期刊
CLINICAL & EXPERIMENTAL METASTASIS
卷 26, 期 1, 页码 51-60出版社
SPRINGER
DOI: 10.1007/s10585-008-9176-0
关键词
Dormancy; Human tumors; Metastasis; Angiogenesis; Microenvironment; Trauma
类别
资金
- Breast Cancer Research Foundation
- NIH [P01CA45548]
- Department of Defense, The Norwegian Cancer Society
- Helse Vest Norway
- NATIONAL CANCER INSTITUTE [P01CA045548] Funding Source: NIH RePORTER
Tumor progression is dependent on a number of sequential steps, including initial recruitment of blood vessels (i.e., angiogenic switch). Failure of a microscopic tumor to complete one or more of these early steps may lead to delayed clinical manifestation of the cancer. In this review we summarize some of the clinical and experimental evidence suggesting that microscopic human cancers can remain in an asymptomatic, non-detectable, and occult state for the life of a person or animal. We present three clinical cases where tumors present shortly after an accidental trauma in otherwise healthy individuals. We also review current experimental human tumor dormancy models with special emphasis on the angiogenic switch which closely recapitulates clinically observed delay in tumor recurrence.
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