Article
Multidisciplinary Sciences
Leonidas Angelakis, Andriana Papaioannou, Evgenia Papathanasiou, Argiro Mazioti, Maria Kallieri, George Papatheodorou, George Patentalakis, Georgios Hillas, Spyridon Papiris, Nikolaos Koulouris, Stelios Loukides, Petros Bakakos
Summary: This study evaluated Sesn2 levels in COPD patients and its association with emphysema and blood eosinophils. The results showed that patients with significant emphysema had higher levels of Sesn2 and lower blood eosinophil counts. Sesn2 could serve as a potential biomarker of emphysema.
Article
Geriatrics & Gerontology
Colin Farrelly
Summary: Despite significant investments in public health and biomedical research, life expectancy and healthy life expectancy have remained stagnant in the United States. This can be attributed to the influence of two contrasting visions of public health – Protean and Post-Protean. While Protean public health successfully reduced early-life mortality risks, it has been less effective in improving the quality of life for older individuals. Post-Protean public health emphasizes experimental methods and research to indirectly improve health, aligning with the Geroscience Hypothesis. To enhance the health prospects of aging populations, the dominance of Protean public health needs to be relaxed, shifting focus towards increasing healthspan and managing late-life multimorbidities.
Article
Biochemistry & Molecular Biology
Crawford Currie, Bomi Framroze, Dave Singh, Simon Lea, Christian Bjerknes, Erland Hermansen
Summary: OmeGo, an enzymatically liberated fish oil, has demonstrated antioxidant and anti-inflammatory properties including the reduction of eosinophilia. In a mouse model of induced asthma, OmeGo showed a significant reduction in eosinophilic lung and systemic inflammation and reduced lung remodeling compared to cod liver oil. The CRTH2 antagonist fevipiprant showed a similar anti-inflammatory profile to OmeGo. OmeGo has the potential to be a pragmatic, cost-effective co-treatment for less severe forms of eosinophilic asthma.
Article
Medicine, Research & Experimental
Xiang Ren, Zhenlin Wang
Summary: The study found significantly higher levels of Eotaxin/CCL11 in the nasal lavage fluid of ECRS mice compared to the control group, showing diagnostic and therapeutic value. However, there were no significant differences in ILC2s and classic cytokines between the groups.
Review
Psychology, Multidisciplinary
Victoria Talwar, Angela Crossman
Summary: This article reviews the impact of social-environmental influences on the development of children's lie-telling knowledge, understanding, and behavior, emphasizing the need for a holistic examination of cognitive, social, environmental, cultural, and child factors in order to understand the divergent trajectories of lying and truth telling across development, particularly at the extremes.
CURRENT OPINION IN PSYCHOLOGY
(2022)
Article
Psychology, Clinical
Jillian Glazer, Kirsten MacDonnell, Christina Frederick, Karen Ingersoll, Lee M. Ritterband
Summary: Online studies can recruit large and diverse samples, but also present risks of applicants providing fraudulent information to gain eligibility for trials. This study found a percentage of fraudulent applications originating from online sources, highlighting the potential risks in online research trials.
INTERNET INTERVENTIONS-THE APPLICATION OF INFORMATION TECHNOLOGY IN MENTAL AND BEHAVIOURAL HEALTH
(2021)
Article
Computer Science, Cybernetics
Marton Gergely, V. Srinivasan (Chino) Rao
Summary: This study empirically assessed the extent of social desirability bias (SDB) in software piracy research through three different conditions. The research found that self-report surveys exhibited high levels of SDB, while behaviour in the experimental condition and responses in the peer-report survey method did not exhibit SDB.
BEHAVIOUR & INFORMATION TECHNOLOGY
(2022)
Article
Physiology
Xia Xu, Ke Huang, Fen Dong, Shiwei Qumu, Qichao Zhao, Hongtao Niu, Xiaoxia Ren, Xiaoying Gu, Tao Yu, Lin Pan, Ting Yang, Chen Wang
Summary: COPD is a heterogeneous disease with eosinophils potentially associated with emphysema, different from neutrophilic inflammation-related emphysema in small airway disease. The characterization of heterogeneity in COPD-associated inflammation may pave the way for personalized medicine and new therapeutic approaches.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Allergy
Akira Kanda, Yasutaka Yun, Dan Van Bui, Linh Manh Nguyen, Yoshiki Kobayashi, Kensuke Suzuki, Akitoshi Mitani, Shunsuke Sawada, Satoko Hamada, Mikiya Asako, Hiroshi Iwai
Summary: Eosinophils have diverse biological functions, playing a critical role in eosinophil-associated diseases and contributing to homeostasis, host defense, immune regulation, antiinflammatory, and anti-tumorigenic activities. Recent studies have highlighted emerging roles of eosinophils in steady-state conditions and their involvement in pathological conditions, reflecting the heterogenous features and distinct subpopulations of eosinophils.
