期刊
JOURNAL OF INVESTIGATIVE DERMATOLOGY
卷 135, 期 6, 页码 1484-1490出版社
ELSEVIER SCIENCE INC
DOI: 10.1038/jid.2015.88
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资金
- US National Institutes on Aging, Cancer and Environmental Health Sciences
- Nippon Boehringer Ingelheim Virtual Research Institute of Aging
- US NIH NCI [CA77852]
- Montagna Symposium on the Biology of Skin NIAMS/NIA [R13-AR009431-48]
The growing diversity of heritable skin diseases, a practical challenge to clinicians and dermatonosologists alike, has nonetheless served as a rich source of insight into skin biology and disease mechanisms. I summarize below some key insights from the recent gene-driven phase of research on Werner syndrome, a heritable adult progeroid syndrome with prominent dermatologic features, constitutional genomic instability, and an elevated risk of cancer. I also indicate how new insights into skin biology, disease, and aging may come from unexpected sources.
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