Article
Genetics & Heredity
Kota Araki, Rie Kinoshita, Nahoko Tomonobu, Yuma Gohara, Shuta Tomida, Yuta Takahashi, Satoru Senoo, Akihiko Taniguchi, Junko Itano, Ken-ichi Yamamoto, Hitoshi Murata, Ken Suzawa, Kazuhiko Shien, Hiromasa Yamamoto, Mikio Okazaki, Seiichiro Sugimoto, Kouichi Ichimura, Masahiro Nishibori, Nobuaki Miyahara, Shinichi Toyooka, Masakiyo Sakaguchi
Summary: S100A8/A9 plays an active role in the development of pulmonary fibrosis by promoting fibroblast proliferation, differentiation into myofibroblasts, and collagen production, through its receptor RAGE. Targeting S100A8/A9 may be a promising therapy for interstitial pneumonia with fibrosis.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Article
Environmental Sciences
Juan Wang, Xiaojuan Wang, Conghui Zhang, Xiao Zhou
Summary: The study reveals the potential harm of microplastics to the human immune system. Microplastics in drinking water cause spleen damage and immune suppression in mice, potentially through modulation of protein expression and signaling pathways.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Peripheral Vascular Disease
Junni Wang, Wanyun Nie, Xishao Xie, Mengqiu Bai, Yanhong Ma, Lini Jin, Liang Xiao, Peng Shi, Yi Yang, Pedro A. Jose, Ines Armando, Jianghua Chen, Weiqiang Lin, Fei Han
Summary: The study identified the role of microRNA-874-3p/ADAM19 in mediating renal fibrosis after acute kidney injury by increasing macrophage infiltration via the Notch1/CCL2 pathway. Modulating the levels of microRNA-874-3p or ADAM19 could potentially slow down the process of renal fibrosis.
Article
Biotechnology & Applied Microbiology
Zhu Wang, Qiong Deng, Yanli Gu, Min Li, Ying Zhang, Qiyi Hu, Shenping Zhang, Xisheng Wang, Hui Liang
Summary: This study investigated the gene expression changes in the kidney of a rat model with kidney stones. The results showed dysregulated genes related to injury, apoptosis, immune response, solute carriers, transporters, and metabolic factors. These findings contribute to a better understanding of the pathogenesis of nephrolithiasis and could potentially lead to the development of new strategies for prevention and treatment.
Article
Multidisciplinary Sciences
Yuanyuan Yang, Senyuan Hong, Cong Li, Jiaqiao Zhang, Henglong Hu, Xiaolong Chen, Kehua Jiang, Fa Sun, Qing Wang, Shaogang Wang
Summary: This study investigated the proteomics of urinary stones and crystals to identify the most frequently found proteins in kidney stones, revealing their involvement in inflammation and immune responses. Immunohistochemistry showed altered expression levels of certain proteins in renal tissues of kidney stone patients. These findings suggest potential diagnostic biomarkers and therapeutic targets for urolithiasis.
Article
Biochemical Research Methods
Sixu Wang, Ming Su, Jun Lin, Lei Zhang, Jun Li, Ye Tian, Wei Qiu
Summary: BK virus (BKV) is a common pathogen in post-transplant infections, particularly in kidney transplantation. This study identifies S100A8/A9 as a potential host biomarker for evaluating BKV-associated allograft function impairment in kidney transplantation.
JOURNAL OF PROTEOME RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Yejin Yang, Sugyeong Ha, Somi Jeong, Chae Won Jang, Jeongwon Kim, Dong-Soon Im, Hae Young Chung, Ki Wung Chung
Summary: This study compared two reliable toxin-induced mouse kidney fibrosis models in terms of fibrosis and inflammation. The adenine diet-induced kidney fibrosis model exhibited higher inflammatory response with increased fibrosis compared to the folic acid-induced kidney fibrosis model.
