Article
Multidisciplinary Sciences
Quoc Cuong Ngo, Rajna Ogrin, Dinesh Kant Kumar
Summary: This study proposed a computerised prediction framework for healing of venous leg ulcers using thermal images, with textural features from the thermal images at week 0 being used to discriminate between healed and unhealed wounds. The optimal Bayesian neural network achieved 78.57% sensitivity and 60.00% specificity in classifying healing outcomes. This non-contact method incorporating machine learning provides earlier prediction compared to current methods requiring contact digital planimetry.
SCIENTIFIC REPORTS
(2022)
Article
Surgery
Thomas E. Serena, Dennis P. Orgill, David G. Armstrong, Robert D. Galiano, Paul M. Glat, Marissa J. Carter, Jarrod P. Kaufman, William W. Li, Charles M. Zelen
Summary: This randomized controlled trial showed that weekly or biweekly applications of dehydrated human amnion and chorion allograft (dHACA) plus standard of care significantly healed more venous leg ulcers than standard of care alone, proving it to be a safe and effective treatment option.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2022)
Article
Dermatology
Klaus Kirketerp-Moller, Petra Doerfler, Nicole Schoefmann, Barbara Wolf-Winiski, Omid Niazi, Vibeke Pless, Tonny Karlsmark, Magnus Agren
Summary: This exploratory study aimed to investigate the association between biomarkers in wound fluid and the healing of split-thickness skin grafts in venous leg ulcers. The study found that the concentration of matrix metalloproteinase-9 in wound fluid was higher in venous leg ulcers showing good healing compared to those with poor healing.
ACTA DERMATO-VENEREOLOGICA
(2022)
Article
Medicine, Research & Experimental
Lihong Chen, Yun Gao, Ming Liu, Qiu Li, Chunmao Han, Yue Zhao, Binghui Li, Jun Xu, Yan Dai, Pei Li, Jianli Li, Yuanyuan Li, Xingwu Ran
Summary: This study aims to evaluate the efficacy and safety of pentoxifylline, an anti-inflammatory drug, for the treatment of venous leg ulcers (VLUs) in the Chinese population. A randomized, double-blinded, placebo-controlled clinical trial will be conducted with 240 patients receiving pentoxifylline or placebo for 24 weeks. The primary outcome is the difference in wound healing rate within 12 weeks. If proven effective, pentoxifylline could be a safe and effective treatment option for VLUs.
Article
Multidisciplinary Sciences
Mahta Monshipouri, Behzad Aliahmad, Rajna Ogrin, Kylie Elder, Jacinta Anderson, Barbara Polus, Dinesh Kumar
Summary: Textural analysis of thermal images can effectively predict which venous leg ulcers among older people being managed at home will not heal by week 12 as early as week 2.
SCIENTIFIC REPORTS
(2021)
Article
Dermatology
Olga Krizanova, Adela Penesova, Alica Hokynkova, Andrea Pokorna, Amir Samadian, Petr Babula
Summary: Chronic venous disease is a condition that affects the veins in the lower extremities, characterized by impaired blood return. This review discusses the etiology, risk factors, and pathophysiology of venous leg ulcers (VLU), and compares the treatment options.
INTERNATIONAL WOUND JOURNAL
(2023)
Review
Medicine, General & Internal
Joseph D. Raffetto, Daniela Ligi, Rosanna Maniscalco, Raouf A. Khalil, Ferdinando Mannello
Summary: Venous leg ulcers (VLUs) are a common type of ulcer in the lower extremity with significant socioeconomic and psychological impact. The pathogenesis involves factors such as endothelial cell injury and inflammatory responses, while treatment primarily includes compression therapy and endovenous ablation. Proper wound care and therapy usually result in healing within 6 months.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Dermatology
Junglyun Kim, Joyce Stechmiller, Michael Weaver, Daniel J. Gibson, Ann Horgas, Debra L. Kelly, Debra E. Lyon
Summary: The purpose of this study was to investigate the association between wound area, wound exudate proteins (CRP and MMPs), and symptoms of fatigue and pain in individuals with chronic venous leg ulcers, as well as identify factors related to wound healing trajectory. The findings suggest that higher fatigue is strongly associated with higher MMPs and lower CRP levels, as well as larger wound areas. Therefore, a multifactorial approach that includes wound treatment and symptom management is necessary to facilitate wound healing.
