Blocking Type I Interferon Production: A New Therapeutic Option to Reduce the HIV-1-Induced Immune Activation

Hydroxychloroquine drastically reduces immune activation in HIV-infected, antiretroviral therapy-treated immunologic nonresponders

(2011) S. Piconi et al.   BLOOD

Plasmacytoid dendritic cells are recruited to the colorectum and contribute to immune activation during pathogenic SIV infection in rhesus macaques

(2011) S. Kwa et al.   BLOOD

Spatiotemporal trafficking of HIV in human plasmacytoid dendritic cells defines a persistently IFN-α–producing and partially matured phenotype

(2011) Meagan O’Brien et al.   JOURNAL OF CLINICAL INVESTIGATION

Thymic plasmacytoid dendritic cells are susceptible to productive HIV-1 infection and efficiently transfer R5 HIV-1 to thymocytes in vitro

(2011) Vanessa A Evans et al.   Retrovirology

Innate Sensing of HIV-Infected Cells

(2011) Alice Lepelley et al.   PLoS Pathogens

A double-blind, randomized controlled trial of the use of imiquimod cream for the treatment of anal canal high-grade anal intraepithelial neoplasia in HIV-positive MSM on HAART, with long-term follow-up data including the use of open-label imiquimod

(2010) Paul A Fox et al.   AIDS

Differential Effects of P-Class Versus Other CpG Oligodeoxynucleotide Classes on the Impaired Innate Immunity of Plasmacytoid Dendritic Cells in HIV Type 1 Infection

(2010) Norbert Donhauser et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Short Communication: Preferential Concentration of Hydroxychloroquine in Adenoid Tissue of HIV-Infected Subjects

(2010) Lucinda Aguirre-Cruz et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

HIV Infection, Inflammation, Immunosenescence, and Aging

(2010) Steven G. Deeks   Annual Review of Medicine

Evidence of dysregulation of dendritic cells in primary HIV infection

(2010) R. L. Sabado et al.   BLOOD

Plasmacytoid dendritic cells in HIV infection: striking a delicate balance

(2010) Patricia Fitzgerald-Bocarsly et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Microbial translocation in simian immunodeficiency virus (SIV)-infected rhesus monkeys (Macaca mulatta)

(2010) C. Leinert et al.   JOURNAL OF MEDICAL PRIMATOLOGY

Reduction of Immune Activation with Chloroquine Therapy during Chronic HIV Infection

(2010) S. M. Murray et al.   JOURNAL OF VIROLOGY

Downregulation of Robust Acute Type I Interferon Responses Distinguishes Nonpathogenic Simian Immunodeficiency Virus (SIV) Infection of Natural Hosts from Pathogenic SIV Infection of Rhesus Macaques

(2010) L. D. Harris et al.   JOURNAL OF VIROLOGY

Chloroquine Modulates HIV-1-Induced Plasmacytoid Dendritic Cell Alpha Interferon: Implication for T-Cell Activation

(2009) J. A. Martinson et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Understanding and managing the adverse effects of antiretroviral therapy

(2009) Trevor Hawkins   ANTIVIRAL RESEARCH

Plasmacytoid dendritic cells accumulate in spleens from chronically HIV-infected patients but barely participate in interferon-  expression

(2009) M. Nascimbeni et al.   BLOOD

Nonpathogenic SIV infection of African green monkeys induces a strong but rapidly controlled type I IFN response

(2009) Béatrice Jacquelin et al.   JOURNAL OF CLINICAL INVESTIGATION

Global genomic analysis reveals rapid control of a robust innate response in SIV-infected sooty mangabeys

(2009) Steven E. Bosinger et al.   JOURNAL OF CLINICAL INVESTIGATION

Highlights in the Discovery of Antiviral Drugs: A Personal Retrospective

(2009) Erik De Clercq   JOURNAL OF MEDICINAL CHEMISTRY

Inability of Plasmacytoid Dendritic Cells To Directly Lyse HIV-Infected Autologous CD4+ T Cells despite Induction of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand

(2009) J. Chehimi et al.   JOURNAL OF VIROLOGY

Is the high virulence of HIV-1 an unfortunate coincidence of primate lentiviral evolution?

(2009) Frank Kirchhoff   NATURE REVIEWS MICROBIOLOGY

HIV-activated human plasmacytoid DCs induce Tregs through an indoleamine 2,3-dioxygenase–dependent mechanism

(2008) Olivier Manches et al.   JOURNAL OF CLINICAL INVESTIGATION

Human Immunodeficiency Virus Viremia Induces Plasmacytoid Dendritic Cell Activation In Vivo and Diminished Alpha Interferon Production In Vitro

(2008) J. C. Tilton et al.   JOURNAL OF VIROLOGY

CD4 Binding Affinity Determines Human Immunodeficiency Virus Type 1-Induced Alpha Interferon Production in Plasmacytoid Dendritic Cells

(2008) S. Haupt et al.   JOURNAL OF VIROLOGY

Plasmacytoid Dendritic Cell Dynamics and Alpha Interferon Production during Simian Immunodeficiency Virus Infection with a Nonpathogenic Outcome

(2008) O. M. Diop et al.   JOURNAL OF VIROLOGY

Differential CD4+ T-Lymphocyte Apoptosis and Bystander T-Cell Activation in Rhesus Macaques and Sooty Mangabeys during Acute Simian Immunodeficiency Virus Infection

(2008) M. Meythaler et al.   JOURNAL OF VIROLOGY

Divergent TLR7 and TLR9 signaling and type I interferon production distinguish pathogenic and nonpathogenic AIDS virus infections

(2008) Judith N Mandl et al.   NATURE MEDICINE

Avoiding the void: cell-to-cell spread of human viruses

(2008) Quentin Sattentau   NATURE REVIEWS MICROBIOLOGY

HIV-Induced Type I Interferon and Tryptophan Catabolism Drive T Cell Dysfunction Despite Phenotypic Activation

(2008) Adriano Boasso et al.   PLoS One

Into the wild: simian immunodeficiency virus (SIV) infection in natural hosts

(2008) Ivona Pandrea et al.   TRENDS IN IMMUNOLOGY