Article
Oncology
Antonios E. Spiliotis, Sebastian Hollaender, Jeannette Rudzitis-Auth, Gudrun Wagenpfeil, Robert Eisele, Spyridon Nika, Orestis Mallis Kyriakides, Matthias W. Laschke, Michael D. Menger, Matthias Glanemann, Gereon Gaebelein
Summary: Electrochemotherapy (ECT) is an effective treatment for hepatic tumors that combines the administration of chemotherapeutic agents with well-dosed electric pulses for cell membrane reversible electroporation. It reduces tumor oxygenation, increases tumor necrosis, and reduces tumor vascularization compared to reversible electroporation and chemotherapy. ECT is a valuable option for treating hepatic tumors with necrosis rates >85% five days post-treatment.
Review
Medicine, General & Internal
Maria Beatrice Bocchi, Cesare Meschini, Silvia Pietramala, Andrea Perna, Maria Serena Oliva, Maria Rosaria Matrangolo, Antonio Ziranu, Giulio Maccauro, Raffaele Vitiello
Summary: This review evaluated the effectiveness of electrochemotherapy in the treatment of bone metastases. The findings suggest that electrochemotherapy can be considered as a minimally invasive and tissue-sparing treatment for patients who have no other alternatives for tumor control and improvement in quality of life.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Oncology
Sebastjan Merlo, Gregor Vivod, Sonja Bebar, Masa Bosnjak, Maja Cemazar, Gregor Sersa, Simona Kranjc Brezar, Nina Kovacevic
Summary: Endometrial carcinoma is a common malignancy in women, with the possibility of cutaneous metastases. Treatment typically involves a multimodal approach including surgery, chemotherapy, and other therapies. Electrochemotherapy may be an effective and safe option for treating multiple skin metastases.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2021)
Review
Biochemistry & Molecular Biology
Paola Maroni, Paola Bendinelli, Anita Ferraretto, Giovanni Lombardi
Summary: Bone metastases are a major issue in the progression of breast cancer, posing a significant treatment challenge. Interleukin-11 plays a key role in bone metastasis and could be a candidate for anti-metastatic therapy. Further research is needed to understand the contribution of different cytokines in breast cancer progression and develop effective therapeutic strategies.
Review
Oncology
Martina Ferioli, Anna Myriam Perrone, Milly Buwenge, Alessandra Arcelli, Alice Zamagni, Gabriella Macchia, Francesco Deodato, Savino Cilla, Luca Tagliaferri, Francesca De Terlizzi, Pierandrea De Iaco, Claudio Zamagni, Alessio Giuseppe Morganti
Summary: This review analyzed the available evidence on electrochemotherapy (ECT) in skin metastases from breast cancer and found that ECT is tolerable and effective in terms of response, especially in less advanced lesions. Further studies are needed to compare ECT with other treatments in this setting.
CLINICAL & EXPERIMENTAL METASTASIS
(2021)
Review
Dermatology
K. Hendel, G. B. E. Jemec, M. Haedersdal, S. R. Wiegell
Summary: This study systematically reviewed the treatment of basal cell carcinoma (BCC) with bleomycin electrochemotherapy (ECT) and found that ECT treatment can achieve a high complete response rate and low risk of recurrence in BCC patients. Future studies should include more large RCTs comparing ECT with standard of care, as well as cost and clinical feasibility analysis.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Urban Stupan, Maja Cemazar, Blaz Trotovsek, Miha Petric, Ales Tomazic, Gorana Gasljevic, Branislava Rankovic, Alenka Seliskar, Tanja Plavec, Jerneja Sredensnsek, Jan Plut, Marina Stukelj, Ursa Lampreht Tratar, Tanja Jesenko, Alenka Nemec Svete, Gregor Sersa, Mihajlo Dokic
Summary: This study aims to demonstrate that electrochemotherapy (ECT) can be safely and effectively used for porcine portal vein anastomosis in order to expand the indications for margin attenuation after resection of locally advanced pancreatic carcinoma. No significant differences were observed between the control group and ECT treated groups. Electroporation caused irreversible damage to the vascular smooth muscle cells in the tunica media, possibly due to the narrow irreversible electroporation zone near the electrodes or vasa vasorum thrombosis in the tunica externa. Based on the absence of vascular complications and similar histological changes in lienal vein anastomosis, it can be concluded that ECT of portal vein anastomosis is safe and feasible.
BIOELECTROCHEMISTRY
(2023)
Article
Dermatology
Milosz Kostusiak, Srinivasen Murugan, Tobian Muir
Summary: Electrosclerotherapy using bleomycin is a promising method for treating vascular malformations, enhancing treatment efficacy and potentially reducing the need for multiple treatment sessions. Most patients treated with this method reported satisfaction with the treatment outcomes.
