Current Concepts of Hyperinflammation in Chronic Granulomatous Disease

Inflammasome activation in NADPH oxidase defective mononuclear phagocytes from patients with chronic granulomatous disease

(2010) F. Meissner et al.   BLOOD

PPAR  activation normalizes resolution of acute sterile inflammation in murine chronic granulomatous disease

(2010) R. Fernandez-Boyanapalli et al.   BLOOD

Human NLRP3 inflammasome activation is Nox1-4 independent

(2010) R. van Bruggen et al.   BLOOD

Tryptophan/kynurenine metabolism in human leukocytes is independent of superoxide and is fully maintained in chronic granulomatous disease

(2010) S. S. De Ravin et al.   BLOOD

Intact indoleamine 2,3-dioxygenase activity in human chronic granulomatous disease

(2010) Birgit Jürgens et al.   CLINICAL IMMUNOLOGY

CD68-expressing cells can prime T cells and initiate autoimmune arthritis in the absence of reactive oxygen species

(2010) Angela Pizzolla et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Impaired Phagocytosis of Apoptotic Cells by Macrophages in Chronic Granulomatous Disease Is Reversed by IFN-  in a Nitric Oxide-Dependent Manner

(2010) R. Fernandez-Boyanapalli et al.   JOURNAL OF IMMUNOLOGY

Reactive oxygen species-independent activation of the IL-1  inflammasome in cells from patients with chronic granulomatous disease

(2010) F. L. van de Veerdonk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Retrovirus gene therapy for X-linked chronic granulomatous disease can achieve stable long-term correction of oxidase activity in peripheral blood neutrophils

(2009) E. M. Kang et al.   BLOOD

Impaired apoptotic cell clearance in CGD due to altered macrophage programming is reversed by phosphatidylserine-dependent production of IL-4

(2008) R. F. Fernandez-Boyanapalli et al.   BLOOD

Regulatory T Cells and Immune Tolerance

(2008) Shimon Sakaguchi et al.   CELL

Dysregulation of innate immune receptors on neutrophils in chronic granulomatous disease

(2008) Dominik Hartl et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Effect of laquinimod on MRI-monitored disease activity in patients with relapsing-remitting multiple sclerosis: a multicentre, randomised, double-blind, placebo-controlled phase IIb study

(2008) G Comi et al.   LANCET

T cells hang in the balance

(2008) Emily A. Stevens et al.   NATURE

Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease

(2008) Luigina Romani et al.   NATURE

The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins

(2008) Marc Veldhoen et al.   NATURE