Review
Cell Biology
Sarah Saxena, Veronique Kruys, Raf De Jongh, Joseph Vamecq, Mervyn Maze
Summary: Aseptic surgical trauma induces the release of HMGB1, triggering the immune response and resulting in postoperative cognitive decline.
Review
Cell Biology
Bram DeWulf, Laurens Minsart, Franck Verdonk, Veronique Kruys, Michael Piagnerelli, Mervyn Maze, Sarah Saxena
Summary: Targeting HMGB1 can be a strategy to reduce sepsis-induced encephalopathy and complement non-pharmacological interventions.
Article
Cardiac & Cardiovascular Systems
Federico Biscetti, Giovanni Tinelli, Maria Margherita Rando, Elisabetta Nardella, Andrea Leonardo Cecchini, Flavia Angelini, Giuseppe Straface, Marco Filipponi, Vincenzo Arena, Dario Pitocco, Antonio Gasbarrini, Massimo Massetti, Andrea Flex
Summary: The study found that HMGB1 is an independent risk factor for carotid plaque vulnerability in diabetic patients, with higher levels of HMGB1 and inflammatory cytokines in ICAS patients compared to WICAS patients. Among ICAS patients, those with unstable plaque had even higher levels of these cytokines. HMGB1 and osteoprotegerin were independently associated with unstable plaque in ICAS patients.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Multidisciplinary Sciences
Varangkana Wairachpanich, Vorapong Phupong
Summary: This study found that serum HMGB1 at 16-20(+6) weeks of gestation were effective in predicting preeclampsia, while the addition of uterine artery Doppler did not improve the prediction performance.
SCIENTIFIC REPORTS
(2022)
Review
Multidisciplinary Sciences
Zhiwu Wu, Liping Liang, Qianliang Huang
Summary: HMGB1 is a cytokine that serves as a marker of inflammation and has multiple functions depending on its subcellular location. CSF HMGB1 may play a role in the pathological mechanisms underlying complications associated with CNS diseases. Measuring the level of HMGB1 in the CSF can help predict disease progression and contribute to pathological alterations in distant areas.
Article
Biochemistry & Molecular Biology
Ilijana Grigorov, Snezana Pejic, Ana Todorovic, Dunja Drakulic, Filip Veljkovic, Jadranka Miletic Vukajlovic, Katarina Bobic, Ivan Soldatovic, Sinisa Durasevic, Nebojsa Jasnic, Sanja Stankovic, Sofija Glumac, Violeta Mihailovic-Vucinic, Branislava Milenkovic
Summary: Careful monitoring of mild/moderate COVID-19 patients is crucial due to the rapid progression of complications. This study identified HMGB1 and HO-1 as potential biomarkers for COVID-19 management, based on their serum concentrations at hospital admission. The increase in HO-1 may provide protection against oxidative stress and inflammation, while the level of HMGB1 reflects the activity of the innate immune system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Anette Teo Hansen Selno, Stephanie Schlichtner, Inna M. Yasinska, Svetlana S. Sakhnevych, Walter Fiedler, Jasmin Wellbrock, Steffen M. Berger, Elena Klenova, Bernhard F. Gibbs, Elizaveta Fasler-Kan, Vadim V. Sumbayev
Summary: HMGB1, a non-histone protein, is released by stressed, dying, or dead cells into the extracellular matrix, potentially impacting cancer cells' ability to evade immune surveillance. Through recognition as a ligand, TLR4 mediates the induction of TGF-beta by HMGB1, leading to the expression of the immunosuppressive protein galectin-9 in cancer cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Tuo Tang, Shengnan Wang, Tianyu Cai, Zhenyu Cheng, Yu Meng, Shimei Qi, Yao Zhang, Zhilin Qi
Summary: This study found that HMGB1 promotes proliferation and migration of gastric cancer cells through the RAGE-mediated signaling pathways, involving multiple molecular mechanisms. It highlights HMGB1 as a potential therapeutic target for GC, providing important evidence for future research and treatment strategies.
