Article
Biochemistry & Molecular Biology
Mark M. Melamud, Evgeny A. Ermakov, Anastasiia S. Boiko, Daria A. Kamaeva, Alexey E. Sizikov, Svetlana A. Ivanova, Natalia M. Baulina, Olga O. Favorova, Georgy A. Nevinsky, Valentina N. Buneva
Summary: The study revealed that 11 cytokines were increased in the cytokine profile of systemic lupus erythematosus patients, while 10 cytokines were significantly decreased in multiple sclerosis patients. These changes were associated with dysregulation of interleukins, TNF superfamily members, and chemokines in SLE, and abnormal levels of growth factors and chemokines in MS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Dionysis Nikolopoulos, Dimitrios Kitsos, Matilda Papathanasiou, Noemin Kapsala, Panagiotis Garantziotis, Antigone Pieta, Ourania Gioti, Alexandros Grivas, Konstantinos Voumvourakis, Dimitrios Boumpas, Antonis Fanouriakis
Summary: In a large SLE cohort, CNS demyelinating syndromes were characterized as neuropsychiatric SLE (NPSLE) or SLE-MS overlap. Patients with SLE-MS overlap had a higher likelihood of neurologic relapses, while those with SLE-demyelination were less likely to have neurological deficits at the last follow-up visit.
FRONTIERS IN NEUROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Patricia Richter, Anca Cardoneanu, Nicoleta Dima, Ioana Bratoiu, Ciprian Rezus, Alexandra Maria Burlui, Damiana Costin, Luana Andreea Macovei, Elena Rezus
Summary: Interstitial lung disease (ILD) is a serious manifestation of connective tissue diseases (CTD) that requires thorough evaluation and treatment. The prevalence of ILD in systemic lupus erythematosus (SLE) is still debated, but it is crucial to exclude an overlap syndrome for an accurate diagnosis. Increasing the identification of SLE-associated ILD cases is important, and various treatment options are being proposed. Systemic sclerosis (SSc)-associated ILD is a leading cause of mortality and should be investigated in all SSc patients. Progress has been made in the treatment of ILD, with tyrosine kinases inhibitor Nintedanib showing promising results in reducing the progression rate compared to placebo.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiao Luo, Sirong Piao, Haiqing Li, Yuxin Li, Wei Xia, Yifang Bao, Xueling Liu, Daoying Geng, Hao Wu, Liqin Yang
Summary: A multi-lesion radiomics model based on MRI was developed to discriminate between RRMS and NPSLE. The model outperformed the single-lesion radiomics method and radiologists in accurately differentiating the two diseases.
EUROPEAN RADIOLOGY
(2022)
Review
Chemistry, Medicinal
Przemyslaw Kotyla, Olga Gumkowska-Sroka, Bartosz Wnuk, Kacper Kotyla
Summary: Systemic sclerosis and systemic lupus erythematosus are two distinct autoimmune diseases belonging to connective tissue disorders, with no groundbreaking therapeutic approaches developed yet. The discovery of JAK kinases may offer a new therapeutic potential for previously untreatable diseases.
