Article
Allergy
Ramin Beheshti, Scott Halstead, Daniel McKeone, Steven D. Hicks
Summary: This study used multi-omic analyses to assess how host and microbial factors contribute to infant atopic dermatitis (AD) development. The results suggest that interactions between the microbiome and host signaling may predispose certain infants to AD.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tianheng Hou, Miranda Sin-Man Tsang, Lea Ling-Yu Kan, Peiting Li, Ida Miu-Ting Chu, Christopher Wai-Kei Lam, Chun-Kwok Wong
Summary: IL-37b has been shown to regulate basophil activation mediated by TSLP and reduce the release of IL-4, suggesting its potential as a target for alleviating symptoms of AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Ju-Hyun Lee, Dong-Soon Im
Summary: The study evaluated the therapeutic effects of honokiol on atopic dermatitis, and found that honokiol significantly suppressed symptoms of atopic dermatitis, indicating its potential as a therapeutic agent for the disease.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Plant Sciences
Jung-Eun Lee, Young-Whan Choi, Dong-Soon Im
Summary: The aim of this study was to identify an active phytochemical from Schisandra chinensis and evaluate its effects on AD-like symptoms. The results showed that alpha-cubebenoate, an active phytochemical in Schisandra chinensis, significantly improved AD-like symptoms by reducing skin hypertrophy and mast cell accumulation, as well as decreasing pro-inflammatory chemokine and cytokine levels. This study provides evidence for the therapeutic efficacy of alpha-cubebenoate in the treatment of AD symptoms.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Tae-Kyeong Lee, Dae Won Kim, Ji Hyeon Ahn, Choong-Hyun Lee, Jae-Chul Lee, Soon Sung Lim, Il Jun Kang, Seongkweon Hong, Soo Young Choi, Moo-Ho Won, Joon Ha Park
Summary: Topical administration of laminarin improved oxazolone-induced atopic dermatitis-like skin lesions in Balb/c mice by reducing swelling, decreasing epidermal and dermal thickness, inhibiting mast cell infiltration, and lowering IgE levels. It also suppressed the expression of proinflammatory cytokines in the skin lesion, suggesting laminarin's potential as a candidate for atopic dermatitis treatment.
Review
Biochemistry & Molecular Biology
Jennifer Fan, Santosh K. Mishra
Summary: Understanding the mechanisms of itch in cutaneous allergic diseases is crucial for developing new therapeutic approaches to relieve itch. Recent studies have focused on endogenous mediators released from immune/nonimmune skin cells and the receptors on sensory neurons, offering potential for more effective treatment of allergic itch.
Article
Immunology
Raquel Freitas Zambonatto, Renata Nakata Teixeira, Sarah de Oliveira Poma, Eliane Borges da Silva, Mariana Mendes de Almeida, Gerson dos Santos Leite, Cesar Miguel Momesso dos Santos, Heloisa Helena de Oliveira Alves, Renata Gorjao, Tania Cristina Pithon-Curi, Celso R. F. Carvalho, Rui Curi, Adriana Cristina Levada-Pires
Summary: The study found that neutrophils from atopic elite runners exhibited lower responses to LPS stimulation compared to non-atopic runners. Both groups responded similarly to fMLP stimulation. Training hours and volume were not associated with neutrophil function.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Ye-Ji Lee, Dong-Soon Im
Summary: Scutellaria baicalensis, a traditional Asian herb, has been used to prevent and treat various diseases. The study focused on a flavone called oroxylin A found in Scutellaria baicalensis and its effects on chemically induced atopic dermatitis. The results showed that oroxylin A could effectively alleviate the symptoms of atopic dermatitis.
