期刊
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
卷 159, 期 1, 页码 65-72出版社
WILEY
DOI: 10.1111/j.1365-2249.2009.04042.x
关键词
allergic disease; allergy; cord blood; cytokines; HLA typing; HLA-C; HLA-DR beta 1; MLR; pregnancy
类别
资金
- National Health and Medical Research Council (NHMRC) of Australia
- Child Health Research Foundation of Western Australia
P>Low-level alloreactivity between mother and fetus may provide stimulation for fetal T helper type 1 (Th1) cell immune maturation. This study explored the effects of human leucocyte antigen (HLA) mismatch on materno-fetal interactions detected as cytokine responses and lymphoproliferation in mixed lymphocyte reactions, and whether this was altered in allergic women (n = 62) who have a Th2 propensity compared with non-allergic women (n = 65). HLA-DR beta 1 mismatch was associated with significantly increased Th1 interferon (IFN)-gamma, Th2 interleukin (IL)-13 and lymphoproliferative responses by both mothers and fetuses. Allergic women showed significantly lower IFN-gamma Th1 production in response to HLA-DR beta 1 mismatch. The infants of these women also showed significantly lower IL-10 and lower IFN-gamma production relative to IL-13. Both HLA-DR beta 1 mismatch and maternal allergy had significant independent effects on maternal IFN-gamma Th1 responses. Maternal allergy modifies HLA-mediated alloreactivity between the mother and the fetus, reducing Th1 activation. This may affect the cytokine milieu at the materno-fetal interface and could be implicated in the attenuated Th1 responses observed commonly in infants of atopic mothers.
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