Article
Immunology
Jialin Zhang, Xiaodong Wu, Jing Xue, Lei Liu
Summary: When a patient with lupus presents with neurologic symptoms, rheumatologists should consider the diagnosis of Neuropsychiatric systemic lupus erythematosus (NPSLE) as the most likely cause. However, neurological symptoms are rare in systemic sclerosis (SSc), and high doses of steroids can trigger scleroderma renal crisis (SRC). It is important to carefully diagnose and decide whether to initiate high-dose glucocorticoid therapy in a patient with SSc overlapping SLE who presents with epilepsy and renal crisis.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Paul Curtiss, Amanda M. Walker, Benjamin F. Chong
Summary: This study reviewed patient cohorts and populations to investigate the progression of cutaneous lupus to systemic lupus. The study found variations in the progression rates between adult and pediatric groups, which were attributed to differences in patient populations, study design, diagnostic criteria, and follow-up time. Risk factors associated with the development of systemic lupus included positive anti-nuclear antibodies, hematologic abnormalities, and a higher number of lupus classification criteria at baseline.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Ioannis Parodis, Charlotte Girard-Guyonvarc'h, Laurent Arnaud, Oliver Distler, Andrea Domjan, Cornelia H. M. Van den Ende, Kim Fligelstone, Agnes Kocher, Maddalena Larosa, Martin Lau, Alexandros Mitropoulos, Mwidimi Ndosi, Janet L. Poole, Anthony Redmond, Valentin Ritschl, Helene Alexanderson, Yvonne Sjoberg, Gunilla von Perner, Till Uhlig, Cecilia Varju, Johanna E. Vriezekolk, Elisabet Welin, Rene Westhovens, Tanja A. Stamm, Carina Bostrom
Summary: The study aims to develop evidence-based recommendations for the non-pharmacological management of systemic lupus erythematosus (SLE) and systemic sclerosis (SSc). Four overarching principles and 12 recommendations were formulated, covering common and disease-specific aspects of non-pharmacological management. The recommendations will guide healthcare professionals and patients towards a holistic and personalised management of SLE and SSc.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Dermatology
Yusheng Zhang, Narges Maskan Bermudez, Brianna Sa, Andrea D. Maderal, Joaquin J. Jimenez
Summary: This article reviews key studies and findings to comprehensively understand how dysregulated epigenetic mechanisms contribute to the development of SLE, SSc, and DM.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Medicine, General & Internal
Alessio Buonavoglia, Patrizia Leone, Marcella Prete, Antonio Giovanni Solimando, Chiara Guastadisegno, Gianvito Lanave, Michele Camero, Vito Martella, Lorenzo Lo Muzio, Vito Racanelli
Summary: This study reveals a significant association between EBV and both SLE and SLE-related oral lesions, providing a basis for further investigation into the role of EBV in SLE pathogenesis. The detection rate of EBV varies among different populations.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Oncology
Kaichi Kaneko, Hao Chen, Matthew Kaufman, Isaak Sverdlov, Emily M. Stein, Kyung-Hyun Park-Min
Summary: Osteonecrosis is a complex and devastating complication of systemic lupus erythematosus, with variable prevalence in SLE patients. The use of high-dose glucocorticoid therapy is strongly associated with the development of osteonecrosis in SLE patients, although the exact pathophysiology and risk factors for osteonecrosis in this population are not fully understood.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Review
Medicine, General & Internal
Liala Moschetti, Silvia Piantoni, Enrico Vizzardi, Edoardo Sciatti, Mauro Riccardi, Franco Franceschini, Ilaria Cavazzana
Summary: This review discusses the complex relationship between inflammation, vasculopathy, and fibrosis in patients with systemic lupus erythematosus and systemic sclerosis. It highlights the importance of evaluating endothelial dysfunction and cardiovascular risk in these patients using new techniques.
FRONTIERS IN MEDICINE
(2022)
Article
Biochemical Research Methods
Helena Beatriz Ferreira, Tania Melo, Ines M. S. Guerra, Ana S. P. Moreira, Paula Laranjeira, Artur Paiva, Laura Goracci, Stefano Bonciarelli, Pedro Domingues, M. Rosario Domingues
Summary: Autoimmune diseases like SLE and SS involve immune system dysregulation. Lipids have potential as biomarkers for improved diagnosis and prediction in these diseases. This study identified differences in lipid profiles in SLE and SS patients, including potential biomarkers like sphingomyelin and ceramide in SS and phosphatidylserine in SLE. Further research is needed to understand the role of lipids in the pathological mechanisms of these diseases.