Article
Biochemistry & Molecular Biology
Minjung Son, Ga Young Kim, Yejin Yang, Sugyeong Ha, Jeongwon Kim, Doyeon Kim, Hae Young Chung, Hyung Ryong Moon, Ki Wung Chung
Summary: The PPAR pan agonist MHY2013 effectively prevents renal fibrosis in both in vitro and in vivo models, suggesting its therapeutic potential against chronic kidney diseases. MHY2013 inhibits fibroblast activation and reduces inflammation through PPAR gamma and beta activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Mingjie Su, Siyao Sang, Taotao Liang, Hui Li
Summary: This study investigated the effects of yellow tea on kidney stone formation and the mechanisms of action. The results showed that yellow tea reduced crystal deposits, inflammation, oxidative stress, and fibrosis in a dose-dependent manner. The study also identified that flavonoids in yellow tea could regulate kidney stone formation by affecting PPARG transcription factor activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Priyal Patel, Sandip Patel, Piyush Chudasama, Shailesh Soni, Manan Raval
Summary: The present investigation explored the potential treatment option of roflumilast as a PDE4 inhibitor for chronic kidney disease. The results demonstrated that roflumilast significantly reduced serum creatinine, urea, uric acid levels, increased serum calcium, and regulated protein expression of inflammatory markers. Moreover, roflumilast noticeably improved the structure and functioning of glomeruli, tubules, and cells. Therefore, roflumilast has the potential to ameliorate renal injury.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Immunology
Yi Wen, Hong-Ru Yan, Bin Wang, Bi-Cheng Liu
Summary: Kidney macrophages play crucial roles in the pathogenesis of kidney diseases, with diverse functions ranging from clearing pathogens to promoting fibrosis. Their origins and proliferation are key factors in the accumulation of macrophages after kidney injury. Understanding the mechanisms driving macrophage heterogeneity and function changes could help in the development of targeted therapies for kidney diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Hui Chen, Na Liu, Shougang Zhuang
Summary: Macrophages play a crucial role in kidney injury, and targeting their activation mechanisms can significantly improve the outcomes of AKI.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Abhi Dutta, Shubham Saha, Ajay Bahl, Anupam Mittal, Trayambak Basak
Summary: Cardiorenal syndrome is a broad spectrum disorder affecting the heart and kidneys. India has a high burden of acute cardiorenal syndrome, with 46.1% of patients diagnosed in India. Acute cardiorenal syndrome involves sudden kidney deterioration in acute heart failure patients. The pathophysiology includes hyperactivation of the sympathetic nervous system and the renin-angiotensin-aldosterone system. Complications increase the risk of mortality, making it a global healthcare burden. Current biomarkers have limitations in early detection, highlighting the need for novel proteomic biomarkers to prevent progression.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lovorka Grgurevic, Rudjer Novak, Grgur Salai, Stela Hrkac, Marko Mocibob, Ivana Kovacevic Vojtusek, Mario Laganovic
Summary: This study reveals the molecular characteristics of different stages of chronic kidney disease (CKD) through proteomic analysis, and identifies key events that may affect disease progression. The study suggests that CKD stage 2 is a turning point in the progression of the disease and a suitable time for developing therapeutic solutions.
Article
Biochemistry & Molecular Biology
Fatimah K. Khalaf, Chrysan J. Mohammed, Prabhatchandra Dube, Jacob A. Connolly, Apurva Lad, Usman M. Ashraf, Joshua D. Breidenbach, Robin C. Su, Andrew L. Kleinhenz, Deepak Malhotra, Amira F. Gohara, Steven T. Haller, David J. Kennedy
Summary: This study found that decreased PON-1 is associated with the progression of renal inflammation and fibrosis independent of blood pressure. By knockout of the Pon1 gene in a rat model, it was discovered that the absence of PON-1 leads to increased renal fibrosis, sclerosis, and tubular injury, as well as increased recruitment of immune cells in the renal interstitium and the expression of inflammatory genes. Furthermore, the absence of PON-1 also results in a decline in renal function and increased renal oxidative stress.
