Article
Immunology
Magdalena Rutkowska, Maria Pokorska-Spiewak
Summary: The study characterized pediatric patients with hepatitis associated with primary Epstein-Barr Virus (EBV) infection. Liver aminotransferases activity and abdominal ultrasonography results were analyzed. Medical records of 166 immunocompetent children diagnosed with primary EBV hepatitis were retrospectively studied. Elevated ALT activity was noted in the first three weeks of the disease, and AST activity showed two peaks in the first and third weeks. Transient cholestatic liver disease was found in 10.8% of children, with older patients being more affected. Hepatitis associated with primary EBV infection is usually mild, but severe cases can show significantly elevated liver enzymes and features of cholestatic liver disease.
Article
Immunology
Zeming Liu, Di Hu, Jinpeng Li, Qing Xia, Yan Gong, Zhengwei Li, Qian Wu, Meilin Yi, Yihui Huang, Meng Wu, Liang Guo, Xiaohui Wu
Summary: Elevated levels of AST and AST/ALT are correlated with severity and mortality of COVID-19. Liver function tests may aid clinicians in determining prognosis for patients undergoing treatment.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yu-Ting Yen, Joo-Hyun Park, Seung-Hyun Kang, Today Su, Howard Cheng, Wu-Che Wen, Shin-Shiou Lin, Yu-Ling Tai, Pei-Ni Chen, Shih-Chang Tsai
Summary: This study evaluated the protective effects of Golden-Antrodia camphorata on liver function in human subjects after alcohol consumption.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Evelyn Ferri, Paolo D. Rossi, Martina Scichilone, Tiziano A. Lucchi, Beatrice Arosio
Summary: Dysfunctions in liver metabolic activities may be associated with an increased risk of cognitive impairment and dementia, with attention to sex differences in liver function.
Article
Environmental Sciences
Weihong Qiu, Yun Zhou, Heng He, Bin Wang, Ge Mu, Min Zhou, Jixuan Ma, Zhuang Zhang, Limin Cao, Lili Xiao, Jing Yuan, Weihong Chen
Summary: The study found that short-term exposure to air pollutants has adverse effects on liver function among urban adults, with the adverse effects lasting longer in high-pollution areas than in low-pollution areas.
ATMOSPHERIC ENVIRONMENT
(2021)
Article
Public, Environmental & Occupational Health
Wangcheng Xie, Weidi Yu, Shanshan Chen, Zhilong Ma, Tingsong Yang, Zhenshun Song
Summary: The study highlights the value of AST/ALT ratio as a predictor for diabetes, with lower ratio associated with higher diabetes risk. A non-linear correlation was observed between AST/ALT ratio and diabetes risk, with risk increasing as the ratio decreases when <= 1.18.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Endocrinology & Metabolism
Xia Yuan, Zhe Gao, Caixuan Yang, Kaixin Duan, Luping Ren, Guangyao Song
Summary: In this network meta-analysis, daily treatment with glucagon-like peptide-1 receptor agonists appears to be more effective for nonalcoholic fatty liver disease and type 2 diabetes mellitus patients. Among the six interventions evaluated, daily semaglutide was found to be the most effective treatment.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Gastroenterology & Hepatology
Lei Sun, Chaohua Deng, Yunpeng Gu, Yining He, Luping Yang, Junping Shi
Summary: This meta-analysis summarized the efficacy and safety of dapagliflozin for nonalcoholic fatty liver disease (NAFLD) in patients. The results showed that dapagliflozin significantly reduced the levels of alanine aminotransferase (ALT) and aspartate aminotransaminase (AST), improved insulin resistance, and metabolic outcomes. However, dapagliflozin may increase total cholesterol levels.
