Review
Pharmacology & Pharmacy
Saeed Alshahrani
Summary: Chronic kidney disease is a complex condition with various underlying causes. Current pharmacotherapeutic treatment options aim to slow disease progression and improve quality of life but cannot achieve complete cure. The first-line treatment for controlling blood pressure in chronic kidney disease is the use of renin-angiotensin-aldosterone system modulators. These modulators, including direct renin inhibitors, angiotensin-converting enzyme inhibitors, and angiotensin II receptor blockers, have different structures and mechanisms of action, leading to varying treatment outcomes. The choice of modulator depends on patient presentation, comorbidities, treatment availability and affordability, and healthcare provider expertise. Comparative studies between these modulators are currently lacking, which could provide valuable information for healthcare providers and researchers. This review compares the direct renin inhibitor (aliskiren) with angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers, aiming to identify specific areas of interest for intervention and the best possible treatment option.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Urology & Nephrology
Marieta P. Theodorakopoulou, Maria-Eleni Alexandrou, Afroditi K. Boutou, Charles J. Ferro, Alberto Ortiz, Pantelis Sarafidis
Summary: Hypertension and chronic kidney disease are common comorbidities associated with COVID-19 severity and mortality. Concerns about the use of RAS blockers increasing the risk of COVID-19 infection and severity have been disproven by recent human studies.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Pharmacology & Pharmacy
Urszula Tyrankiewicz, Mariola Olkowicz, Piotr Berkowicz, Magdalena Jablonska, Ryszard T. Smolenski, Jerzy A. Zoladz, Stefan Chlopicki
Summary: The study found that combined spontaneous physical activity and ACE-I treatment had additive beneficial effects on ACE/ACE-2 balance in a mouse model of heart failure, but did not result in improvement in cardiac function.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Mauro G. Silva, Gerardo R. Corradi, Juan Perez Duhalde, Myriam Nunez, Eliana M. Cela, Daniel H. Gonzales Maglio, Ana Brizzio, Martin R. Salazar, Walter G. Espeche, Mariela M. Gironacci
Summary: This study found that COVID-19 patients have higher levels of ACE2 expression and enzymatic activity in their blood compared to healthy individuals, while levels of AngII and Ang-(1-7) are lower. Even when excluding COVID-19 patients under RAS blockade treatment, ACE2 expression and enzymatic activity remain higher in COVID-19 patients, suggesting the involvement of RAS in COVID-19.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Geriatrics & Gerontology
Robert MacLachlan, Patrick Gavin Kehoe, J. Scott Miners
Summary: The activity of angiotensin-converting enzyme-1 (ACE-1) is induced in the early stages of Alzheimer's disease (AD), independently from the normal physiological changes in ACE-1 protein during aging.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Medicine, General & Internal
Aimin Yang, Mai Shi, Eric S. H. Lau, Hongjiang Wu, Xinge Zhang, Baoqi Fan, Alice P. S. Kong, Andrea O. Y. Luk, Ronald C. W. Ma, Juliana C. N. Chan, Elaine Chow
Summary: Discontinuation of ACEi/ARBs in Chinese patients with type 2 diabetes and advanced-CKD is associated with increased risk of cardiovascular-renal events, emphasizing the importance of their continued use.
Article
Multidisciplinary Sciences
Jakub Jankowski, Hye Kyung Lee, Julia Wilflingseder, Lothar Hennighausen
Summary: This study reports on the genetic programs activated in kidney cells in response to interferons during COVID-19, and the inhibitory effect of a Janus kinase inhibitor. The findings help identify kidney-specific interferon responses.
Article
Cell Biology
Jorge F. Giani, Luciana C. Veiras, Justin Z. Y. Shen, Ellen A. Bernstein, DuoYao Cao, Derick Okwan-Duodu, Zakir Khan, Romer A. Gonzalez-Villalobos, Kenneth E. Bernstein
Summary: Renal angiotensin-converting enzyme (ACE) plays a key role in the development of various kidney diseases, particularly hypertension. Studies suggest that ACE may mediate its effects through mechanisms independent of Ang II conversion, involving other substrates.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Genetics & Heredity
Hendri Susilo, Budi Susetyo Pikir, Mochammad Thaha, Mochamad Yusuf Alsagaff, Satriyo Dwi Suryantoro, Citrawati Dyah Kencono Wungu, Ifan Ali Wafa, Cennikon Pakpahan, Delvac Oceandy
Summary: In Javanese CKD patients, the association between ACE I/D polymorphism and high plasma ACE levels indirectly contributes to the increased risk of ASCVD and cardiovascular mortality.
Article
Medicine, General & Internal
Narayan Prasad, Ashok Kumar Yadav, Monica Kundu, Ajay Jaryal, Dipankar Sircar, Gopesh Modi, Manisha Sahay, Natarajan Gopalakrishnan, Sanjay Vikrant, Santosh Varughese, Seema Baid-Agrawal, Shivendra Singh, Sishir Gang, Sreejith Parameswaran, Arpita Ghosh, Vivek Kumar, Vivekanand Jha
Summary: ACEI/ARB users have a slower decline in eGFR, lower risk of renal outcomes, and cardiovascular mortality in CKD patients.
