Article
Pharmacology & Pharmacy
Wei Leik Ng, Kheng Seang Lim, Vidhya Hariraj, Sing Chet Lee, Wee Kee Wo, Azuana Ramli, Pauline Siew Mei Lai, Si Lei Fong, Jing Ran Lim
Summary: This study aimed to determine the incidence of allopurinol-induced severe cutaneous adverse drug reactions (SCAR) in Malaysia. The retrospective analysis revealed an average incidence of 2.5 cases per 1000 new users over the 5-year period, with a decreasing trend. Stevens-Johnson syndrome was the most common type of allopurinol-induced SCAR reported. Among the three main ethnicities in Malaysia, the Chinese had the highest percentage of allopurinol-induced SCAR.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Dermatology
C-B Chen, Y-E Chen, M-T Chu, C-W Wang, R. C-Y Hui, C-W Lu, Y-P Hsiao, C-Y Chu, M. M. Chang, C. M-T Cheung, C-Y Cheng, Y-W Wang, Y-J Lin, C-J Chang, S- Hung, W-H Chung
Summary: Research in Taiwan and Hong Kong focused on characterizing patients with AOA-SCAR, investigating the HLA association, and examining the utility of in vitro diagnostic methods. The study identified strontium ranelate as the most common causality of AOA-SCAR in Asian populations, with HLA-A*33:03 genetic allele being significantly associated with SR-SJS. The sensitivity of lymphocyte activation test (LAT) for identifying the culprit drug of SR-SJS was 83.3%.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Article
Multidisciplinary Sciences
Menglin Jiang, Jin Yang, Linlin Yang, Lina Wang, Ting Wang, Shengna Han, Ye Cheng, Zihua Chen, Yu Su, Lirong Zhang, Fanping Yang, Sheng-an Chen, Jin Zhang, Hao Xiong, Lanting Wang, Zhen Zhang, Li Ma, Xiaoqun Luo, Qinghe Xing
Summary: An association study was conducted to investigate the relationship between human leukocyte antigen (HLA) alleles and levofloxacin-induced severe cutaneous adverse drug reactions (LEV-SCARs). The study found that the carrier frequencies of HLA-B*13:01, HLA-B*13:02, and serotype B13 were significantly higher in patients with LEV-SCARs compared to levofloxacin-tolerant individuals. Molecular docking analysis and mass spectrometry provided insights into the binding and structural changes between levofloxacin and HLA-B*13:01/HLA-B*13:02. Prospective screening for serotype B13 and alternative drug treatment for carriers may reduce the incidence of LEV-SCARs.
Article
Dermatology
Christina Sze-Man Wong, Chi-Keung Yeung, Chun-Yin Chan, Desmond Yat-Hin Yap, Sydney Chi-Wai Tang, Bernard Man-Yung Cheung, Janette Siu-Yin Kwok, Henry Hin-Lee Chan
Summary: Pre-treatment HLA-B*58:01 screening in Chinese CKD patients can effectively prevent allopurinol-induced severe cutaneous adverse reactions, with cost-effectiveness.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2022)
Article
Health Care Sciences & Services
Lin Cheng, Bao Sun, Yan Xiong, Lei Hu, Lichen Gao, Ji Li, Hongfu Xie, Xiaoping Chen, Wei Zhang, Hong-Hao Zhou
Summary: This study analyzed the DNA methylation profiling in severe cutaneous adverse reactions (SCARs) induced by allopurinol, and found that this methylation profile is associated with autophagy and microRNAs (miRNAs). The turquoise and yellow modules on the chromosomes were found to be correlated with allopurinol hypersensitivity.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Medicine, Research & Experimental
Tsugumichi Sato, Ching-Lan Cheng, Heung-Woo Park, Yea-Huei Kao Yang, Min-Suk Yang, Mizuki Fujita, Yuji Kumagai, Masahiro Tohkin, Yoshiro Saito, Kimie Sai
Summary: This study revealed population differences in the incidence of allopurinol-related severe cutaneous adverse reactions among East Asians, with Taiwan having the highest incidence and Japan the lowest. The differences were influenced by genetic and other common risk factors, indicating the importance of appropriate risk management based on ethnic origins.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2021)
Article
Pharmacology & Pharmacy
Dinh van Nguyen, Hieu Chi Chu, Christopher Vidal, Richard B. Fulton, Nguyet Nhu Nguyen, Nga Thi Quynh, Tu Linh Tran, Thuy Ninh Nguyen, Ha Thi Thu Nguyen, Hanh Hong Chu, Huyen Thi Thanh Thuc, Huong Thi Minh Le, Sheryl van Nunen, Janet Anderson, Suran L. Fernando
Summary: The study found that HLA-B*58:01 and HLA-B*15:02 are associated with allopurinol-induced SCARs and CBZ-induced SJS/TEN in Vietnamese, with rs9263726 serving as a surrogate marker for HLA-B*58:01. HLA-A*31:01 was not associated with CBZ-induced SCARs.