Article
Urology & Nephrology
Wattanachai Ungjaroenwathana, Thanida Chiramongkolsiri, Thasinas Dissayabutra, Chanchai Boonla, Phisit Prapunwattana, Kriang Tungsanga, Piyaratana Tosukhowong
Article
Immunology
Nicolas Neidert, Alexander von Ehr, Tanja Zoeller, Bjorn Spittau
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Patcharawalai Whongsiri, Chaowat Pimratana, Udomsak Wijitsettakul, Anapat Sanpavat, Depicha Jindatip, Michele J. Hoffmann, Wolfgang Goering, Wolfgang A. Schulz, Chanchai Boonla
FREE RADICAL BIOLOGY AND MEDICINE
(2019)
Article
Clinical Neurology
Wolfgang H. Jost, Tobias Baeumer, Rainer Laskawi, Bjoern Spittau, Armin Steffen, Martin Winterholler
FORTSCHRITTE DER NEUROLOGIE PSYCHIATRIE
(2019)
Article
Neurosciences
Alexander von Ehr, Abdelraheim Attaai, Nicolas Neidert, Phani Sankar Potru, Tamara Russ, Tanja Zoeller, Bjoern Spittau
FRONTIERS IN CELLULAR NEUROSCIENCE
(2020)
Review
Biochemistry & Molecular Biology
Johannes Wurm, Henna Konttinen, Christian Andressen, Tarja Malm, Bjoern Spittau
Summary: Microglia are resident immune cells in the central nervous system and play critical roles in brain development, homeostasis, and pathologies. Human-induced pluripotent stem cells have been successfully differentiated into microglia-like cells, but the differentiation protocols vary and may impact the similarity to primary human microglia and study outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Anatomy & Morphology
Volker A. Coenen, Mate D. Doebroessy, Shi Jia Teo, Johanna Wessolleck, Bastian E. A. Sajonz, Peter C. Reinacher, Annette Thierauf-Emberger, Bjoern Spittau, Jochen Leupold, Dominik von Elverfeldt, Thomas E. Schlaepfer, Marco Reisert
Summary: Recent uncertainties have arisen regarding the anatomy and function of cortico-subcortical projections, particularly the distinction between cortico-subthalamic (hyperdirect) and cortico-tegmental projections (slMFB). Deep Brain Stimulation of the slMFB has been found to impact not only reward-associated pathways but other structures as well. This research clarifies the co-existence of slMFB and prefrontal hyperdirect pathways, supporting the efficacy of slMFB DBS in treating MD and OCD.
BRAIN STRUCTURE & FUNCTION
(2022)
Article
Biochemistry & Molecular Biology
Rasem Mustafa, Chahinaz Rawas, Nadja Mannal, Grzegorz Kreiner, Bjoern Spittau, Katarzyna Kaminska, Ruestem Yilmaz, Christina Poetschke, Joachim Kirsch, Birgit Liss, Kerry L. Tucker, Rosanna Parlato
Summary: Primary cilia play a crucial role in maintaining vulnerable dopaminergic neurons in Parkinson's disease, regulating their spontaneous activity and susceptibility to neurotoxic substances. These findings highlight the significance of primary cilia in dopamine system disorders and stress responses.
Article
Clinical Neurology
Wolfgang H. Jost, Rainer Laskawi, Anja Palmowski-Wolfe, Bjoern Spittau, Peter P. Urban
Summary: Botulinum toxin injections are the preferred treatment for hemifacial spasm and have been approved for use in Germany. Hemifacial spasm is a common condition characterized by involuntary contractions of the facial muscles on one side of the face. Diagnosis is based on clinical observation, and magnetic resonance imaging of the skull is recommended to identify the most common cause and rule out other pathologies.
FORTSCHRITTE DER NEUROLOGIE PSYCHIATRIE
(2022)
Article
Biology
Felix Kretzschmar, Robin Piecha, Jannik Jahn, Phani Sankar Potru, Bjoern Spittau
Summary: This study provides a detailed characterization of Lilrb4 expression in microglia and peripheral myeloid cells, demonstrating that LILRB4 is a surface marker for activated microglia. The research also shows that microglial TGF beta signaling is involved in regulating Lilrb4 expression during LPS-induced microglia activation.
Article
Clinical Neurology
Wolfgang H. Jost, Tobias Baeumer, Steffen Berweck, Rainer Laskawi, Bjoern Spittau, Armin Steffen, Martin Winterholler
Summary: The most important salivary glands are the paired parotid and submandibular glands. Increased saliva production can impair quality of life, and treatment options include conservative measures, anticholinergic medication, and injection therapy.
