Article
Biotechnology & Applied Microbiology
Xiaoyu Liu, Wanqi Yang, Chao Zhang, Heng Wu, Ruize Wang, Qiang Ding, Yan Hu, Yongli Xiong, Shaobai Zhang, Lin Wang
Summary: This study demonstrated that the co-administration of enterovirus 71 (EV71) vaccine with measles-mumps-rubella (MMR) vaccine and live-attenuated Japanese encephalitis vaccine (LA-JEV) showed no interference with antibody response and had good safety profiles. This strategy is suitable for healthy infants in increasing vaccination uptake and reducing clinic visits.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Article
Immunology
Leyi Lin, Michael A. Koren, Kristopher M. Paolino, Kenneth H. Eckels, Rafael De La Barrera, Heather Friberg, Jeffrey R. Currier, Gregory D. Gromowski, Naomi E. Aronson, Paul B. Keiser, Marvin J. Sklar, Erica L. Sondergaard, Louis E. Jasper, Timothy P. Endy, Richard G. Jarman, Stephen J. Thomas
Summary: The study demonstrates that the heterologous prime-boost vaccination strategy can induce higher levels of immune response and may be superior to homologous strategies in maintaining durable tetravalent immunity.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Byung Ok Kwak, Young Se Kwon, Young Jin Hong, Seon Hee Shin, Byung Wook Eun, Young Min Ahn, Hwang Min Kim, Nam Hee Kim, Dong Hyun Kim
Summary: The study aimed to investigate the immunogenicity and safety of the third booster dose of the inactivated JE vaccine in Korean children, and found that it is both safe and effective in boosting immunity.
Article
Multidisciplinary Sciences
Lorena Sanchez-Felipe, Thomas Vercruysse, Sapna Sharma, Ji Ma, Viktor Lemmens, Dominique Van Looveren, Mahadesh Prasad Arkalagud Javarappa, Robbert Boudewijns, Bert Malengier-Devlies, Laurens Liesenborghs, Suzanne J. F. Kaptein, Carolien De Keyzer, Lindsey Bervoets, Sarah Debaveye, Madina Rasulova, Laura Seldeslachts, Li-Hsin Li, Sander Jansen, Michael Bright Yakass, Babs E. Verstrepen, Kinga P. Boszormenyi, Gwendoline Kiemenyi-Kayere, Nikki van Driel, Osbourne Quaye, Xin Zhang, Sebastiaan ter Horst, Niraj Mishra, Ward Deboutte, Jelle Matthijnssens, Lotte Coelmont, Corinne Vandermeulen, Elisabeth Heylen, Valentijn Vergote, Dominique Schols, Zhongde Wang, Willy Bogers, Thijs Kuiken, Ernst Verschoor, Christopher Cawthorne, Koen Van Laere, Ghislain Opdenakker, Greetje Vande Velde, Birgit Weynand, Dirk E. Teuwen, Patrick Matthys, Johan Neyts, Hendrik Jan Thibaut, Kai Dallmeier
Summary: The candidate vaccine YF-S0, utilizing the YF17D vaccine as a vector to express noncleavable prefusion form of the SARS-CoV-2 spike antigen, showed excellent safety, immunogenicity, and efficacy in animal models. It induced high levels of neutralizing antibodies, provided protective immunity against SARS-CoV-2, and prevented infection in hamsters and macaques. A single dose was able to confer protection from lung disease in most vaccinated hamsters within 10 days, highlighting the potential of YF-S0 as a potent SARS-CoV-2 vaccine candidate.
Article
Biochemistry & Molecular Biology
Ekachai Dumkliang, Boonnada Pamornpathomkul, Prasopchai Patrojanasophon, Tanasait Ngawhirunpat, Theerasak Rojanarata, Sutee Yoksan, Praneet Opanasopit
Summary: The study evaluated the immunization effect of mucoadhesive nanoparticles loaded with live attenuated Japanese encephalitis-chimeric virus vaccine through the intranasal route, demonstrating that intranasal immunization stimulated immune protection and enhanced mucosal immune response.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Pediatrics
Andrew G. Sokolow, Amy P. Stallings, Carolyn Kercsmar, Theresa Harrington, Natalia Jimenez-Truque, Yuwei Zhu, Katherine Sokolow, M. Anthony Moody, Elizabeth P. Schlaudecker, Emmanuel B. Walter, Mary Allen Staat, Karen R. Broder, C. Buddy Creech
Summary: This study found that among children with asthma aged 5 to 17 years, LAIV4 was not associated with an increased frequency of asthma exacerbations or asthma-related symptoms compared to IIV4. There were no significant differences in asthma symptoms or lung function changes within 14 days post-vaccination between the two groups.