Article
Pharmacology & Pharmacy
Tran Thu Ha Pham, Binh Tran Quang, Chi Hieu Chu, Thi Quynh Nga Do, Hoang Anh Nguyen, Dinh Van Nguyen, Thanh Huong Phung
Summary: This study revealed a strong association between HLA-B*58:01, HLA-C*03:02 and allopurinol-induced severe cutaneous adverse reactions in Vietnamese patients, especially in those with impaired renal function. The testing of HLA-B*58:01 and HLA-C*03:02 can serve as important indicators for preventing severe cutaneous adverse reactions.
Article
Medical Informatics
Sing Chet Lee, Wee Kee Wo, Hee Sheong Yeoh, Norleen Mohamed Ali, Vidhya Hariraj
Summary: The Malaysian pharmacovigilance data indicate that predictors of allopurinol-induced severe cutaneous adverse drug reactions (SCARs) include elderly females, patients with underlying renal disease, and high allopurinol doses. These patients require close monitoring and should be educated to discontinue allopurinol at the first signs of rash.
THERAPEUTIC INNOVATION & REGULATORY SCIENCE
(2021)
Article
Allergy
F. Hali, H. Chagraoui, A. Meftah, F. Marnissi, S. Chaabi, S. Chiheb, H. Filali
Summary: This study retrospectively reviewed patients hospitalized for severe cutaneous adverse reactions (SCARs) induced by allopurinol from 2011 to 2021. The study identified 31 cases and found that allopurinol was mostly prescribed for asymptomatic hyperuricemia. It highlights the misuse of allopurinol and the need to raise awareness among physicians about its potential risks.
REVUE FRANCAISE D ALLERGOLOGIE
(2023)
Article
Allergy
Chuang-Wei Wang, Wichittra Tassaneeyakul, Chun-Bing Chen, Wei-Ti Chen, Yu-Chuan Teng, Cheng-Yang Huang, Chonlaphat Sukasem, Chun-Wei Lu, Yun-Shien Lee, Siew-Eng Choon, Nontaya Nakkam, Rosaline Chung-Yee Hui, Yen-Hua Huang, Ya-Ching Chang, Yang Yu-Wei Lin, Chee-Jen Chang, Tsu-Man Chiu, Wasun Chantratita, Parinya Konyoung, Chaw-Ning Lee, Jettanong Klaewsongkram, Ticha Rerkpattanapipat, Warayuwadee Amornpinyo, Niwat Saksit, Pawinee Rerknimitr, Yu Huei Huang, Shang-Hung Lin, Chao-Kai Hsu, Cheng-Chi Chan, Yu- Lin, Shuen-Iu Hung, Wen-Hung Chung
Summary: The study identified HLA-B*13:01 as an important genetic factor associated with co-trimoxazole-induced severe cutaneous adverse reactions (SCAR) in Asians.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Dermatology
C-B Chen, Y-E Chen, M-T Chu, C-W Wang, R. C-Y Hui, C-W Lu, Y-P Hsiao, C-Y Chu, M. M. Chang, C. M-T Cheung, C-Y Cheng, Y-W Wang, Y-J Lin, C-J Chang, S- Hung, W-H Chung
Summary: Research in Taiwan and Hong Kong focused on characterizing patients with AOA-SCAR, investigating the HLA association, and examining the utility of in vitro diagnostic methods. The study identified strontium ranelate as the most common causality of AOA-SCAR in Asian populations, with HLA-A*33:03 genetic allele being significantly associated with SR-SJS. The sensitivity of lymphocyte activation test (LAT) for identifying the culprit drug of SR-SJS was 83.3%.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Article
Allergy
Chun-Bing Chen, Kang-Ling Kuo, Chuang-Wei Wang, Chun-Wei Lu, Rosaline Chung-Yee Hui, Kun-Lin Lu, Wan-Chun Chang, Wei-Ti Chen, Fu Yun, Yu-Chuan Teng, Hua-En Lee, Jing-Yi Lin, Hsin-Chun Ho, Min-Hui Chi, Yang Yu-Wei Lin, Chee Jen Chang, Yu Lin, Cheng-Lung Ku, Shuen-Iu Hung, Ya-Ching Chang, Wen-Hung Chung
Summary: This study demonstrates that blister fluid levels of granulysin can help differentiate between SJS/TEN or similar CTL-mediated bullous reactions and other autoimmune bullous disorders. Patients with CTL-mediated diseases had significantly higher granulysin levels in blister fluids compared to non-CTL-mediated bullous disorders, and blister granulysin levels correlated with the clinical severity of SJS/TEN.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Dermatology
