Article
Pharmacology & Pharmacy
Kun Zhao, Yong Li, Zihao Zhou, Yukang Mao, Xiaoguang Wu, Dongxu Hua, Yonghong Yong, Peng Li
Summary: Ginkgolides, specific terpenoids in Ginkgo biloba, have protective properties against cardiac diseases. This study found that ginkgolide A (GA) could improve cardiac dysfunction and alleviate cardiac remodeling by binding to MMP9 to attenuate inflammation.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Shreyas Bhave, Michele Esposito, Lija Swain, Xiaoying Qiao, Gregory Martin, Sakshi Wadhwa, Kay Everett, Navin K. Kapur
Summary: This study identifies bone morphogenetic protein-9 (BMP-9) as a crucial component in cardiac remodeling after myocardial infarction (MI). Loss of BMP-9 leads to decreased survival, increased risk of cardiac rupture, increased collagen abundance, and enhanced matrix metalloproteinase-9 activity for collagen degradation after MI.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Amit Itzhar, Gal Yosef, Maayan Eilon-Ashkenazy, Yulia Shmidov, Hadas Gil, Shiran Lacham-Hartman, Sigal Elyagon, Sharon Etzion, Ronit Bitton, Smadar Cohen, Yoram Etzion, Niv Papo
Summary: Sustained drug-release systems prolong the retention of therapeutic drugs within target tissues, reducing the need for repeated drug administration. The presented system provides controlled and universal drug-release by binding therapeutic proteins to alginate sulfate through heparin-binding peptide repeats.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Biochemistry & Molecular Biology
Weiwei Wang, Zhang Guo, Dahua Xie, Zhiyong Lin, Ruisheng Lin
Summary: This study investigated the relationship between MMP-9 gene polymorphism and intracranial aneurysm, and the results showed a correlation between the two.
CELLULAR AND MOLECULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ya-Tang Chiang, Yu-Bai Xiao, Shan-hui Hsu, Shu-Wei Chang, Chia-Ching Chou
Summary: Tannic acid (TA) has antibacterial, antioxidant, and anti-inflammatory properties and acts as an adhesive, hemostatic, and crosslinking agent in hydrogels. TA has been reported to inhibit MMP-2/- 9 activities, thereby improving tissue remodeling and wound healing. In this study, atomistic modeling was used to explore the mechanisms and structures of TA binding with MMP-2 and MMP-9, revealing the specific binding regions and molecular interactions involved. Understanding the binding mechanism and dynamics of TA with these MMPs provides crucial knowledge on the effects of TA on MMPs.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Shinji Takai, Denan Jin
Summary: Chymase-activated MMP-9 is closely related to the pathogenesis of various diseases, especially inflammation-related diseases. Upregulated chymase and MMP-9 have been observed in tissues from patients and animal models of these diseases. Chymase inhibitors attenuate MMP-9 formation and reduce inflammatory cell numbers, thereby ameliorating the development and progression of these disorders.
Review
Biochemistry & Molecular Biology
Zainab Ahmed Rashid, Sanaa K. Bardaweel
Summary: Matrix metalloproteinases (MMPs), especially MMP-9, play a significant role in cancer pathogenesis and progression. However, no effective MMP-9 inhibitor has been approved by the FDA. This review focuses on exploring the strategies for designing MMP-9 inhibitors and their anticancer effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Ionut Luchian, Mihaela Moscalu, Ancuta Goriuc, Ludovica Nucci, Monica Tatarciuc, Ioana Martu, Mihai Covasa
Summary: Periodontitis results in destructive effects on periodontium, with increased levels of MMP-9. Periodontal treatment alone or combined with orthodontic treatment can improve clinical parameters and lower MMP-9 levels. The degree of malocclusion affects the treatment's impact on MMP-9 levels.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Clinical Neurology
Saif Mashaqi, Heidi M. Mansour, Hanan Alameddin, Daniel Combs, Salma Patel, Lauren Estep, Sairam Parthasarathy
Summary: This study investigates the role of MMP-9 in OSA and cardiovascular diseases, emphasizing its importance as an inflammatory mediator in these conditions.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2021)
Article
Medicine, Research & Experimental
Xiaojuan Wei, Si Chen, Tian Xie, Hongchi Chen, Xin Jin, Jumin Yang, Shafaq Sahar, Huanlei Huang, Shuoji Zhu, Nanbo Liu, Changjiang Yu, Ping Zhu, Wei Wang, Wei Zhang
Summary: This report introduces a novel conductive and injectable hydrogel for treating myocardial infarction. The hydrogel stabilizes HIF-1 alpha to recover heart function and shows promising therapeutic effects by reducing inflammation, promoting vasculogenesis, and enhancing the expression of connexin 43.
Article
Cardiac & Cardiovascular Systems
Marta Banaszkiewicz, Anna Krzywonos-Zawadzka, Agnieszka Olejnik, Agnieszka Noszczyk-Nowak, Iwona Bil-Lula
Summary: This study investigated the effect of MMP-2 siRNA on I/R heart and found that MMP-2 siRNA improved heart mechanical function, reduced cardiac damage, and prevented contractile protein degradation.
CARDIOVASCULAR THERAPEUTICS
(2022)
Review
Chemistry, Medicinal
Sanjib Das, Sk Abdul Amin, Tarun Jha
Summary: Matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) play significant roles in solid tumor invasion, metastasis, and angiogenesis, while their role in hematological malignancies is less understood. Recent studies have shown correlations between gelatinases and hematological malignancies, leading to the development of potential inhibitors for these conditions.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
M. Sayyah, M. MalekiPooya, M. Khansooz, M. S. Pourabbasi, K. Irandoust, M. Taheri, C. H'mida, J. Halouani, K. Trabelsi, H. Chtourou, N. L. Bragazzi, C. C. T. Clark
Summary: The aim of this study was to investigate the effects of acute endurance exercise and electrical stimulation on matrix metalloproteinase responses in induced myocardial infarcted Wistar rats. The results showed that a single session of endurance exercise or electrical stimulation, or their combination, had no significant effect on the levels of MMPs.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Oksana S. Pogorielova, Viktoriia V. Korniienko, Yaroslav D. Chumachenko, Olha A. Obukhova, Igor Martsovenko, Viktoriia Yu Harbuzova
Summary: Coronary artery disease (CAD) is a leading cause of death in Europe, and atherosclerosis is its primary risk factor. This study investigated the impact of the MMP-9 gene on CAD development, and found that AG-carriers have a lower risk of myocardial infarction in the Ukrainian population.
CARDIOLOGY RESEARCH AND PRACTICE
(2022)
Article
Cardiac & Cardiovascular Systems
Stephanie L. Thorn, James A. Shuman, Mitchel R. Stacy, Brendan P. Purcell, Heather Doviak, Jason A. Burdick, Francis G. Spinale, Albert J. Sinusas
Summary: Following myocardial infarction, intramyocardial delivery of hydrogels containing rTIMP-3 can modulate MMP activity and reduce cardiac remodeling. The study showed significant improvement in cardiac structure and function in animals treated with hydrogels compared to the saline group.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2023)