期刊
CLINICAL AND EXPERIMENTAL ALLERGY
卷 44, 期 4, 页码 553-562出版社
WILEY
DOI: 10.1111/cea.12239
关键词
asthma; epidemiology; immunoglobulin E; Staphylococcus aureus
资金
- Korean Healthcare Technology R&D Project, Ministry of Health, Welfare, Republic of Korea [A102065]
- National Cancer Center [0710140]
- Flemish Scientific Research Board, FWO
- Predicta FP7 Collaborative Project [260895]
BackgroundRecent studies suggest that Staphylococcus aureus enterotoxin sensitization is a risk factor for asthma. However, there is a paucity of epidemiologic evidence on adult-onset asthma in community-based populations. ObjectiveWe sought to evaluate the epidemiology and the clinical significance of staphylococcal enterotoxin sensitization in community-based adult populations. MethodsThe present analyses were performed using the baseline data set of Korean adult population surveys, consisting of 1080 adults (mean age=60.2years) recruited from an urban and a rural community. Questionnaires, methacholine challenge tests, and allergen skin tests were performed for defining clinical phenotypes. Sera were analysed for total IgE and enterotoxin-specific IgE using ImmunoCAP. ResultsStaphylococcal enterotoxin sensitization (0.35kU/L) had a prevalence of 27.0%. Risk factors were identified as male sex, current smoking, advanced age (61years), and inhalant allergen sensitization. Current asthma was mostly adult onset (18years old) and showed independent associations with high enterotoxin-specific IgE levels in multivariate logistic regression tests. In multivariate linear regressions, staphylococcal enterotoxin-specific IgE level was identified as the major determinant factor for total IgE level. Conclusions and Clinical RelevanceStaphylococcal enterotoxin sensitization was independently associated with adult-onset asthma in adult community populations. Strong correlations between the enterotoxin-specific IgE and total IgE levels support the clinical significance. The present findings warrant further studies for the precise roles of staphylococcal enterotoxin sensitization in the asthma pathogenesis.
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