Mu-Tzu Chu, Chuang-Wei Wang, Wan-Chun Chang, Chun-Bing Chen, Wen-Hung Chung, Shuen-Iu Hung
Summary: The study highlights the effectiveness of granulysin-based lymphocyte activation tests in identifying aromatic antiepileptic drugs (AEDs) as culprits for severe cutaneous adverse reactions, assisting in confirming drug causality and preventing adverse drug reactions.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Review
Immunology
Yun-Shiuan Olivia Hsu, Kun-Lin Lu, Yun Fu, Chuang-Wei Wang, Chun-Wei Lu, Yu-Fen Lin, Wen-Cheng Chang, Kun-Yun Yeh, Shuen-Iu Hung, Wen-Hung Chung, Chun-Bing Chen
Summary: The immunomodulatory effects of regulatory T cells and co-signaling receptors are important in balancing immunogenic and immunotolerant responses, which may be disrupted in autoimmune and infectious diseases. Drug hypersensitivity has a wide range of manifestations, from mild to severe, and recent studies suggest that insufficient regulation by Tregs may play a role in severe hypersensitivity reactions.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biology
Wei-Ting Hung, Yi-Ming Chen, Shuen-Iu Hung, Hsin-Hua Chen, Ning-Rong Gung, Chia-Wei Hsieh, Kuo-Tung Tang, Der-Yuan Chen
Summary: A study found that the SNP rs11672725 of the CARD8 gene is significantly associated with AOSD susceptibility, with patients carrying the CC genotype and C allele having lower CARD8 levels and being predisposed to a systemic pattern of disease outcome with elevated inflammasome signaling expression.
Article
Allergy
Chih-Yung Chiu, Gigin Lin, Chia-Jung Wang, Shuen-Iu Hung, Wen-Hung Chung
Summary: This study identified a correlation between metabolomic profiles in AD patients with FLG mutations and allergic responses, revealing metabolic pathways associated with AD such as nitrogen and amino acid metabolism, microbe-related methane and propanoate metabolism. FLG mutations were positively correlated with total serum IgE levels, with microbial-derived metabolites like dimethylamine and isopropanol strongly associated with methane and propanoate metabolism in AD.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Article
Genetics & Heredity
Wei-Ting Hung, Shuen-Iu Hung, Yi-Ming Chen, Chia-Wei Hsieh, Hsin-Hua Chen, Kuo-Tung Tang, Der-Yuan Chen, Tsuo-Hung Lan
Summary: The study found that the AA/CC/TT haplotype of ATG16L1 was not significantly associated with susceptibility to AOSD, but patients carrying this haplotype had lower mRNA expression levels of LC3-II, reflecting lower autophagosome formation. Additionally, patients carrying the AA/CC/TT haplotype had a significantly higher proportion of skin rash and a lower proportion of arthritis, which was significantly associated with the systemic pattern of AOSD.
Review
Pharmacology & Pharmacy
Shih-Cheng Pao, Mu-Tzu Chu, Shuen-Iu Hung
Summary: Cancer immunotherapy has become indispensable in cancer treatment, with a focus on targeting tumor-specific antigens or neoantigens. Advanced technologies have allowed for the identification and application of neoantigens in cancer vaccines. Therapeutic vaccines have shown success in activating the immune system to kill cancer cells.
Review
Biochemistry & Molecular Biology
Shuen-Iu Hung, Ivan Arni C. Preclaro, Wen-Hung Chung, Chuang-Wei Wang
Summary: As the world deals with the COVID-19 pandemic, vaccination remains crucial. However, vaccine hesitancy is partly caused by immediate hypersensitivity reactions induced by COVID-19 vaccines. Various strategies have been suggested to prevent hypersensitivity reactions.