DERMATOLOGIC SURGERY
(2022)
Article
Oncology
Laura Campanacci, Giuseppe Bianchi, Luca Cevolani, Costantino Errani, Giovanni Ciani, Giancarlo Facchini, Paolo Spinnato, Andrea Tognu, Leo Massari, Francois H. Cornelis, Mario Mosconi, Daniele Screpis, Francesco Benazzo, Barbara Rossi, Enrico Bonicoli, Flavio Fazioli, Mario Nicolosi, Michele Boffano, Raimondo Piana, Francesca De Terlizzi, Matteo Cadossi, Davide Maria Donati
Summary: This multicentre study confirmed the safety and efficacy of ECT in treating metastatic bone disease, as well as identifying appropriate operating procedures for different MBD conditions. The results showed a significant decrease in pain intensity and better quality of life after ECT sessions at follow-up.
Article
Multidisciplinary Sciences
Baha Zengel, Mustafa Kilic, Funda Tasli, Cenk Simsek, Murat Karatas, Ozlem Ozdemir, Demet Cavdar, Raika Durusoy, Kadir Koray Bas, Adam Uslu
Summary: This study investigated the clinical course of patients with breast cancer with OMBD, finding that OMBD may be a different disease than breast cancer with isolated bone metastases. The high risk of developing OMBD, especially following locoregional recurrence, increases the importance of locoregional therapy in large T and N stage tumors.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Ruohan Yang, Lin Jia, Guanyu Lu, Zheng Lv, Jiuwei Cui
Summary: Symptomatic bone marrow metastasis in breast cancer is rare and has a poor prognosis. Chemotherapy is the primary treatment, but its efficacy is limited, resulting in dose reduction and decreased quality of life. This study aimed to explore the clinicopathological characteristics, treatment modalities, and prognosis of breast cancer patients with bone marrow metastasis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Laura Campanacci, Luca Cevolani, Francesca De Terlizzi, Laura Saenz, Nikolin Ali, Giuseppe Bianchi, Davide Maria Donati
Summary: Electrochemotherapy (ECT) is an effective and feasible treatment for bone metastases, reducing pain and improving quality of life.
Article
Medicine, General & Internal
Lucija Kovacevic, Mislav Cavka, Zlatko Marusic, Elvira Kresic, Andrija Stajduhar, Lora Grbanovic, Ivo Dumic-Cule, Maja Prutki
Summary: CT-guided bone lesion biopsy has high diagnostic accuracy in confirming bone metastases and assessing hormone receptor status in patients with breast cancer. This study suggests that CT-guided biopsy is crucial for patients with breast cancer and suspicious bone lesions.
Article
Public, Environmental & Occupational Health
Chaofan Li, Mengjie Liu, Jia Li, Weiwei Wang, Cong Feng, Yifan Cai, Fei Wu, Xixi Zhao, Chong Du, Yinbin Zhang, Yusheng Wang, Shuqun Zhang, Jingkun Qu
Summary: This study utilized an artificial intelligence model to predict the survival of BMBC patients and identified potential prognostic factors. Additionally, survival outcomes of breast cancer patients treated with neoadjuvant chemotherapy plus surgical treatment and chemotherapy alone were investigated, showing survival benefits in selected patient subgroups with neoadjuvant chemotherapy plus surgical treatment.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Oncology
Luca G. Campana, Barbara Peric, Matteo Mascherini, Romina Spina, Christian Kunte, Erika Kis, Petra Rozsa, Pietro Quaglino, Rowan Pritchard Jones, A. James P. Clover, Pietro Curatolo, Roberto Giorgione, Maja Cemazar, Francesca de Terlizzi, Masa Bosnjak, Gregor Sersa
Summary: An investigation into the effectiveness of Electrochemotherapy (ECT) in combination with pembrolizumab for cutaneous melanoma metastases showed that the combined therapy was safer and more efficacious in preventing further growth of metastases compared to pembrolizumab alone. Patients treated with the combined therapy had lower disease progression rates and longer survival. The study suggests that ECT may enhance the effects of pembrolizumab by acting as an in situ vaccination against cancer cells. Prospective studies are needed to validate these findings.