ALLERGOLOGY INTERNATIONAL
(2021)
Article
History & Philosophy Of Science
Peter Eldridge-Smith
Summary: This article discusses some paradoxes and hypodoxes of sets, as well as their importance in solving paradoxes.
Review
Gastroenterology & Hepatology
Grigorios Leontiadis, George F. Longstreth
Summary: Evolutionary medicine integrates various scientific disciplines to provide explanations for the causes of many diseases, improving physicians' understanding of disease processes, care, and research.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Cell Biology
Xingen Wang, Chi-Sing Ng, Weihua Yin
Summary: KD and IgG4RD exhibit overlapping clinical, pathological, and immunohistological features, but they still have some distinct differences.
Article
Chemistry, Multidisciplinary
Jian Zhang, Yingying Xie, Jushuai Ma, Kaiqiang Liu, Yunshu Ding, Yong Li, Xiaoyun Jiao, Xilei Xie, Xu Wang, Bo Tang
Summary: Two fluorescent probes (QM-S and QM-Se) with AIE properties were developed to reveal the increased intracellular hypobromous acid (HOBr) in cardiomyocytes during myocardial ischemia-reperfusion injury (MIRI). It was observed that MIRI could be alleviated by combating oxidative stress, as well as inhibiting inflammation and ferroptosis, which mediate oxidative stress.
CHEMICAL COMMUNICATIONS
(2023)
Review
Biochemistry & Molecular Biology
Christopher Simon, Tomoko Soga, Hirotaka James Okano, Ishwar Parhar
Summary: Dementia with Lewy bodies (DLB) is characterized by the presence of alpha-synuclein-laden Lewy bodies in the brain, leading to significant damage to the brain's neuropsychological networks. However, there is still uncertainty surrounding the pathogenic role of alpha-synuclein in DLB pathobiology.
CELL AND BIOSCIENCE
(2021)
Review
Medicine, General & Internal
Rong Huang, Liangcai Xie, Junpeng He, Hong Dong, Tianchun Liu
Summary: The study found that the eosinophil counts in severe COVID-19 patients were significantly lower compared to mild cases. Subgroup analysis by different countries and pneumonia severity also supported this finding. Sensitivity analyses indicated the credibility and stability of the results.
Review
Gastroenterology & Hepatology
B. L. Wright, S. I. Ochkur, N. S. Olson, K. P. Shim, E. A. Jacobsen, M. A. Rank, E. S. Dellon, J. J. Lee
DISEASES OF THE ESOPHAGUS
(2018)
Article
Allergy
Benjamin L. Wright, Nathalie Nguyen, Kelly P. Shim, Joanne C. Masterson, Elizabeth A. Jacobsen, Sergei I. Ochkur, James J. Lee, Glenn T. Furuta
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2018)
Article
Respiratory System
Alfred D. Doyle, Manali Mukherjee, William E. LeSuer, Tyler B. Bittner, Saif M. Pasha, Justin J. Frere, Joseph L. Neely, Jake A. Kloeber, Kelly P. Shim, Sergei Ochkur, Terence Ho, Sarah Svenningsen, Benjamin L. Wright, Matthew A. Rank, James J. Lee, Parameswaran Nair, Elizabeth A. Jacobsen
EUROPEAN RESPIRATORY JOURNAL
(2019)
Article
Allergy
Devyani Lal, Benjamin L. Wright, Kelly P. Shim, Matthew A. Zarka, James J. Lee, Yu-Hui Chang, Sergei I. Ochkur, Rohit Divekar, Alfred D. Doyle, Elizabeth A. Jacobsen, Hirohito Kita, Matthew A. Rank
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2019)
Review
Surgery
