Article
Allergy
I Perez-Lucendo, E. Gomez Torrijos, P. Donado, R. Melero, F. Feo-Brito, J. M. Urra
Summary: This study found a significant decrease in ICAM-1 expression in peripheral blood eosinophils in patients with EoE, which may provide a useful noninvasive marker for the diagnosis and assessment of EoE patients.
JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Cell Biology
Katarzyna Mycroft, Magdalena Paplinska-Goryca, Malgorzata Proboszcz, Patrycja Nejman-Gryz, Rafal Krenke, Katarzyna Gorska
Summary: This study compared the eosinophil phenotypes in blood and induced sputum among patients with COPD, asthma, and controls. It was found that the eosinophil phenotype in COPD patients' sputum differed from that of the other groups, indicating a distinct phenotype of eosinophils in COPD patients compared to asthma or healthy individuals.
Article
Immunology
Deborah L. W. Chong, Carine Rebeyrol, Ricardo J. Jose, Andrew E. Williams, Jeremy S. Brown, Chris J. Scotton, Joanna C. Porter
Summary: Neutrophil migration into the lung is mediated by cell adhesion molecules such as ICAM-1 and ICAM-2, which are upregulated during inflammatory stimulation. While beta(2) integrins interacting with ICAMs may regulate neutrophil traffic in healthy lung, these interactions may become redundant later in inflammation when epithelial junctions are disrupted.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Claire T. Deakin, John Bowes, Lisa G. Rider, Frederick W. Miller, Lauren M. Pachman, Helga Sanner, Kelly Rouster-Stevens, Gulnara Mamyrova, Rodolfo Curiel, Brian M. Feldman, Adam M. Huber, Ann M. Reed, Heinrike Schmeling, Charlotte G. Cook, Lucy R. Marshall, Meredyth G. Ll Wilkinson, Stephen Eyre, Soumya Raychaudhuri, Lucy R. Wedderburn
Summary: Juvenile dermatomyositis (JDM) is a rare and severe autoimmune disease that shares similarities with adult-onset dermatomyositis (DM). This study analyzed the genetic factors associated with JDM and confirmed the strong association of HLA-DRB1 *03:01 with the disease. It also identified a novel association with amino acid position 37 within HLA-DRB1, which may distinguish JDM from adult DM.
HUMAN MOLECULAR GENETICS
(2022)
Article
Immunology
Cassandra Ballou, Franca Barton, Elizabeth H. Payne, Thierry Berney, Jean Villard, Raphael P. H. Meier, David Baidal, Rodolfo Alejandro, Mark Robien, Thomas L. Eggerman, Malek Kamoun, Yannick D. Muller
Summary: The exact contribution of HLA matching to graft survival in pancreatic islet transplantation remains unclear. This study evaluated the impact of HLA-DR matching, including the presence of diabetogenic HLA-DR3 or HLA-DR4 matches, on long-term islet survival.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Rheumatology
Hiroki Yamada, Takanori Sasaki, Kotaro Matsumoto, Katsuya Suzuki, Masaru Takeshita, Shuhei Tanemura, Noriyasu Seki, Hideto Tsujimoto, Tsutomu Takeuchi
Summary: The study found that HLA-DR+ Tph cells were correlated with DAS28-ESR, while HLA-DR- Tph cells accurately reflected disease activity during treatment. MTX treatment independently reduced the proportion of HLA-DR+ Tph cells.
Article
Allergy
Nikolaos Tsolakis, Tiago Jacinto, Christer Janson, Magnus Borres, Andrei Malinovschi, Kjell Alving
Summary: In young asthmatics, IgE levels declined over 43 months, while FeNO and B-Eos remained unchanged. Despite improved asthma control, an accelerated decline in lung function was observed in patients with detectable sIgE at baseline, and this decline correlated with changes in type-2 biomarkers. Specifically, the increase in individualized FeNO was independently associated with decline in FEV1 in females.
CLINICAL AND TRANSLATIONAL ALLERGY
(2021)
Article
Biochemistry & Molecular Biology
Katrin Kuck, Guido Juergenliemk, Bartosz Lipowicz, Joerg Heilmann
Summary: By using various chromatographic steps, 16 sesquiterpenes were isolated from an ethanolic extract of myrrh resin, including 6 previously unknown compounds and 4 metabolites not described for the genus Commiphora before. Among them, new compounds exhibited unprecedented sesquiterpene carbon skeleton. The study also provided new insights on the activity of sesquiterpenes in ICAM-1 inhibition and the possible modes of action of myrrh in anti-inflammatory processes.