Review
Immunology
Hayder M. Al-kuraishy, Ali I. Al-Gareeb, Luay Alkazmi, Ola A. Habotta, Gaber El-Saber Batiha
Summary: HMGB1 is a multifunctional nuclear protein that plays a critical role in the inflammatory signaling pathway. Elevated levels of HMGB1 in COVID-19 patients are associated with disease severity and complications. Targeting the HMGB1 pathway may be beneficial in reducing the severity of the disease.
INFLAMMOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Chao Ren, Ren-qi Yao, Li-xue Wang, Jun-cong Li, Kun-wei Chen, Yao Wu, Ning Dong, Yong-wen Feng, Yong-ming Yao
Summary: This study found that HMGB1 plays a critical role in dysregulating immune response in sepsis, with the relationship between cerebral HMGB1 and splenic DC dysfunction being dependent on cholinergic system activity. The findings shed light on the mechanisms of immune dysfunction in sepsis and the potential therapeutic targets involving HMGB1 and cholinergic pathways.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Hyun Jin Min, Joon Soon Park, Kyung Soo Kim, Seung Yong Park, Honghwan Choi, Ju Hee Seo, Miran Kang, Joo-Heon Yoon, Chang-Hoon Kim, Sehoon Kim, Hyung-Ju Cho
Summary: The function of HMGB1 varies according to its location, and the mechanism behind its translocation remains unclear. Th2 cytokines play a role in the translocation of HMGB1 in the upper airway epithelium. The up-regulation of ROS induced by Th2 cytokines and the subsequent translocation of HMGB1 are important in the pathogenesis of allergic rhinitis.
Article
Oncology
Kanako Yokomizo, Kayoko Waki, Miyako Ozawa, Keiko Yamamoto, Sachiko Ogasawara, Hirohisa Yano, Akira Yamada
Summary: Knocking out HMGB1 in tumor cells suppresses tumor growth in vivo, mediated by CD8 T cells, and leads to accelerated infiltration of CD8 T cells, macrophages, and dendritic cells in the tumor tissues. Manipulation of tumor-derived HMGB1 could improve the clinical outcomes of cancer immunotherapies.
Article
Obstetrics & Gynecology
Carlo Ticconi, Stefania Mardente, Emanuela Mari, Federica Barreca, Manuela Montanaro, Alessandro Mauriello, Giuseppe Rizzo, Alessandra Zicari
Summary: The levels of HMGB1 in plasma, platelets, and plasma-derived microvesicles were significantly higher in women with unexplained recurrent pregnancy loss (uRPL) compared to control women. Expression of HMGB1 in the endometrium was also higher in women with uRPL. These findings suggest the involvement of HMGB1 in uRPL.
JOURNAL OF PERINATAL MEDICINE
(2023)
Article
Chemistry, Medicinal
Verena Peek, Lois M. Harden, Jelena Damm, Ferial Aslani, Stephan Leisengang, Joachim Roth, Ruediger Gerstberger, Marita Meurer, Maren von Koeckritz-Blickwede, Sabine Schulz, Bernhard Spengler, Christoph Rummel
Summary: This study revealed the mechanisms of HMGB1 action in the brain during rat sepsis, finding that HMGB1 enhances brain inflammatory responses and is associated with sustained sepsis symptoms.
Article
Medicine, Research & Experimental
Shang -En Huang, Cheng-Hsiang Kuo, Si -Yu Shiao, Chia-Rui Shen, Fang-Tzu Lee, Bi-Ing Chang, Jong-Hau Hsu, Hua-Lin Wu, Jwu-Lai Yeh, Chao -Han Lai
Summary: This study found that soluble CD93 (sCD93) can bind to the proinflammatory factor HMGB1 and block its interaction with receptors, thereby exerting anti-inflammatory effects. sCD93 can inhibit the production of inflammatory cytokines and reduce the activation of intracellular signaling pathways, thereby alleviating inflammation. This finding reveals a novel mechanism by which sCD93 alleviates inflammation by blocking the interaction between HMGB1 and effector cells.