Article
Immunology
Remo Poto, Isabella Quinti, Gianni Marone, Maurizio Taglialatela, Amato de Paulis, Vincenzo Casolaro, Gilda Varricchi
Summary: Release of proinflammatory mediators and cytokines from basophils and mast cells mediated by IgE is a key event in allergic disorders. The presence and functional activity of anti-IgE autoantibodies in atopic dermatitis (AD) are largely unknown. This study evaluated the ability of IgG anti-IgE from patients with AD to induce in vitro IgE-dependent activation of basophils and mast cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Allergy
Adali Martinez, Rosemarie de la Rosa, Mahasin Mujahid, Neeta Thakur
Summary: This study highlights the disproportionate burden of asthma and atopic dermatitis on Black, Latinx, and Indigenous populations in the United States, attributing structural racism as the root cause of these disease disparities. The impact of structural racism is seen through residential segregation, socioeconomic position, and mass incarceration, affecting the innate and adaptive immune responses and stress levels, leading to a higher disease burden for racial and ethnic groups.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Review
Immunology
Chiara Tontini, Silvia Bulfone-Paus
Summary: Allergy is a type-I hypersensitivity reaction that can lead to life-threatening systemic symptoms. Novel therapeutic options targeting mast cells activation, such as monoclonal antibodies and allergen-specific immunotherapy, are promising for severe allergies treatment.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Allergy
Jacob P. Thyssen, Anne-Sofie Halling, Peter Schmid-Grendelmeier, Emma Guttman-Yassky, Jonathan I. Silverberg
Summary: Atopic dermatitis is a common disease associated with both atopic and nonatopic comorbidities. The presence or risk of comorbidities can significantly affect the management of AD patients. This review article provides an update on various comorbidities of AD based on recent systematic reviews and meta-analyses, highlighting the importance of studies presenting both relative risk and absolute risk. It discusses the association of AD with atopic comorbidities (such as asthma, rhinitis, and food allergy) and nonatopic comorbidities (including ocular, psychiatric, infectious, endocrine, autoimmune, and cardiovascular diseases, as well as certain cancers). Clinicians need to be aware of these associations and consider the positive and negative effects of different treatments for AD.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Review
Allergy
Daniil Lisik, Saliha Selin Ozuygur Ermis, Athina Ioannidou, Gregorio Paolo Milani, Sungkutu Nyassi, Giulia Carla Immacolata Spolidoro, Hannu Kankaanranta, Emma Goksor, Goeran Wennergren, Bright Ibeabughichi Nwaru
Summary: This study is the first systematic synthesis of the literature on the association between birth order, sibship size, atopic dermatitis, food allergy, and atopy. The results showed that having more siblings and being second-born or later were associated with a lower risk of atopic dermatitis, food allergy, and positive skin prick test to common allergens. However, there was no significant protection against IgE sensitization.
CLINICAL AND TRANSLATIONAL ALLERGY
(2023)
Article
Biochemistry & Molecular Biology
Shereen A. Baioumy, Dina E. Sallam, Shaimaa A. Abdalgeleel, Shaimaa H. Fouad, Ahmed S. Khedr, Sara Taha
Summary: Patients with atopic dermatitis (AD) have higher serum IL-17A levels and a positive family history of allergies. They commonly react to milk, eggs, and nuts. IL-17A does not correlate significantly with disease severity, age, sex, or the number and type of reactive food allergens.
EUROPEAN CYTOKINE NETWORK
(2021)
Article
Allergy
Evgeny Berdyshev, Elena Goleva, Irina Bronova, Anna-Sofia Bronoff, Bryce C. Hoffman, Marco A. Ramirez-Gama, Shannon L. Garcia, Debra Crumrine, Peter M. Elias, Christine B. Cho, Donald Y. M. Leung
Summary: The nonlesional skin of children with atopic dermatitis and peanut allergy is associated with decreased skin cis-UCA and PCA content, as well as alterations in the ratio of certain ceramide products. The presence of peanut allergy in children with atopic dermatitis appears to have a distinct impact on skin barrier abnormalities.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Sport Sciences
Mike Schmidt, Daniela Ohlendorf, David A. Groneberg, Eileen M. Wanke
Summary: The study highlights the importance of good cardiorespiratory capacity for dance teachers to maintain their health and long-term professional careers. There were discrepancies between dance teachers' self-perception of their fitness levels and the objective measurements. Results indicated that the levels of vitamin D3 and ferritin in dance teachers were generally suboptimal.
JOURNAL OF STRENGTH AND CONDITIONING RESEARCH
(2021)
Article
Sport Sciences
Saskia Salzer, Raffaela Heansel, Julia Rey, Laura Maltry, Fabian Holzgreve, Jasmin Lampe, Eileen M. Wanke, David A. Groneberg, Daniela Ohlendorf
INTERNATIONAL JOURNAL OF SPORTS MEDICINE
(2020)
Review
Environmental Sciences
Eszter Fuezeki, Theresa Weber, David A. Groneberg, Winfried Banzer
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2020)
Article
Public, Environmental & Occupational Health
Daniela Ohlendorf, Laura Maltry, Jasmin Haenel, Werner Betz, Christina Erbe, Christian Maurer-Grubinger, Fabian Holzgreve, Eileen M. Wanke, Doerthe Brueggmann, Albert Nienhaus, David A. Groneberg
JOURNAL OF OCCUPATIONAL MEDICINE AND TOXICOLOGY
(2020)
Review
Public, Environmental & Occupational Health
Eszter Fuezeki, David A. Groneberg, Winfried Banzer
JOURNAL OF OCCUPATIONAL MEDICINE AND TOXICOLOGY
(2020)
Article
Dentistry, Oral Surgery & Medicine
Daniela Ohlendorf, V. Fay, I. Avaniadi, C. Erbe, E. M. Wanke, D. A. Groneberg
Summary: The study showed that there is a relationship between weight, BMI, laterotrusion, and angle class II malocclusion with postural control in women aged between 41 and 50 years. Interdisciplinary functional examinations of mandibular movements could help improve postural control by addressing any limitations.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Emergency Medicine
Marc S. Schehadat, Guido Scherer, David A. Groneberg, Manfred Kaps, Michael H. K. Bendels
Summary: The study highlights the increase in utilization of emergency devices in the German emergency medical service, with on-site treatment operations causing higher economic loss compared to patient transport operations. Operations performed by the EMS are more frequent in urban areas, while patient transport operations are more common in rural areas. Overall, appropriate patient management is necessary from both medical and economic perspectives to optimize resource allocation.
