Recent advances in oncolytic virus design

Carrier cell-based delivery of replication-competent HSV-1 mutants enhances antitumor effect for ovarian cancer

(2010) S Fujiwara et al.   CANCER GENE THERAPY

Development of an oncolytic herpes simplex virus using a tumor-specific HIF-responsive promoter

(2010) S L Longo et al.   CANCER GENE THERAPY

Treatment of metastatic neuroblastoma with systemic oncolytic virotherapy delivered by autologous mesenchymal stem cells: an exploratory study

(2010) J García-Castro et al.   CANCER GENE THERAPY

Oncolytic measles viruses encoding interferon β and the thyroidal sodium iodide symporter gene for mesothelioma virotherapy

(2010) H Li et al.   CANCER GENE THERAPY

Liver Cancer Protease Activity Profiles Support Therapeutic Options with Matrix Metalloproteinase-Activatable Oncolytic Measles Virus

(2010) M. D. Muhlebach et al.   CANCER RESEARCH

Oncolytic Adenovirus Coding for Granulocyte Macrophage Colony-Stimulating Factor Induces Antitumoral Immunity in Cancer Patients

(2010) Vincenzo Cerullo et al.   CANCER RESEARCH

A Hypoxia- and  -Fetoprotein-Dependent Oncolytic Adenovirus Exhibits Specific Killing of Hepatocellular Carcinomas

(2010) O.-J. Kwon et al.   CLINICAL CANCER RESEARCH

Targeted Chemotherapy for Head and Neck Cancer with a Chimeric Oncolytic Adenovirus Coding for Bifunctional Suicide Protein FCU1

(2010) J. D. Dias et al.   CLINICAL CANCER RESEARCH

Phase I/II Study of Oncolytic HSVGM-CSF in Combination with Radiotherapy and Cisplatin in Untreated Stage III/IV Squamous Cell Cancer of the Head and Neck

(2010) K. J. Harrington et al.   CLINICAL CANCER RESEARCH

Oncolytic herpes simplex virus armed with xenogeneic homologue of prostatic acid phosphatase enhances antitumor efficacy in prostate cancer

(2010) P Castelo-Branco et al.   GENE THERAPY

TRAIL gene-armed oncolytic poxvirus and oxaliplatin can work synergistically against colorectal cancer

(2010) M F Ziauddin et al.   GENE THERAPY

Antiangiogenic cancer therapy combined with oncolytic virotherapy leads to regression of established tumors in mice

(2010) Timothy Kottke et al.   JOURNAL OF CLINICAL INVESTIGATION

Development of a Regulatable Oncolytic Herpes Simplex Virus Type 1 Recombinant Virus for Tumor Therapy

(2010) F. Yao et al.   JOURNAL OF VIROLOGY

Minimal RB-responsive E1A Promoter Modification to Attain Potency, Selectivity, and Transgene-arming Capacity in Oncolytic Adenoviruses

(2010) Juan J Rojas et al.   MOLECULAR THERAPY

Bone Marrow Mesenchymal Stem Cells Loaded With an Oncolytic Adenovirus Suppress the Anti-adenoviral Immune Response in the Cotton Rat Model

(2010) Atique U Ahmed et al.   MOLECULAR THERAPY

Potent Oncolytic Activity of Raccoonpox Virus in the Absence of Natural Pathogenicity

(2010) Laura Evgin et al.   MOLECULAR THERAPY

Urokinase-Targeted Fusion by Oncolytic Sendai Virus Eradicates Orthotopic Glioblastomas by Pronounced Synergy With Interferon-β Gene

(2010) Yuzo Hasegawa et al.   MOLECULAR THERAPY

Transcriptional and Translational Dual-regulated Oncolytic Herpes Simplex Virus Type 1 for Targeting Prostate Tumors

(2010) Cleo YF Lee et al.   MOLECULAR THERAPY

Potentiating Cancer Immunotherapy Using an Oncolytic Virus

(2010) Byram W Bridle et al.   MOLECULAR THERAPY

Targeting Localized Immune Suppression Within the Tumor Through Repeat Cycles of Immune Cell-oncolytic Virus Combination Therapy

