Article
Pediatrics
Lara Gonzalez-Garcia, Laura Mantecon-Fernandez, Marta Suarez-Rodriguez, Rosa Arias-Llorente, Sonia Lareu-Vidal, Aleida Ibanez-Fernandez, Maria Caunedo-Jimenez, Clara Gonzalez-Lopez, Eva Fernandez-Moran, Belen Fernandez-Colomer, Gonzalo Solis-Sanchez
Summary: In the last two decades, there has been a decrease in the prevalence of postnatal growth faltering in preterm infants with very low birth weight. There has also been an increase in growth rate during the neonatal period and improvements in height at 2 years of age.
Review
Medicine, General & Internal
Jessie Morgan, Lauren Young, William McGuire
Summary: The delayed introduction of progressive enteral feeds beyond four days after birth may not reduce the risk of necrotising enterocolitis or death in very preterm or VLBW infants. It may slightly reduce feed intolerance and probably increase the risk of invasive infection.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2022)
Article
Medicine, General & Internal
Seong Hee Oh, Hyun-Jeong Do, Ji Sook Park, Jae Young Cho, Chan-Hoo Park
Summary: Red cell distribution width (RDW) is a useful marker for assessing the severity and prognosis of various diseases in adults. This study investigated the RDW values of preterm infants and evaluated its predictive ability for bronchopulmonary dysplasia (BPD). The results showed no correlation between RDW and the development of BPD.
Review
Medicine, General & Internal
Sam J. Oddie, Lauren Young, William McGuire
Summary: The study aimed to determine the effects of slow rates of enteral feed advancement on the risk of NEC, mortality, and other morbidities in very preterm or VLBW infants. The results of 14 trials involving 4033 infants showed that slow advancement of enteral feed volumes probably does not reduce the risk of NEC, death, or feed intolerance, but may slightly increase the risk of invasive infection.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Pediatrics
Chung-Wei Lin, Hsiang-Yun Ko, Chih-Chi Huang, Chiu-Yu Yeh, Yen-Chun Chiu, Hsiu-Lin Chen
Summary: This study evaluated the effect of body weight gain and intake-calorie gain on the incubator weaning process for very low birth weight premature infants. The results showed that there was no association between body weight gain, intake-calorie gain, and incubator weaning.
Article
Pediatrics
Tianchan Lyu, Yibo Tao, Wei Hua, Liling Li, Yunfei Tang, Yumei Jin, Yan Wang, Yuelan Ma, Futing Ji, Yalan Dou, Yun Cao, Xiao-Jing Hu
Summary: The study found that most VLBWIs in the Yangtze River Delta region were infants with birth weights between 750g and 1500g, with premature rupture of membranes being the main cause of preterm birth. In terms of care practices, the rates of umbilical vein catheterization and peripherally inserted central catheter were 25.0% and 64.4% respectively. The study also showed that the mortality rate of preterm infants was 3.4%, with main complications including BPD, PDA, ROP, NEC and sepsis.
Article
Medicine, General & Internal
Hyun Jeong Do, Kyoung Min Moon, Hyun-Seung Jin
Summary: This study compared the performance of machine learning methods and logistic regression in predicting mortality of very low birth weight infants. The results showed that artificial neural network, random forest, and logistic regression had similar predictive performance, while support vector machine performed lower.
Review
Medicine, General & Internal
Robyn Richards, Jann P. Foster, Kim Psaila
Summary: This study aimed to investigate whether continuous or intermittent bolus intragastric tube feeding affects the incidence and severity of gastro-oesophageal reflux disease in preterm and low birth weight infants. However, no randomized trials meeting the inclusion criteria were found. Well-designed and adequately powered trials are needed in the future.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Pediatrics
Jing Li, Jing Zhang, Qingfei Hao, Ziyun Shen, Yanna Du, Haoming Chen, Xiuyong Cheng
Summary: This study explored the association between the time from the first extubation to reintubation and the occurrence of moderate-to-severe bronchopulmonary dysplasia (BPD) or death in very low birth weight infants. The findings showed that reintubation within 72 hours after the initial extubation was independently associated with an increased likelihood of moderate-to-severe BPD/death and death, while reintubation within the first 48 hours post-extubation posed the greatest risk.