Article
Allergy
Hyun Lee, Sang-Heon Kim, Byung-Keun Kim, Youngsoo Lee, Hwa Young Lee, Ga-Young Ban, Min-Hye Kim, Joo-Hee Kim, Jae-Woo Kwon, So-Young Park, Jae-Woo Jung, So Young Park, Chan Sun Park, Chin Kook Rhee, Taehoon Lee, Jae-Hyun Lee, So Ri Kim, Jong-Sook Park, Heung-Woo Park, Kwang Ha Yoo, Yeon-Mok Oh, Young-Il Koh, Byung-Jae Lee, An-Soo Jang, Sang-Heon Cho, Hae-Sim Park, Choon-Sik Park, You Sook Cho, Ho Joo Yoon
Summary: Among patients with severe asthma, those with ACO were older, predominantly male, more likely to have a smoking history, used more systemic corticosteroid, and had more frequent exacerbations related to emergency department visits than those with severe asthma only.
Article
Cardiac & Cardiovascular Systems
Kyung-Min Ahn, Sun-Sin Kim, Suh-Young Lee, So-Hee Lee, Heung-Woo Park
Summary: A large-scale study using health screening database found that individuals with low serum vitamin D levels are more likely to experience lung function decline in smokers, but no significant differences were observed in non-smokers.
RESPIRATORY MEDICINE
(2021)
Article
Geriatrics & Gerontology
Han-Ki Park, So-Hee Lee, Suh-Young Lee, Sun-Sin Kim, Heung-Woo Park
Summary: This study revealed that a decrease in MMI was associated with accelerated FEV1 decline in men, while an increase in FMI was linked to accelerated FEV1 decline in both women and men. In body composition analysis, it was found that an increase in MMI was only associated with attenuated FEV1 decline in men, while an increase in FMI was significantly linked to accelerated FEV1 decline in both genders. Individuals characterized by an increase in MM combined with a loss of FM showed the most favorable outcome in terms of FEV1 decline rate.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Article
Cell Biology
Hyun Seung Lee, Heung-Woo Park
Summary: Recent research has shown that exposure to particulate matter (PM) increases the risk and exacerbation of allergic asthma, but the underlying mechanisms and factors associated with increased allergic responses are still unclear. This study investigated the expression of IL-23 and IL-23R, as well as changes in the asthmatic phenotype, in mice exposed to PM and a low dose of house dust mite (HDM). The results showed that IL-23 expression was significantly increased in certain cell types, and administration of anti-IL-23 antibody led to decreased airway hyperresponsiveness and immune activation. In addition, IL-23 affected immunological changes in airway epithelial cells. These findings suggest that IL-23 may play a role in the development and exacerbation of asthma caused by PM exposure and low-dose HDM.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Letter
Allergy
Ji-Su Shim, Min-Hye Kim, Sang Min Lee, Sae-Hoon Kim, Jae-Woo Kwon, Catherine Song, Kyung-Min Ahn, Sung-Yoon Kang, Han-Ki Park, Heung-Woo Park, Byung-Keun Kim, Min-Suk Yang
Review
Allergy
Heung-Woo Park, Sang Heon Cho
Summary: The aging lung undergoes changes that make the elderly more susceptible to obstructive airway disease, including asthma. Elderly asthma (EA) is a significant burden in terms of mortality, morbidity, and expenditure. However, clinicians often lack knowledge of EA and must understand its distinct characteristics, appropriate diagnostic methods, and specific management strategies.
ALLERGY ASTHMA & IMMUNOLOGY RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Kiyon Rhew, Jisu Choi, Kyungim Kim, Kyung Hee Choi, So -Hee Lee, Heung-Woo Park
Summary: Asthma is associated with an increased risk of anemia, especially in patients older than 65 years. Regular monitoring for anemia is recommended for asthma patients.
CLINICAL EPIDEMIOLOGY
(2023)
Article
Medicine, General & Internal
Ji-Su Shim, Sun-Sin Kim, So-Hee Lee, Min-Hye Kim, Young-Joo Cho, Heung-Woo Park
Summary: This study investigated the effect of changes in fat mass on the development of asymptomatic airway hyperresponsiveness (AHR) in adults. The results showed that a rapid gain of fat mass over time may be a risk factor for the development of AHR. Further prospective studies are needed to confirm the results and evaluate the role of fat mass reduction in preventing AHR development in obese adults.
