Article
Biochemistry & Molecular Biology
Yuxin Zhang, Zhonglong Liu, Kexin Wang, Shenji Lu, Shuai Fan, Lili Xu, Bin Cai
Summary: This study revealed the role of MIF and TGF-β1 in post-traumatic joint contracture, showing that MIF can enhance TGF-β1 production in fibroblasts through MAPK signaling, leading to fibroblast function changes and joint capsule fibrosis. Further investigation into this mechanism may lead to potential therapeutic targets for PTJC.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Cell Biology
Yuxin Zhang, Shenji Lu, Shuai Fan, Lili Xu, Xin Jiang, Kexin Wang, Bin Cai
Summary: The study revealed that MIF plays a role in promoting inflammation and fibrosis in post-traumatic joint contracture (PTJC). MIF regulates the proliferation, migration, and inflammation of JFs by coupling with CD74. This research provides new therapeutic targets for joint capsule fibrosis in PTJC.
Article
Rheumatology
Maya Malaab, Ludivine Renaud, Naoko Takamura, Kip D. Zimmerman, Willian A. da Silveira, Paula S. Ramos, Sandra Haddad, Marc Peters-Golden, Loka R. Penke, Bethany Wolf, Gary Hardiman, Carl D. Langefeld, Thomas A. Medsger, Carol A. Feghali-Bostwick
Summary: Our study identified distinct molecular features in dermal fibroblasts of systemic sclerosis patients, including dysregulated transcription factors and microRNAs, suggesting a role for epigenetic dysregulation in disease susceptibility. This highlights the potential for using epigenetic modifiers as future therapies in systemic sclerosis.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Dermatology
Xuefen Wu, Bingxia Ming, Tong Wu, Rongfen Gao, Peng Hu, Jungen Tang, Jixin Zhong, Fang Zheng, Lingli Dong
Summary: IL-33/ST2 axis plays a crucial role in the fibrotic disorder of SSc by promoting fibroblast activation, and IL-33/ST2 blockade could be a potential novel strategy to inhibit fibrosis progression in SSc patients.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2022)
Article
Virology
Alperen Aksakal, Bugra Kerget, Ferhan Kerget, Seda Askin
Summary: The study revealed the correlation between serum migration inhibitory factor (MIF) level and disease severity in COVID-19, with higher MIF levels potentially indicating a more severe condition. MIF levels can serve as an important predictive indicator for early disease prognosis in COVID-19.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Review
Medicine, General & Internal
Napoleon Bellua Sam, Shi-Yang Guan, Peng Wang, Xiao-Mei Li, De-Guang Wang, Hai-Feng Pan, Dong-Qing Ye
Summary: This study revealed significantly higher MIF levels in SLE patients compared to healthy controls, with Asians and younger patients showing even higher MIF levels. The association between SLE and MIF-173 C/G was supported, while no significant relationship was found between MIF-794 CATT and SLE.
ARCHIVES OF MEDICAL SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Juan Cai, Lin Huang, Hongri Tang, Hongling Xu, Lingjun Wang, Minghui Zheng, Hongsong Yu, Hui Liu
Summary: The MIF produced by Thelazia callipaeda can induce M2-like macrophage polarization through TLR4-mediated activation of the PI3K-Akt pathway, potentially aiding in disrupting the host immune system.
Article
Biochemistry & Molecular Biology
Mauro Vasella, Stefan Wolf, Eamon C. Francis, Gerrit Grieb, Pablo Pfister, Gregory Reid, Juergen Bernhagen, Nicole Lindenblatt, Epameinondas Gousopoulos, Bong-Sung Kim
Summary: Lipedema is a chronic disorder mainly affecting women, with an unknown etiology. Recent research suggests that the accumulation and polarization of macrophages may be involved in lipedema. This study provides evidence for the potential involvement of the MIF family, specifically the MIF-1-CD74 axis, in lipedema.
Review
Multidisciplinary Sciences
Mingyue Hu, Zhongliu Yao, Li Xu, Muzi Peng, Guiming Deng, Liang Liu, Xueyu Jiang, Xiong Cai
Summary: Systemic sclerosis (SSc, scleroderma) is an autoimmune rheumatic disease characterized by fibrosis and vasculopathy. Targeting M2 macrophages, which play a crucial role in the fibrotic process, could be a potential therapeutic strategy for SSc. In this review, we discuss the molecular mechanisms underlying the regulation of M2 macrophage polarization in SSc-related organ fibrosis, potential inhibitors targeting M2 macrophages, and the involvement of M2 macrophages in fibrosis.