Article
Biochemical Research Methods
Rosa Peltrini, Rebecca L. Cordell, Wadah Ibrahim, Michael J. Wilde, Dahlia Salman, Amisha Singapuri, Beverley Hargadon, Christopher E. Brightling, C. L. Paul Thomas, Paul S. Monks, Salman Siddiqui
Summary: This study characterized the background signal generated from a headspace sampling system in a clinical site, evaluated intra- and inter-day variation of background VOC, and investigated the impact of a sample itself upon commonly reported background VOC using sputum headspace samples from severe asthmatics. The results indicated no significant intra- or inter-day variations in compound levels and underscored the need to consider the background signal derived from the headspace sampling system when developing and validating headspace biomarker signatures using clinical samples.
JOURNAL OF BREATH RESEARCH
(2021)
Article
Oncology
Yang Xiao, Jinghong Chen, Jia Wang, Wei Guan, Mengzhen Wang, Linlin Zhang, Zhiding Wang, Lixin Wang, Li Yu
Summary: In patients with AML, the expression of ICAM-1 is silenced, but the hypomethylating agent can upregulate its expression, facilitating NK cells to kill AML cells. High expression of ICAM-1 can reverse AML immune evasion and activate NK cell function, suggesting a new strategy for AML treatment.
FRONTIERS IN ONCOLOGY
(2021)
Article
Allergy
Sara Gerday, Florence Schleich, Monique Henket, Francoise Guissard, Virginie Paulus, Renaud Louis
Summary: This study compared atopic and non-atopic asthmatics and found differences in demographics, functional characteristics, and inflammatory profiles. While atopic asthmatics showed a consistent eosinophilic pattern, non-atopic asthmatics exhibited neutrophilic inflammation before the age of 50 and eosinophilic inflammation above 50 years old.
WORLD ALLERGY ORGANIZATION JOURNAL
(2022)
Article
Endocrinology & Metabolism
Antigoni Eleftheriou, Clive J. Petry, Ieuan A. Hughes, Ken K. Ong, David B. Dunger
Summary: The study found variable associations of DR3, DR4, and DQ8 alleles with growth measures and IGF-I levels in infants from the general population, which could explain the heterogeneous growth trajectories observed in genetically at-risk cohorts. These findings suggest distinct mechanisms involving endocrine pathways related to the HLA-conferred type 1 diabetes risk.
Article
Biochemistry & Molecular Biology
Kenji Tanimura, Shigeru Saito, Sayaka Tsuda, Yosuke Ono, Hajime Ota, Shinichiro Wada, Masashi Deguchi, Mikiya Nakatsuka, Takeshi Nagamatsu, Tomoyuki Fujii, Gen Kobashi, Hisashi Arase, Hideto Yamada
Summary: The anti-beta 2-glycoprotein I/HLA-DR antibody is associated with antiphospholipid syndrome and recurrent pregnancy loss. This study demonstrates that the antibody is significantly associated with adverse obstetric outcomes and recurrent pregnancy loss.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Respiratory System
F. Schleich, S. Graff, F. Guissard, M. Henket, V. Paulus, R. Louis
Summary: The study found that asthmatics older than 70 years old have more severe bronchial neutrophilic inflammation, poorer lung function, signs of air trapping, and lower airway variability. Older asthmatics have longer disease duration and a lower occurrence of the allergic component.
RESPIRATORY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Bibiana Quirant-Sanchez, Oriol Plans-Galvan, Ester Lucas, Eduard Argudo, Eva Maria Martinez-Caceres, Fernando Armestar
Summary: The early identification and treatment of at-risk patients with sepsis is crucial for reducing mortality. This study assessed the correlation between HLA-DR expression on monocytes ((M)HLA-DR ratio), sepsis index (CD64 expression on neutrophils/(M)HLA-DR ratio), C-reactive protein (CRP), and sepsis development. Biomarkers were tested in 77 critically ill patients over a period of 15 days. Most patients (71%) developed sepsis within 4.2±1.3 days after admission. On day 3, patients who subsequently developed sepsis had lower (M)HLA-DR+ levels and higher sepsis indexes compared to those who did not develop sepsis. The (M)HLA-DR ratio recovered slowly before day 6, while the sepsis index remained elevated up to day 9 in septic patients. Optimal cut-offs for predicting sepsis development were CRP levels > 106.90 mg/mL and (M)HLA-DR expression rate < 72.80%. Periodic monitoring of (M)HLA-DR expression, CRP, and sepsis index may help identify high-risk sepsis patients in the ICU.