Article
Dermatology
Chun-Wei Lu, Jong-Hwei Su Pang, Yu-Shien Ko, Chih-Jung Chang, Chuang-Wei Wang, Wei-Ti Chen, Chun-Bing Chen, Rosaline Chung-yee Hui, Shuen-Iu Hung, Lai-Ying Lu, Kun Lin Lu, Chih-Liang Wang, Chiao-En Wu, Ping-Chih Hsu, Yueh-Fu Fang, Shih-Hong Li, How-Wen Ko, Li-Chuan Tseng, Feng-Ya Shih, Mei-Jun Chen, Wen-Hung Chung
Summary: This study investigated the role of zinc deficiency in EGFR-TKI-induced skin toxicities and found that zinc supplementation can ameliorate skin impairment following EGFR-TKI therapy.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Correction
Biotechnology & Applied Microbiology
Chih-Hung Chiang, Ching-Chih Chang, Hui-Chun Huang, Yi-Jen Chen, Ping-Hsing Tsai, Shaw-Yeu Jeng, Shuen-Iu Hung, Jung-Hung Hsieh, Hsu-Shan Huang, Shih-Hwa Chiou, Fa-Yauh Lee, Shou-Dong Lee
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Immunology
Chuang-Wei Wang, Ming-Ying Wu, Chun-Bing Chen, Wei-Chen Lin, Jennifer Wu, Chun-Wei Lu, Wei-Ti Chen, Fang-Ying Wang, Rosaline Chung-Yee Hui, Min-Hui Chi, Tsu-Man Chiu, Ya-Ching Chang, Jing Yi Lin, Yang Yu-Wei Lin, Wan-Ting Tsai, Shuen-Iu Hung, Wen-Hung Chung
Summary: This study found that immune-mediated alopecia can occur following COVID-19 vaccinations, and it is associated with T cell-mediated cytotoxicity.
CLINICAL IMMUNOLOGY
(2023)
Article
Oncology
Wen-Kuan Huang, Hung-Chih Hsu, Tsai-Sheng Yang, Chun-Wei Lu, Yi-Ru Pan, Chiao-En Wu, Wen-Hung Chung, Shuen-Iu Hung, Chun-Nan Yeh
Summary: This study investigated the impact of zinc supplementation on the severity of regorafenib-induced HFSR. The results have important clinical implications for the management and prevention of HFSR.
EUROPEAN JOURNAL OF CANCER
(2023)
Correction
Dermatology
Wan-Chun Chang, Riichiro Abe, Paul Anderson, Wanpen Anderson, Michael R. Ardern-Jones, Thomas M. Beachkofsky, Teresa Bellon, Agnieszka K. Biala, Charles Bouchard, Gianpiero L. Cavalleri, Nicole Chapman, James Chodosh, Hyon K. Choi, Ricardo R. Cibotti, Sherrie J. Divito, Karen Dewar, Ulrike Dehaeck, Mahyar Etminan, Diane Forbes, Esther Fuchs, Jennifer L. Goldman, James H. Holmes, Elyse A. Hope, Shuen-Iu Hung, Chia-Ling Hsieh, Alfonso Iovieno, Julienne Jagdeo, Mee Kum Kim, David M. Koelle, Mario E. Lacouture, Sophie Le Pallec, Rannakoe J. Lehloenya, Robyn Lim, Angie Lowe, Jean McCawley, Julie McCawley, Robert G. Micheletti, Maja Mockenhaupt, Katie Niemeyer, Michael A. Norcross, Douglas Oboh, Cristina Olteanu, Helena B. Pasieka, Jonathan Peter, Munir Pirmohamed, Michael Rieder, Hajirah N. Saeed, Neil H. Shear, Christine Shieh, Sabine Straus, Chonlaphat Sukasem, Cynthia Sung, Jason A. Trubiano, Sheng-Ying Tsou, Mayumi Ueta, Simona Volpi, Chen Wan, Hongsheng Wang, Zhao-Qing Wang, Jessica Weintraub, Cindy Whale, Lisa M. Wheatley, Sonia Whyte-Croasdaile, Kristina B. Williams, Galen Wright, Sonia N. Yeung, Li Zhou, Wen-Hung Chung, Elizabeth J. Phillips, Bruce C. Carleton
JOURNAL OF DERMATOLOGICAL SCIENCE
(2021)