Review
Endocrinology & Metabolism
Isabelle Hue, Encarnacion Capilla, Enrique Rosell-Moll, Sara Balbuena-Pecino, Valentine Goffette, Jean-Charles Gabillard, Isabel Navarro
Summary: Control of tissue metabolism and growth involves interactions between organs, tissues, and cell types, mediated by cytokines or direct communication through cellular exchanges. Many peptides produced by adipose tissue, skeletal muscle and bone have been identified in mammals playing key roles in organ/tissue development and function. Some of them have been identified in fish models, and this review summarizes their characteristics and interactions with different tissues.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Clinical Neurology
Merel van Andel, Natasja M. van Schoor, Nicole C. Korten, Annemieke C. Heijboer, Madeleine L. Drent
Summary: The study revealed significant associations between ghrelin and depressive symptoms in older adults, particularly in younger age groups and those with lower waist-hip ratios. In men, leptin was associated with depressive symptoms, while there was no significant association for high-molecular-weight adiponectin.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Yuying Qiu, Meijuan Li, Yonghui Zhang, Ying Liu, Yongping Zhao, Jing Zhang, Qiong Jia, Jie Li
Summary: Berberine could reduce weight gain in schizophrenia patients, with significant weight loss observed in the berberine group compared to placebo. The effect may be related to the regulation of leptin levels.
ASIAN JOURNAL OF PSYCHIATRY
(2022)
Article
Immunology
Florenzo Iannone, Emanuela Praino, Cinzia Rotondo, Dorotea Natuzzi, Rita Bizzoca, Nunzia Lacarpia, Marco Fornaro, Fabio Cacciapaglia
Summary: The study found that levels of certain adipokines and cytokines were correlated with BMI and specific disease features in systemic sclerosis (SSc) patients. For example, SSc patients with obesity had the highest levels of IL-17A, IL-2, IL-10, leptin, and visfatin, while underweight patients showed the highest levels of TNF-alpha.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2021)
Article
Environmental Sciences
Aina Jansen, Jan O. Aaseth, Jan L. Lyche, Jens P. Berg, Mette H. B. Muller, Stian Lydersen, Per G. Farup
Summary: Bariatric surgery leads to the release of persistent organic pollutants (POPs), which may cause endocrine disruption. This study aimed to explore the associations between POPs and adiponectin, leptin, and ghrelin in subjects undergoing bariatric surgery. The results showed significant increases in adiponectin and all POPs levels after surgery, as well as a decrease in leptin. The main finding was the highly significant associations between adiponectin and all POPs.
Article
Biochemistry & Molecular Biology
Silke Zimmermann, Maria Beatriz Walter Costa, Akash Mathew, Shruthi Krishnan, Jochen G. Schneider, Kirsten Roomp, Berend Isermann, Ronald Biemann
Summary: Bone-derived osteocalcin has been suggested as a metabolic regulator and its increased serum levels following lifestyle-induced weight loss in individuals with metabolic syndrome were primarily associated with reduced inflammation rather than improvements in insulin sensitivity, fat mass, or bone mineral density.
Article
Oncology
Agnes Bocian-Jastrzebska, Anna Malczewska-Herman, Violetta Rosiek, Beata Kos-Kudla
Summary: This study investigated the potential relationship between leptin, adiponectin, and the leptin-adiponectin ratio with the grade, stage, and metastases of PanNENs. It was found that adiponectin concentration was significantly higher in the control group compared to the study group, and both leptin and adiponectin levels were higher in females than males. An increased leptin-adiponectin ratio was observed in well-differentiated PanNENs and PanNENs with low Ki-67. Additionally, lower leptin levels and a decreased leptin-adiponectin ratio were found in PanNENs with distal disease. These findings suggest that leptin, adiponectin, and their ratio may serve as potential biomarkers for the diagnosis, prognosis, and prediction of PanNENs.