JOURNAL OF PROTEOME RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Valeria Rella, Cinzia Rotondo, Alberto Altomare, Francesco Paolo Cantatore, Addolorata Corrado
Summary: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a wide range of clinical manifestations. Dysregulation of the immune system due to genetic, hormonal, and environmental factors can lead to various complications, including bone involvement such as osteoporosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Leonardo Martin Calderon, Janet E. Pope
Summary: The pathogenesis of connective tissue diseases involves immune system derangements, chronic inflammation, and autoimmunity. Pre-clinical states with biochemical and autoimmune abnormalities can increase the risk of developing established connective tissue diseases. Early identification and treatment in these states can limit disease progression and improve prognosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Urology & Nephrology
Christof Aigner, Martina Gaggl, Gunar Stemer, Michael Eder, Georg Bohmig, Renate Kain, Zoltan Prohaszka, Nora Garam, Dorottya Csuka, Raute Sunder-Plassmann, Leah Charlotte Piggott, Natalja Haninger-Vacariu, Alice Schmidt, Gere Sunder-Plassmann
Summary: The study examined the indications and outcomes of eculizumab therapy in a tertiary care nephrology center, showing that it is the treatment of choice for patients with complement gene-variant mediated TMA who do not respond to plasma therapy. However, response rates to therapy were lower in patients with secondary TMA and C3 glomerulopathy, highlighting the importance of carefully considering the decision to start therapy.
JOURNAL OF NEPHROLOGY
(2022)
Article
Clinical Neurology
Asta Theodorsdottir, Pia Veldt Larsen, Helle Hvilsted Nielsen, Zsolt Illes, Mads Henrik Ravnborg
Summary: In patients with secondary progressive MS (SPMS), the Multiple Sclerosis Impairment Scale (MSIS) correlated with functional motor tests. MSIS had stronger correlations with atrophy of central nervous system areas and may be more sensitive in assessing cerebellar and sensory function compared to the Expanded Disability Status Scale (EDSS).
ACTA NEUROLOGICA SCANDINAVICA
(2022)
Article
Immunology
Reka Varnai, Tihamer Molnar, Laszlo Zavori, Margit Tokes-Fuzesi, Zsolt Illes, Andrea Kanizsai, Peter Csecsei
Summary: This study found that antibody titers were associated with the severity of symptoms and remission status in long COVID patients. The immune response against SARS-CoV-2 nucleocapsid may play a more important role than the spike protein.
Article
Immunology
Keld-Erik Byg, Zsolt Illes, Tobias Sejbaek, Kate L. Lambertsen, Torkell Ellingsen, Helle H. Nielsen
Summary: Neurosarcoidosis patients have significantly elevated levels of cytokines, chemokines, vascular angiogenesis, and vascular injury biomarkers in cerebrospinal fluid (CSF) and plasma.
JOURNAL OF NEUROIMMUNOLOGY
(2022)
Article
Immunology
Vojtech Petr, Dorottya Csuka, Petra Hruba, Agnes Szilagyi, Marek Kollar, Antonij Slavcev, Zoltan Prohaszka, Ondrej Viklicky
Summary: De novo thrombotic microangiopathy (TMA) is associated with poor kidney graft survival, and there is a recipient-driven process with suspected genetic background. Carriers of the MCPggaac haplotype have a higher risk of graft loss, and longer cold ischemia time is associated with worse graft survival.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Aida Hougaard Andersen, Zsolt Illes, Kirsten Kaya Roessler
Summary: This study investigates patients' experiences of existential communication with their physicians in the treatment of multiple sclerosis or chronic pain. Patients found it challenging when physicians focused only on medical aspects and neglected psychological and existential aspects of their illness. Patients needed a transition from dependency to autonomy for shared decision-making, and existential communication about transitional objects supported this transition.
