Article
Engineering, Biomedical
Yuanmeng He, Kaiyue Liu, Shen Guo, Rong Chang, Chen Zhang, Fangxia Guan, Minghao Yao
Summary: A multifunctional hydrogel (OGF) based on oxidized dextran, gallic acid-grafted gelatin, and Ferric ion showed excellent antibacterial ability and promoted the healing of infected wounds in diabetic patients.
ACTA BIOMATERIALIA
(2023)
Review
Biochemistry & Molecular Biology
Daniela Oatis, Erika Simon-Repolski, Cornel Balta, Alin Mihu, Gorizio Pieretti, Roberto Alfano, Luisa Peluso, Maria Consiglia Trotta, Michele D'Amico, Anca Hermenean
Summary: This review summarizes the existing knowledge on COVID-19 and pulmonary fibrosis, including the pathological and molecular mechanisms, as well as the clinical therapeutic solutions. The study suggests that Galactin-1, -3, -8, and -9 may serve as potential biomarkers and therapeutic targets for lung fibrosis post-COVID-19.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Suhua Wu, Yueling Huang, Xinliang Huang, Xiaoyan Dai
Summary: LPS promotes Nrp1 protein degradation via a Dyn1-dependent pathway, revealing a previously unknown role of Dyn1 in LPS-regulated Nrp1 protein decay.
Article
Cell & Tissue Engineering
Haijun Li, Jing Ren, Huiling Cui, Di Wang, Rumeng Zhao, Xiaohui Liu, Shuai Tian, Jing Wang, Jingyi Zhang, Peng Li, Rick F. Thorne, Shichao Duan
Summary: Using RNA-Seq and bioinformatic analysis, this study investigated the effects of dexamethasone (DEX) on human trabecular meshwork cells (HTMCs). It was found that DEX induces cellular senescence in HTMCs by activating the TGF beta/Smad3/NOX4 pathway, leading to increased oxidative stress and the development of glaucoma.
CELL TRANSPLANTATION
(2023)
Article
Engineering, Biomedical
Hao Cheng, Zhe Shi, Kan Yue, Xusheng Huang, Yichuan Xu, Chenghao Gao, Zhongqi Yao, Yu Shrike Zhang, Jian Wang
Summary: The study introduces a novel sprayable hydrogel wound dressing loaded with cerium oxide nanoparticles and an antimicrobial peptide, providing ROS-scavenging and antibacterial properties. By adopting a mussel-inspired strategy, the hydrogel exhibited improved binding affinity to wet skin surfaces and demonstrated excellent biocompatibility.
ACTA BIOMATERIALIA
(2021)
Article
Food Science & Technology
Ye Han, Ruirui Yang, Xuejiao Zhang, Qihui Wang, Bin Wang, Xiaoyuan Zheng, Yongcai Li, Dov Prusky, Yang Bi
Summary: This study demonstrates that brassinosteroid (BR) can accelerate wound healing in potato tubers by activating reactive oxygen metabolism and phenylpropanoid metabolism, promoting the accumulation of lignin and suberin polyphenolic (SPP), and reducing weight loss and disease index.