FORTSCHRITTE DER NEUROLOGIE PSYCHIATRIE
(2022)
Article
Neurosciences
Eugenia Falomir-Lockhart, Franco Juan Cruz Dolcetti, Macarena Lorena Herrera, Jeronimo Pennini, Maria Florencia Zappa Villar, Gabriela Salinas, Enrique Portiansky, Bjoern Spittau, Ezequiel Lacunza, Claudia Beatriz Herenu, Maria Jose Bellini
Summary: The study revealed that overexpression of IGF-1 can shift aged microglia towards an anti-inflammatory state and improve motor function. IGF-1 gene transfer may counteract neuroinflammatory effects associated with aging and enhance physiological functions in senile animals.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jannik Jahn, Antonia Bollensdorf, Christopher Kalischer, Robin Piecha, Jana Weiss-Mueller, Phani Sankar Potru, Tamara Russ, Bjoern Spittau
Summary: It has been found that TGF beta regulates the activation of microglia by inhibiting the expression of Cd74 in these cells. Additionally, silencing of TGF beta signaling leads to upregulation of CD74, further demonstrating the importance of microglial TGF beta signaling in regulating microglia activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Clinical Neurology
Wolfgang H. Jost, Tobias Baeumer, Rainer Laskawi, Jaroslaw Slawek, Bjoern Spittau, Armin Steffen, Martin Winterholler, Ganesh Bavikatte
NEUROLOGY AND THERAPY
(2019)
Article
Biochemistry & Molecular Biology
Nittiya Suwannasom, Kathrin Smuda, Chiraphat Kloypan, Waraporn Kaewprayoon, Nuttakorn Baisaeng, Chanchai Boonla, Radostina Georgieva, Hans Baumler
GENERAL PHYSIOLOGY AND BIOPHYSICS
(2019)
Article
Medical Laboratory Technology
Jiansheng Lin, Weihua Lin, Yiming Lin, Weilin Peng, Zhenzhu Zheng
Summary: This study retrospectively analyzed the cases of Chinese infants with NICCD and identified multiple genetic mutations. The study also found comorbidity of NICCD and other inborn errors of metabolism in some patients.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Lihua Guan, Wei Su, Jian Zhong, Ling Qiu
Summary: Multiple myeloma is characterized by excessive production of monoclonal immunoglobulins. Routine screening methods are insufficient for detecting low levels of M proteins, but advances in mass spectrometry enable reliable detection of low abundance serum biomarkers for minimal residual disease assessment in multiple myeloma.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Liya Zhu, Chao Zhu, Jialie Jin, Jinxin Wang, Xiaojing Zhao, Rongxi Yang
Summary: This study found an association between blood-based ITGB2 methylation and coronary heart disease (CHD), with hypomethylation of ITGB2 being a risk factor for CHD. Additionally, the combination of ITGB2 methylation and conventional CHD risk factors could efficiently discriminate CHD patients from controls.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
H. Al Habobe, E. B. Haverkort, K. Nazmi, A. P. Van Splunter, R. H. H. Pieters, F. J. Bikker
Summary: Saliva diagnostics have become popular due to their non-invasive nature and patient-friendly collection process. However, the choice of saliva collection method can affect the measured levels of various biomarkers.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Abdurrahman Coskun, Anna Carobene, Ozlem Demirelce, Michele Mussap, Federica Braga, Ebru Sezer, Aasne Karine Aarsand, Sverre Sandberg, Pilar Fernandez Calle, Jorge Diaz-Garzon, Metincan Erkaya, Cihan Coskun, Esila Nur Erol, Hunkar Dag, Bill Bartlett, Mustafa Serteser, Niels Jonker, Ibrahim Unsal
Summary: In this study, BV estimates for 22 AAs were provided based on a large sample size, and it was found that there are differences in CVI estimates between males and females for most AAs, which has implications for the clinical interpretation and use of AAs.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Valentinus Besin, Farizky Martriano Humardani, Trilis Yulianti, Matthew Justyn
Summary: The study of Parkinson's Disease in Asian populations has revealed the impact of genetic variants on multiple biological pathways and highlighted shared genetic susceptibility with other diseases. These findings emphasize the importance of personalized treatment based on individual genetic profiles.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Simona Ferraro, Sara Benedetti, Savina Mannarino, Santica Marcovina, Elia Mario Biganzoli, Gianvincenzo Zuccotti
