Article
Cell Biology
Agnese Fiori, Stefanie Uhlig, Harald Kluter, Karen Bieback
Summary: Mesenchymal stromal cells (MSC) have immunomodulatory effects on various immune cells. In this study, human adipose tissue-derived MSC (ASC) were found to inhibit CD4 + T cell proliferation, induce Treg cells, and modulate cytokine secretion, suggesting a potential role in immune regulation. These findings highlight the complex interplay between ASC and CD4 + T cells.
Review
Immunology
Jason Cheung, Beata Zahorowska, Michael Suranyi, Jeffrey K. W. Wong, Jason Diep, Stephen T. T. Spicer, Nirupama D. D. Verma, Suzanne J. Hodgkinson, Bruce M. M. Hall
Summary: The immune response to an allograft can activate lymphocytes that cause rejection. The activation of T regulatory cells can reduce allograft rejection and induce immune tolerance. Activated T regulatory cells can be distinguished by various markers. A more detailed characterization of these cells may help reduce non-specific immunosuppression.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Eunbyeol Go, Su-Jin Yoo, Suyoung Choi, Pureum Sun, Min Kyung Jung, Somin Kwon, Bu Yeon Heo, Yeeun Kim, Ju-Gyeong Kang, Jinhyun Kim, Eui-Cheol Shin, Seong Wook Kang, Jaeyul Kwon
Summary: In patients with Rheumatoid arthritis (RA), there is a significant decrease in the frequency of effector T-reg cells and a reduction in overall CD25 expression in T-reg cells in peripheral blood. These findings suggest altered T-reg homeostasis associated with RA pathogenesis.
Article
Medicine, Research & Experimental
Aditi Narsale, Breanna Lam, Rosa Moya, TingTing Lu, Alessandra Mandelli, Irene Gotuzzo, Benedetta Pessina, Glanmaria Giamporcaro, Rhonda Geoffrey, Kerry Buchanan, Mark Harris, Anne-Sophie Bergot, Ranjeny Thomas, Martin J. Hessner, Manuela Battaglia, Elisavet Serti, Joanna D. Davies
Summary: The study confirms the important role of CD4(+)CD25(+)CD127(hi) cells in partial remission and immunotherapy outcomes in T1D patients, showing their maintenance of an antiinflammatory environment is crucial for partial remission, 11 cell survival, and response to antiinflammatory immunotherapy.
Article
Immunology
Gokul Raj Kathamuthu, Nathella Pavan Kumar, Kadar Moideen, Pradeep A. Menon, Subash Babu
Summary: In latent tuberculosis, individuals with diabetes mellitus or pre-diabetes, as well as non-diabetes comorbidities, show significantly reduced expression of cytokines, cytotoxic factors, and immune markers in gamma-delta T cells upon stimulation with specific antigens.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Clinical Neurology
Le-Minh Dao, Marie-Luise Machule, Petra Bacher, Julius Hoffmann, Lam-Thanh Ly, Florian Wegner, Alexander Scheffold, Harald Pruess
Summary: NMDAR encephalitis patients have lower frequencies of NR1-reactive CD4(+) T helper cells and produce significantly less inflammatory cytokines, indicating disease-specific functional alterations compared to healthy controls, not influenced by therapeutic immunosuppression.
JOURNAL OF NEUROLOGY
(2021)
Article
Medicine, General & Internal
Leah Zuroff, Ayman Rezk, Koji Shinoda, Diego A. Espinoza, Yehezqel Elyahu, Bo Zhang, Andrew A. Chen, Russell T. Shinohara, Dina Jacobs, Roy N. Alcalay, Thomas F. Tropea, Alice Chen-Plotkin, Alon Monsonego, Rui Li, Amit Bar-Or
Summary: In the study comparing untreated MS patients with normal controls, it was found that MS patients exhibited early and persistent redistribution of naive and memory CD4 T-cell compartments. While most CD4 and CD8 T-cell aging trajectories were similar between groups, MS patients demonstrated abnormal age-associated increases, particularly in patients over 60.
