Article
Biochemical Research Methods
Daishen Luo, Erika M. Chelales, Millicent M. Beard, Nithya Kasireddy, Damir B. Khismatullin
Summary: The study introduces a containerless drop-of-blood method for coagulation analysis, termed i-QATT (TM), which can rapidly detect hyper- and hypo-coagulable states and identify single deficiency in coagulation factors.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Apostolos Z. Skouras, Dimitrios Antonakis-Karamintzas, Charilaos Tsolakis, Argirios E. Tsantes, Georgia Kourlaba, Ioannis Zafeiris, Fotini Soucacos, Georgios Papagiannis, Athanasios Triantafyllou, Dimitra Houhoula, Olga Savvidou, Panagiotis Koulouvaris
Summary: Hip fractures are a major health concern, especially for older adults, with negative impacts on quality of life, mobility, and mortality. This study aims to investigate the short-term benefits of a supervised preoperative aerobic moderate-intensity interval training (MIIT) program and the added effect of an 8-week postoperative MIIT aerobic exercise program. The study also aims to explore the amelioration of surgical outcomes and hemostatic balance through exercise.
Article
Environmental Sciences
Denise L. Smith, Gavin P. Horn, Steven J. Petruzzello, Gregory G. Freund, Samuel I. Bloom, Bo Fernhall
Summary: While women's participation in firefighting has increased in recent years, this study found that male and female firefighters do not differ in their hemostatic response to multiple bouts of firefighting, despite some sex differences in hemostatic variables.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Gastroenterology & Hepatology
Alberto Zanetto, Patrick Northup, Lara Roberts, Marco Senzolo
Summary: Hospitalised patients with decompensated cirrhosis experience a rebalanced haemostasis, but this balance can easily be disrupted, leading to bleeding. Acute kidney injury, bacterial infections/sepsis, and progression to acute-on-chronic liver failure further increase the risk of bleeding. Unfortunately, there is no single laboratory method to accurately assess bleeding risk and guide preventive measures. Understanding the haemostatic alterations during acute illness could improve the management of these patients.
JOURNAL OF HEPATOLOGY
(2023)
Article
Hematology
Johannes Thaler, Ton Lisman, Peter Quehenberger, Lena Hell, Philipp Schwabl, Bernhard Scheiner, Theresa Bucsics, Rienk Nieuwland, Cihan AY, Michael Trauner, Ingrid Pabinger, Thomas Reiberger, Mattias Mandorfer
Summary: This study investigated the coagulation system in ascites of patients with cirrhosis and found that ascitic fluid was procoagulant with high extracellular vesicle-associated tissue factor activity. Fibrinolytic enzymes were activated in ascitic fluid, potentially re-entering the systemic circulation and inducing systemic fibrinolysis. Plasma D-dimer levels were independently linked to ascites severity in a separate cohort of patients.
THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Biochemistry & Molecular Biology
Claire S. Whyte, Akriti Rastogi, Ellis Ferguson, Michela Donnarumma, Nicola J. Mutch
Summary: This study compared the efficacy of cryoprecipitate and two fibrinogen concentrates in restoring clot integrity in a trauma-induced coagulopathy (TIC) model. Results showed that FibCLOT(R) was superior in normalizing clot structure and stabilizing clots against mechanical and fibrinolytic degradation compared to the other treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Analytical
Jikang Wang, Cheol Ung Choi, Sehyun Shin
Summary: In this study, we propose an innovative method of microfluidic thromboelastography (mu-TEG) that rapidly measures the viscoelastic properties of blood coagulation in oscillating flow through circular tubes. The mu-TEG system showed good agreement with the TEG5000 and can be a useful tool for analyzing hemostasis and fibrinolysis in emergency and operating rooms.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Review
Biochemistry & Molecular Biology
Sabina Ugovsek, Miran Sebestjen
Summary: Increased levels of lipoprotein(a) are associated with coronary artery disease, degenerative aortic stenosis, and heart failure. These levels are determined by genetic variations of the LPA gene encoding the apolipoprotein(a) component of lipoprotein(a). Lipoprotein(a) increases cardiovascular risk through various mechanisms.
Article
Multidisciplinary Sciences
Ryogo Yoshii, Teiji Sawa, Hidetake Kawajiri, Fumimasa Amaya, Kenichi A. Tanaka, Satoru Ogawa
Summary: This study compared the ClotPro system with ROTEM and plasma coagulation assays in cardiac surgery patients. The results showed a strong correlation between ClotPro and ROTEM, with EX-test and IN-test parameters being interchangeable. ClotPro was capable of emulating well-established ROTEM thresholds, providing a new tool for assessing hemostasis.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Machteld Sillen, Paul J. Declerck
Summary: TAFI, a proenzyme, is converted to a potent attenuator of the fibrinolytic system upon activation by thrombin, plasmin, or the thrombin/thrombomodulin complex. The development of molecules antagonizing TAFI function has gained much interest in the field.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Hematology
Takumi Tsuchida, Mineji Hayakawa, Osamu Kumano
Summary: This study aimed to investigate the characteristics of clot-fibrinolysis waveform analysis (CFWA) using plasma samples from patients in the critical care unit. The results showed that there were significant differences in FMC, Fbg, and fibrinolysis-related markers (a(2)-PI and Plg) among the three groups. In conclusion, CFWA has the potential to reflect the fibrinolysis status in one global assay.
THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Cardiac & Cardiovascular Systems
C. Ibanez, J. Perdomo, A. Calvo, C. Ferrando, J. C. Reverter, D. Tassies, A. Blasi
Summary: In COVID-19 patients, a hypercoagulable state with decreased fibrinolytic capacity is observed in ROTEM profiles despite increased D-dimer levels, suggesting lungs may be the main source of D-dimer while a systemic hypofibrinolytic state coexists. Future studies should confirm this hypothesis.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2021)
Article
Cardiac & Cardiovascular Systems
Claire S. Whyte, Gael B. Morrow, Julia S. Gauer, Samantha J. Montague, Philip L. R. Nicolson
Summary: The 2023 annual meeting of the British Society for Haemostasis and Thrombosis (BSHT) was held in Birmingham, United Kingdom, focusing on novel therapeutics and emerging technology. This article discusses the exciting research presented at the meeting.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Andras Bikov, Martina Meszaros, Esther Irene Schwarz
Summary: Obstructive sleep apnoea (OSA) is a common disease characterized by upper airway collapse during sleep, leading to chronic intermittent hypoxaemia and systemic inflammation. OSA is associated with increased risk for cardiovascular morbidity and mortality, affecting coagulation and fibrinolysis processes. Further research is needed to understand the mechanisms and clinical implications of OSA-related changes in these processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Vassilios P. Memtsas, Deepa R. J. Arachchillage, Diana A. Gorog
Summary: This review article discusses the pathophysiological role and laboratory assessment of fibrin, factor XIII, and endogenous fibrinolysis in the final phase of coagulation cascade and fibrinolysis, as well as their involvement in various disease states and assessment of cardiovascular risk with the most up-to-date evidence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Letter
Hematology
Alessandra Tedeschi, Richard Greil, Fatih Demirkan, Tadeusz Robak, Carol Moreno, Paul M. Barr, Bertrand Anz, David Simpson, Gianluca Gaidano, Osnat Bairey, Don Stevens, Devinder Gill, Ian W. Flinn, Thomas J. Kipps, Jan A. Burger, Jennifer Lin, Thomas Webb, Viktor Fedorov, Lori Styles, John G. Gribben
Article
Oncology
Graeme A. M. Fraser, Asher Chanan-Khan, Fatih Demirkan, Rodrigo Santucci Silva, Sebastian Grosicki, Ann Janssens, Jiri Mayer, Nancy L. Bartlett, Marie-Sarah Dilhuydy, Javier Loscertales, Abraham Avigdor, Simon Rule, Olga Samoilova, Miguel A. Pavlovsky, Andre Goy, Anthony Mato, Michael Hallek, Mariya Salman, Monelle Tamegnon, Steven Sun, Anne Connor, Kerri Nottage, Natasha Schuier, Sriram Balasubramanian, Angela Howes, Paula Cramer
LEUKEMIA & LYMPHOMA
(2020)
Article
Medicine, Research & Experimental
Ajai Chari, Markus Munder, Katja Weisel, Matthew Jenner, Ceri Bygrave, Maria Teresa Petrucci, Mario Boccadoro, Michele Cavo, Niels W. C. J. van de Donk, Mehmet Turgut, Fatih Demirkan, Ihsan Karadogan, Edward Libby, Robert Kleiman, Steven Kuppens, Rajesh Bandekar, Tobias Neff, Christoph Heuck, Ming Qi, Pamela L. Clemens, Hartmut Goldschmidt
Summary: The study on daratumumab showed a small but clinically insignificant effect on ECG intervals and concentration-QTc relationships.
ADVANCES IN THERAPY
(2021)
Article
Genetics & Heredity
Beyhan Durak Aras, Sevgi Isik, Hava Uskudar Teke, Abdulvahap Aslan, Filiz Yavasoglu, Zafer Gulbas, Fatih Demirkan, Hulya Ozen, Oguz Cilingir, Nur Sena Inci, Gulcin Gunden, Tuba Bulduk, Ebru Erzurumluoglu Gokalp, Sinem Kocagil, Sevilhan Artan, Olga Meltem Akay
Summary: The study found no significant association between RB1 deletion and TTFT, stage, and OS, but there was a significant association between high del(13q) and TTFT. The deletion burden may have an impact on prognosis.