Summary: Risk stratification for cardio-vascular disease should be implemented in childhood to promote early prevention strategies, as atherosclerotic lesions can be present even in very young individuals. Evaluating pediatric CV risk factors/clinical conditions and conducting lipid profile and genetic testing can help identify children at risk of future CV events and guide appropriate therapeutic options.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Ahmad Mobed, Bita Abdi, Sajjad Masoumi, Mohammad Mikaeili, Elham Shaterian, Hamed Shaterian, Esmat Sadat Kazemi, Mahdiye Shirafkan
Summary: Reproductive biomarkers play important regulatory roles in women. The discovery and quantification of these biomarkers are clinically significant. Various detection strategies, including nanotechnology-based methods, have been developed. This article provides an in-depth introduction to the latest advances in biosensor and nanosensor research for detecting and quantitatively identifying reproductive biomarkers.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Chengfang Tang, Fang Tang, Yanna Cai, Minyi Tan, Sichi Liu, Ting Xie, Xiang Jiang, Yonglan Huang
Summary: This study proposes an effective method for screening X-ALD and evaluates the performance of newborn screening for X-ALD in Guangzhou. The LC-MS/MS method can accurately identify X-ALD through analysis of C26:0-LPC.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Lan Liu, Jiamin Wang, Xijing Liu, Jing Wang, Lin Chen, Hongmei Zhu, Jingqun Mai, Ting Hu, Shanling Liu
Summary: The 16p11.2 deletion is a common genetic cause of neurodevelopmental disorders, with prenatal and postnatal presentations including vertebral malformations and language impairment. The majority of deletions are de novo and may be associated with MAPK3 and histidine-associated metabolism.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Sneha Venkatesalu, Shanmugapriya Dilliyappan, Avanthika Satish Kumar, Thirunavukkarasu Palaniyandi, Gomathy Baskar, Maddaly Ravi, Asha Sivaji
Summary: Microfluidics is a science and technology that deals with less sample-to-more precision in vitro analysis. It has wide applications in cancer theranostics, enabling precise diagnosis and personalized treatment.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Yuanqin Zhao, Wei Deng, Zhaoyue Wang, Yanxia Wang, Hongyu Zheng, Kun Zhou, Qian Xu, Le Bai, Huiting Liu, Zhong Ren, Zhisheng Jiang
Summary: The cardiovascular system and the central nervous system exhibit a coordinated developmental process during embryonic development. Congenital heart disease (CHD) is the most common congenital disorder, and neurodevelopmental disorders (NDD) are common complications in CHD patients. Both genetic and non-genetic factors contribute to the co-occurrence of CHD and NDD. Further research should focus on identifying common molecular mechanisms underlying this co-occurrence and promoting the research and treatment of developmental disorders related to the cardiovascular and central nervous systems.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Karol Gostomczyk, Ewelina Lukaszewska, Jedrzej Borowczak, Anita Bator, Marek Zdrenka, Magdalena Bodnar, Lukasz Szylberg
Summary: Flow cytometry improves the detection of epithelial cancer cells in peritoneal and pleural fluids compared to conventional cytology. Due to similar speciflcity and higher sensitivity, flow cytometry offers a promising alternative to cytology for patient screening.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Heping Tian, Genghuan Wang, Qi Zhong, Haihang Zhou
Summary: This study found that the decline of serum ITIH4 concentrations during the early phase after aneurysmal subarachnoid hemorrhage (aSAH) was closely related to the severity and poor prognosis of the disease. Serum ITIH4 may represent a promising prognostic biomarker of aSAH.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Xueting Zhu, Yang Yu, Jun Zhang, Yuxia Zhan, Guanghua Luo, Lu Zheng
Summary: This study successfully established a 2D-PCR method for identifying HLA-B*15:02 through a two-tube reaction. This method can distinguish HLA-B*15:02 from 16 highly homologous HLA-B*15 alleles. Among 1830 samples from the clinical general population, 3 HLA-B*15:02 homozygotes and 84 HLA-B*15:02 heterozygotes were detected.
CLINICA CHIMICA ACTA
(2024)