FRONTIERS IN PEDIATRICS
(2022)
Article
Medicine, General & Internal
Ga Won Jeon, Jang Hoon Lee, Minkyung Oh, Yun Sil Chang
Summary: This study evaluated the long-term growth and neurodevelopmental outcomes of very-low-birth-weight infants born between 2013 and 2018. The results showed improvements in weight growth and cerebral palsy rates, but an increase in the proportion of children with language delays.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2022)
Article
Medicine, General & Internal
Ga Won Jeon, Jang Hoon Lee, Minkyung Oh, Yun Sil Chang
Summary: Since the launch of the KNN in 2013, the survival rates of infants with a GA of 26 weeks and short-term outcomes have improved, indicating an enhancement in antenatal and delivery room care quality.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2022)
Article
Pediatrics
J. L. Tapia, A. Toso, C. Vaz Ferreira, J. Fabres, G. Musante, G. Mariani, T. Herrera, I D'Apremont
Summary: Neonatal mortality rates in South America vary significantly, especially for very low birth weight infants. Initiatives like the NEOCOSUR Network have been collecting and analyzing data on outcomes for this group, but face challenges in improving survival rates and reducing mortality.
SEMINARS IN FETAL & NEONATAL MEDICINE
(2021)
Article
Pediatrics
Margaret G. Parker, Lisa M. Stellwagen, Lawrence Noble, Jae H. Kim, Brenda B. Poindexter, Karen M. Puopolo
Summary: Providing mother's own milk for hospitalized very low birth weight infants in the NICU has short- and long-term health benefits. When mother's own milk is not available, pasteurized human donor milk is recommended as an alternative. Neonatal health care providers can support lactation in the NICU to reduce disparities in provision of mother's own milk.
Article
Obstetrics & Gynecology
Hye-Rim Kim, Young Hwa Jung, So Young Kim, Chang Won Choi
Summary: This study compared the neurodevelopmental outcomes at 18-24 months of corrected age between preterm infants with very low birth weight (VLBW) conceived with and without the assistance of in vitro fertilization (IVF). The results showed no significant differences in neurodevelopmental outcomes between the two groups.
FERTILITY AND STERILITY
(2022)
Article
Pediatrics
Jiun Lee, Cheryl Yen May Lee, Krishnamoorthy Naiduvaje, Yoko Wong, Ashwani Bhatia, Imelda Lustestica Ereno, Selina Kah Yin Ho, Cheo Lian Yeo, Victor Samuel Rajadurai
Summary: The care practices and clinical outcomes of very-low-birth-weight (VLBW) infants in Singapore have improved over the past decade, with significant differences observed among different NICUs. Compared to counterparts from the Australian and New Zealand Neonatal Network (ANZNN), Singaporean infants showed better survival rates and outcomes.
PEDIATRICS AND NEONATOLOGY
(2023)
Article
Obstetrics & Gynecology
Ga Young Park, Won Soon Park, Se In Sung, Min Sun Kim, Myung Hee Lee, Ga Won Jeon, Sung Shin Kim, Yun Sil Chang
Summary: The outcomes of very low birth weight infants (VLBWIs) are significantly influenced by maternal mid-trimester prolonged preterm premature rupture of membranes (PPROM) and subsequent early pulmonary hypertension (PH), impacting survival rates, bronchopulmonary dysplasia (BPD), and severe intraventricular hemorrhage (IVH).