Article
Multidisciplinary Sciences
Xixi Chen, Kaiwen Wang, Tao Lu, Jiajia Wang, Ting Zhou, Juan Tian, Bin Zhou, Li Long, Qiao Zhou
Summary: This study investigated the relationship between serum adiponectin level and disease activity in treatment-naive Han Chinese RA patients, finding a negative correlation with DAS28(ESR) and the Sharp score. These results suggest that adiponectin may be useful for assessing disease activity and radiographic progression of RA.
SCIENTIFIC REPORTS
(2022)
Article
Pediatrics
A. P. C. Candido, B. Geloneze, A. Calixto, A. C. J. Vasques, R. N. Freitas, S. N. Freitas, G. L. L. Machado-Coelho
Summary: In children and adolescents, HOMA-AD and HOMA-IR are associated with metabolic risk and are the most suitable methods for screening metabolic syndrome, while adiponectin levels are not as indicative of metabolic risk.
INDIAN JOURNAL OF PEDIATRICS
(2021)
Article
Nutrition & Dietetics
Sara Becerril, Amaia Rodriguez, Victoria Catalan, Beatriz Ramirez, Amaia Mentxaka, Gabriela Neira, Javier Gomez-Ambrosi, Gema Fruhbeck
Summary: Biological sex and aging play a role in obesity development and type 2 diabetes, affecting the secretion of leptin and adiponectin. The Adpn/Lep ratio is proposed as a reliable biomarker for adipose tissue dysfunction. The study found that female mice were more metabolically protected from obesity and its comorbidities than males, with an increased Adpn/Lep ratio in aged females negatively correlated with body weight gain and insulin resistance.
Article
Endocrinology & Metabolism
Junting Weng, Min Chen, Rongjie Guo, Shuzhen Yang, Danjuan Liu, Dexiang Fang
Summary: The study demonstrated that the antihypertensive effect of IRB in SHR rats may be achieved through improving insulin resistance and correcting the LPN-APN imbalance.
Article
Endocrinology & Metabolism
Jessie Nallely Zurita-Cruz, Miguel Angel Villasis-Keever, Leticia Manuel-Apolinar, Leticia Damasio-Santana, Eulalia Garrido-Magana, Aleida de Jesus Rivera-Hernandez
Summary: In girls with central precocious puberty (CPP) undergoing GnRH analogs treatment, leptin levels and higher leptin/adiponectin ratio (LAR) are associated with greater weight gain. This association is particularly evident in girls with BMI < 94th percentile.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Chia-Wen Lu, Kuen-Cheh Yang, Yu-Chiao Chi, Tsan-Yu Wu, Chien-Hsieh Chiang, Hao-Hsiang Chang, Kuo-Chin Huang, Wei-Shiung Yang
Summary: Lean non-alcoholic fatty liver disease (NAFLD) is similar to overweight NAFLD and should be detected early. The adiponectin-leptin ratio (AL ratio) may serve as a reliable marker for early detection of lean NAFLD independent of insulin resistance.
ANNALS OF MEDICINE
(2023)
Article
Medicine, General & Internal
Jean-Eric Tarride, Aristithes G. Doumouras, Dennis Hong, J. Michael Paterson, Semra Tibebu, Francis Nguyen, Richard Perez, Valerie H. Taylor, Feng Xie, Vanessa Boudreau, Eleanor Pullenayegum, David R. Urbach, Mehran Anvari
Summary: This study compared 4-year health care expenditures after RYGB and sleeve gastrectomy, finding no significant differences in all-cause mortality and number of hospital admissions between the two procedures, but more frequent nonelective hospitalizations with RYGB. Patients who underwent RYGB had a lower rate of subsequent bariatric procedures.