(2010) Stephen H Thorne et al.   MOLECULAR THERAPY

Identification of Genetically Modified Maraba Virus as an Oncolytic Rhabdovirus

(2010) Jan Brun et al.   MOLECULAR THERAPY

Synergistic Interaction Between Oncolytic Viruses Augments Tumor Killing

(2010) Fabrice Le Boeuf et al.   MOLECULAR THERAPY

Enhanced Antitumor Effects of an Engineered Measles Virus Edmonston Strain Expressing the Wild-type N , P , L Genes on Human Renal Cell Carcinoma

(2010) Xin Meng et al.   MOLECULAR THERAPY

Efficacy and Safety/Toxicity Study of Recombinant Vaccinia Virus JX-594 in Two Immunocompetent Animal Models of Glioma

(2010) XueQing Lun et al.   MOLECULAR THERAPY

Systemic Therapy of Disseminated Myeloma in Passively Immunized Mice Using Measles Virus-infected Cell Carriers

(2010) Chunsheng Liu et al.   MOLECULAR THERAPY

Hyaluronidase Expression by an Oncolytic Adenovirus Enhances Its Intratumoral Spread and Suppresses Tumor Growth

(2010) Sonia Guedan et al.   MOLECULAR THERAPY

Regression of advanced rat and human gliomas by local or systemic treatment with oncolytic parvovirus H-1 in rat models

(2010) K. Geletneky et al.   NEURO-ONCOLOGY

Low-dose paclitaxel synergizes with oncolytic adenoviruses via mitotic slippage and apoptosis in ovarian cancer

(2010) C K Ingemarsdotter et al.   ONCOGENE

Double-Detargeted Oncolytic Adenovirus Shows Replication Arrest in Liver Cells and Retains Neuroendocrine Cell Killing Ability

(2010) Justyna Leja et al.   PLoS One

Vesicular stomatitis virus oncolysis is potentiated by impairing mTORC1-dependent type I IFN production

(2010) T. Alain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Local and Distant Immunity Induced by Intralesional Vaccination with an Oncolytic Herpes Virus Encoding GM-CSF in Patients with Stage IIIc and IV Melanoma

(2009) Howard L. Kaufman et al.   ANNALS OF SURGICAL ONCOLOGY

Systemic treatment of xenografts with vaccinia virus GLV-1h68 reveals the immunologic facet of oncolytic therapy

(2009) Andrea Worschech et al.   BMC GENOMICS

Combination of adenoviral virotherapy and temozolomide chemotherapy eradicates malignant glioma through autophagic and apoptotic cell death in vivo

(2009) I V Ulasov et al.   BRITISH JOURNAL OF CANCER

Oncolytic and immunostimulatory efficacy of a targeted oncolytic poxvirus expressing human GM-CSF following intravenous administration in a rabbit tumor model

(2009) J-H Lee et al.   CANCER GENE THERAPY

Oncolytic herpes simplex virus vectors and taxanes synergize to promote killing of prostate cancer cells

(2009) B J Passer et al.   CANCER GENE THERAPY

Human Bone Marrow-Derived Mesenchymal Stem Cells for Intravascular Delivery of Oncolytic Adenovirus  24-RGD to Human Gliomas

(2009) R. L. Yong et al.   CANCER RESEARCH

Antitumoral Immune Response by Recruitment and Expansion of Dendritic Cells in Tumors Infected with Telomerase-Dependent Oncolytic Viruses

(2009) Edukulla Ramakrishna et al.   CANCER RESEARCH

Tumor and Vascular Targeting of a Novel Oncolytic Measles Virus Retargeted against the Urokinase Receptor

(2009) Yuqi Jing et al.   CANCER RESEARCH

Expression of IFN-  Enhances Both Efficacy and Safety of Oncolytic Vesicular Stomatitis Virus for Therapy of Mesothelioma

(2009) C. L. Willmon et al.   CANCER RESEARCH

Human Glioblastoma-Derived Cancer Stem Cells: Establishment of Invasive Glioma Models and Treatment with Oncolytic Herpes Simplex Virus Vectors

(2009) H. Wakimoto et al.   CANCER RESEARCH

Oncolytic Adenoviral Mutants with E1B19K Gene Deletions Enhance Gemcitabine-induced Apoptosis in Pancreatic Carcinoma Cells and Anti-Tumor Efficacy In vivo

(2009) S. Leitner et al.   CLINICAL CANCER RESEARCH

A Novel A33 Promoter-Based Conditionally Replicative Adenovirus Suppresses Tumor Growth and Eradicates Hepatic Metastases in Human Colon Cancer Models

