Article
Immunology
Deborah L. W. Chong, Carine Rebeyrol, Ricardo J. Jose, Andrew E. Williams, Jeremy S. Brown, Chris J. Scotton, Joanna C. Porter
Summary: Neutrophil migration into the lung is mediated by cell adhesion molecules such as ICAM-1 and ICAM-2, which are upregulated during inflammatory stimulation. While beta(2) integrins interacting with ICAMs may regulate neutrophil traffic in healthy lung, these interactions may become redundant later in inflammation when epithelial junctions are disrupted.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biology
Cameron D. Haydinger, Liam M. Ashander, Alwin Chun Rong Tan, Justine R. Smith
Summary: Intercellular adhesion molecule 1 (ICAM-1) is a transmembrane protein that plays important roles in the immune system and is involved in various diseases. It mediates cellular adhesive interactions and is upregulated in inflammation. This review provides a comprehensive summary of the structure and regulation of ICAM1 gene and the ICAM-1 protein, discusses its functions in the immune system and diseases, and explores current therapeutics and future advancements.
Article
Multidisciplinary Sciences
Dicky L. Tahapary, Tasykuru Rizqa, Cut Vania Syarira, Lusiani Lusiani, Aulia Rizka, Syahidatul Wafa, Wismandari Wisnu, Tri Juli Edi Tarigan, Dante Saksono Harbuwono
Summary: This study aimed to determine the changes in ICAM-1 levels in patients with type 2 diabetes mellitus (T2DM) and non-DM patients during Ramadan fasting. The results showed that both T2DM and non-DM patients had a significant decrease in ICAM-1 levels after Ramadan fasting, but only non-DM patients had a significantly lower post-Ramadan ICAM-1 level.
Article
Oncology
Bing Zhu, Xinyan Wang, Takaya Shimura, Andrew C. Huang, Nana Kong, Yujie Dai, Jianmin Fang, Peng Guo, Jie-Er Ying
Summary: This preclinical study reports two effective targeted therapeutics for the treatment of cholangiocarcinoma. By conjugating ICAM1 antibodies with different cytotoxic payloads, tumor growth was successfully attenuated. This study paves the road for developing a promising targeted therapeutic candidate for clinical treatment of cholangiocarcinoma.
NPJ PRECISION ONCOLOGY
(2023)
Article
Cell Biology
Eun-Ji Lim, Jae-Hyeok Kang, Yeon-Ju Kim, Seungmo Kim, Su-Jae Lee
Summary: ICAM-1 is a potential therapeutic target for colorectal cancer (CRC) that enhances treatment effectiveness by promoting the c-MET-SRC signaling axis. Treatment with antibodies targeting ICAM-1 can reduce metastasis and angiogenesis in CRC.
CELL DEATH & DISEASE
(2022)
Review
Immunology
Shakti D. Shukla, Madhur D. Shastri, Swaroop K. Vanka, Niraj Kumar Jha, Harish Dureja, Gaurav Gupta, Dinesh Kumar Chelappan, Brian G. Oliver, Kamal Dua, E. Haydn Walters
Summary: Asthma and COPD are major causes of global mortality and morbidity, with HRV being implicated in exacerbations of both diseases. ICAM-1 plays a crucial role in facilitating HRV adhesion and transmission to the respiratory system, with smoking leading to up-regulation of ICAM-1 and increased susceptibility to viral infections in individuals with chronic lung diseases. Therapeutic strategies focusing on blocking ICAM-1 are being explored to prevent viral adhesion and exacerbations of COPD.
INFLAMMOPHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Akira Sakamoto, Hiroyuki Inoue, Shohei Miyamoto, Shun Ito, Yasushi Soda, Kenzaburo Tani
Summary: Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related deaths globally. This study highlights the potential of oncolytic virotherapy using coxsackievirus A11 (CVA11) as a less toxic and more effective treatment for NSCLC. CVA11 infection showed extensive oncolytic activity in human NSCLC cell lines and induced immunogenic cell death. In vivo experiments also demonstrated complete tumor regression without significant weight loss. Further investigation in clinical trials, especially in combination with immunotherapy, is warranted.