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Young Eun Kim, So Yoon Ahn, Dong Kyung Sung, Yun Sil Chang, Won Soon Park
Summary: This study investigates the role of Formyl peptide receptor (FPR) 2 in neonatal hyperoxia-induced lung injury and the potential of mesenchymal stem cells (MSCs) to attenuate this injury by regulating FPR2 activity. The findings suggest that MSCs can reduce FPR2 activity and protect against hyperoxic lung injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pediatrics
Ji Sook Kim, Yun Sil Chang, So Yoon Ahn, Se In Sung, Mi Sun Yang, Won Soon Park
Summary: This study investigated the feasibility of early discontinuation of levothyroxine replacement therapy (LRT) for delayed hyperthyrotropinemia in extremely low birth weight infants. The results showed no significant differences in short-term and long-term outcomes between the short-term and long-term LRT groups, but the mortality rate was significantly higher in the no LRT required group compared to the long-term LRT group.
Article
Nutrition & Dietetics
Sihan Song, Bo Mi Song, Hyun-Young Park
Summary: This study examined the associations between serum folate and homocysteine concentrations and the risk of all-cause, CVD, and cancer mortality in Korean adults. The findings suggest that higher serum homocysteine and lower serum folate concentrations are associated with an increased risk of all-cause, CVD, and cancer-related mortality.
JOURNAL OF NUTRITION
(2023)
Article
Pediatrics
Misun Yang, Yun Sil Chang, So Yoon Ahn, Se In Sung, Won Soon Park
Summary: Recent evidence suggests that the survival rate of periviable infants with birth weight (BW) 5.500 g could be improved with better care practices in the neonatal intensive care unit (NICU). This study aimed to investigate the care quality level of NICU-dependent variations in the survival rate of infants with BW <= 500 g. The results showed that providing better NICU quality care practices, including better cardiorespiratory management starting from delivery room resuscitation, can improve the survival rate of infants with BW <= 500 g.
Article
Medical Laboratory Technology
Beomki Lee, Won Young Heo, Jee Ah Kim, Hyun Seung Lee, Narae Hwang, Hyung-Doo Park, Se In Sung, Yun Sil Chang, Won Soon Park, Soo-Youn Lee
Summary: The NeoBase 2 assay was comprehensively evaluated and found to be able to distinguish between transient tyrosinemia of the newborn (TTN) and tyrosinemia type 1 (TYR 1) using succinylacetone (SUAC). Different cutoffs were established for analytes in preterm neonates. Simultaneous measurement of tyrosine (Tyr) and SUAC successfully differentiated between TYR 1 and TTN.
ANNALS OF LABORATORY MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Young Eun Kim, Dong Kyung Sung, Yuna Bang, Se In Sung, Misun Yang, So Yoon Ahn, Yun Sil Chang
Summary: Mesenchymal stem cells (MSCs) have immunomodulatory properties and can be used as therapeutic agents for inflammatory diseases. The suppressor of cytokine signaling (SOCS) proteins play a key role in macrophage modulation in MSCs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Hyeonseek Park, Doo Ri Kim, Areum Shin, Eunjung Jeong, Sohee Son, Jin-Hyun Ahn, So Yoon Ahn, Suk-Joo Choi, Soo-young Oh, Yun Sil Chang, Yae-Jean Kim, Minhee Kang
Summary: Congenital CMV infection is a common cause of hearing loss and neurodevelopmental impairment in newborns. A robust LAMP assay was developed for large-scale screening of newborns, providing higher sensitivity and shorter detection time compared to qPCR. The colorimetric LAMP assay can also be used for point-of-care testing in low-resource environments.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Medicine, General & Internal
Nayoung Jung, Chan Kim, Hanna Kim, Yekyeng Seo, Jieun Hwang, Misun Yang, So Yoon Ahn, Se In Sung, Yun Sil Chang
Summary: The study evaluated the implementation of a modified blood-sampling protocol in extremely low-birth-weight infants and found that it successfully reduced iatrogenic blood loss and the frequency of blood transfusion without negatively affecting neonatal outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pediatrics
Heui Seung Jo, Misun Yang, So Yoon Ahn, Se In Sung, Won Soon Park, Ja-Hyun Jang, Yun Sil Chang
Summary: Standardized protocols have been developed for clinical information collection and obtaining genomic information from infants with congenital anomalies and their parents. These protocols enable the establishment of an important platform for early genetic diagnosis and diagnostic research.
