Article
Genetics & Heredity
Pablo Serrano-Lorenzo, Maria Rabasa, Jesus Esteban, Irene Hidalgo Mayoral, Cristina Dominguez-Gonzalez, Agustin Blanco-Echevarria, Rocio Garrido-Moraga, Alejandro Lucia, Alberto Blazquez, Juan C. Rubio, Carmen Palma-Milla, Joaquin Arenas, Miguel A. Martin
Summary: The article presents two young adult female patients who showed intolerance to anaerobic exercise, episodes of rhabdomyolysis, and, in one patient, psoriasis-like dermatitis. Through genetic mutation testing and lactate curve analysis, LDH-A deficiency was diagnosed.
Review
Oncology
Tina B. S. Miholjcic, Heloise Halse, Melodie Bonvalet, Amelie Bigorgne, Mathieu Rouanne, Laurent Dercle, Vishnu Shankar, Aurelien Marabelle
Summary: Immunotherapies have improved cancer patients' survival, but many encounter primary and secondary resistances. Investigating resistance mechanisms to cancer immunotherapies is an active area of research. Recent evidence suggests that elevated levels of LDH may have negative predictive value independent of tumor burden and guide treatment strategies in immuno-oncology. This review explores the potential of LDH-targeted therapeutic strategies to overcome the immunosuppressive effects of LDH and enhance patient survival with cancer immunotherapies.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Ilkay Ergenc, Emre Capar, Buket Erturk SengeI, Gunel Bahramzade, Fatih Atalah, Derya Kocakaya, Sait Karakurt, Goncagul Haklar, Zekaver Odabasi
Summary: This study investigated LDH isoenzyme levels in COVID-19 patients to identify the tissue responsible for serum LDH elevation. LDH3 was found to be an independent risk factor for deterioration in COVID-19 patients.
JOURNAL OF MEDICAL BIOCHEMISTRY
(2023)
Article
Medicine, General & Internal
Murat Yilmaz, Beliz Oztok Tekten
Summary: This study aimed to determine the potential role of postictal serum LDH activities in differentiating epileptic seizures from non-epileptic seizures. The results showed significantly higher LDH activities in patients with epileptic seizures compared to those with non-epileptic seizures, suggesting the potential use of LDH activities as a diagnostic tool in distinguishing between seizure types.
Article
Microbiology
Adam Lynch, Patrick Pearson, Sergey N. Savinov, Andrew Y. Li, Stephen M. Rich
Summary: Borrelia burgdorferi is the cause of Lyme disease and heavily relies on glycolysis for carbon metabolism. In this study, lactate dehydrogenase (LDH) inhibitors were evaluated for their effects on B. burgdorferi growth in culture, and it was found that racemic and enantiopure gossypol, as well as oxamate, galloflavin, and stiripentol, suppressed the growth of B. burgdorferi in a dose-dependent manner. Racemic gossypol and AT-101 fully inhibited spirochetal growth at concentrations of 70.5 and 187.5 μM, respectively. The differences in efficacy between racemic gossypol and AT-101 suggest that the dextrorotatory enantiomer of gossypol may be a more effective inhibitor of B. burgdorferi growth. Overall, LDH inhibition shows promise as a mechanism for suppressing Borrelia growth, especially with bulky LDH inhibitors like gossypol.
Article
Oncology
Angelina Tjokrowidjaja, Sarah J. Lord, Thomas John, Craig R. Lewis, Peey-Sei Kok, Ian C. Marschner, Chee K. Lee
Summary: This study explores the prognostic and predictive value of lactate dehydrogenase (LDH) in advanced non-small cell lung cancer (NSCLC) patients treated with immune checkpoint inhibitors (ICIs). The findings suggest that elevated pretreatment LDH is associated with worse prognosis, regardless of treatment. Persistently elevated on-treatment LDH is also associated with decreased overall survival (OS) rates.
Article
Biochemistry & Molecular Biology
Divyang H. Gandhi, Foram U. Vaidya, Chandramani Pathak, Tushar N. Patel, Bhupesh S. Bhatt
Summary: Cu(II) complexes with substituted isatin and Pefloxacin ligands were synthesized and characterized. These complexes showed efficient inhibition of HCT 116 cancer cell proliferation and potential anticancer activity. Further cellular assays revealed compound-1 induced cell apoptosis mechanism. Additionally, the compounds were screened for antibacterial and cytotoxic activities in vitro.
