Article
Biochemistry & Molecular Biology
Chunli Xue, Zuxian Yang, Ben Yang, Hailin Xiong, Wei Ye
Summary: The study found that LINC00460 is significantly upregulated in cutaneous squamous cell carcinoma (CSCC) and promotes tumor proliferation, migration, and invasion. Mechanistically, LINC00460 binds to ELAVL1 and enhances its stability, thereby regulating cell function. These findings highlight the critical role of LINC00460 in CSCC and provide potential targets for clinical diagnosis and treatment.
MOLECULAR BIOTECHNOLOGY
(2023)
Review
Oncology
Minna Piipponen, Pilvi Riihila, Liisa Nissinen, Veli-Matti Kahari
Summary: Skin cancers, including cutaneous squamous cell carcinoma (cSCC), are the most common types of cancer worldwide, primarily caused by long-term exposure to solar ultraviolet radiation. cSCC is the most common metastatic skin cancer associated with poor prognosis. The inactivation mutation of p53 and accumulation of additional oncogenic mutations play a critical role in the progression of cSCC.
Article
Biochemistry & Molecular Biology
Li Li, Ye Yin, Fanglong Nan, Zeyu Ma
Summary: circ_LPAR3 is upregulated in oral squamous cell carcinoma (OSCC), and its knockdown can inhibit tumor growth and angiogenesis by sponging miR-513b-5p and activating VEGFC and AKT1.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biotechnology & Applied Microbiology
Xiaoyan Lu, Quan Gan, Caibin Gan
Summary: CircSEC24A interference suppressed the progression of CSCC by regulating the miR-1193/MAP3K9 axis, which may provide a promising strategy for CSCC treatment.
ONCOTARGETS AND THERAPY
(2021)
Article
Oncology
Hanjing Gao, Zheng Yan, Haiyan Sun, Yanfang Chen
Summary: The study showed that FOXA2 is significantly increased in ESCC tissues, and high expression of FOXA2 promotes ESCC progression by regulating ZEB2 at the transcription level. The results suggest that FOXA2 plays a critical role in ESCC and may be a potential target for ESCC treatment.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Yen-Hao Chen, Hung- Lu, Chien-Ming Lo, Shau-Hsuan Li
Summary: CD73 is a key molecule in tumor immune suppression and is associated with worse outcomes in various cancers. Its overexpression promotes the malignant properties of cancers and affects the efficacy of immunotherapy.
Article
Oncology
Miao-Fen Chen, Ming-Shian Lu, Ching-Chuan Hsieh, Wen-Cheng Chen
Summary: Increasing evidence suggests that the microbiome can influence tumor growth and the tumor microenvironment in gastrointestinal cancers. Porphyromonas gingivalis, a periodontal pathogen, is associated with the development and progression of esophageal squamous cell carcinoma. Targeting P. gingivalis or blocking IL-6 signaling may be a potential strategy to prevent and treat EsoSCC associated with this oral bacterium.
Article
Cell Biology
Ji Ma, Shudong Ma, Ying Zhang, Yi Shen, Lei Huang, Tianhao Lu, Lu Wang, Yunhan Wen, Zhenhua Ding
Summary: Depletion of kinectin1 (KTN1) inhibits tumorigenesis of cutaneous squamous cell carcinoma (cSCC) by reducing epidermal growth factor receptor (EGFR) protein levels. The underlying mechanism involves KTN1 knockdown promoting EGFR degradation in cSCC cells through the ubiquitin-proteasome system. KTN1 depletion also leads to tumor suppressor functions mediated by CCDC40, PSMA1, and ADRM1, providing novel insights into EGFR degradation in cSCC.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Jiongyu Chen, Zhangzhu Zhou, Xueqiong Lin, Jiahui Liao, Yujie Zhang, Bingmeng Xie, Yiteng Huang, Lin Peng
Summary: This study investigates the relationship between cadmium (Cd) exposure and the development, progression, and therapeutic resistance of esophageal squamous cell carcinoma (ESCC). The results show that ESCC patients have higher levels of blood Cd compared to controls, and Cd exposure is associated with increased risk and rapid progression of ESCC. Long-term Cd exposure in ESCC cells leads to enhanced cell proliferation, invasion, and migration, as well as reduced efficacy of chemotherapy and irradiation. Cd also stimulates cancer cell stemness and activates the Wnt/β-catenin signaling pathway.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Xiaoxuan Duan, Yihuan Chen, Kai Zhang, Wei Chen, Jun Zhao, Xiaoshuo Dai, Wenbo Cao, Ziming Dong, Saijun Mo, Jing Lu
Summary: This study found that phosphoglycerate dehydrogenase (PHGDH) was highly expressed in esophageal squamous carcinoma (ESCC), and high expression was associated with poor prognosis. In vitro and in vivo experiments demonstrated that PHGDH knockdown inhibited ESCC progression by suppressing Wnt/beta-catenin signaling pathway. These results indicate that PHGDH may be a potential therapeutic target for ESCC.