Oscar Okwudiri Onyema, Yizhan Guo, Atsushi Hata, Daniel Kreisel, Andrew E. Gelman, Elizabeth A. Jacobsen, Alexander Sasha Krupnick
AMERICAN JOURNAL OF TRANSPLANTATION
(2020)
Article
Gastroenterology & Hepatology
Benjamin L. Wright, Nielsen Q. Fernandez-Becker, Neeraja Kambham, Natasha Purington, Shu Cao, Dana Tupa, Wenming Zhang, Sayantani B. Sindher, Matthew A. Rank, Hirohito Kita, David A. Katzka, Kelly P. Shim, Bryan J. Bunning, Alfred D. Doyle, Elizabeth A. Jacobsen, Mindy Tsai, Scott D. Boyd, Monali Manohar, R. Sharon Chinthrajah
Summary: In this pilot study, peanut OIT-induced EE and gastrointestinal eosinophilia are usually transient and are not always associated with gastrointestinal symptoms.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Benjamin L. Wright, Alfred D. Doyle, Kelly P. Shim, Rish K. Pai, Suzanne M. Barshow, Jennifer L. Horsley-Silva, Huijun Luo, Matthew A. Rank, Elizabeth A. Jacobsen, David A. Katzka, Hirohito Kita, Evan S. Dellon
Summary: This study evaluated image analysis of EPX immunohistochemistry as an automated method for histologic diagnosis of EoE. EPX/mm(2) correlates strongly with eos/hpf, accurately identifies subjects with EoE, and decreases in treatment responders.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Review
Cell Biology
William N. T. Nguyen, Elizabeth A. Jacobsen, Constance A. M. Finney, Pina Colarusso, Kamala D. Patel
JOURNAL OF LEUKOCYTE BIOLOGY
(2020)
Article
Immunology
Sang Hun Lee, Mariana M. Chaves, Olena Kamenyeva, Pedro H. Gazzinelli-Guimaraes, Byunghyun Kang, Gabriela Pessenda, Katiuska Passelli, Fabienne Tacchini-Cottier, Juraj Kabat, Elizabeth A. Jacobsen, Thomas B. Nutman, David L. Sacks
SCIENCE IMMUNOLOGY
(2020)
Editorial Material
Cell Biology
Elizabeth A. Jacobsen
JOURNAL OF LEUKOCYTE BIOLOGY
(2020)
Article
Multidisciplinary Sciences
James D. Hernandez, Ben Yi Tew, Ting Li, Gerald C. Gooden, Hamza Ghannam, Mia Masuda, James Madura, Bodour Salhia, Elizabeth A. Jacobsen, Eleanna De Filippis
SCIENTIFIC REPORTS
(2020)
Article
Allergy
William E. LeSuer, Melanie Kienzl, Sergei I. Ochkur, Rudolf Schicho, Alfred D. Doyle, Benjamin L. Wright, Matthew A. Rank, Alexander S. Krupnick, Hirohito Kita, Elizabeth A. Jacobsen
Summary: This study demonstrates the reciprocal role of eosinophils in the activation of ILC2s in allergic asthma and in vitro models. Eosinophils release mediators that promote ILC2 proliferation and chemotaxis, while ILC2s also have feedback effects on eosinophils.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Oscar Okwudiri Onyema, Yizhan Guo, Bayan Mahgoub, Qing Wang, Amir Manafi, Zhongcheng Mei, Anirban Banerjee, Dongge Li, Mark H. Stoler, Melissa T. Zaidi, Adam G. Schrum, Daniel Kreisel, Andrew E. Gelman, Elizabeth A. Jacobsen, Alexander Sasha Krupnick
Article
Biology
Andrew Chojnacki, Katarzyna Wojcik, Bjorn Petri, Gurpreet Aulakh, Elizabeth A. Jacobsen, William E. LeSuer, Pina Colarusso, Kamala D. Patel
COMMUNICATIONS BIOLOGY
(2019)
Article
Biology
Lian Willetts, Lindsey C. Felix, Elizabeth A. Jacobsen, Lakshmi Puttagunta, Rachel M. Condjella, Katie R. Zellner, Sergei Ochkur, John D. Kim, Huijun Luo, Nancy A. Lee, James J. Lee, Redwan Moqbel, Paige Lacy
COMMUNICATIONS BIOLOGY
(2018)