(2009) E. G. Cafferata et al.   CLINICAL CANCER RESEARCH

Targeted Radionuclide Therapy Using a Wnt-Targeted Replicating Adenovirus Encoding the Na/I Symporter

(2009) I. Peerlinck et al.   CLINICAL CANCER RESEARCH

Mesenchymal Stem Cell Carriers Protect Oncolytic Measles Viruses from Antibody Neutralization in an Orthotopic Ovarian Cancer Therapy Model

(2009) E. K. Mader et al.   CLINICAL CANCER RESEARCH

Immune-Mediated Antitumor Activity of Reovirus Is Required for Therapy and Is Independent of Direct Viral Oncolysis and Replication

(2009) R. J. Prestwich et al.   CLINICAL CANCER RESEARCH

MicroRNA Regulation of Oncolytic Herpes Simplex Virus-1 for Selective Killing of Prostate Cancer Cells

(2009) C. Y. F. Lee et al.   CLINICAL CANCER RESEARCH

Antitumor Activity of an Oncolytic Adenoviral-CD40 Ligand (CD154) Transgene Construct in Human Breast Cancer Cells

(2009) E. M. Gomes et al.   CLINICAL CANCER RESEARCH

Effect of decorin on overcoming the extracellular matrix barrier for oncolytic virotherapy

(2009) I-K Choi et al.   GENE THERAPY

A modified E2F-1 promoter improves the efficacy to toxicity ratio of oncolytic adenoviruses

(2009) J J Rojas et al.   GENE THERAPY

Ad5/3-9HIF-Δ24-VEGFR-1-Ig, an infectivity enhanced, dual-targeted and antiangiogenic oncolytic adenovirus for kidney cancer treatment

(2009) K Guse et al.   GENE THERAPY

Dendritic cells and T cells deliver oncolytic reovirus for tumour killing despite pre-existing anti-viral immunity

(2009) E J Ilett et al.   GENE THERAPY

Potent Antitumor Effect of Interleukin-24 Gene in the Survivin Promoter and Retinoblastoma Double-Regulated Oncolytic Adenovirus

(2009) Kang Jian Zhang et al.   HUMAN GENE THERAPY

Cetuximab Retargeting of Adenovirus via the Epidermal Growth Factor Receptor for Treatment of Intraperitoneal Ovarian Cancer

(2009) Joanne Morrison et al.   HUMAN GENE THERAPY

Interference of CD40L-Mediated Tumor Immunotherapy by Oncolytic Vesicular Stomatitis Virus

(2009) Feorillo Galivo et al.   HUMAN GENE THERAPY

Phase II Clinical Trial of a Granulocyte-Macrophage Colony-Stimulating Factor–Encoding, Second-Generation Oncolytic Herpesvirus in Patients With Unresectable Metastatic Melanoma

(2009) Neil N. Senzer et al.   JOURNAL OF CLINICAL ONCOLOGY

Targeting the Intratumoral Dendritic Cells by the Oncolytic Adenoviral Vaccine Expressing RANTES Elicits Potent Antitumor Immunity

(2009) Natalia Lapteva et al.   JOURNAL OF IMMUNOTHERAPY

In Vivo Retargeting of Adenovirus Type 5 to  v 6 Integrin Results in Reduced Hepatotoxicity and Improved Tumor Uptake following Systemic Delivery

(2009) L. Coughlan et al.   JOURNAL OF VIROLOGY

Attenuation of Vesicular Stomatitis Virus Encephalitis through MicroRNA Targeting

(2009) E. J. Kelly et al.   JOURNAL OF VIROLOGY

Effective gene-viral therapy of leukemia by a new fiber chimeric oncolytic adenovirus expressing TRAIL: in vitro and in vivo evaluation

(2009) J. Jin et al.   MOLECULAR CANCER THERAPEUTICS

Regression of human pancreatic tumor xenografts in mice after a single systemic injection of recombinant vaccinia virus GLV-1h68

(2009) Y. A. Yu et al.   MOLECULAR CANCER THERAPEUTICS

Attraction and Activation of Dendritic Cells at the Site of Tumor Elicits Potent Antitumor Immunity

(2009) Natalia Lapteva et al.   MOLECULAR THERAPY

Noninvasive Imaging and Radiovirotherapy of Prostate Cancer Using an Oncolytic Measles Virus Expressing the Sodium Iodide Symporter