Article
Biochemistry & Molecular Biology
Karol Makiel, Agnieszka Suder, Aneta Targosz, Marcin Maciejczyk, Alon Haim
Summary: This study aimed to evaluate the changes in hormone concentrations, insulin-resistance indices, and body composition after two types of training. Results showed that aerobic exercise did not significantly affect ADIPO concentration, but could reduce GYNOID and insulin-resistance indices; while combined aerobic and resistance training improved body composition, decreased waist circumference, and improved insulin-resistance indices.
Article
Endocrinology & Metabolism
Bo-Yeon Kim, Bongseong Kim, Kyungdo Han, Seung Joo Chon, Soon Jib Yoo, Kyoung-Kon Kim
Summary: The presence of pre-pregnancy obesity/central obesity and metabolic syndrome in Korean mothers is associated with an increased risk of insulin use in GDM.
OBESITY RESEARCH & CLINICAL PRACTICE
(2021)
Editorial Material
Primary Health Care
Jungun Lee
KOREAN JOURNAL OF FAMILY MEDICINE
(2021)
Review
Endocrinology & Metabolism
Bo-Yeon Kim, Seon Mee Kang, Jee-Hyun Kang, Seo Young Kang, Kyoung Kon Kim, Kyoung-Bae Kim, Bomtaeck Kim, Seung Jun Kim, Yang-Hyun Kim, Jung-Hwan Kim, Jae Hyun Kim, Eun Mi Kim, Ga Eun Nam, Ji Yeon Park, Jang Won Son, Yun-A Shin, Hye-Jung Shin, Tae Jung Oh, Hyug Lee, Eon-Ju Jeon, Sochung Chung, Yong Hee Hong, Chong Hwa Kim
Summary: Obesity is on the rise in Korea, with abdominal obesity being a common issue. Treatment and management of obesity are evolving based on new clinical evidence, as summarized in the 2020 Korean Society for the Study of Obesity Guideline.
JOURNAL OF OBESITY & METABOLIC SYNDROME
(2021)
Article
Health Care Sciences & Services
Sang Woo Oh, Kyoung-Kon Kim, Sung Soo Kim, Su Kyung Park, Sangshin Park
Summary: This pilot study evaluated the effects of an integrative mHealth approach on obesity, hypertension, and type 2 diabetes. The results showed that mHealth apps had an impact on body fat and blood glucose levels, but did not demonstrate clinical improvement.
JMIR MHEALTH AND UHEALTH
(2022)
Article
Endocrinology & Metabolism
Seung Joon Choi, Seong Min Kim, Yun Soo Kim, Oh Sang Kwon, Seung Kak Shin, Kyoung Kon Kim, Kiyoung Lee, Ie Byung Park, Cheol Soo Choi, Dong Hae Chung, Jaehun Jung, MunYoung Paek, Dae Ho Lee
Summary: The study found that MRI-PDFF correlates better with hepatic fat than TE-CAP, and that MRE shows stronger correlations with various pathophysiologic parameters and fibrosis scores. MRI-based assessment is identified as the best non-invasive tool for evaluating NAFLD.
DIABETES & METABOLISM JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Aron Park, Seung Joon Choi, Sungjin Park, Seong Min Kim, Hye Eun Lee, Minjae Joo, Kyoung Kon Kim, Doojin Kim, Dong Hae Chung, Jae Been Im, Jaehun Jung, Seung Kak Shin, Byung-Chul Oh, Cheolsoo Choi, Seungyoon Nam, Dae Ho Lee
Summary: Through computational secretome analyses, we identified a blood biomarker AKR1B10 that reflects the progression of nonalcoholic fatty liver disease (NAFLD). Plasma AKR1B10 has a good diagnostic accuracy for nonalcoholic steatohepatitis (NASH) and fibrosis, and it can be further improved when combined with C3. Plasma AKR1B10 is also a specific biomarker for NAFLD progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
Jong Han Choi, Yoon Jeong Cho, Hyun-Jin Kim, Seung-Hyun Ko, Suk Chon, Jee-Hyun Kang, Kyoung-Kon Kim, Eun Mi Kim, Hyun Jung Kim, Kee-Ho Song, Ga Eun Nam, Kwang Il Kim
Summary: Carbohydrate-restricted diets and intermittent fasting have gained interest among the general population and patients with cardiometabolic disease. This study evaluated the scientific evidence and made responsible recommendations, suggesting moderately-low carbohydrate or low carbohydrate diet for weight reduction and improving glycemic control in overweight or obese adults and adults with type 2 diabetes, while recommending against very-low carbohydrate diet and intermittent fasting in patients with diabetes.