Article
Medicine, General & Internal
Jungeun Park, Mi Kyoung Son, Hyun-Young Park
Summary: This study aimed to investigate lipid changes in Korean middle-aged women during the perimenopausal period. The results showed that lipid levels significantly increased from 3 to 5 years before menopause to 1 year after menopause in all women, regardless of their premenopausal body mass index. However, lipid changes slowed down after 1 year postmenopause, indicating the importance of early intervention strategies for cardiovascular disease prevention in women.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Medicine, General & Internal
Yejin Kim, Yoo-min Kim, Doo Ri Kim, Han Gyeol Kim, Ji-Hee Sung, Suk-Joo Choi, Soo-young Oh, Yae-Jean Kim, Yun Sil Chang, Dongsub Kim, Jung -Sun Kim, Il Joon Moon, Cheong-Rae Roh
Summary: This study aimed to investigate the clinical characteristics of congenital CMV infection from diagnosis to treatment using a multidisciplinary approach. The results showed that prenatal findings have limited ability to detect congenital CMV in Korea. Developmental delay and hearing loss were common long-term outcomes, emphasizing the need for early antiviral treatment and specific diagnostic strategies to reduce the risks of neurologic impairment.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Medicine, General & Internal
Kyunghee Han, Nam-Kyoo Lim, Hansol Choi, Bo Mi Song, Hyun-Young Park
Summary: This study aimed to assess the prevalence of dysmenorrhea in young Korean women and investigate the impact of weight changes or unhealthy weight control behaviors on dysmenorrhea. The findings indicate that weight changes (≥3 kg) or unhealthy weight control behaviors are common among young women and may have a negative effect on dysmenorrhea. Therefore, it is important to pay attention to excessive weight changes and unhealthy weight control behaviors to improve dysmenorrhea in young women.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Sein Hwang, Dong Kyung Sung, Young Eun Kim, Misun Yang, So Yoon Ahn, Se In Sung, Yun Sil Chang
Summary: TLR3 and TLR4 priming of hUCB-MSCs can induce an anti-inflammatory phenotype, potentially mediated by extracellular vesicles (EVs). In an LPS-induced lung injury model, TLR3 and TLR4-primed hUCB-MSCs were more effective than naive MSCs in reducing inflammatory cytokines and promoting M2 polarization of macrophages. Moreover, EVs derived from TLR-primed MSCs exhibited comparable anti-inflammatory and immunosuppressive effects to MSC treatment alone.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Jin A. Lee, Soon Min Lee, Sung-Hoon Chung, Jang Hoon Lee, Jae Won Shim, Jae Woo Lim, Chang-Ryul Kim, Yun Sil Chang
Summary: This study investigated the prevalence of 67 major congenital anomalies in Korea and compared it with the European data. The results showed that the prevalence of spina bifida, atrial septal defect, congenital megacolon, hip dislocation and/or dysplasia, and skeletal dysplasia in Korea was more than five times higher than in Europe. However, the prevalence of aortic atresia/interrupted aortic arch and gastroschisis in Korea was less than one-fifth of that in Europe. Preterm births accounted for 15.7% of the cases, with more than 40% of infants with anencephaly, annular pancreas, and gastroschisis being born prematurely. Neonatal intensive care unit admission rate was 29.2%, and surgical operation rate was 25.6%. The mortality rate was 1.7%, with 78.2% of the deaths occurring within the first year of life. ASD and ventricular septal defect were the most common anomalies, while trisomy 18 and hypoplastic left heart syndrome were the most fatal anomalies. All infants with aortic atresia/interrupted aortic arch and conjoined twins received surgery.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)