SCIENTIFIC REPORTS
(2023)
Article
Ophthalmology
Natalia I. Khramenko, Natalia V. Konovalova, Volodymyr Ya. Usov, Liudmyla M. Velychko, Olexandra V. Bogdanova
Summary: The parameters of the T-cell link of the immune response and the parameters of humoral immunity were different between patients with uncomplicated recurrent anterior uveitis (AU) and those with recurrent AU complicated by uveitic macular edema (UME). The patients with UME had increased T-cell immune response parameters and decreased humoral immunity parameters. The relative numbers of natural killer cells and phagocytic neutrophils were also different between the two groups. The expression levels of ICAM-1 and CD5 seem to play a role in uveitic macular edema.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Oncology
Xiang Shu, Qin Zhou, Xiaohui Sun, Michelle Flesaker, Xingyi Guo, Jirong Long, Mark E. Robson, Xiao-Ou Shu, Wei Zheng, Jonine L. Bernstein
Summary: This study identified 98 proteins that may have potential causal associations with the risk of breast cancer subtypes. The associations of ICAM1, PLA2R1, and TXNDC12 varied significantly across the subtypes. These findings contribute to understanding the heterogeneity in the etiology of different subtypes of breast cancer and may aid in personalized risk assessment of the disease.
BRITISH JOURNAL OF CANCER
(2022)
Article
Immunology
Jae-Young Park, Hyo-Min Park, Seonhwa Kim, Kyeong-Bae Jeon, Chae-Min Lim, Jin Tae Hong, Do-Young Yoon
Summary: IL-32 theta A94V, a mutant isoform, can inhibit monocyte-endothelial adhesion by binding to integrins aVb3 and aVb6, thus reducing the early step of atherosclerosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jia Guo, Zeyu Xu, Rachel C. Gunderson, Baohui Xu, Sara A. Michie
Summary: In this study, the researchers found that ICAM-1 is expressed on the sinus endothelia of lymph nodes, but not on the lymphatic vessels of peripheral tissues. Memory CD4(+) T cells migrated to lymph nodes from peripheral tissues more efficiently than from blood vessels. ICAM-1 deficiency significantly inhibited the migration of lymphocytes from peripheral tissues into lymph nodes, and the absence of ICAM-1 or LFA-1 reduced the number of memory T cells in lymph nodes.
Article
Biotechnology & Applied Microbiology
Weiwei Cao, Yu Chen, Wei Han, Juzheng Yuan, Weimin Xie, Kun Liu, Yan Qiu, Xudan Wang, Xiao Li
Summary: This study found that patients with normal or normalized AFP and sICAM-1 levels in liver cancer had lower tumor recurrence rates and better survival rates, while those with elevated levels of both markers had poorer outcomes. AFP and ICAM-1 play crucial roles in the diagnosis, prognostic prediction, and immunotherapy of HCC, and their combined application can improve predictive accuracy.
Article
Microbiology
Lisa C. Hennemann, Shantelle L. LaFayette, Julien K. Malet, Perrine Bortolotti, Tianxiao Yang, Geoffrey A. McKay, Daniel Houle, Danuta Radzioch, Simon Rousseau, Dao Nguyen
Summary: Loss-of-function lasR mutants of Pseudomonas aeruginosa induce increased levels of airway epithelial ICAM-1, leading to enhanced neutrophilic inflammation and exacerbating lung disease progression. This study sheds light on the intricate interplay between lasR mutants, LasR-regulated proteases, and airway epithelial ICAM-1 expression, revealing a new mechanism involved in the exaggerated inflammatory response induced by lasR mutants.
Article
Biochemistry & Molecular Biology
Vladana Domazetovic, Irene Falsetti, Caterina Viglianisi, Kristian Vasa, Cinzia Aurilia, Maria Stio, Stefano Menichetti, Teresa Iantomasi
Summary: The study found that tocopherol derivatives can prevent TNFα-induced oxidative stress and inhibit the increase of ICAM-1 and Cl-2 expression. Among them, (δ-Toc)2S and (δ-Toc)2S-2 were more effective than δ-Toc and α-Toc.
Article
Oncology
Jing Zhang, Rongrong Zhang, Zhenhong Zhao
Summary: Clinical treatment can significantly reduce the levels of autoantibodies and ICAM-1 in patients with Graves disease, improve thyroid function, and alleviate inflammation. Detection of these indicators can provide guidance for disease progression and treatment.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)