Article
Biochemistry & Molecular Biology
Ji Ae Kim, Ye Young Kim, Seung Hak Lee, Chul Jung, Mi Hee Kim, Dae Yul Kim
Summary: The macrophage migration inhibitory factor (MIF) exerts a neuroprotective effect, facilitating neurological recovery and protecting brain tissue from ischemic injury in an in vivo model of ischemic stroke.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Fisheries
Zhengshi Zhang, Xiucong Hu, Qianying Diao, Panpan Zhang, Ying Wu, Zhenjie Cao, Yongcan Zhou, Chunsheng Liu, Yun Sun
Summary: In this study, a macrophage migration inhibitory factor (TroMIF) was identified from golden pompano and its function was analyzed. TroMIF showed high similarity with other known MIF sequences and was most closely related to large yellow croaker. TroMIF was highly expressed in the liver and head kidney and its expression was up-regulated after E. tarda infection. In vitro experiments showed that rTroMIF could inhibit the migration of lymphocytes and macrophages and enhance macrophage phagocytic activity. Furthermore, rTroMIF increased the expression levels of pro-inflammatory cytokines and had enzymatic redox activity. Overexpression of TroMIF enhanced the ability to resist E. tarda infection, while knockdown of TroMIF expression increased the bacterial load. These results suggest that TroMIF plays an important role in antibacterial immunity.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2022)
Article
Veterinary Sciences
Saki Nomura, Yui Kobatake, Satoshi Takashima, Hiroaki Kamishina, Makoto Urushitani, Naohito Nishii
Summary: Canine degenerative myelopathy (DM) is a progressive neurodegenerative disorder commonly associated with a specific mutation in the SOD1 gene. This study investigates the role of MIF in inhibiting the misfolding and accumulation of mutant SOD1 in DM. The results suggest that MIF can regulate the accumulation of SOD1 aggregates through its chaperone activity. Enhancing intracellular MIF chaperone activity may be an effective therapeutic strategy for DM.
RESEARCH IN VETERINARY SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Caroline Swoboda, Lena Deloch, Claudia von Zimmermann, Tanja Richter-Schmidinger, Bernd Lenz, Johannes Kornhuber, Christiane Muehle
Summary: This study investigated the potential of MIF at genetic, expression, and protein levels as a risk factor and biomarker for diagnosing, monitoring, or predicting MDD. The results suggest a genetic effect of MIF in women but do not provide strong evidence for its utility as a biomarker for MDD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
D. Zhang, T. Xu, Q. Xu, Q. Dong, Y. Luo, L. Gao, Y. Pan
Summary: This study revealed significant increases in levels of MCP-1 and MIF in periodontitis patients, along with enhanced secretion of MIF in gingival epithelial tissue. Limited evidence suggested a correlation between MIF and periodontal conditions, with Porphyromonas gingivalis potentially contributing to periodontitis development and progression through MIF.
ARCHIVES OF ORAL BIOLOGY
(2021)
Article
Critical Care Medicine
Tianlong Li, Jiahao Zhang, Minghui Long, Xiaofang Jiang, Cheng Yang, Fengqin Wang, Lianjiu Su, Zhiyong Peng
Summary: This study found that serum MIF level might serve as a biomarker for predicting the occurrence, development, and outcomes of septic AKI.