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2022)
Review
Nutrition & Dietetics
Danielle Lee, Laura Chiavaroli, Sabrina Ayoub-Charette, Tauseef A. Khan, Andreea Zurbau, Fei Au-Yeung, Annette Cheung, Qi Liu, Xinye Qi, Amna Ahmed, Vivian L. Choo, Sonia Blanco Mejia, Vasanti S. Malik, Ahmed El-Sohemy, Russell J. de Souza, Thomas M. S. Wolever, Lawrence A. Leiter, Cyril W. C. Kendall, David J. A. Jenkins, John L. Sievenpiper
Summary: This systematic review and meta-analysis investigated the effects of fructose-containing sugars from different food sources and different levels of energy control on non-alcoholic fatty liver disease (NAFLD) markers. The results showed that fructose-containing sugars increased intrahepatocellular lipid (IHCL), especially from sugar-sweetened beverages (SSBs), while the removal of energy from mixed sources (with SSBs) decreased aspartate aminotransferase (AST). However, there is still uncertainty about the effects of other important food sources of fructose-containing sugars.
Review
Infectious Diseases
Yuting Diao, Juan Tang, Xuerong Wang, Wei Deng, Jing Tang, Chunfang You
Summary: Chronic hepatitis B often coexists with metabolic syndrome and nonalcoholic fatty liver disease. Both metabolic syndrome and nonalcoholic fatty liver disease are associated with obesity and insulin resistance, which can lead to adverse effects on the liver and other organs. The relationship among chronic hepatitis B, metabolic syndrome, and nonalcoholic fatty liver disease is complex and requires further investigation.
INFECTIOUS DISEASES AND THERAPY
(2023)
Article
Peripheral Vascular Disease
Kerim Esenboga, Alparslan Kurtul, Huseyin Nazman, Cemre Gul Tekin, Nil Ozyuncu, Turkan Seda Tan, Eralp Tutar, Sibel Tekin Turhan
Summary: The study showed that treatment with ranolazine for 6 months led to a significant reduction in the activities of both serum aminotransferases in patients with stable CAD and NAFLD.
Article
Medical Laboratory Technology
Gjin Ndrepepa, Stefan Holdenrieder, Adnan Kastrati
Summary: It is unclear whether the aspartate aminotransferase (AST) to alanine aminotransferase (ALT) ratio (De Ritis ratio) with AST and ALT activities within the reference range has prognostic value in stable coronary artery disease patients. This study found that an elevated De Ritis ratio within the reference range was associated with an increased risk of mortality.
CLINICA CHIMICA ACTA
(2023)
Article
Oncology
Daiki Kobayashi, Kazuki Yamamoto, Takeshi Kimura, Takuro Shimbo
Summary: The study found that men with higher AST/ALT ratios tended to have a higher risk of developing any type of cancer, especially among regular drinkers, while the risk was lower among abstainers. However, among women, there was no significant association between AST/ALT ratio and the development of any type of cancer.
Article
Medicine, General & Internal
Hong Lin, Guoyou Dai, Song Huang, Zhaoyang Chen, Zhaohui Jin, Zhiyao He
Summary: This study evaluated the association between serum uric acid (SUA) levels and alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in the US population aged 20 years and older. The results showed a positive correlation between SUA and ALT/AST. Stratified analysis by sex and race also supported this association. Therefore, liver function should be monitored or intervened with as SUA levels rise in individuals aged 20 years and older in the United States (excluding Non-Hispanic Black individuals).