Article
Immunology
Zhongbing Qi, Jing Zhao, Yuhua Li, Bin Zhang, Shichuan Hu, Yanwei Chen, Jinhu Ma, Yongheng Shu, Yunmeng Wang, Ping Cheng
Summary: In this study, the researchers discovered that JEV-LAV had oncolytic activity against GBMs, inhibiting their growth in vivo. It also increased CD8+ T cell infiltration in tumor tissues and remodeled the immunosuppressive GBM microenvironment, improving the response of aPD-L1 blockade therapy. The safety of JEV-LAV intracerebral injection in animals supported its potential for clinical use in GBM treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Virology
Yi-Chin Fan, Yi-Ying Chen, Jo-Mei Chen, Chienjin Huang, Mei Huang, Shyan-Song Chiou
Summary: The expansion of genotype I (GI) Japanese encephalitis viruses (JEV) has raised concerns over the effectiveness of genotype III (GIII) virus-derived vaccines. This study used swine as a model to evaluate the effectiveness of GIII live-attenuated vaccines against GI virus infection.
Article
Immunology
Mya Myat Ngwe Tun, Aung Kyaw Kyaw, Khine Mya Nwe, Shingo Inoue, Kyaw Zin Thant, Kouichi Morita
Summary: A study conducted among monastic school children in Mandalay, Myanmar showed that 87% of students still had neutralizing antibodies against JEV six months after receiving the SA-14-14-2 live-attenuated vaccine. Antibody titers increased with age, with statistically significant differences noted across age groups.
Article
Immunology
Termpong Dumrisilp, Jongkonnee Wongpiyabovorn, Supranee Buranapraditkun, Chomchanat Tubjaroen, Nataruks Chaijitraruch, Sittichoke Prachuapthunyachart, Palittiya Sintusek, Voranush Chongsrisawat
Summary: This study evaluated the effect of overweight and obesity on the response to live attenuated hepatitis A virus (HAV) vaccine in children and young adults. The results demonstrated that obesity did not significantly impact vaccine response, with females and subjects with truncal obesity showing higher antibody titers post-vaccination.
Review
Immunology
Giulia Perego, Giacomo Pietro Vigezzi, Giulia Cocciolo, Federica Chiappa, Stefano Salvati, Federica Balzarini, Anna Odone, Carlo Signorelli, Vincenza Gianfredi
Summary: This study conducted a systematic review and meta-analysis on the efficacy and safety of spray live attenuated influenza vaccine (LAIV), finding that LAIV was associated with a higher probability of seroconversion for the A/H1N1 serotype, and had no significant association with systemic adverse events, with only rhinorrhea, nasal congestion, and sore throat being significantly associated with LAIV compared to the placebo.
Article
Biotechnology & Applied Microbiology
Dapeng Sun, Dan Yu, Zhenhua Du, Ningning Jia, Xiaodong Liu, Jianwen Sun, Qing Xu, Zhuoqun Sun, Chunfang Luan, Jingjing Lv, Ping Xiong, Li Zhang, Xueyan Sha, Yongjun Gao, Dianmin Kang
Summary: Co-administration of live attenuated varicella vaccine and inactivated hepatitis A vaccine in children aged 12-15 months showed non-inferior immunogenicity and safety profiles compared to separate administration of the vaccines.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2023)
Article
Immunology
Yukai Zhang, Lei Wang, Yanxia Wang, Wei Zhang, Ningning Jia, Zhiqiang Xie, Lili Huang, Wangyang You, Weifeng Lu, Erwei Li, Feilong Gao, Yuansheng Hu, Fanhong Meng, Shengli Xia
Summary: This study evaluated the immunogenicity and safety of Sinovac's attenuated varicella vaccine (VarV) booster dose, as well as the immune persistence of a primary dose in 2- to 6-year-old children. The results showed that VarV had good immune persistence in the 1 to 3 years after primary immunization, and the booster dose recalled a specific immune response to varicella-zoster virus in children aged 1 to 3 years after primary immunization, with no safety concerns increased.
Article
Health Care Sciences & Services
Zhao-Jun Mo, Shou-Jie Huang, Ling-Xian Qiu, Chang-Gui Li, Xiao-Juan Yu, Ming-Qiang Li, Zhen Chen, Guo-Hua Zhong, De-Quan Pan, Li-Rong Huang, Bang-Jun Lv, Xue-Lian Cui, Qiao-Qiao Song, Ji-Zong Jia, Jin-Le Han, Wei Wang, Hua Zhu, Tong Cheng, Ying-Ying Su, Yi-Min Li, Xiang-Zhong Ye, Ting Wu, Jun Zhang, Ning-Shao Xia
Summary: This study evaluated the safety and immunogenicity of a skin and neuro-attenuated varicella vaccine candidate. The results showed that the vaccine candidate was well-tolerated and immunogenic in humans.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2023)
Review
Immunology
James E. Galen, Rezwanul Wahid, Amanda D. Buskirk
Summary: The use of live-attenuated bacterial vaccines as carriers for mucosal delivery of foreign antigens has been studied for over three decades, but has shown limited success in inducing robust foreign antigen-specific immunity. Research aims to deconstruct bacterial immunity in the human gut to improve carrier vaccine design and enhance immune responses.
