期刊
JOURNAL OF INVESTIGATIVE DERMATOLOGY
卷 135, 期 4, 页码 1065-1073出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/jid.2014.480
关键词
-
类别
资金
- National Science Council of Taiwan [NSC100-2325-B-002-065, NSC 99-2628-B-002-084-MY3, 101-2321-B-002-032]
- National Core Facility Program for Biotechnology Grants of National Science Council [NSC 100-2319-B-001-002]
- National Taiwan University Hospital [NTUH 101-N1950, NTUH 102-N2274]
ICE II nnRNA-binding protein 3 (IMP-3) has been reported to be a marker of melanoma progression. However, the mechanisms by which it impacts melanoma are incompletely understood. In this study, we investigate the clinical significance of IMP-3 in melanoma progression and also its underlying mechanisms. We found that IMP-3 expression was much higher in advanced-stage/metastatic melanomas and that it was associated with a poor prognosis (P=0.001). Univariate analysis showed that IMP-3 expression was associated with stage III/1V melanomas (odds ratio =5.40, P=0.031) and the acral lentiginous subtype (odds ratio =3.93, P=0.0034). MeWo cells with overexpression of IMP-3 showed enhanced proliferation and migration and significantly increased tumorigenesis and metastatic ability in nude mice. We further demonstrated that IMP-3 could bind and enhance the stability of the mRNA of high mobility group AT-hook 2 (HMGA2). It was also confirmed that IMP-3 had an important role in melanoma invasion and metastasis through regulating HMGA2 mRNA expression. IMP-3 expression was positively correlated with HMGA2 expression in melanoma cells and also in melanoma tissues. Our results show that IMP-3 expression is a strong prognostic factor for melanoma, especially acral lentiginous melanoma.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据