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Vo Duy Thong, Bui Thi Huong Quynh
Summary: This study aimed to investigate the correlation of serum ALT and AST with liver stiffness in Vietnamese NAFLD patients. The results showed that ALT levels were significantly higher in advanced fibrosis NAFLD patients. ALT had high sensitivity and specificity for detecting moderate to moderate liver fibrosis in NAFLD patients.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Medicine, General & Internal
Claudio Chiesa, Lucia Pacifico, John F. Osborn, Enea Bonci, Nora Hofer, Bernhard Resch
Article
Cardiac & Cardiovascular Systems
L. Pacifico, E. Bonci, M. Di Martino, P. Versacci, G. Andreoli, L. M. Silvestri, C. Chiesa
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2015)
Review
Biotechnology & Applied Microbiology
Enea Bonci, Claudio Chiesa, Paolo Versacci, Caterina Anania, Lucia Silvestri, Lucia Pacifico
BIOMED RESEARCH INTERNATIONAL
(2015)
Article
Respiratory System
Raffaella Nenna, Renato Cutrera, Antonella Frassanito, Claudia Alessandroni, Ambra Nicolai, Giulia Cangiano, Laura Petrarca, Serena Arima, Serena Caggiano, Nicola Ullmann, Paola Papoff, Enea Bonci, Corrado Moretti, Fabio Midulla
THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE
(2017)
Article
Oncology
Amalia Schiavetti, Valeria Pedetti, Giulia Varrasso, Oriana Marrucci, Camilla Celani, Gianmarco Andreoli, Enea Bonci
PEDIATRIC HEMATOLOGY AND ONCOLOGY
(2018)
Article
Immunology
D. Savi, M. Mordenti, E. Bonci, P. Troiani, B. Giordani, V. D'Alu, S. Bertasi, G. Cimino, P. Rossi, C. Poggi, P. Palange, S. Quattrucci
TRANSPLANTATION PROCEEDINGS
(2018)
Review
Chemistry, Medicinal
Lucia Pacifico, John F. Osborn, Enea Bonci, Pasquale Pierimarchi, Claudio Chiesa
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2019)
Article
Medicine, Research & Experimental
Silvia Lai, Sandro Mazzaferro, Anna Paola Mitterhofer, Enea Bonci, Paolo Giangreco Marotta, Francesco Pelligra, Manuel Murciano, Camilla Celani, Patrizia Troiani, Giuseppe Cimino, Paolo Palange
JOURNAL OF TRANSLATIONAL MEDICINE
(2019)
Article
Surgery
Amalia Schiavetti, Enea Bonci, Giulia Varrasso, Alessandra De Grazia, Denis A. Cozzi
JOURNAL OF SURGICAL RESEARCH
(2020)
Article
Medicine, General & Internal
Flavio Maria Ceci, Marco Fiore, Francesca Gavaruzzi, Antonio Angeloni, Marco Lucarelli, Carolina Scagnolari, Enea Bonci, Francesca Gabanella, Maria Grazia Di Certo, Christian Barbato, Carla Petrella, Antonio Greco, Marco De Vincentiis, Massimo Ralli, Claudio Passananti, Roberto Poscia, Antonio Minni, Mauro Ceccanti, Luigi Tarani, Giampiero Ferraguti
Summary: This study suggests that high levels of LDH, Ferritin, CRP, and D-dimer may serve as potential predictors of COVID-19 severity and death, based on analysis of early routine blood biomarkers in COVID-19 patients.
Article
Medicine, General & Internal
Carla Petrella, Raffaella Nenna, Laura Petrarca, Francesca Tarani, Roberto Paparella, Enrica Mancino, Greta Di Mattia, Maria Giulia Conti, Luigi Matera, Enea Bonci, Flavio Maria Ceci, Giampiero Ferraguti, Francesca Gabanella, Christian Barbato, Maria Grazia Di Certo, Luca Cavalcanti, Antonio Minni, Fabio Midulla, Luigi Tarani, Marco Fiore
Summary: COVID-19 is an infectious disease caused by the SARS-CoV-2 virus. This study aimed to investigate the changes in NGF and BDNF levels in infected adolescents and their relationship with inflammatory biomarkers. The results showed that NGF serum content was lower in post-infected-COVID-19 individuals, and BDNF levels were higher in symptomatic and future long-COVID-19 girls. Inflammatory biomarkers and oxidative stress index remained unchanged in male and female adolescents.