FRONTIERS IN MEDICINE
(2022)
Article
Urology & Nephrology
Roemer J. Janse, Edouard L. Fu, Catherine M. Clase, Laurie Tomlinson, Bengt Lindholm, Merel van Diepen, Friedo W. Dekker, Juan-Jesus Carrero
Summary: Stopping RASi use after acute kidney injury is associated with similar risk of recurrent AKI but higher risk of death, myocardial infarction, and stroke.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Plant Sciences
Carla Georgia Rodrigues Guimaraes Souto, Bethania Rosa Lorencone, Aline Aparecida Macedo Marques, Rhanany Alan Calloi Palozi, Paulo Vitor Moreira Romao, Lucas Pires Guarnier, Cleide Adriane Signor Tirloni, Ariany Carvalho dos Santos, Roosevelt Isaias Carvalho Souza, Priscila Megda Joao Job Zago, Francislaine Aparecida dos Reis Livero, Emerson Luiz Botelho Lourenco, Denise Brentan Silva, Arquimedes Gasparotto Junior
Summary: The ethanolic extract of Talinum paniculatum showed significant cardiorenal protective effects in rats, normalizing electrocardiographic and hemodynamic alterations, and preventing ventricle remodeling. These effects were associated with serum antioxidant activity and angiotensin-converting enzyme (ACE) inhibition, indicating potential benefits for hypertensive patients with doxorubicin-induced cardiotoxicity.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Xiao-Ce Dai, Zhuo-Yu An, Zi-Yang Wang, Zi-Zhen Wang, Yi-Ren Wang
Summary: The use of ACEIs/ARBs does not appear to have a significant impact on mortality, disease severity, or duration of hospitalization in COVID-19 patients. Based on the findings of this meta-analysis, there is no support for discontinuing treatment with ACEIs or ARBs in patients with COVID-19.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Urology & Nephrology
L. Parker Gregg, Peter A. Richardson, Michael A. Herrera, Julia M. Akeroyd, Shehrezade A. Jafry, Glenn T. Gobbel, Sheena Wydermyer, Jennifer Arney, Adriana Hung, Michael E. Matheny, Salim S. Virani, Sankar D. Navaneethan
Summary: ACE inhibitors (ACEis) and angiotensin receptor blockers (ARBs) are often discontinued in chronic kidney disease (CKD) patients. A study on US veterans from 2005 to 2019 found that adverse drug reactions (ADRs) leading to treatment discontinuation were infrequently documented and varied in types. ADRs related to angioedema, hyperkalemia, peripheral edema, or acute kidney injury were significantly associated with treatment discontinuation.
AMERICAN JOURNAL OF NEPHROLOGY
(2023)
Article
Pharmacology & Pharmacy
Shuwei Wang, Qi Han, Zhaolan Wei, Yunyi Wang, Lingfu Deng, Mingqing Chen
Summary: The study found that exposure to formaldehyde can cause an increase in blood pressure and damage to the heart, aortic vessels, and kidneys. By blocking the ACE/AT1R axis using an ACE inhibitor, the increase in blood pressure and pathological changes caused by formaldehyde exposure can be alleviated. This result improves our understanding of the impact of formaldehyde exposure on the development of hypertension.
Article
Engineering, Biomedical
Fernanda Silva Tenorio, Luiz Eduardo Galvao Martins, Tatiana Sousa Cunha
Summary: This study evaluates the accuracy and precision of a low-cost insulin infusion pump prototype using two different methods, showing that the prototype can accurately infuse programmed fluid doses with good performance in repeatability tests. It is presented as a candidate for type 1 diabetic patients in Brazil and developing countries for public health purposes.
ANNALS OF BIOMEDICAL ENGINEERING
(2021)
Article
Behavioral Sciences
Rafaela Costa, Maeline Santos Morais Carvalho, Juliana Dineia Perez Brandao, Roseli Peres Moreira, Tatiana Sousa Cunha, Dulce Elena Casarini, Fernanda Klein Marcondes
Summary: The study evaluated the effects of environmental enrichment on hormonal and behavioral responses induced by chronic stress in rats. The results showed that environmental enrichment improved stress hormone secretion, depression-like behaviors, and memory impairment, while reducing anxiety-like behavior and norepinephrine secretion.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Multidisciplinary Sciences
Leticia Barssotti, Isabel C. M. E. Abreu, Ana Beatriz P. Brandao, Raquel C. M. F. Albuquerque, Fabiana G. Ferreira, Miguel A. C. Salgado, Danielle D. S. Dias, Katia De Angelis, Rodrigo Yokota, Dulce E. Casarini, Livia B. Souza, Carla R. Taddei, Tatiana S. Cunha
Summary: The study found that Saccharomyces boulardii can alleviate liver injury and oxidative stress in STZ-induced diabetic mice, while also modulating the concentration of renin angiotensin system peptides in the liver.
