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CLINICAL & DEVELOPMENTAL IMMUNOLOGY
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HINDAWI LTD
DOI: 10.1155/2012/829584
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- Istituto Superiore di Sanita [45G.5, 40G.16]
Alterations of B cell subpopulations have been described up to date as characterizing advanced stage of HIV-1 infection. However, whether such defects are relevant in subjects with a preserved number of CD4(+) T cells (>350 cells/mu L) is unclear. In a cross-sectional study, we investigated if signs of B cells exhaustion and impaired viral immune surveillance are present in a cohort of 43 asymptomatic HIV-1-infected patients with preserved CD4(+) T cell counts (>350 cells/mu L) and highly active antiretroviral therapy (HAART) untreated. A dramatic expansion of exhausted tissue-like memory B cells (CD10(-)CD21(low)CD27(-)) was observed. B cells alteration was related to an increase in Torque teno virus (TTV) load, used as surrogate marker of immune function. Successfully HAART-treated patients showed normalization of B cell subpopulations frequency and TTV load. These results provide new insights on B cell in HIV-1 infection and show that development of B cell abnormalities precedes CD4(+) T cell decline.
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