Article
Endocrinology & Metabolism
Federica Coccia, Moira Testa, Gloria Guarisco, Enea Bonci, Claudio Di Cristofano, Gianfranco Silecchia, Frida Leonetti, Amalia Gastaldelli, Danila Capoccia
Article
Pediatrics
Elena Bozzola, Stefano Guolo, Enea Bonci, Chiara Rossetti, Mauro Bozzola, Massimiliano Raponi, Alberto Villani
ITALIAN JOURNAL OF PEDIATRICS
(2019)
Article
Biochemistry & Molecular Biology
Lucia Pacifico, Enea Bonci, Gian Marco Andreoli, Michele Di Martino, Alessia Gallozzi, Ester De Luca, Claudio Chiesa
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2016)
Review
Nutrition & Dietetics
Silvia Lai, Sandro Mazzaferro, Anna Paola Mitterhofer, Francesca Tinti, Enea Bonci, Antonello Giovannetti, Claudio Casella, Adolfo Marco Perrotta, Domenico Bagordo, Manuel Murciano, Alessandro Galani, Camilla Celani, Patrizia Troiani, Giuseppe Cimino, Paolo Palange
JOURNAL OF NUTRITION AND METABOLISM
(2020)
Article
Medical Laboratory Technology
Jiansheng Lin, Weihua Lin, Yiming Lin, Weilin Peng, Zhenzhu Zheng
Summary: This study retrospectively analyzed the cases of Chinese infants with NICCD and identified multiple genetic mutations. The study also found comorbidity of NICCD and other inborn errors of metabolism in some patients.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Lihua Guan, Wei Su, Jian Zhong, Ling Qiu
Summary: Multiple myeloma is characterized by excessive production of monoclonal immunoglobulins. Routine screening methods are insufficient for detecting low levels of M proteins, but advances in mass spectrometry enable reliable detection of low abundance serum biomarkers for minimal residual disease assessment in multiple myeloma.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Liya Zhu, Chao Zhu, Jialie Jin, Jinxin Wang, Xiaojing Zhao, Rongxi Yang
Summary: This study found an association between blood-based ITGB2 methylation and coronary heart disease (CHD), with hypomethylation of ITGB2 being a risk factor for CHD. Additionally, the combination of ITGB2 methylation and conventional CHD risk factors could efficiently discriminate CHD patients from controls.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
H. Al Habobe, E. B. Haverkort, K. Nazmi, A. P. Van Splunter, R. H. H. Pieters, F. J. Bikker
Summary: Saliva diagnostics have become popular due to their non-invasive nature and patient-friendly collection process. However, the choice of saliva collection method can affect the measured levels of various biomarkers.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Abdurrahman Coskun, Anna Carobene, Ozlem Demirelce, Michele Mussap, Federica Braga, Ebru Sezer, Aasne Karine Aarsand, Sverre Sandberg, Pilar Fernandez Calle, Jorge Diaz-Garzon, Metincan Erkaya, Cihan Coskun, Esila Nur Erol, Hunkar Dag, Bill Bartlett, Mustafa Serteser, Niels Jonker, Ibrahim Unsal
Summary: In this study, BV estimates for 22 AAs were provided based on a large sample size, and it was found that there are differences in CVI estimates between males and females for most AAs, which has implications for the clinical interpretation and use of AAs.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Valentinus Besin, Farizky Martriano Humardani, Trilis Yulianti, Matthew Justyn
Summary: The study of Parkinson's Disease in Asian populations has revealed the impact of genetic variants on multiple biological pathways and highlighted shared genetic susceptibility with other diseases. These findings emphasize the importance of personalized treatment based on individual genetic profiles.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Simona Ferraro, Sara Benedetti, Savina Mannarino, Santica Marcovina, Elia Mario Biganzoli, Gianvincenzo Zuccotti
Summary: Risk stratification for cardio-vascular disease should be implemented in childhood to promote early prevention strategies, as atherosclerotic lesions can be present even in very young individuals. Evaluating pediatric CV risk factors/clinical conditions and conducting lipid profile and genetic testing can help identify children at risk of future CV events and guide appropriate therapeutic options.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Ahmad Mobed, Bita Abdi, Sajjad Masoumi, Mohammad Mikaeili, Elham Shaterian, Hamed Shaterian, Esmat Sadat Kazemi, Mahdiye Shirafkan