Article
Multidisciplinary Sciences
Nirupama D. Verma, Andrew D. Lam, Christopher Chiu, Giang T. Tran, Bruce M. Hall, Suzanne J. Hodgkinson
Summary: The study found significant shifts in CD4(+) T cell subpopulations in multiple sclerosis (MS) patients, with reduced resting Treg, increased activated Treg, and increased effector CD4(+) cells. Additionally, some MS patients showed reduced CCR6(+)Th17-like Treg, which may contribute to the activity of MS.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Ying Pan, Huiping Wang, Furun An, Fan Wu, Qianshan Tao, Yingwei Li, Yanjie Ruan, Zhimin Zhai
Summary: This study found that higher levels of circulating Tregs, especially one week after CD19 CAR-T cell infusion, served as a poor predictor for CD19 CAR-T therapy in R/R B-ALL patients, indicating a significant association with treatment efficacy and prognosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Cell Biology
Ling Wang, Wei Chen, Fu-Biao Kang, Ya-Hui Zhang, Li-Li Qi, Ying-Ze Zhang
Summary: Hip fracture patients experience immunological changes, with blood transfusion potentially helping to rebalance the immune response and improve prognosis.
Article
Gastroenterology & Hepatology
Wei Wang, Chun-Hui Ye, Zhen-Feng Deng, Ji-Long Wang, Ling Zhang, Li Bao, Bang-Hao Xu, Hai Zhu, Ya Guo, Zhang Wen
Summary: This study investigated the relationship between CD4+CD25+ regulatory T cells (Tregs) and liver regeneration in patients with hepatocellular carcinoma. The results showed that the proportion of CD4+CD25+ Tregs before liver resection was negatively correlated with indicators of liver regeneration and may influence the degree of liver fibrosis. The percentage of Tregs showed high accuracy in predicting liver regeneration.
WORLD JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Article
Immunology
Mostafa G. G. Aly, Eman H. H. Ibrahim, Hristos Karakizlis, Rolf Weimer, Gerhard Opelz, Christian Morath, Martin Zeier, Naruemol Ekpoom, Volker Daniel
Summary: In this study, the relationship between regulatory cells and immunosuppressive drugs in transplant recipients was investigated. The results showed a negative correlation between CD4+CD25+CD127-Foxp3+ Tregs and CD19+IL-10+ Bregs in early transplant recipients, with Tregs being affected by steroid dose and tacrolimus levels, while Bregs seemed less affected by potent immunosuppression. It was also found that CD4+CD25+CD127-Foxp3+ Tregs were lower in patients treated with certain antibodies compared to end-stage kidney disease patients. Early transplant recipients exhibited different patterns of Tregs and Bregs within the first 3 months post-transplant, indicating a complex relationship between these regulatory cells and immunosuppression.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Jessica G. Lee, Kathleen E. Jaeger, Yoichi Seki, Yi Wei Lim, Christina Cunha, Aleksandra Vuchkovska, Alexander J. Nelson, Anya Nikolai, Dan Kim, Michael Nishimura, Katherine L. Knight, Paula White, Makio Iwashima
Summary: The study reveals that a subset of CD14(+) monocytes can generate regulatory Foxp3(+) T-bet(+) T cells from umbilical cord blood, which suppress T-cell proliferation and ameliorate graft-versus-host disease. Additionally, adult peripheral blood monocytes are capable of inducing Foxp3(+) T cells, but their induction is inhibited by lymphoid cells from adult peripheral blood in neonates. This suggests a novel immunoregulatory role of monocytes in generating regulatory T cells with implications for both neonates and adults.