Article
Orthopedics
Deyanira Contartese, Francesca Salamanna, Silvia Brogini, Konstantinos Martikos, Cristiana Griffoni, Alessandro Ricci, Andrea Visani, Milena Fini, Alessandro Gasbarrini
Summary: Fast-track is an evidence-based strategy for managing patients before, during, and after major surgery. This review aims to assess the specific interventions, measurement methods, and outcomes associated with enhanced recovery pathways in spine surgery.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Review
Biochemistry & Molecular Biology
Stefania Pagani, Melania Maglio, Laura Sicuro, Milena Fini, Gianluca Giavaresi, Silvia Brogini
Summary: The increase in degenerative diseases involving articular cartilage has led to greater focus on understanding their causes and finding effective treatments. One area of research is RNA extraction from musculoskeletal tissue, particularly cartilage, which remains challenging. This review provides an overview of techniques for RNA extraction, highlighting the limitations and possibilities. Although there is a lack of comparative studies and detailed protocols, the findings can serve as a starting point for further research in this area.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Deyanira Contartese, Maria Sartori, Giuseppe Tedesco, Alessandro Gasbarrini, Gianluca Giavaresi, Francesca Salamanna
Summary: Researchers provide a scientific opinion on the use of a vertebral bone marrow clot as a local delivery system for stem cells, biomolecules, and antimicrobial factors. The clot contains mesenchymal stem cells and platelets, which can release antimicrobial proteins and molecules. Further studies are needed to explore the potential of the vertebral bone marrow clot as a multifunctional bioscaffold for spinal fusion surgery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Melania Maglio, Maria Sartori, Alessandro Gambardella, Tatiana Shelyakova, Valentin Alek Dediu, Matteo Santin, Yolanda Pineiro, Manuel Banobre Lopez, Jose Rivas, Anna Tampieri, Simone Sprio, Lucia Martini, Alessandro Gatti, Alessandro Russo, Gianluca Giavaresi, Milena Fini
Summary: The use of functionalized scaffolds incorporated with superparamagnetic nanoparticles and vascular endothelial growth factor (VEGF) injection into a magnetic scaffold resulted in increased bone regeneration in a large bone defect in sheep metatarsus. The magnetic field generated by implanted magnets allowed the capture of the injected nanoparticles, forming a VEGF gradient in the scaffold's porosity. Histomorphometric measurements showed improved bone growth and bone-to-implant contact, while atomic force microscopy (AFM) analysis revealed similar nanomechanical behavior of the regenerated tissue to the magnetic field distribution. This study demonstrates the potential of magnetic technologies combined with functionalized scaffolds to enhance bone formation and improve bone/scaffold interaction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Huanyu Zhang, Faruk Okur, Claudia Cancellieri, Lars P. H. Jeurgens, Annapaola Parrilli, Dogan Tarik Karabay, Martin Nesvadba, Sunhyun Hwang, Antonia Neels, Maksym V. Kovalenko, Kostiantyn V. Kravchyk
Summary: Li dendrites form in Li7La3Zr2O12 (LLZO) solid electrolytes due to volume changes and voids at the Li metal/LLZO interface. Dense-porous LLZO membranes provide a solution by storing lithium in the pores, avoiding volume changes and void formation. The reported method of sequential tape-casting allows for the production of bilayer membranes with high performance.
Article
Biophysics
Fatehia Bushara, Melania Maglio, Gregorio Marchiori, Gianluca Giavaresi, Alberto Signoroni, Fabrizio Guerrini, Nicola Francesco Lopomo
Summary: In this study, a microCT system was used to acquire human hamstring tendons after specific preparations to enhance image contrast. The acquired images were then processed using dedicated techniques to highlight the fibrous structure and identify specific geometric features. This study designed and preliminarily validated a novel microCT protocol for the microstructural analysis of fibrous tissues.
JOURNAL OF MECHANICS IN MEDICINE AND BIOLOGY
(2023)
Article
Chemistry, Physical
Faruk Okur, Huanyu Zhang, Dogan Tarik Karabay, Konrad Muench, Annapaola Parrilli, Antonia Neels, Walid Dachraoui, Marta D. Rossell, Claudia Cancellieri, Lars P. H. Jeurgens, Kostiantyn V. Kravchyk, Maksym V. Kovalenko
Summary: The formation of cavities at the LLZO/Li interface hinders the further development of Li-garnet solid-state batteries. To address this issue, a method of fabricating porous LLZO membranes is proposed, which not only reduces cavity formation but also increases energy densities. The fabricated porous LLZO membranes exhibit long cycling stability.