POSTGRADUATE MEDICINE
(2023)
Article
Medicine, General & Internal
Heung-Woo Park
Summary: The use of biological products (BPs) or molecularly targeted drugs has significantly improved the treatment of allergic diseases, providing effective and low-risk options for severe cases. BPs have also advanced our understanding of disease mechanisms and the prediction of therapeutic responses. However, their high cost and long-term administration limit their widespread use.
JOURNAL OF THE KOREAN MEDICAL ASSOCIATION
(2023)
Article
Allergy
Ha-Kyeong Won, Woo -Jung Song, Sung do Moon, Kyoung-Hee Sohn, Ju-Young Kim, Byung-Keun Kim, Heung-Woo Park, Claus Bachert, Sang Heon Cho
Summary: The study aimed to examine the relationship between SE-sIgE and FAO in elderly asthmatics. The analysis of 223 elderly asthmatics and 89 controls showed that baseline SE-sIgE sensitization was consistently associated with FAO after a 2-year follow-up, and was significantly correlated with the number of asthma exacerbations. Further investigation is needed to understand the role of SE-sIgE sensitization in airway remodeling.
ALLERGY ASTHMA & IMMUNOLOGY RESEARCH
(2023)
Article
Genetics & Heredity
Heung-Woo Park, Hyun Seung Lee
Summary: Exposure to particulate matter and house dust mites during the early life of mice increases allergic phenotypes and allergen-specific memory responses. Interleukin-23 plays a role in enhancing effector/memory Th2/Th17 cells and allergic phenotypes.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Article
Allergy
Chin Kook Rhee, Jung-Won Park, Heung-Woo Park, You Sook Cho
Summary: In Korean patients, dupilumab treatment reduced annualized severe exacerbation rates, improved FEV1, asthma control, and quality of life, while decreasing inflammatory biomarkers levels. The incidence of adverse events was comparable between the dupilumab and placebo group.
ALLERGY ASTHMA & IMMUNOLOGY RESEARCH
(2022)
Article
Allergy
Mi-Ae Kim, Heung-Woo Park, Byung-Keun Kim, So-Young Park, Ga-Young Ban, Ji-Hyang Lee, Jin An, Ji-Su Shim, Youngsoo Lee, Ha-Kyeong Won, Hwa Young Lee, Kyoung-Hee Sohn, Sung-Yoon Kang, So Young Park, Hyun Lee, Min-Hye Kim, Jae-Woo Kwon, Sun-Young Yoon, Jae-Hyun Lee, Chin Kook Rhee, Ji-Yong Moon, Taehoon Lee, So Ri Kim, Jong Sook Park, Sang-Heon Kim, Jae Won Jeong, Sang-Hoon Kim, Young-Il Koh, Yeon-Mok Oh, An-Soo Jang, Kwang Ha Yoo, You Sook Cho
Summary: The expert opinion paper on severe asthma management in Korea outlined common definitions and diagnostic procedures for assessing severe asthma, highlighting the importance of appropriate biologic treatments for patients with uncontrolled severe asthma accompanied by type 2-high inflammation. The findings from the survey of Korean specialists shed light on gaps in current treatments for T2-low asthma and will help inform the development of personalized therapy using emerging new drugs.
ALLERGY ASTHMA & IMMUNOLOGY RESEARCH
(2021)
Correction
Allergy
Kyoung-Hee Sohn, Woo-Jung Song, Jong-Sook Park, Heung-Woo Park, Tae-Bum Kim, Choon-Sik Park, Sang-Heon Cho
ALLERGY ASTHMA & IMMUNOLOGY RESEARCH
(2021)
Article
Clinical Neurology
Soo Jie Chung, Kyung-Min Ahn, Ji Hyun Oh, Ji-Su Shim, Heung-Woo Park
Summary: This study is the first in Asia to determine the IRs of SCARs for various ASMs and compare the rates across drugs using a large dataset. The results from this study should help clinicians select safer ASMs in practice.