Article
Medicine, General & Internal
Hong Ki Min, Youn Soo Lee, Suk-Woo Yang, Jennifer Lee, Seung-Ki Kwok, Ji Hyeon Ju, Wan-Uk Kim, Sung-Hwan Park
KOREAN JOURNAL OF INTERNAL MEDICINE
(2019)
Article
Immunology
Saseong Lee, Jin-Sun Kong, Sungyong You, H. Moo Kwon, Seung-Ah Yoo, Chul-Soo Cho, Wan-Uk Kim
JOURNAL OF IMMUNOLOGY
(2018)
Article
Immunology
Heeju Ryu, Hoyong Lim, Garam Choi, Young-Jun Park, Minkyoung Cho, Hyeongjin Na, Chul Won Ahn, Young Chul Kim, Wan-Uk Kim, Sang-Hak Lee, Yeonseok Chung
Article
Biochemistry & Molecular Biology
Ji-Won Kim, Jin-Sun Kong, Saseong Lee, Seung-Ah Yoo, Jung Hee Koh, Jingchun Jin, Wan-Uk Kim
EXPERIMENTAL AND MOLECULAR MEDICINE
(2020)
Article
Medicine, Research & Experimental
Jin-Sun Kong, Ji-Hwan Park, Seung-Ah Yoo, Ki-Myo Kim, Yeung-Jin Bae, Yune-Jung Park, Chul-Soo Cho, Daehee Hwang, Wan-Uk Kim
JOURNAL OF CLINICAL INVESTIGATION
(2020)
Article
Oncology
Riri Kwon, Bong-Ki Hong, Kang-Gu Lee, Eunbyeol Choi, Laurent Sabbagh, Chul-Soo Cho, Naeun Lee, Wan-Uk Kim
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2020)
Article
Biochemistry & Molecular Biology
Jung Hee Koh, Sang Jun Yoon, Mina Kim, Seonghun Cho, Johan Lim, Youngjae Park, Hyun-Sook Kim, Sung Won Kwon, Wan-Uk Kim
Summary: Changes in lipid profile in rheumatoid arthritis can serve as potential biomarkers for tracking and treating the disease.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Article
Rheumatology
Youngjae Park, Mei-Ling Li, Ji-Won Kim, Jung Hee Koh, Yune-Jung Park, Wan-Uk Kim
Summary: Cumulative activity better reflects the radiographic progression of rheumatoid arthritis (RA) than measurement of activity at a single time point, and cumulative swollen joint count (SJC) shows the best predictive performance for radiographic progression.
JOURNAL OF RHEUMATIC DISEASES
(2022)
Article
Immunology
Yu-Mi Kim, Jin-Ouk Choi, Yong-Joon Cho, Bong-Ki Hong, Hoh-Jeong Shon, Bum-Joon Kim, Joo-Hong Park, Wan-Uk Kim, Donghyun Kim
Summary: This study suggests a possible inverse correlation between tuberculosis and colorectal cancer, and demonstrates the ability of mycobacteria to ameliorate CRC development. The protective effects of mycobacteria are mediated by gut microbial alterations and modulation of antimicrobial activities including the Reg3 family genes.
Article
Rheumatology
Saseong Lee, Eunbyeol Choi, Sehyun Chae, Jung Hee Koh, Yoolim Choi, Jung Gon Kim, Seung-Ah Yoo, Daehee Hwang, Wan-Uk Kim
Summary: This study aimed to investigate the secretome profile of synovial fibroblasts of patients with rheumatoid arthritis (RA-FLSs) and its impact on the formation of invasive pannus. 843 proteins secreted from RA-FLSs were identified, with 48.5% of them associated with pannus-driven pathologies. MYH9 was identified as one of the key proteins related to "invasive pannus".
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Jung Hee Koh, Bong-Woo Lee, Wan-Uk Kim
JOURNAL OF RHEUMATIC DISEASES
(2023)
Review
Immunology
Seung Min Jung, Wan-Uk Kim
Summary: Biological drugs and small molecule inhibitors have become the standard-of-care for treating autoimmune diseases, but there are still challenges in terms of therapeutic efficacy and safety profiles. Emerging therapies using advanced molecular engineering techniques aim to induce immune tolerance and overcome these challenges.
Article
Medicine, General & Internal
Jung Hee Koh, Saseong Lee, Hyun-Sook Kim, Kyuheon Lee, Chang Seop Lee, Seung-Ah Yoo, Naeun Lee, Wan-Uk Kim
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Rheumatology
Jung Hee Koh, Yune-Jung Park, Saseong Lee, Young-Shick Hong, Kwan Soo Hong, Seung-Ah Yoo, Chul-Soo Cho, Wan-Uk Kim
JOURNAL OF RHEUMATIC DISEASES
(2019)
Review
Immunology
Naeun Lee, Donghyun Kim, Wan-Uk Kim
FRONTIERS IN IMMUNOLOGY
(2019)