CELLULAR SIGNALLING
(2023)
Article
Cell Biology
Jie Gao, Ying Meng, Xin Ge, Chen-Xing Hou, Qing-Hai Zhu, Yi-Zhou Wang, Li-Fan Sun, Chen-Xing Wang, Huai-Qi Li, Tianzhu Zhang, Jin-Hai Ye
Summary: This study revealed the expression and function of SATB2 in oral squamous cell carcinoma, showing that high expression of SATB2 is associated with poor prognosis. Overexpression of SATB2 promotes proliferation, migration, invasion, and tumor growth of OSCC cells, and NOX4 is identified as a downstream target of SATB2. This suggests that SATB2 may play a key role in OSCC tumorigenesis and could be a potential target for future therapeutic development.
CELLULAR SIGNALLING
(2021)
Article
Medicine, General & Internal
Cheng-Gang Qiu, Bin Shen, Xiao-Qi Sun
Summary: This study aimed to identify significant genes associated with cutaneous squamous cell carcinoma (CSCC) initiation and development. The results revealed that MYBL2 and TK1 were the most significant biomarkers associated with CSCC initiation and progression, and they may act as promising therapeutic targets for accurate diagnosis and treatment of CSCC.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Nan Wang, Xuanyu Huang, Jinsheng Cheng
Summary: The study found that BIRC5 was strongly correlated with higher tumor grade and differentiation in Laryngeal squamous cell carcinoma (LSCC), and increased expression of BIRC5 was associated with overall survival in LSCC patients. Suppression of BIRC5 induced cell apoptosis and cell cycle arrest, inhibiting proliferation of LSCC cells. Higher level of BIRC5 expression predicted poor prognosis of LSCC patients, suggesting BIRC5 as a promising prognostic biomarker for LSCC.
Article
Biochemistry & Molecular Biology
Jia Chen, Shu-Fen Hou, Feng-Jie Tang, Dai-Song Liu, Zi-Zi Chen, Hong-Lian Zhang, Shao-Hua Wang
Summary: HOTAIR, through up-regulating Sp1 and targeting miR-199a, promotes stemness and progression of CSCC. Targeting HOTAIR, Sp1 or the underlying mechanisms may benefit CSCC treatment, as shown by functional assays and in vivo models.
Review
Medicine, General & Internal
Che-Yuan Hsu, Teruki Yanagi, Hideyuki Ujiie
Summary: TRIM proteins, including TRIM29, are essential in a variety of cell processes and have been linked to functions such as DNA binding, carcinogenesis, DNA damage signaling, and radioresistance. In particular, TRIM29 plays a significant role in regulating keratin distribution and is involved in cutaneous squamous cell carcinoma.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, General & Internal
Emma K. Rousi, Roope A. Kallionpaa, Roosa E. Kallionpaa, Susanna M. Juteau, Lauri A. Talve, Micaela M. Hernberg, Pia P. Vihinen, Veli-Matti Kahari, Ilkka O. Koskivuo
Summary: The incidence of pediatric and adolescent melanoma has significantly increased in Finland from 1990 to 2014, especially among adolescents and in the Spitzoid melanoma subtype. There is no evidence of overdiagnosis of Spitzoid melanomas as the cause of the increased incidence.
ANNALS OF MEDICINE
(2022)
Article
Dermatology
Kristina Viiklepp, Liisa Nissinen, Marjaana Ojalill, Pilvi Riihila, Markku Kallajoki, Seppo Meri, Jyrki Heino, Veli-Matti Kahari
Summary: This study investigates the mechanistic role of serine proteinase C1r in cutaneous squamous cell carcinoma (cSCC). Knockout of C1r in cSCC cells leads to a decrease in proliferation, migration, and invasion. Additionally, knockout of C1r inhibits tumor growth and vascularization, promotes apoptosis of tumor cells, and reduces MMP production and collagen degradation. These findings highlight the importance of C1r in promoting the invasion of cSCC cells and provide potential therapeutic targets.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Oncology
Pegah Rahmati Nezhad, Pilvi Riihilae, Jaakko S. Knuutila, Kristina Viiklepp, Sirkku Peltonen, Markku Kallajoki, Seppo Meri, Liisa Nissinen, Veli-Matti Kahari
Summary: The most common metastatic skin cancer, cutaneous squamous cell carcinoma (cSCC), is growing worldwide, and there are no biomarkers or therapeutic targets for high-risk cSCCs. Recent studies have identified the essential role of autocrine complement synthesis in cSCC progression. This study evaluates the role of complement Factor D (FD), the rate-limiting enzyme of the alternative complement pathway, in cSCC development. The results identify FD as a novel biomarker and potential therapeutic target for cSCC, and propose the small-molecule FD inhibitor Danicopan as a highly specific drug candidate in the therapy of advanced cSCC. Discovery of complement-associated molecular markers for cSCC progression would improve diagnosis, classification, prognostication, and targeted therapy of cSCC and its precursors in the future.