BMC EMERGENCY MEDICINE
(2021)
Article
Chemistry, Analytical
Laura Fraeulin, Christian Maurer-Grubinger, Fabian Holzgreve, David A. Groneberg, Daniela Ohlendorf
Summary: The study compared the joint kinematics of elite long-distance triathletes during transition running, revealing significant differences in trunk and leg movements such as spinal extension, pelvic rotation, hip flexion, internal hip rotation, knee adduction, and complex knee flexion patterns. These findings contribute to a better understanding of coordination issues in transition running.
Article
Environmental Sciences
Salim Ahmadi, Doris Klingelhoefer, Christina Erbe, Fabian Holzgreve, David A. Groneberg, Daniela Ohlendorf
Summary: This study reveals that key players in oral hygiene research are concentrated in high-income countries, with minimal participation from lower income economies. The burden situations are shifting towards low-income countries, calling for an expansion of international network to address future global oral health challenges. The USA and Western European nations are leading in research output on oral hygiene, with Brazil emerging as a significant player.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Environmental Sciences
Kim Sarah Blume, Fabian Holzgreve, Laura Fraeulin, Christina Erbe, Werner Betz, Eileen M. Wanke, Doerthe Brueggmann, Albert Nienhaus, Christian Maurer-Grubinger, David A. Groneberg, Daniela Ohlendorf
Summary: Despite their young age and short duration of practice, dental students are already experiencing musculoskeletal disorders (MSD). The study found that MSD in dental students is mainly related to poor posture during dental work, with the highest ergonomic risk observed in body parts such as the wrists, neck, and trunk. More focus on theoretical and practical ergonomics in dental education is necessary to reduce the occurrence of MSD.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Environmental Sciences
Janis Droege, Ibrahim El Moussaoui, Doris Klingelhoefer, Hannelore Held, David A. Groneberg, Marcel A. Verhoff, Stefanie Plenzig
Summary: Particulate matter emitted during autopsies may act as a medium for the transmission of various viruses or bacteria, leading to infections. Thus, it is crucial to reduce the exposure to these particles in indoor working environments. In this study, particulate matter in the ambient air during autopsies was measured using an aerosol spectrometer. The particle emissions from using an ordinary oscillating saw and an adapted saw with a suction unit were compared to evaluate the effectiveness of technical adaptation in reducing particles. Additionally, the impact of wearing a face mask and variations in room background concentration were analyzed. The results showed high particle concentrations while using the ordinary saw, but the exposure could be mostly avoided by using the adapted saw or wearing a face mask. On most working days, an increase in background concentration was observed. Based on these findings, the use of a proper suction unit and face mask during autopsies is necessary, along with sufficient ventilation to prevent long-lasting high background concentrations.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Substance Abuse
Markus Braun, Laura Lian Marsidi, Doris Klingelhoefer, David A. Groneberg
Summary: This study reveals that PM emissions from Kretek cigarettes in Indonesia can be very high. It is important to inform and warn the Indonesian public, considering the prevalent smoking and SHS exposure. The implementation of a serious and effective tobacco control policy is overdue in Indonesia.
NICOTINE & TOBACCO RESEARCH
(2022)
Review
Rehabilitation
Laura Maltry, Daniela Ohlendorf, Michael Bendels, David A. Groneberg, Christoph Mickel
Summary: The impact of sleep on the consolidation of motor memory remains controversial, with publications presenting different views and highlighting methodological issues in research. Reasons for the difficulty in understanding include numerous influencing factors and complexity in terminology.
Article
Public, Environmental & Occupational Health
S. Rautiainen, D. Dryhorub, D. A. Groneberg, E. M. Wanke
ZENTRALBLATT FUR ARBEITSMEDIZIN ARBEITSSCHUTZ UND ERGONOMIE
(2020)
Correction
Ophthalmology
P. W. Kramer, T. Kohnen, D. A. Groneberg, M. H. K. Bendels
JAMA OPHTHALMOLOGY
(2020)