DIABETES & METABOLISM JOURNAL
(2022)
Editorial Material
Primary Health Care
Jungun Lee
KOREAN JOURNAL OF FAMILY MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Moongi Ji, Yunju Jo, Seung Joon Choi, Seong Min Kim, Kyoung Kon Kim, Byung-Chul Oh, Dongryeol Ryu, Man-Jeong Paik, Dae Ho Lee
Summary: Machine learning-based targeted metabolomics analysis identified metabolites that distinguish the progression of nonalcoholic fatty liver disease (NAFLD). An equation called MetaNASH score was formulated using three metabolites to effectively discriminate nonalcoholic steatohepatitis (NASH).
Review
Endocrinology & Metabolism
Jong Han Choi, Yoon Jeong Cho, Hyun-Jin Kim, Seung-Hyun Ko, Suk Chon, Jee-Hyun Kang, Kyoung-Kon Kim, Eun Mi Kim, Hyun Jung Kim, Kee-Ho Song, Ga Eun Nam, Kwang Il Kim
Summary: Carbohydrate-restricted diets and intermittent fasting have gained interest as dietary regimens for weight reduction and glycemic control in overweight, obese, and diabetic adults. However, very-low carbohydrate diets and intermittent fasting are not recommended for patients with diabetes. Limited evidence exists for these dietary regimens in patients with hypertension.
JOURNAL OF OBESITY & METABOLIC SYNDROME
(2022)
Article
Medicine, General & Internal
Yoon Jeong Cho, Kyoung-Kon Kim
Summary: The prevalence of obesity in Korea is rapidly increasing, and more effective treatment tools are needed. Currently approved drugs for obesity treatment include appetite suppressants, dietary fat absorption inhibitors, GLP-1 receptor agonists, and fixed-dose combination drugs. However, these drugs have limited weight reduction effects. Newly developed agents such as semaglutide and tirzepatide show promise in being more effective, but may cause gastrointestinal adverse events.
JOURNAL OF THE KOREAN MEDICAL ASSOCIATION
(2022)
Article
Environmental Sciences
Ji-Hee Haam, Yang-Im Hur, Young-Sang Kim, Kyoung-Kon Kim, Jee-Hyun Kang, Hae-Jin Ko, Yoon Jeong Cho, Hye-In Choi, Kyu Rae Lee, Jung Ha Park, Soo Hyun Cho, Jong-Koo Kim, Taesic Lee, Myung-Jae Seo, Yeong Sook Yoon, Yoobin Seo, Ga Eun Nam, Sun Hyun Kim
Summary: The study found that the South Korean government's systematic social distancing measures may have an impact on the changes in fatty liver for individuals who regularly consume alcohol, particularly during the transition period. Fatty liver development and aggravation were more prominent during the transition period, and abnormal alanine transaminase levels were more common in men during this time.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Editorial Material
Primary Health Care
Jungun Lee
KOREAN JOURNAL OF FAMILY MEDICINE
(2022)
Review
Peripheral Vascular Disease
Jong Han Choi, Yoon Jeong Cho, Hyun-Jin Kim, Seung-Hyun Ko, Suk Chon, Jee-Hyun Kang, Kyoung-Kon Kim, Eun Mi Kim, Hyun Jung Kim, Kee-Ho Song, Ga Eun Nam, Kwang Il Kim
Summary: This study evaluated the benefits and harms of carbohydrate-restricted diets and intermittent fasting (IF) and provided recommendations based on scientific evidence. Moderate-low carbohydrate or low carbohydrate diets were suggested for weight reduction in adults with overweight or obesity. In adults with type 2 diabetes, moderate-low carbohydrate diets were recommended for improving glycemic control and reducing body weight. Very-low carbohydrate diets and IF were not recommended for patients with diabetes. No specific recommendations were given for very-low carbohydrate diets and IF in adults with overweight or obesity and carbohydrate-restricted diets and IF in patients with hypertension.