Article
Dermatology
Rahime Inci, Theofanis Zagoras, Despoina Kantere, Peter Holmstrom, Martin Gillstedt, Sam Polesie, Sirkku Peltonen
Summary: Porokeratosis is a common genodermatosis that is associated with an increased risk of skin cancer.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Editorial Material
Dermatology
Liisa Nissinen, Veli-Matti Kahari
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Neurosciences
Dani Flinkman, Ye Hong, Jelena Gnjatovic, Prasannakumar Deshpande, Zsuzsanna Ortutay, Sirkku Peltonen, Valtteri Kaasinen, Peter James, Eleanor Coffey
Summary: Deficits in protein synthesis are associated with Parkinson's disease (PD). We conducted a study to identify the specific proteins affected and differences in synthesis between sporadic and LRRK2-G2019S PD patients. Through proteomic analysis, we found that regulators of endo-lysosomal sorting, mRNA processing, and components of the translation machinery were consistently low in both sporadic and LRRK2-G2019S PD patients. This study provides valuable insights into the dysregulation of proteostasis in PD.
NPJ PARKINSONS DISEASE
(2023)
Review
Biochemistry & Molecular Biology
Iida Jaaskelainen, Tiina Petaisto, Elahe Mirzarazi Dahagi, Mahdokht Mahmoodi, Taina Pihlajaniemi, Mari T. Kaartinen, Ritva Heljasvaara
Summary: The increasing prevalence of obesity globally is linked to the development of metabolic diseases such as type 2 diabetes, dyslipidemia, and fatty liver. Adipose tissue dysfunction and systemic metabolic dysfunction occur due to excessive adipose tissue, which functions as an active endocrine system. This review summarizes the current understanding of vertebrate collagens and other important extracellular matrix (ECM) components in adipose tissue development and function, with a focus on the role of adipose tissue collagens in metabolic diseases.
Article
Oncology
Aini Hyytiainen, Katja Korelin, Mervi Toriseva, Tommy Wilkman, Satu Kainulainen, Karri Mesimaki, Johannes Routila, Sami Ventela, Heikki Irjala, Matthias Nees, Ahmed Al-Samadi, Tuula Salo
Summary: This study investigated the changes in gene expression and response to anti-cancer treatments of head and neck squamous cell carcinoma (HNSCC) cells under different culturing conditions. The results showed that culturing conditions can alter the gene expression of cancer cells, and Myogel is more effective at upregulating pathways related to cancer cell proliferation and invasion. The effectiveness of anti-cancer treatments varied depending on the culturing conditions.
CANCER CELL INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Roope A. Kallionpaa, Edvard Johansson, Petri Bockerman, Juha Peltonen, Sirkku Peltonen
Summary: Neurofibromatosis 1 (NF1) is a multisystem disorder associated with a high risk for cancer, behavioral and cognitive deficits, low educational attainment, and decreased income. This study analyzed labor market participation in individuals with NF1 in Finland and found that they had significantly fewer working days per year, higher unemployment, and more sickness absence compared to a control group. The causes of sickness absence were consistent with the morbidity profile of NF1. Overall, NF1 significantly interferes with labor market participation through both unemployment and morbidity.
EUROPEAN JOURNAL OF HUMAN GENETICS
(2023)
Article
Biochemistry & Molecular Biology
Elina Siljamaki, Pilvi Riihila, Ujjwal Suwal, Liisa Nissinen, Pekka Rappu, Markku Kallajoki, Veli-Matti Kahari, Jyrki Heino
Summary: Metastatic cSCC has a poor prognosis and requires new therapeutic approaches. Our findings suggest that PLX8394 may inhibit cSCC invasion and tumor growth, making it a potential therapeutic compound for advanced cSCC.
Article
Multidisciplinary Sciences
Arkadiusz Czerwonka, Joanna Kalafut, Shaoxia Wang, Alinda Anameric, Alicja Przybyszewska-Podstawka, Jesse Mattsson, Mahtab Karbasian, Doriane Le Manach, Mervi Toriseva, Matthias Nees
Summary: This study investigated the effects of different small molecule Notch modulators on head and neck squamous cell carcinoma (HNSCC), compared to the conventional NOTCH interfering compound DAPT. The results showed that RIN-1 had the most pronounced, pleiotropic effects as a Notch modulator. Activation of Notch signaling by RIN-1 led to inhibition of proliferation, growth, and motility of HNSCC cells, as well as induction of cell cycle arrest and apoptosis. Similar anticancer effects were observed in 3D cultures and in the zebrafish model. In contrast, RIN-1 treatment resulted in inhibition of Notch signaling and growth of HNSCC spheroids under non-adherent cell culture conditions.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Verneri Virtanen, Kreetta Paunu, Antti Kukkula, Saana Niva, Ylva Junila, Mervi Toriseva, Terhi Jokilehto, Sari Makela, Riikka Huhtaniemi, Matti Poutanen, Ilkka Paatero, Maria Sundvall
Summary: The downregulation of l-CaD, regulated by GR, reduces the metastatic potential of PCa, both in vitro and in vivo. CALD1 gene is co-expressed with GR and GR activation upregulates l-CaD expression. This indicates that l-CaD is involved in PCa metastasis and its expression is clinically relevant in the development of antiandrogen resistance.
