH). The literature agrees that S1P increases in cerebrospinal fluid following aSAH and contributes to cerebral artery vasospasm. However, the role of S1P in the parenchyma is less clear, with conflicting studies suggesting both beneficial and harmful effects. This review provides a concise interpretation of the conflicting data and discusses the potential repurposing of S1P receptor modulators for aSAH.
TRANSLATIONAL STROKE RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Ling-Wei Hii, Felicia Fei-Lei Chung, Chun-Wai Mai, Pei Yuen Ng, Chee-Onn Leong
Summary: SPHK1 is a conserved lipid enzyme that catalyzes the formation of S1P, and has been implicated in oncogenic functions, particularly in breast cancer. Recent evidence suggests a role for SPHK1 in regulating CSCs, indicating the therapeutic potential of targeting SPHK1 in refractory cancers enriched with CSCs.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Biology
Cristina Almeida-Santiago, Juan Carlos Quevedo-Abeledo, Maria Vanesa Hernandez-Hernandez, Antonia de Vera-Gonzalez, Alejandra Gonzalez-Delgado, Miguel Angel Gonzalez-Gay, Ivan Ferraz-Amaro
Summary: This study aimed to analyze the linear correlation between IL-1ra and IL-6 in patients with rheumatoid arthritis (RA) and their relationship with disease's inflammatory activity. IL-6 and IL-1ra levels were measured in 407 RA patients. No correlation was found between serum levels of IL-6 and IL-1ra. However, both cytokines were positively associated with disease activity and acute phase reactants. After controlling for covariates, disease activity scores were more strongly associated with IL-1ra compared to IL-6.
Article
Medicine, General & Internal
Zhihui Zhu, Liping Zhang, Ahmed Elsherbini, Simone M. Crivelli, Priyanka Tripathi, Carmen Harper, Zainuddin Quadri, Stefka D. Spassieva, Erhard Bieberich
Summary: This study found that Ponesimod, as a S1PR1 receptor antagonist, can prevent the activation of glial cells and Alzheimer's disease (AD) pathology caused by β-amyloid peptide (AP). Ponesimod inhibits the increase of S1PR1 receptor and Toll-like receptor 4 (TLR4), activates the anti-inflammatory Stat6 signaling pathway, enhances the phagocytosis of β-amyloid peptide (AP) in microglia, reduces inflammation and amyloid plaque deposition, and improves spatial memory.