CLINICAL HYPERTENSION
(2022)
Article
Primary Health Care
Kyung Hyun Bae, Yong Ho Jo, Dong Ryul Lee, Jungun Lee
Summary: The study showed that decreased handgrip strength was associated with increased all-cause mortality among older adults. Different trajectory groups of handgrip strength were identified for men and women. Compared to the highest handgrip strength group, lower handgrip strength groups had higher adjusted hazard ratios for all-cause mortality.
KOREAN JOURNAL OF FAMILY MEDICINE
(2021)
Article
Medical Laboratory Technology
Jiansheng Lin, Weihua Lin, Yiming Lin, Weilin Peng, Zhenzhu Zheng
Summary: This study retrospectively analyzed the cases of Chinese infants with NICCD and identified multiple genetic mutations. The study also found comorbidity of NICCD and other inborn errors of metabolism in some patients.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Lihua Guan, Wei Su, Jian Zhong, Ling Qiu
Summary: Multiple myeloma is characterized by excessive production of monoclonal immunoglobulins. Routine screening methods are insufficient for detecting low levels of M proteins, but advances in mass spectrometry enable reliable detection of low abundance serum biomarkers for minimal residual disease assessment in multiple myeloma.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Liya Zhu, Chao Zhu, Jialie Jin, Jinxin Wang, Xiaojing Zhao, Rongxi Yang
Summary: This study found an association between blood-based ITGB2 methylation and coronary heart disease (CHD), with hypomethylation of ITGB2 being a risk factor for CHD. Additionally, the combination of ITGB2 methylation and conventional CHD risk factors could efficiently discriminate CHD patients from controls.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
H. Al Habobe, E. B. Haverkort, K. Nazmi, A. P. Van Splunter, R. H. H. Pieters, F. J. Bikker
Summary: Saliva diagnostics have become popular due to their non-invasive nature and patient-friendly collection process. However, the choice of saliva collection method can affect the measured levels of various biomarkers.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Abdurrahman Coskun, Anna Carobene, Ozlem Demirelce, Michele Mussap, Federica Braga, Ebru Sezer, Aasne Karine Aarsand, Sverre Sandberg, Pilar Fernandez Calle, Jorge Diaz-Garzon, Metincan Erkaya, Cihan Coskun, Esila Nur Erol, Hunkar Dag, Bill Bartlett, Mustafa Serteser, Niels Jonker, Ibrahim Unsal
Summary: In this study, BV estimates for 22 AAs were provided based on a large sample size, and it was found that there are differences in CVI estimates between males and females for most AAs, which has implications for the clinical interpretation and use of AAs.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Valentinus Besin, Farizky Martriano Humardani, Trilis Yulianti, Matthew Justyn
Summary: The study of Parkinson's Disease in Asian populations has revealed the impact of genetic variants on multiple biological pathways and highlighted shared genetic susceptibility with other diseases. These findings emphasize the importance of personalized treatment based on individual genetic profiles.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Simona Ferraro, Sara Benedetti, Savina Mannarino, Santica Marcovina, Elia Mario Biganzoli, Gianvincenzo Zuccotti
Summary: Risk stratification for cardio-vascular disease should be implemented in childhood to promote early prevention strategies, as atherosclerotic lesions can be present even in very young individuals. Evaluating pediatric CV risk factors/clinical conditions and conducting lipid profile and genetic testing can help identify children at risk of future CV events and guide appropriate therapeutic options.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Ahmad Mobed, Bita Abdi, Sajjad Masoumi, Mohammad Mikaeili, Elham Shaterian, Hamed Shaterian, Esmat Sadat Kazemi, Mahdiye Shirafkan