MOLECULAR CYTOGENETICS
(2021)
Article
Hematology
Richard Greil, Alessandra Tedeschi, Carol Moreno, Bertrand Anz, Loree Larratt, Martin Simkovic, Devinder Gill, John G. Gribben, Ian W. Flinn, Zhengyuan Wang, Leo W. K. Cheung, Aaron N. Nguyen, Cathy Zhou, Lori Styles, Fatih Demirkan
Summary: In a study comparing ibrutinib-obinutuzumab and chlorambucil-obinutuzumab treatments for chronic lymphocytic leukemia/small lymphocytic lymphoma, it was found that ibrutinib could reduce the incidence of infusion-related reactions and lower the levels of inflammatory cytokines. Elevated levels of IL-6 and IL-8 were associated with the occurrence of IRRs, supporting the immunomodulatory mechanism of action for ibrutinib.
ANNALS OF HEMATOLOGY
(2021)
Article
Hematology
Serhat celik, Leylagul Kaynar, Zeynep Tugba Guven, Mustafa Baydar, Muzaffer Keklik, Mustafa cetin, Ali Unal, Fatih Demirkan
Summary: Secondary hypogammaglobulinemia (SHG) is a common complication of CLL patients receiving ibrutinib treatment, leading to decreased IgG levels. Patients with SHG had higher rates of adverse effects but also higher rates of complete and partial remission compared to those without SHG. Overall survival (OS) and progression free survival (PFS) were not significantly different between the two groups.
INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION
(2022)
Article
Hematology
Ahmet Seyhanli, Boran Yavuz, Ismail Selimoglu, Ihsan Sukru Sengun, Abdullah Taha Aslan, Guner Hayri Ozsan, Inci Alacacioglu, Fatih Demirkan
Summary: The study found that between 2008 and 2019, the most common indication for TPE was Myasthenia-Gravis syndrome (34.7%) among 207 patients who underwent 1459 TPE procedures. The overall complication rate for TPE was 1.6%, with allergic reactions (5.3%) and hypotension (2.9%) being the most commonly reported adverse events. In experienced hands, TPE was shown to be safe and manageable with low complication rates.
THERAPEUTIC APHERESIS AND DIALYSIS
(2022)
Article
Hematology
Ahmet Seyhanli, Yazgulu Cansu Ozkan, Goksel Bengi, Inci Alacacioglu, Guner Hayri Ozsan, Fatih Demirkan
Summary: This study evaluated FFP transfusions in patients with cirrhosis and found a significant proportion of inappropriate use, mainly for correcting prolonged INR. Regular utilization reviews and formal education programs are important to avoid inappropriate FFP usage and improve transfusion management quality.
TRANSFUSION AND APHERESIS SCIENCE
(2021)
Article
Oncology
Jan A. Burger, Tadeusz Robak, Fatih Demirkan, Osnat Bairey, Carol Moreno, David Simpson, Talha Munir, Don A. Stevens, Sandra Dai, Leo W. K. Cheung, Kevin Kwei, Indu Lal, Emily Hsu, Thomas J. Kipps, Alessandra Tedeschi
Summary: This study found that first-line ibrutinib-based therapy can improve outcomes in chronic lymphocytic leukemia, regardless of high-risk genomic features.
LEUKEMIA & LYMPHOMA
(2022)
Article
Biochemistry & Molecular Biology
Egemen Manci, Ozan C. Deniz, Cagdas Guducu, Erkan Gunay, Cem S. Bediz
Summary: By comparing sedentary individuals and athletes, this study found that athletes showed better performance and faster recovery of hemodynamic changes in the prefrontal cortex during sprint interval training and recovery periods, despite increased fatigue.
GENERAL PHYSIOLOGY AND BIOPHYSICS
(2021)
Meeting Abstract
Oncology
Mary Ann Anderson, Matthew Steven Davids, Arnon P. Kater, Tara Cochrane, Fatih Demirkan, Yair Herishanu, Brian Leber, Eugene Nikitin, Abdullah A. Masud, Tanya S. Rosenberg, Simon Sharmokh, Stan Fort, Francesco Forconi
JOURNAL OF CLINICAL ONCOLOGY
(2020)
Meeting Abstract
Hematology
Jan A. Burger, Tadeusz Robak, Fatih Demirkan, Osnat Bairey, Carol Moreno, David Simpson, Talha Munir, Don A. Stevens, Sandra Dai, Leo W. K. Cheung, Kevin Kwei, Indu Lal, Emily Hsu, Thomas J. Kipps, Alessandra Tedeschi
Meeting Abstract
Oncology
Fatih Demirkan, Omur Gokmen Sevindik
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
(2020)
Meeting Abstract
Oncology
Mary Ann Anderson, Matthew S. Davids, Arnon P. Kater, Tara Cochrane, Fatih Demirkan, Yair Herishanu, Brian Leber, Eugene Nikitin, Abdullah A. Masud, Tanya S. Rosenberg, Simon Sharmokh, Stan Fort, Francesco Forconi
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
(2020)
Correction
Oncology
C. Moreno, R. Greil, F. Demirkan