Review
Immunology
Shareni Jeyamogan, Joseph R. Leventhal, James M. Mathew, Zheng Jenny Zhang
Summary: Solid organ transplantation (SOT) and vascularized composite allotransplantation (VCA) are the gold-standard treatments for end-stage organ failure and complex tissue defects. However, ischemia reperfusion injury (IRI) is a major factor that can negatively impact transplant outcomes. CD4+CD25+FOXP3+ regulatory T cells (Tregs) have immunomodulatory potential and can prevent and mitigate IRI. Increasing the number of Tregs and targeted delivery can improve the outcomes of SOT and VCA.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Endocrinology & Metabolism
Ziyi Chen, Yufeng Liu, Shiqian Hu, Meng Zhang, Bingyin Shi, Yue Wang
Summary: The study compared T cell profiles between patients with persistent Graves' disease (pGD) and newly diagnosed GD (nGD), finding lower proportions of Th17 and Treg cells in pGD, along with decreased TCR diversity. pGD patients showed marked clonal expansion and more public T cell clonotypes. Additionally, upregulation of inflammation and chemotaxis pathways, coupled with downregulation of Th17 and Treg cell-associated genes, was observed in pGD.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Letter
Allergy
Miroslaw Kwasniewski, Urszula Korotko, Karolina Chwialkowska, Magdalena Niemira, Jerzy Jaroszewicz, Barbara Sobala-Szczygiel, Beata Puzanowska, Anna Moniuszko-Malinowska, Slawomir Pancewicz, Anna Parfieniuk-Kowerda, Diana Martonik, Dorota Zarebska-Michaluk, Krzysztof Simon, Monika Pazgan-Simon, Iwona Mozer-Lisewska, Maciej Bura, Agnieszka Adamek, Krzysztof Tomasiewicz, Malgorzata Pawlowska, Anna Piekarska, Aleksandra Berkan-Kawinska, Andrzej Horban, Justyna Kowalska, Regina Podlasin, Piotr Wasilewski, Arsalin Azzadin, Miroslaw Czuczwar, Michal Borys, Pawel Piwowarczyk, Slawomir Czaban, Jacek Bogocz, Magdalena Ochab, Anna Kruk, Sandra Uszok, Agnieszka Bielska, Anna Szalkowska, Justyna Raczkowska, Gabriela Sokolowska, Joanna Chorostowska-Wynimko, Aleksandra Jezela-Stanek, Adriana Rozy, Urszula Lechowicz, Urszula Polowianiuk, Agnieszka Tycinska, Kamil Grubczak, Aleksandra Starosz, Wiktoria Izdebska, Tadeusz F. Krzeminski, Jean Bousqet, Genoveffa Franchini, Jennifer Hadlock, Adam Kretowski, Mubeccel Akdis, Cezmi A. Akdis, Milena Sokolowska, Andrzej Eljaszewicz, Robert Flisiak, Marcin Moniuszko
Article
Environmental Sciences
Kacper Wrobel, Beata Zastawna, Anna Justyna Milewska, Michal Marczak, Remigiusz Kozlowski
Summary: Many Polish patients fail to disclose their use of supplements to physicians due to the perception that dietary supplements are natural products that do not pose health risks. However, this study highlights the need for a registration system in Poland to monitor adverse effects of dietary supplements, as seen in France and the United States. The comparison between American and European monitoring systems reveals the link between specific components in supplements and reported side effects among patients.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Review
Environmental Sciences
Adrianna Zanko, Katarzyna Siewko, Adam Jacek Kretowski, Robert Milewski
Summary: Infertility is a complex issue affecting millions of couples worldwide. Male infertility can be caused by various factors, including mechanical issues and abnormal sperm production. Semen quality is influenced by lifestyle factors, including diet, physical activity, sleep quality, and stress, which are also related to insulin resistance. To understand the connections between lifestyle, insulin resistance, and semen quality, a review of literature from 1989 to 2020 was conducted. Further research is recommended to explore the relationship between insulin resistance and semen quality by comparing men with and without insulin resistance.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Medicine, Research & Experimental
Marcin Warpechowski, Jedrzej Warpechowski, Anita Pienkowska, Szymon Sagala, Robert Milewski
Summary: This retrospective study aimed to evaluate the clinical utility of neutrophil-to-platelet ratio in 35 patients with ulcerative colitis undergoing biologic therapy. The results suggest that neutrophil-to-platelet ratio might be a promising biomarker of loss of response in biologic therapy of ulcerative colitis. However, further studies are needed to confirm this conclusion.
