Need for Inferior Vena Cava Filters in Cancer Patients: A Surrogate Marker for Poor Outcome

Background. Cancer patients have an increased incidence of venous thromboembolism (VTE). Inferior vena cava (IVC fitters are used extensively in the US, and more than 40000 are inserted annually The impact on survival of cancer patients receiving IVC filters has not been studied. Methods. A retrospective study examined 206 consecutive cancer patients with VTE to compare the effects of IVC filter placement with anticoagulation (AC) therapy on overall survival (OS), as measured from the time of VTE. Patients were classified into 3 treatment groups: AC (n = 62), IVC filter (77), or combination IVC filter + AC (67). Results. Treatment groups did not differ with respect to age, sex, or albumin levels. Median OS was significantly greater in patients treated with AC (13 months) compared with those treated with IVC filters (2 months) or IVC +AC (3.25 months; P <.0002). IVC patients were 1.9 times more at risk of death than AC only (hazard ratio =.528; 95% confidence interval =.374 to.745). Multivariate analysis revealed that performance status and type of thrombus were not confounders and had 110 effect On OS. Conclusion. The need for the insertion of an IVC filter projected markedly reduced Survival. Patients requiring an IVC filter rather than AC as initial therapy face a 2-fold increase in risk of death. Whether or not this therapeutic procedure has a positive impact on outcome in cancer patients is uncertain. Complications resulting from thrombosis were also analyzed in this cohort. A prospective randomized trial at our institution is addressing this issue.