JOURNAL OF RELIGION & HEALTH
(2023)
Review
Clinical Neurology
Christoph Mueller, Saskia Elben, Gregory S. Day, Pedro Alves, Julien Hebert, David F. Tang-Wai, Olga Holtmann, Raffaele Iorio, Daniela Perani, Maarten J. Titulaer, Niels Hansen, Thorsten Bartsch, Andreas Johnen, Zslot Illes, Leah Borm, Alice G. Willison, Heinz Wiendl, Sven G. Meuth, Stjepana Kovac, Jens Boelte, Nico Melzer
Summary: This study aims to investigate whether autoimmune limbic encephalitis (ALE) with different associated autoantibodies (AABs) exhibit distinct neuropsychological manifestations and respond differently to immunotherapy. The results show that ALE patients with AABs against LGI1, CASPR2, and GAD65 commonly have memory deficits, along with deficits in attention, executive functions, and psychological function. However, there is currently no definite evidence supporting the notion that different AAB-types of ALE have distinct neuropsychological manifestations and respond differently to immunotherapy.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2023)
Article
Biochemistry & Molecular Biology
Lydia Gonzalez-del-Barrio, Laura Perez-Alos, Leon Cyranka, Anne Rosbjerg, Simon Nagy, Zoltan Prohaszka, Peter Garred, Rafael Bayarri-Olmos
Summary: The complement system is a complex cascade involved in pathogen defense and disease pathogenesis. Complement modulators, such as the fused MAP-2:CD55(1-4) inhibitor, show promising potential for treating complement-driven inflammatory diseases. This chimeric inhibitor effectively inhibits complement activation at multiple levels and demonstrates strong inhibitory activity in vitro.
Article
Urology & Nephrology
Simon Aberger, Nicolas Kozakowski, Zoltan Prohazka, Thomas Pleininger, Hermann Salmhofer
Summary: This study reports a case of severe hantavirus disease with coinciding SARS-CoV-2 infection, presenting as thrombotic microangiopathy with rapid response to eculizumab. These findings support a disease model involving virus-associated endothelial injury and complement activation.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Allergy
Marius-Ionut Iurascu, Zsuzsanna Balla, Catarina Pereira, Noemi Andrasi, Lilian Varga, Dorottya Csuka, Agnes Szilagyi, Kornelia Tripolszki, Suliman Khan, Iuliana Susnea, Peter Bauer, Claudia Cozma, Henriette Farkas
Summary: This study developed and tested a reliable two-tier method using C1-INH and C4 quantitation followed by genetic analysis from dried blood spots (DBS) for diagnosing C1-INH-HAE. The quantification of C1-INH and C4 in DBS showed the same pattern as plasma, allowing for screening of patients with angioedema symptoms. DNA extracted from DBS is suitable for identifying various types of SERPING1 gene mutations.
CLINICAL AND TRANSLATIONAL ALLERGY
(2023)
Article
Clinical Neurology
Agnes Patzko, Gabriella Deli, Tamas Cseh, Zsuzsanna Beleznay, Lajos Nagy, Sandor Keki, Andrea Mike, Endre Pal, Samuel Komoly, Zsolt Illes, Alexandra Csongor, Zoltan Pfund
Summary: This study found elevated levels of dimethylamine in the serum of patients with multifocal motor neuropathy, which were responsive to IVIG therapy, indicating the presence of oxidative stress in MMN.
IDEGGYOGYASZATI SZEMLE-CLINICAL NEUROSCIENCE
(2022)
Article
Hematology
Zita Radnay, Arpad Illes, Miklos Udvardy, Zoltan Prohaszka, Gyorgy Sinkovits, Maria Csilla Csanyi, Miklos Kellermayer, Attila Kiss, Jolan Harsfalvi
Summary: This prospective observational study compares the changes in platelet count, VWF levels, ADAMTS13 activity, and CRP levels in lymphoma and multiple myeloma patients who underwent autologous hematopoietic stem cell transplantation (HSCT). The study explores the potential markers that vary in response to therapy, differ between the two groups, and correlate with the remission state at 100 days after HSCT. The results suggest that VWF and platelet count may have clinical significance in predicting the remission state after HSCT.
TRANSPLANTATION AND CELLULAR THERAPY
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Dorottya Csuka, Agnes Szilagyi, Zoltan Prohaszka
MOLECULAR IMMUNOLOGY
(2022)