MEDICAL SCIENCE MONITOR
(2023)
Article
Otorhinolaryngology
Grzegorz Turek, Sebastian Dzierzecki, Pawel Obierzynski, Adrian Rogala, Zuzanna Zabek, Robert Milewski, Dorota Kiprian, Justyna Zielinska-Turek, Miroslaw Zabek
Summary: This study aimed to investigate the relationship between the results of radiosurgery treatment for IVS and age, gender, tumor volume, distance to fundus, microcyst existence, and radiosensitivity. The results showed that age, gender, tumor volume, proximity to the fundus, and the existence of a microcyst had no effect on treatment outcomes. Initial larger tumor volume was associated with an increased risk of pseudoprogression.
ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Katarzyna Aneta Pankowska, Grazyna Ewa Bedkowska, Joanna Chociej-Stypulkowska, Malgorzata Rusak, Milena Dabrowska, Joanna Osada
Summary: Ovarian cancer is a highly lethal gynecological cancer due to its rapid metastasis and drug resistance. The immune system and immune cells such as T cells, NK cells, and dendritic cells play a crucial role in the tumor microenvironment of ovarian cancer. However, ovarian tumor cells have various mechanisms to evade immune surveillance and recruit immune-suppressive cells, promoting disease progression. Platelets are also involved in immune evasion and tumor growth by interacting with tumor cells and secreting growth factors and cytokines. This review discusses the role of immune cells and platelets in the tumor microenvironment, as well as their potential prognostic significance in early detection and disease outcome prediction of ovarian cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
E. Zmyslowska-Polakowska, T. Ploszaj, S. Skoczylas, P. Mojsak, M. Ciborowski, A. Kretowski, M. Lukomska-Szymanska, A. Szadkowska, W. Mlynarski, A. Zmyslowska
Summary: The study compared the oral microbiome and metabolome in Wolfram syndrome (WFS) patients with type 1 diabetes mellitus (T1DM) patients and healthy controls. The analysis showed specific microbial components and metabolites in the oral cavity of WFS patients, which may be associated with neurodegenerative disorders and potential therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Emilia Kurpiewska, Sebastian Ciezki, Milena Jamiolkowska-Sztabkowska, Agnieszka Polkowska, Aleksandra Starosz, Kamil Grubczak, Marcin Moniuszko, Artur Bossowski, Barbara Glowinska-Olszewska
Summary: This study examines the impact of BMI on C-peptide secretion in children with T1D and finds that higher BMI is associated with the preservation of C-peptide at T1D diagnosis, but is not beneficial for long-term preservation of residual beta-cell function. This process appears to be mediated by inflammatory cytokines.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Emergency Medicine
Marta Komarowska, Malgorzata Kowalska, Kamil Grubczak, Alicja Pawelczyk, Adam Hermanowicz, Wojciech Debek, Ewa Matuszczak
Summary: This study aimed to assess the impact of the COVID-19 pandemic on the presentation of testicular torsion and the frequency of orchiectomy. The results showed that there was no increase in the number of testicular torsion cases during the COVID-19 outbreak, and the rates of orchiectomy did not significantly differ between the patients with testicular torsion presenting during the pandemic.