Article
Immunology
Ki Wook Yun, Kyuyol Rhie, Jin Han Kang, Kyung-Hyo Kim, Jong Gyun Ahn, Yae-Jean Kim, Byung Wook Eun, Sung Hee Oh, Hye-Kyung Cho, Young Jin Hong, Nam Hee Kim, Yun-Kyung Kim, Hyunju Lee, Taekjin Lee, Hwang Min Kim, Eun Young Cho, Chun Soo Kim, Su Eun Park, Chi Eun Oh, Dae Sun Jo, Eun Song Song, Jina Lee, Jae Hong Choi, Joon Kee Lee, Hoan Jong Lee, Eun Hwa Choi
Summary: After the introduction of extended-valency pneumococcal conjugate vaccines, the replacement with nonvaccine serotypes among invasive pneumococcal diseases varies by country. In South Korea, the most common nonvaccine serotype in pediatric IPD cases was 10A, with a significant increasing trend over the study period. Other nonvaccine serotypes showed a decreasing trend, with notable reductions in serotype 12F.
Article
Medicine, General & Internal
Hyunju Lee, Sujin Choi, Ji Young Park, Dae Sun Jo, Ui Yoon Choi, Heayon Lee, Yun Tae Jung, In Hyuk Chung, Young June Choe, Jin Yong Kim, Young-Joon Park, Eun Hwa Choi
Summary: Critical COVID-19 cases in children are rare but can occur, especially in children with obesity and underlying diseases. Treatment for critical cases includes medication and mechanical ventilation. Monitoring the clinical burden of COVID-19 in children is crucial for developing appropriate policies.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2022)
Article
Immunology
Ye Kyung Kim, Youn Young Choi, Hyunju Lee, Eun Song Song, Jong Gyun Ahn, Su Eun Park, Taekjin Lee, Hye-Kyung Cho, Jina Lee, Yae-Jean Kim, Dae Sun Jo, Hyun Mi Kang, Joon Kee Lee, Chun Soo Kim, Dong Hyun Kim, Hwang Min Kim, Jae Hong Choi, Byung Wook Eun, Nam Hee Kim, Eun Young Cho, Yun-Kyung Kim, Chi Eun Oh, Kyung-Hyo Kim, Eun Hwa Choi
Summary: Nonpharmaceutical interventions (NPIs) implemented during the COVID-19 pandemic reduced the incidence of invasive diseases caused by Streptococcus pneumoniae and Salmonella spp. in children in Korea.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2022)
Article
Pediatrics
Soo Yeun Sim, Hye Yeon Choi, Min Ho Jung, Soo Young Lee, Jung Woo Rhim, Hyun Mi Kang, Dae Chul Jeong
Summary: This study compared the growth patterns of babies born to mothers with autoimmune rheumatic disorders (ARD) and healthy mothers. The findings suggest that babies born to mothers with ARD have lower birth weight and height than normal babies, but they show catch-up growth by 2 years of age.
PEDIATRIC RHEUMATOLOGY
(2022)
Article
Rheumatology
Jin Hwan Jeon, Hye Yeon Choi, Jung Woo Rim, Soo Young Leeh, Young Gun Park, Dae Chul Jeong
Summary: Ischemic vaso-occlusive retinopathy as an initial manifestation is rare in pediatric systemic lupus erythematosus (pSLE). This study reported a case of a 13-year-old girl who presented with impaired vision and ocular lesions, which improved after treatment.
JOURNAL OF RHEUMATIC DISEASES
(2022)
Article
Biotechnology & Applied Microbiology
Jun Won Yang, Dae Sun Jo
Summary: Lower respiratory tract infections (LRTIs) are a significant cause of death, with bacterial pneumonia being one of the most common causes of mortality in South Korea. However, there is limited data on the epidemiology of pediatric LRTIs in primary care clinics. This study evaluated 1,497 cases of pediatric LRTI over a two-year period, assessing clinical and radiological signs, as well as pathogen detection through PCR. The results showed a high proportion of bacterial infections, with Streptococcus pneumoniae, Haemophilus influenzae, and Mycoplasma pneumoniae being the most common pathogens. The study also highlighted the importance of M. pneumoniae as an additional cause of LRTI in primary pediatric care in Korea.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Article
Pediatrics
Kyo Jin Jo, Soo-Han Choi, Chi Eun Oh, HyeonA Kim, Bong Seok Choi, Dae Sun Jo, Su Eun Park
Summary: This study retrospectively analyzed the epidemiological and clinical characteristics of HCoV-associated infection in Korean children. The study found that HCoV infections showed marked seasonality, with the highest detection rate in winter. The main clinical manifestations of HCoV infection in children were upper respiratory tract infections and pneumonia, and some patients required hospitalization and oxygen therapy.