Summary: Reproductive biomarkers play important regulatory roles in women. The discovery and quantification of these biomarkers are clinically significant. Various detection strategies, including nanotechnology-based methods, have been developed. This article provides an in-depth introduction to the latest advances in biosensor and nanosensor research for detecting and quantitatively identifying reproductive biomarkers.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Chengfang Tang, Fang Tang, Yanna Cai, Minyi Tan, Sichi Liu, Ting Xie, Xiang Jiang, Yonglan Huang
Summary: This study proposes an effective method for screening X-ALD and evaluates the performance of newborn screening for X-ALD in Guangzhou. The LC-MS/MS method can accurately identify X-ALD through analysis of C26:0-LPC.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Lan Liu, Jiamin Wang, Xijing Liu, Jing Wang, Lin Chen, Hongmei Zhu, Jingqun Mai, Ting Hu, Shanling Liu
Summary: The 16p11.2 deletion is a common genetic cause of neurodevelopmental disorders, with prenatal and postnatal presentations including vertebral malformations and language impairment. The majority of deletions are de novo and may be associated with MAPK3 and histidine-associated metabolism.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Sneha Venkatesalu, Shanmugapriya Dilliyappan, Avanthika Satish Kumar, Thirunavukkarasu Palaniyandi, Gomathy Baskar, Maddaly Ravi, Asha Sivaji
Summary: Microfluidics is a science and technology that deals with less sample-to-more precision in vitro analysis. It has wide applications in cancer theranostics, enabling precise diagnosis and personalized treatment.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Yuanqin Zhao, Wei Deng, Zhaoyue Wang, Yanxia Wang, Hongyu Zheng, Kun Zhou, Qian Xu, Le Bai, Huiting Liu, Zhong Ren, Zhisheng Jiang
Summary: The cardiovascular system and the central nervous system exhibit a coordinated developmental process during embryonic development. Congenital heart disease (CHD) is the most common congenital disorder, and neurodevelopmental disorders (NDD) are common complications in CHD patients. Both genetic and non-genetic factors contribute to the co-occurrence of CHD and NDD. Further research should focus on identifying common molecular mechanisms underlying this co-occurrence and promoting the research and treatment of developmental disorders related to the cardiovascular and central nervous systems.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Karol Gostomczyk, Ewelina Lukaszewska, Jedrzej Borowczak, Anita Bator, Marek Zdrenka, Magdalena Bodnar, Lukasz Szylberg
Summary: Flow cytometry improves the detection of epithelial cancer cells in peritoneal and pleural fluids compared to conventional cytology. Due to similar speciflcity and higher sensitivity, flow cytometry offers a promising alternative to cytology for patient screening.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Heping Tian, Genghuan Wang, Qi Zhong, Haihang Zhou
Summary: This study found that the decline of serum ITIH4 concentrations during the early phase after aneurysmal subarachnoid hemorrhage (aSAH) was closely related to the severity and poor prognosis of the disease. Serum ITIH4 may represent a promising prognostic biomarker of aSAH.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Xueting Zhu, Yang Yu, Jun Zhang, Yuxia Zhan, Guanghua Luo, Lu Zheng
Summary: This study successfully established a 2D-PCR method for identifying HLA-B*15:02 through a two-tube reaction. This method can distinguish HLA-B*15:02 from 16 highly homologous HLA-B*15 alleles. Among 1830 samples from the clinical general population, 3 HLA-B*15:02 homozygotes and 84 HLA-B*15:02 heterozygotes were detected.
CLINICA CHIMICA ACTA
(2024)