INTERNATIONAL WOUND JOURNAL
(2023)
Review
Medicine, General & Internal
Cibele T. D. Ribeiro, Fernando A. L. Dias, Guilherme A. F. Fregonezi
Summary: The effectiveness of hydrogel dressings for treating venous leg ulcers remains uncertain. More research is needed to determine the efficacy of hydrogel dressings compared to gauze and saline, alginate dressing, manuka honey, or hydrocolloid in promoting the healing of venous leg ulcers.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2022)
Article
Cell Biology
Margit Mahlapuu, Adam Sidorowicz, Jacek Mikosinski, Mikolaj KrzyZanowski, Jakub Orleanski, Krystyna Twardowska-Saucha, Andrzej Nykaza, Michal Dyaczynski, Beata Belz-Lagoda, Grzegorz Dziwiszek, Monika Kujawiak, Marek Karczewski, Folke Sjoberg, Tomasz Grzela, Adam Wegrzynowski, Fredrik Thunarf, Jakob Bjork, Jonas Ekblom, Arkadiusz Jawien, Jan Apelqvist
Summary: The clinical trial did not find significant differences in healing of venous lower leg ulcers between patients treated with LL-37 and the placebo overall, but a subgroup analysis indicated potential treatment benefits for patients with large ulcers, suggesting the need for further research to validate these findings.
WOUND REPAIR AND REGENERATION
(2021)
Review
Biochemistry & Molecular Biology
Hubert Aleksandrowicz, Agnieszka Owczarczyk-Saczonek, Waldemar Placek
Summary: The prevalence of venous leg ulcers (VLUs) ranges from 1.5% to 3% in the general population, with common challenges being recurrence and resistance to healing. New technologies, such as biophysical interventions and advanced wound therapies, have been increasingly used in treating VLUs in recent years.
Review
Food Science & Technology
Simona Serini, Gabriella Calviello
Summary: Long-chain Omega-3 polyunsaturated fatty acids are recognized as powerful regulators of acute inflammation, with potential applications in chronic pathologies. Current research focuses on their specific effects on wound healing, particularly in patients with diabetes or venous insufficiency, highlighting the mechanisms through which these compounds may act. Considerations on optimal dietary doses and future perspectives in this area are also discussed.
Review
Medicine, General & Internal
Niamh E. M. McLain, Zena E. H. Moore, Pinar Avsar
Summary: This study aimed to evaluate the effects of wound cleansing, wound cleansing solutions and wound cleansing techniques for treating venous leg ulcers. Four studies including 254 participants were analyzed, but with insufficient evidence to demonstrate the effectiveness of different cleansing solutions in treating venous leg ulcers.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Dermatology
Junglyun Kim, Diana J. Wilkie, Michael Weaver, Debra Lyon, Debra L. Kelly, Susan B. Millan, Jungmin Park, Joyce Stechmiller
Summary: Pain in chronic venous leg ulcers (CVLU) impacts wound healing, quality of life, and treatment. This study aimed to describe the multidimensional pain characteristics of CVLU patients using data collected before debridement. Patients reported tolerating a relatively high level of pain and experiencing pain as expected, while often choosing not to share their pain with others. Multidimensional pain assessment can help clinicians tailor individualized therapies to manage pain and improve quality of life for CVLU patients.
ADVANCES IN WOUND CARE
(2021)
Article
Multidisciplinary Sciences
Debbie X. E. Lim, Toby Richards, Muholan Kanapathy, Thankiah Sudhaharan, Graham D. Wright, Anthony R. J. Phillips, David L. Becker
Summary: The study found a strong correlation between the presence of senescent cells and decreased collagen area in human chronic wounds, aiding in predicting healing trajectory of wounds; higher levels of senescent cells were found in male venous leg ulcer patients, while those under 60 years old with wounds persisting for over 24 months had the lowest levels of collagen.Dispensing method founded by Wang et al. requires less effort and cost and is highly accurate when it comes to protein liquid handling.
SCIENTIFIC REPORTS
(2021)