MOLECULAR DIVERSITY
(2022)
Article
Oncology
Long Bai, Ze-Yu Lin, Yun-Xin Lu, Qin Chen, Han Zhou, Qi Meng, Chun-Ping Lin, Wan-Lan Huang, Yun-Le Wan, Zhi-Zhong Pan, De-Shen Wang
Summary: The study demonstrates that serum LDH is a reliable and independent laboratory biomarker for predicting the clinical outcome of curative-intent surgery for CRLM. Combining LDH with the Fong score could be a potential stratification tool for CRLM resection.
Article
Chemistry, Multidisciplinary
Panasa Mahesh, Parameswari Akshinthala, Naresh Kumar Katari, Lavleen Kumar Gupta, Dikshita Panwar, Manoj Kumar Sharma, Sreekantha Babu Jonnalagadda, Rambabu Gundla
Summary: In this study, two new series of 3,5-dimethyl-1H-pyrazole-4-sulfonamide and 1,3,5-trimethyl-1H-pyrazole-4-sulfonamide derivatives were designed and synthesized. These derivatives were characterized by various analytical techniques and their biological evaluation data were presented, paving the way for the development of new pyrazole-4-sulfonamide derivatives.
Article
Chemistry, Analytical
Zhuo Wang, Xueer Qiu, Wensong Xi, Ming Tang, Jinliang Liu, Hong Jiang, Lining Sun
Summary: The study developed an upconversion hybrid nano fluorescent sensor (HNFS) for evaluating the LDH inhibitors efficacy in cancer cells, showing excellent biocompatibility in living cells. By analyzing the changes in mean fluorescence intensities of confocal images after incubating HNFS with different cells, the efficacy of LDH inhibitors on various cancer cells and differentiation between healthy and cancer cells were illustrated.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Oncology
Dolly Sharma, Mamta Singh, Reshma Rani
Summary: Lactate dehydrogenase plays a crucial role in tumor metabolism, and its inhibition may be a potential approach for anticancer therapy.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Oncology
Jialing Wu, Kaiyun You, Changlong Chen, Huimin Zhong, Yanhui Jiang, Huaqian Mo, Juanjuan Song, Xingsheng Qiu, Yimin Liu
Summary: This study retrospectively analyzed data from 198 patients with hypopharyngeal cancer and found that elevated pretreatment LDH levels were associated with poorer disease-free survival and overall survival. LDH was confirmed to be an independent predictor for both DFS and OS in multivariate analysis. Additional factors such as N status and age were also significantly associated with clinical outcomes.
FRONTIERS IN ONCOLOGY
(2021)
Article
Immunology
Lan He, Reginaldo G. Bastos, Long Yu, Jacob M. Laughery, Carlos E. Suarez
Summary: Babesia bigemina infection, responsible for bovine babesiosis, can be targeted by inhibiting lactate dehydrogenase (LDH) in the parasite's metabolic pathway. Gossypol, a known LDH inhibitor, shows significant inhibitory effects on B. bigemina growth. However, gossypol also affects the viability of cattle cells and the parasite displays higher LDH expression and resistance to gossypol in a low oxygen environment.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Medical Laboratory Technology
Zuomiao Xiao, Rongpeng Gong, Xianchun Chen, Dejun Xiao, Shi Luo, Yanhong Ji
Summary: There was evidence in this study that serum LDH level is associated with 60-day mortality in patients with acute myeloid leukemia (AML), especially for those with LDH levels greater than or equal to 570U/L. The results suggest that LDH level is closely related to the prognosis of AML.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Multidisciplinary Sciences
Dawei Yang, Jie Yin, Liuqun Shan, Xingling Yi, Wei Zhang, Yongbin Ding
Summary: Cancer cells utilize aerobic glycolysis to promote lysine lactylation, a post-translational modification that plays a crucial role in gene expression regulation. Lactylated proteins are more abundant in gastric tumors and high levels of lysine lactylation are associated with poor prognosis, making it a potential prognostic marker for gastric cancer.