EMERGENCY MEDICINE INTERNATIONAL
(2023)
Editorial Material
Public, Environmental & Occupational Health
Piotr Kosiorek, Samuel Stroz, Anna Hryniewicz, Dorota E. Kazberuk, Robert Milewski, Klaudia Bartoszewicz, Magdalena J. Borkowska, Anna Stasiak-Barmuta
HEALTH SCIENCE REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Anna Kretowska-Grunwald, Malgorzata Sawicka-Zukowska, Malgorzata Kowalska, Aleksandra Basaj, Maryna Krawczuk-Rybak, Marcin Moniuszko, Kamil Grubczak
Summary: This study evaluated the associations between Treg and Th17 lymphocytes and the clinical presentation of ALL pediatric patients to validate their value in monitoring treatment outcome. The numbers of Th17 lymphocytes and Tregs were increased in the bone marrow of ALL patients at the moment of diagnosis compared to the healthy control group, with the latter significantly decreasing during the course of ALL treatment. It was found that patients with lower Th17 demonstrated higher risk of blasts prevalence in bone marrow at day 33, and ALL patients with lower WBC demonstrated higher frequency of Tregs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Public, Environmental & Occupational Health
Marzena Garley, Wioleta Justyna Omeljaniuk, Radoslaw Motkowski, Wioletta Ratajczak-Wrona, Ewa Jablonska, Daniel Filipkowski, Angelika Edyta Charkiewicz
Summary: This study evaluated the impact of aging on the formation of neutrophil extracellular traps (NETs). The results showed that levels of myeloperoxidase (MPO) and circulating free DNA (cfDNA), which are biomarkers of NETs, increased with age until adulthood, but were lower in older men, suggesting impaired NET formation.
INTERNATIONAL JOURNAL OF OCCUPATIONAL MEDICINE AND ENVIRONMENTAL HEALTH
(2023)
Review
Medicine, General & Internal
Magdalena Skowronska, Michal Pawlowski, Robert Milewski
Summary: This article is a literature review focusing on the connections between lifestyle factors and ovulatory infertility. It discusses the relationships between diet, physical exercise, oxidative stress, sleep, supplementation, and ovulatory infertility, with special emphasis on obesity and insulin resistance. The classification of relationships between ovulation disorders and lifestyle factors is proposed, and areas for further research are indicated. The study shows that diet and physical exercise are promising areas for robust clinical studies, while the relationships between oxidative stress, sleep, and supplementation do not seem to be clinically significant.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Lukasz Bolkun, Marlena Tynecka, Alicja Walewska, Malgorzata Bernatowicz, Jaroslaw Piszcz, Edyta Cichocka, Tomasz Wandtke, Magdalena Czemerska, Agnieszka Wierzbowska, Marcin Moniuszko, Kamil Grubczak, Andrzej Eljaszewicz
Summary: Despite promising results in clinical trials, the use of immune checkpoint inhibitors (ICI) in acute myeloid leukaemia (AML) is limited. This study analysed the expression patterns of selected checkpoint proteins in AML patients and found that the expression of certain proteins was associated with the response to therapy and overall survival. Further validation through multicentre studies is needed.
Article
Cell & Tissue Engineering
Grubczak Kamil, Stozek Karolina, Starosz Aleksandra, Bossowski Filip, Paslawska Marta, Bossowski Artur, Moniuszko Marcin
Summary: The pathway involving insulin-like growth factor 1 (IGF-1) has a significant role in growth and development. Deficient patients with short stature, including those with Laron syndrome, have elevated values for certain stem cell populations. This study investigated the role of these stem cells (VSEL and HSC) in the pathology and observed their response to rhIGF-1 therapy in pediatric patients with IGF-1 deficiency syndrome. The study found that IGF-1 deficient patients initially have higher levels of VSEL and HSC, which gradually decrease with therapy. These changes are associated with SDF-1 plasma levels and growth-related parameters. Notably, rhIGF-1 therapy efficiently promotes growth in Laron patients.
STEM CELL REVIEWS AND REPORTS
(2023)