(2009) Pavlos Msaouel et al.   MOLECULAR THERAPY

Enhancement of Oncolytic Properties of Recombinant Newcastle Disease Virus Through Antagonism of Cellular Innate Immune Responses

(2009) Dmitriy Zamarin et al.   MOLECULAR THERAPY

Treatment of Pancreatic Cancer With an Oncolytic Adenovirus Expressing Interleukin-12 in Syrian Hamsters

(2009) Sergia Bortolanza et al.   MOLECULAR THERAPY

Cell Carriers for Oncolytic Viruses: Fed Ex for Cancer Therapy

(2009) Candice Willmon et al.   MOLECULAR THERAPY

Expanded Anticancer Therapeutic Window of Hexon-modified Oncolytic Adenovirus

(2009) Elena V Shashkova et al.   MOLECULAR THERAPY

Adipose-derived Stem Cells as Therapeutic Delivery Vehicles of an Oncolytic Virus for Glioblastoma

(2009) Darnell T Josiah et al.   MOLECULAR THERAPY

Therapeutic and Tumor-specific Immunity Induced by Combination of Dendritic Cells and Oncolytic Adenovirus Expressing IL-12 and 4-1BBL

(2009) Jing-Hua Huang et al.   MOLECULAR THERAPY

Engineered Newcastle Disease Virus as an Improved Oncolytic Agent Against Hepatocellular Carcinoma

(2009) Jennifer Altomonte et al.   MOLECULAR THERAPY

p53-dependent antiviral RNA-interference facilitates tumor-selective viral replication

(2009) E. Gurlevik et al.   NUCLEIC ACIDS RESEARCH

Neuroblastoma Cell Lines Contain Pluripotent Tumor Initiating Cells That Are Susceptible to a Targeted Oncolytic Virus

(2009) Yonatan Y. Mahller et al.   PLoS One

Tumor Associated Stromal Cells Play a Critical Role on the Outcome of the Oncolytic Efficacy of Conditionally Replicative Adenoviruses

(2009) M. Verónica Lopez et al.   PLoS One

Inhibition of human tumor growth in mice by an oncolytic herpes simplex virus designed to target solely HER-2-positive cells

(2009) L. Menotti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Use of Tissue-Specific MicroRNA to Control Pathology of Wild-Type Adenovirus without Attenuation of Its Ability to Kill Cancer Cells

(2009) Ryan Cawood et al.   PLoS Pathogens

An oncolytic adenovirus expressing granulocyte macrophage colony-stimulating factor shows improved specificity and efficacy for treating human solid tumors

(2008) N Lei et al.   CANCER GENE THERAPY

Combination therapy with radiation or cisplatin enhances the potency of Ad5/35 chimeric oncolytic adenovirus in a preclinical model of head and neck cancer

(2008) S Ganesh et al.   CANCER GENE THERAPY

Macrophage Depletion Combined with Anticoagulant Therapy Increases Therapeutic Window of Systemic Treatment with Oncolytic Adenovirus

(2008) E. V. Shashkova et al.   CANCER RESEARCH

Bioselection of a Gain of Function Mutation that Enhances Adenovirus 5 Release and Improves Its Antitumoral Potency

(2008) Alena Gros et al.   CANCER RESEARCH

Low-Dose Radiation Enhances Survivin-Mediated Virotherapy against Malignant Glioma Stem Cells

(2008) S. Nandi et al.   CANCER RESEARCH

Adenovirus Serotype 5 Hexon Mediates Liver Gene Transfer

(2008) Simon N. Waddington et al.   CELL

Stem and progenitor cell-mediated tumor selective gene therapy

(2008) K S Aboody et al.   GENE THERAPY

Neural stem cells target intracranial glioma to deliver an oncolytic adenovirus in vivo

(2008) M A Tyler et al.   GENE THERAPY

Generation of a Conditionally Replicating Adenovirus Based on Targeted Destruction of E1A mRNA by a Cell Type-Specific MicroRNA

(2008) E. Ylosmaki et al.   JOURNAL OF VIROLOGY

The Immunogenicity of Adenovirus Vectors Limits the Multispecificity of CD8 T-cell Responses to Vector-encoded Transgenic Antigens

(2008) Reinhold Schirmbeck et al.   MOLECULAR THERAPY

Use of Biological Therapy to Enhance Both Virotherapy and Adoptive T-Cell Therapy for Cancer

(2008) Timothy Kottke et al.   MOLECULAR THERAPY