期刊
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
卷 173, 期 3, 页码 493-501出版社
WILEY
DOI: 10.1111/cei.12137
关键词
apoptosis; autoreactive TCR; Bim; V beta 8(+) lymphocytes
类别
资金
- Swiss National Foundation [31003A_127247]
- Broad Medical Research Program [IBD-0324R]
- Swiss National Science Foundation (SNF) [31003A_127247] Funding Source: Swiss National Science Foundation (SNF)
We investigated the role of B cell lymphoma (BCL)-2-interacting mediator of cell death (Bim) for lymphocyte homeostasis in intestinal mucosa. Lymphocytes lacking Bim are refractory to apoptosis. Chronic colitis was induced in Bim-deficient mice (Bim(-/-)) with dextran sulphate sodium (DSS). Weight loss and colonoscopic score were increased significantly in Bim(-/-) mice compared to wild-type mice. As Bim is induced for the killing of autoreactive cells we determined the role of Bim in the regulation of lymphocyte survival at mucosal sites. Upon chronic dextran sulphate sodium (DSS)-induced colitis, Bim(-/-) animals exhibited an increased infiltrate of lymphocytes into the mucosa compared to wild-type mice. The number of autoreactive T cell receptor (TCR) V8(+) lymphocytes was significantly higher in Bim(-/-) mice compared to wild-type controls. Impaired removal of autoreactive lymphocytes in Bim(-/-) mice upon chronic DSS-induced colitis may therefore contribute to aggravated mucosal inflammation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据