SCIENTIFIC REPORTS
(2021)
Review
Medicine, Research & Experimental
Nayara Azinheira Nobrega Cruz, Danielle Stoll, Dulce Elena Casarini, Mariane Bertagnolli
Summary: This review explores the impact of SARS-CoV-2 infection on pregnancy, focusing on the role of ACE2 in viral entry and potential risks related to ACE2 changes in COVID-19 pregnancies. The study highlights the importance of understanding ACE2's functions in physiological systems during pregnancy and the necessity of filling knowledge gaps to improve management of high-risk pregnancies with COVID-19 exposure.
Article
Urology & Nephrology
Roseli Peres Moreira, Nadia S. C. Bertoncello, Juliana Almada Colucci, Danielle Yuri Arita, Maria Claudina Camargo de Andrade, Fernanda Aparecida Ronchi, Tatiana Sousa Cunha, Dulce Elena Casarini
Summary: The study found that 8 weeks of diabetes induction altered the kidney catecholaminergic system in a very specific manner, with a significant reduction in norepinephrine levels in both the diabetic and control groups.
JORNAL BRASILEIRO DE NEFROLOGIA
(2021)
Article
Urology & Nephrology
Ho Chi Hsien, Dulce Elena Casarini, Joao Tomas de Abreu Carvalhaes, Fernanda Aparecida Ronchi, Lilian Caroline Goncalves de Oliveira, Josefina Aparecida Pellegrini Braga
Summary: Children with sickle cell disease have significantly higher urinary ACE 1 activity compared to healthy children, but no significant difference was found in serum ACE activity. This suggests a dissociation between intrarenal and systemic RAAS in SCD patients.
JORNAL BRASILEIRO DE NEFROLOGIA
(2021)
Review
Engineering, Biomedical
Fernanda Silva Tenorio, Luiz Eduardo Galvao Martins, Gloria Sthefany Pereira da Silva, Camila Bertini Martins, Ana Lucia Domingues Neves, Tatiana Sousa Cunha
Summary: This study aims to evaluate the methods used to assess the accuracy of insulin infusion pumps and compile the findings. It highlights the need for a standardized protocol to evaluate patch pumps.
ANNALS OF BIOMEDICAL ENGINEERING
(2022)
Article
Gastroenterology & Hepatology
Mariana Ferreira-Duarte, Lilian Caroline Goncalves Oliveira, Clara Quintas, Marisa Esteves-Monteiro, Margarida Duarte-Araujo, Teresa Sousa, Dulce Elena Casarini, Manuela Morato
Summary: This study evaluated the catalytic activity of ACE and ACE2 in the intestinal content and corresponding intestinal tissue of Wistar Han rats. The results showed that ACE and ACE2 have catalytic activity in the rat gut, with higher activity of the ACE N-domain compared to the C-domain. Additionally, ACE and ACE2 were more active in the intestinal content than in the corresponding intestinal tissue. In the intestinal tissue, there was a distal-to-proximal prevalence of ACE2 over ACE. This study is the first to report the presence of catalytically active ACE and ACE2 in the rat intestinal content, supporting future research on the regulatory role of the intestinal RAAS on gut function and a putative link to the microbiome.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Review
Engineering, Biomedical
Anderson Faria Claret, Karina Rabello Casali, Tatiana Sousa Cunha, Matheus Cardoso Moraes
Summary: Emotions play a vital role in human cognition and have garnered significant interest in the field of artificial intelligence and machine learning. However, accurately identifying human emotions remains a challenge due to various factors and physiological changes. This study conducted a systematic review to explore the current trends in the detection, recognition, and classification of emotions based on cardiac signals. The findings provide insights into techniques for designing automatic emotion recognition applications using low-cost, wearable, and unobtrusive devices.
ANNALS OF BIOMEDICAL ENGINEERING
(2023)
Article
Toxicology
Lilian Caroline Goncalves Oliveira, Nayara Azinheira Nobrega Cruz, Bruna Ricelli, Helio Tedesco-Silva Jr, Jose Osmar Medina-Pestana, Dulce Elena Casarini
Summary: This review explores the history and interactions of the RAAS and KKS systems in the context of COVID-19, discussing the viral-cell interaction, system imbalance, and potential therapies for the disease. It also emphasizes the importance of exploring these systems and their components in the treatment of coronavirus disease.
JOURNAL OF VENOMOUS ANIMALS AND TOXINS INCLUDING TROPICAL DISEASES
(2021)
Meeting Abstract
Sport Sciences
Marcos A. Nascimento, Henrique A. Amorim, Catharina M. C. Scassola, Tatiana S. Cunha, Karina R. Casali
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2021)
Article
Behavioral Sciences
Rafaela Costa, Maeline Santos Morais Carvalho, Juliana Dineia Perez Brandao, Roseli Peres Moreira, Tatiana Sousa Cunha, Dulce Elena Casarini, Fernanda Klein Marcondes
Summary: Environmental enrichment (EE) was found to reduce stress hormone secretion, depression-like behaviors, and memory impairment, while also decreasing angiotensin II induced by stress. It also reduced anxiety-like behavior and norepinephrine secretion, providing protection against the effects of chronic mild unpredictable stress (CMS) in adult rats.
BEHAVIOURAL BRAIN RESEARCH
(2021)