ADVANCED ENERGY MATERIALS
(2023)
Article
Medicine, General & Internal
Alberto Ruffilli, Marco Manzetti, Francesca Barile, Marco Ialuna, Tosca Cerasoli, Giovanni Viroli, Francesca Salamanna, Deyanira Contartese, Gianluca Giavaresi, Cesare Faldini
Summary: Proximal junctional disease (PJD) and surgical site infection (SSI) are common complications after spine surgery. This study aimed to evaluate the influence of sarcopenia and osteopenia on these complications. Preoperative MRI was used to measure central sarcopenia and osteopenia. The analysis showed that comorbidity index and dural tear were independent risk factors for SSI, while age and diabetes were risk factors for PJD. However, there was no correlation between low M-score and PLVI and a higher complications rate.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Francesca Salamanna, Deyanira Contartese, Veronica Borsari, Stefania Pagani, Maria Sartori, Matilde Tschon, Cristiana Griffoni, Gianluca Giavaresi, Giuseppe Tedesco, Giovanni Barbanti Brodano, Alessandro Gasbarrini, Milena Fini
Summary: Recently, our group studied the use of vertebral bone marrow (vBMA) clot as a cell therapy for spinal fusion. We compared the properties of vBMA clots and derived vertebral mesenchymal stem cells (MSCs) from female and male patients who underwent spinal fusion procedures and received vBMA clot treatment. The results showed that vBMA clots and MSCs from males had higher expression of growth factors (GFs) and greater osteogenic and chondrogenic potential compared to females. The findings also revealed differences in the gene expression profiles of MSCs derived from vBMA clots between female and male donors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Francesca Veronesi, Melania Maglio, Silvia Brogini, Antonio Mazzotti, Elena Artioli, Gianluca Giavaresi
Summary: Retrograde drilling (RD) is a minimally invasive surgical procedure used for non-displaced osteochondral lesions, showing positive results with a good rate of patient satisfaction, improvements in clinical scores, pain reduction, and return to daily activities and sports. Further studies are necessary to investigate post-surgical complications and gender-related responses.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Francesca Salamanna, Silvio Caravelli, Laura Marchese, Melania Carniato, Emanuele Vocale, Giammarco Gardini, Giulia Puccetti, Massimiliano Mosca, Gianluca Giavaresi
Summary: This review systematically analyzes the changes in proprioception and related mechanoreceptors in osteoarthritis (OA) patients. The studies found that OA patients may have impaired proprioceptive accuracy in the posterior cruciate ligament (PCL), possibly due to changes in mechanoreceptors. Significant proprioceptive deficits were also identified in patients with knee articular cartilage lesions. Further research is needed to clarify the role of proprioception and related mechanoreceptors in OA.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Automation & Control Systems
Fabian Wiesemueller, Severin Meyer, Yijie Hu, Dominik Bachmann, Annapaola Parrilli, Gustav Nystrom, Mirko Kovac
Summary: Aerial robots can collect high-resolution environmental data, which can be used to develop mathematical models for understanding the impact of climate change. The introduction of transient robotics allows for the development of biodegradable drones that can degrade in the environment. However, there is a lack of discussion on manufacturing methods for environmental-sensing transient drones.
ADVANCED INTELLIGENT SYSTEMS
(2023)
Article
Neurosciences
Gabriela O. Bom Braga, Annapaola Parrilli, Robert Zboray, Milica Bulatovic, Franca Wagner
Summary: This study used microCT technology to anatomically demonstrate the osseous spiral lamina (OSL) and found that it has porosity. These findings contribute to our understanding of hearing mechanisms and improve the accuracy and effectiveness of cochlear models.
JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY
(2023)
Article
Otorhinolaryngology
Alberto Ruffilli, Francesca Barile, Tosca Cerasoli, Marco Manzetti, Giovanni Viroli, Marco Ialuna, Matteo Traversari, Francesca Salamanna, Antonio Mazzotti, Milena Fini, Cesare Faldini
Summary: The aim of this retrospective study is to determine whether sarcopenia and osteopenia are independent risk factors for proximal junctional disease (PJD) in patients undergoing lumbar fusion. The study found that sarcopenia and osteopenia are indeed independent risk factors for PJD.
JOURNAL OF CRANIOVERTEBRAL JUNCTION AND SPINE
(2023)
Review
Biochemistry & Molecular Biology
Deyanira Contartese, Laura Di Sarno, Francesca Salamanna, Lucia Martini, Milena Fini, Gianluca Giavaresi, Francesca Veronesi
Summary: This systematic review examines the current body of research on in vivo models of musculoskeletal frailty, delving into various animal models simulating specific features of the condition. The review also explores the translational prospects of these models in enhancing our understanding and streamlining the production of therapeutic approaches. It provides valuable insights and guidance for researchers and practitioners in combating musculoskeletal frailty.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)