Summary: Reproductive biomarkers play important regulatory roles in women. The discovery and quantification of these biomarkers are clinically significant. Various detection strategies, including nanotechnology-based methods, have been developed. This article provides an in-depth introduction to the latest advances in biosensor and nanosensor research for detecting and quantitatively identifying reproductive biomarkers.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Chengfang Tang, Fang Tang, Yanna Cai, Minyi Tan, Sichi Liu, Ting Xie, Xiang Jiang, Yonglan Huang
Summary: This study proposes an effective method for screening X-ALD and evaluates the performance of newborn screening for X-ALD in Guangzhou. The LC-MS/MS method can accurately identify X-ALD through analysis of C26:0-LPC.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Lan Liu, Jiamin Wang, Xijing Liu, Jing Wang, Lin Chen, Hongmei Zhu, Jingqun Mai, Ting Hu, Shanling Liu
Summary: The 16p11.2 deletion is a common genetic cause of neurodevelopmental disorders, with prenatal and postnatal presentations including vertebral malformations and language impairment. The majority of deletions are de novo and may be associated with MAPK3 and histidine-associated metabolism.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Sneha Venkatesalu, Shanmugapriya Dilliyappan, Avanthika Satish Kumar, Thirunavukkarasu Palaniyandi, Gomathy Baskar, Maddaly Ravi, Asha Sivaji
Summary: Microfluidics is a science and technology that deals with less sample-to-more precision in vitro analysis. It has wide applications in cancer theranostics, enabling precise diagnosis and personalized treatment.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Yuanqin Zhao, Wei Deng, Zhaoyue Wang, Yanxia Wang, Hongyu Zheng, Kun Zhou, Qian Xu, Le Bai, Huiting Liu, Zhong Ren, Zhisheng Jiang
Summary: The cardiovascular system and the central nervous system exhibit a coordinated developmental process during embryonic development. Congenital heart disease (CHD) is the most common congenital disorder, and neurodevelopmental disorders (NDD) are common complications in CHD patients. Both genetic and non-genetic factors contribute to the co-occurrence of CHD and NDD. Further research should focus on identifying common molecular mechanisms underlying this co-occurrence and promoting the research and treatment of developmental disorders related to the cardiovascular and central nervous systems.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Karol Gostomczyk, Ewelina Lukaszewska, Jedrzej Borowczak, Anita Bator, Marek Zdrenka, Magdalena Bodnar, Lukasz Szylberg
Summary: Flow cytometry improves the detection of epithelial cancer cells in peritoneal and pleural fluids compared to conventional cytology. Due to similar speciflcity and higher sensitivity, flow cytometry offers a promising alternative to cytology for patient screening.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Heping Tian, Genghuan Wang, Qi Zhong, Haihang Zhou
Summary: This study found that the decline of serum ITIH4 concentrations during the early phase after aneurysmal subarachnoid hemorrhage (aSAH) was closely related to the severity and poor prognosis of the disease. Serum ITIH4 may represent a promising prognostic biomarker of aSAH.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Xueting Zhu, Yang Yu, Jun Zhang, Yuxia Zhan, Guanghua Luo, Lu Zheng
Summary: This study successfully established a 2D-PCR method for identifying HLA-B*15:02 through a two-tube reaction. This method can distinguish HLA-B*15:02 from 16 highly homologous HLA-B*15 alleles. Among 1830 samples from the clinical general population, 3 HLA-B*15:02 homozygotes and 84 HLA-B*15:02 heterozygotes were detected.
CLINICA CHIMICA ACTA
(2024)