Article
Pharmacology & Pharmacy
Junjun Li, Rong Du, Qiong Bian, Danping Zhang, Siqian Gao, Anran Yuan, Xiaoying Ying, Youqing Shen, Jianqing Gao
Summary: In this study, a novel HA material modified with ATEMPO was synthesized to promote angiogenesis and prevent excessive ROS production, leading to alleviation of oxidative stress response and enhancement of chronic wound healing. Through experiments in rat models, it was found that HA-g-TEMPO significantly improved wound closure efficacy and potentially reduced scar formation.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Wenyan Li, Yongjia Sheng, Jin Wang, Shasha Wu, Chenyang Han
Summary: This study reveals that the expression of miRNA-9a-5p is decreased in inflammatory bowel diseases, and it demonstrates the effects and mechanisms of miRNA-9a-5p in regulating the progression of these diseases. The study shows that miRNA-9a-5p targets NOX4 to suppress the production of ROS, which is crucial in mucosal barrier damage in inflammatory bowel diseases.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Engineering, Environmental
Na Xu, Yuanping Gao, Zheng Li, Yu Chen, Menglong Liu, Jiezhi Jia, Rui Zeng, Gaoxing Luo, Jiangfeng Li, Yunlong Yu
Summary: Diabetic wound management faces challenges due to immune disorders. Targeted regulation of macrophage polarization could be a useful approach. The synthesized composite hydrogel showed good mechanical properties and antibacterial capacity, and promoted wound healing through anti-inflammation and pro-angiogenesis.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Environmental
Lu Yan, Kai Han, Bing Pang, Han Jin, Xixi Zhao, Xiaoguang Xu, Chunmei Jiang, Ning Cui, Tingli Lu, Junling Shi
Summary: The newly developed hydrogel shows great potential in treating chronic wounds of diabetic patients by regulating macrophage polarization and promoting angiogenesis.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Plant Sciences
Li Ma, Hong Jiang, Yang Bi, Yong-Cai Li, Jiang-Wei Yang, Huai-Jun Si, Ying-Yue Ren, Dov Prusky
Summary: The production of reactive oxygen species (ROS) plays a crucial role in physiological processes and plant responses to environmental stress. This study investigated the involvement of calcium-dependent protein kinases (CDPKs) in ROS generation induced by benzo-(1, 2, 3)-thiadiazole-7-carbothioic acid S-methyl ester (BTH) during wound healing of potato tubers. The results showed that StCDPK14, one of the StCDPKs significantly induced by BTH treatment, plays a key role in ROS generation by interacting with StRbohB during wound healing processes.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Engineering, Biomedical
Kui Xu, Sijie Deng, Yabin Zhu, Wei Yang, Weizhen Chen, Liang Huang, Chi Zhang, Ming Li, Lijiao Ao, Yibo Jiang, Xiangyu Wang, Qiqing Zhang
Summary: This study introduces a platelet rich plasma (PRP) loaded multifunctional hydrogel with reactive oxygen species (ROS) and glucose dual-responsive property, which can accelerate diabetic wound healing. The hydrogel possesses several desirable properties and can release cytokines to promote wound healing in an oxidative stress or hyperglycemia state.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Biomedical
Meng-Qi Tong, Cui-Tao Lu, Lan-Tian Huang, Jiao-Jiao Yang, Si-Ting Yang, Hang-Bo Chen, Peng-Peng Xue, Lan-Zi Luo, Qing Yao, He-Lin Xu, Ying-Zheng Zhao
Summary: A polyphenol-driven assembly of nano-sized coacervates (AE-NPs) composed of Epigallocatechin-3-gallate (EGCG) and acid fibroblast growth factor (aFGF) was successfully constructed for the healing of diabetic wounds. The AE-NPs exhibited higher stability under hostile conditions and showed the ability to scavenge reactive oxygen species (ROS) and promote angiogenesis. This resulted in accelerated wound healing and suppressed scar formation in diabetic mice.
ACTA BIOMATERIALIA
(2023)
Article
Biophysics
Xiaomei Dai, Xiaojun Liu, Lele Yang, Siyuan Yuan, Qingqing Xu, Yu Li, Feng Gao
Summary: This study aimed to develop antibiotic-free pH-responsive polymeric prodrugs to combat intracellular S. aureus infection by damaging the bacterial membrane and activating the immune system.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Plant Sciences
Yutao Huang, Min Lu, Huaping Wu, Tiyuan Zhao, Pin Wu, Dongdong Cao
Summary: The drying temperature of sunflower seeds significantly affects seed vigor and deterioration during storage. A temperature of 40 degrees Celsius is safe for sunflower seeds, but higher drying temperatures reduce seed vigor by regulating metabolism and balance. High drying temperatures increase activities that lead to over-accumulation of harmful substances and inhibit crucial enzyme activities during germination.
FRONTIERS IN PLANT SCIENCE
(2021)