FRONTIERS IN PEDIATRICS
(2022)
Article
Pediatrics
Sangwon Rhee, Danbi Kim, Kyoungsoon Cho, Jung Woo Rhim, Soo-Young Lee, Dae Chul Jeong
Summary: This study investigated the incidence of macrophage activation syndrome (MAS) in patients with refractory Kawasaki disease (KD) and compared the characteristics between refractory KD and MAS. The results showed a relatively high incidence of MAS in children with refractory KD, and there were differences in certain characteristics between the two groups. Therefore, it is recommended to include MAS screening in routine laboratory tests for refractory KD.
Editorial Material
Pediatrics
Eun Young Cho, Dong Hyun Kim, Soo-Han Choi, Ki Wook Yun, Jong Gyun Ahn, Hye-Kyung Cho, Hyunju Lee, Jina Lee, Taek-Jin Lee, Byung-Wook Eun, Jin Lee, Dae Sun Jo, Yun-Kyung Kim, Yae-Jean Kim
CLINICAL AND EXPERIMENTAL PEDIATRICS
(2022)
Article
Immunology
Yoonsun Yoon, Hyejin So, Joon Kee Lee, Dongsub Kim, Kyo Jin Jo, Hyun Ho Kim, Yoo-Jin Kim, Jina Lee, Dae Sun Jo, Yun-Kyung Kim, Su Eun Park, Yun Sil Chang, Yae-Jean Kim
Summary: This study is the first multicenter study on the epidemiology of early-onset sepsis (EOS) in neonates born at ≥35 0/7 weeks' gestation in Korea and found that group B Streptococcus was the most common pathogen.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2023)
Article
Virology
Hyun Mi Kang, Kyu Ri Kang, Ye Ji Kim, Jin Han Kang, Soo-Young Lee
Summary: Live varicella vaccines, while providing strong immunity against varicella zoster virus (VZV) infections, may cause varicella-like rash and herpes zoster in immunocompetent children due to viral attenuation issues. We report the first fatal case of VZV infection caused by the OKA/SK strain in a booster shot administered to an immunocompetent child. This strain is independent from currently available varicella vaccines. The patient died due to secondary complications of VZV pneumonitis, specifically sudden pulmonary alveolar hemorrhage.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Pediatrics
Jin Lee, Beom Joon Kim, Kyoung-Soon Cho, Jung Woo Rhim, Soo-Young Lee, Dae Chul Jeong
Summary: This study investigated the characteristics of COVID-19-associated multisystem inflammatory syndrome in children (MIS-C) and Kawasaki disease shock syndrome (KDSS), comparing the similarities and differences between the two diseases. The study found that patients in the KDSS group had longer hospital stays and more severe systemic inflammation and organ dysfunction compared to the MIS-C group. MIS-C and KDSS shared demographic, clinical, and laboratory characteristics, as well as treatment and outcomes. The main difference between the two diseases was the identification of SARS-CoV-2 as an infectious trigger in the MIS-C group.
Article
Rheumatology
Songmi Lee, Danbi Kim, Beom Joon Kim, Jung Woo Rhim, Soo-Young Lee, Dae Chul Jeong
Summary: Multisystem inflammatory syndrome in children (MIS-C) and Kawasaki disease shock syndrome (KDSS) have similarities and differences in terms of hyperinflammation and organ dysfunction. MIS-C shares more clinical phenotypes with KDSS than with Kawasaki disease (KD).
JOURNAL OF RHEUMATIC DISEASES
(2023)
Article
Immunology
Seung Ha Song, Hoan Jong Lee, Eun Song Song, Jong Gyun Ahn, Su Eun Park, Taekjin Lee, Hye-Kyung Cho, Jina Lee, Yae-Jean Kim, Dae Sun Jo, Jong-Hyun Kim, Hyun Mi Kang, Joon Kee Lee, Chun Soo Kim, Dong Hyun Kim, Hwang Min Kim, Jae Hong Choi, Byung Wook Eun, Nam Hee Kim, Eun Young Cho, Yun-Kyung Kim, Chi Eun Oh, Kyung-Hyo Kim, Sang Hyuk Ma, Hyun Joo Jung, Kun Song Lee, Kwang Nam Kim, Hyunju Lee, Eun Hwa Choi
Summary: This study analyzed the epidemiology of invasive bacterial infection (IBI) among infants in Korea. The most common pathogens were S. agalactiae, E. coli, and S. aureus, with a decreasing trend in S. aureus proportion and an increasing trend in S. agalactiae proportion observed between 2006 and 2020.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2022)